Mammalian Microsporidiosis

Veterinary Pathology

Volumn 37, Issue 2, 2000, Pages 113-128

  Wasson, K ^a,b   Peper, R L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Animal model; Encephalitozoon cuniculi; Encephalitozoon hellem; Encephalitozoon intestinalis; Enterocytozoon bieneusi; HIV; Microspora; Opportunistic pathogens; Review

Indexed keywords

ANIMALIA; AVES; CANIDAE; CANIS FAMILIARIS; CANIS LUPUS; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOON HELLEM; ENCEPHALITOZOON INTESTINALIS; ENTEROCYTOZOON BIENEUSI; HEXAPODA; INVERTEBRATA; MAMMALIA; MICROSPORIDIA; ORYCTOLAGUS CUNICULUS; PROTOZOA; RODENTIA; VERTEBRATA;

AIDS RELATED COMPLEX; ANIMAL; ANIMAL DISEASE; CEREBELLUM; DISEASE MODEL; DOG; ELECTRON MICROSCOPY; ENCEPHALITOZOON CUNICULI; FOX; GUINEA PIG; HAPLORHINI; HUMAN; INTESTINE; MOUSE; PARASITOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTOZOAL INFECTION; RABBIT; REVIEW; ULTRASTRUCTURE;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANIMALS; CEREBELLUM; DISEASE MODELS, ANIMAL; DOGS; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOONOSIS; FOXES; GUINEA PIGS; HAPLORHINI; HUMANS; INTESTINES; MICE; MICROSCOPY, ELECTRON; RABBITS;

EID: 0034145520     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.37-2-113     Document Type: Article

References (154)

1. Achbarou A, Ombrouck C, Gneragbe T, Charlotte F, Renia L, Desportes-Livage I, Mazier D: Experimental model for human intestinal microsporidiosis in interferon gamma receptor knockout mice infected by Encephalitozoon intestinalis. Parasit Immunol 18:387-392, 1996
2. Albrecht H, Sobottka I: Enterocytozoon bieneusi infection in patients who are not infected with human immunodeficiency virus. Clin Infect Dis 25:344, 1997
3. Amao H, Komukai Y, Sugiyama M, Takahashi KW, Sawada T, Saito M: Natural habitats of Corynebacterium kutscheri in subclinically infected ICGN and DBA/2 strains of mice. Lab Anim Sci 45:6-10, 1995
4. Anvik JO: Clinical considerations of canine herpesvirus infection. Vet Med 86:394-403, 1991
5. Arison RN. Cassaro JA, Pruss MP: Studies on a murine ascites-producing agent and its effect on tumor development. Cancer 26:1915-1920, 1966
6. Bagley RS: Intracranial disease. Vet Clin North Am Small Anim Pract 26:667-980, 1996
7. Baskin G: Encephalitozoon cuniculi infection, squirrel monkey. In: Nonhuman Primates II, ed. Jones TC, Mohr U, and Hunt RD, pp. 193-196. Springer-Verlag, Berlin, Germany, 1993
8. Basson PA, McCully RM, Warnes WEJ: Nosematosis: report of a canine case in the Republic of South Africa. J S Afr Vet Med Assoc 37:3-9, 1966
9. Behm CA: The role of trehalose in the physiology of nematodes. Int J Parasitol 27:215-229, 1997
10. Bergquist NR, Stintzing G, Smedman L, Waller T, Andersson T: Diagnosis of encephalitozoonosis in man by serological tests. Br Med J 288:902, 1984
11. Biderre C, Pages M, Metenier G, Canning EU, Vivares CP: Evidence for the smallest nuclear genome (2.9 Mb) in the microsporidium Encephalitozoon cuniculi. Mol Biochem Parasitol 74:229-231, 1995
12. Black SS, Steinohrt LA, Bertucci DC, Rogers LB, Didier ES: Encephalitozoon hellem in budgerigars (Melopsittacus undulatus). Vet Pathol 34:189-198, 1997
13. Boot R, van Knapen F, Kruijt BC, Walvoort HC: Serological evidence for Encephalitozoon cuniculi infection (nosemiasis) in gnotobiotic guinea pigs. Lab Anim 22:337-342, 1988
14. Bornay-Llinares F, da Silva A, Moura H, Schwartz DA, Visvesvara GS, Pieniazek NJ, Cruz-Lopez A, Hernandez-Jauregui P, Guerrero J, Enriquez FJ: Immunologic, microscopic and molecular evidence of Encephalitozoon intestinalis (Septata intestinalis) infection in mammals other than humans. J Infect Dis 178:820-826, 1998
15. Bryan RT: Microsporidiosis as an AIDS-related opportunistic infection. Clin Infect Dis 21:S62-S65, 1995
16. Bryan RT, Schwartz DA: Epidemiology of microsporidiosis. In: The Microsporidia and Microsporidiosis, ed. Wittner M, pp. 502-516. ASM Press, Herdon, VA, 1999
17. Bull CG: The pathologic effects of streptococci from cases of poliomyelitis and other sources. J Exp Med 25:557-580, 1917
18. Cali A, Kolter DP, Orenstein JM: Septata intestinalis n. g., n. sp., an intestinal microsporidian associated with chronic diarrhea and dissemination in AIDS patients. J Eukaryot Microbiol 40:101-112, 1993
19. Cali A, Owen RL: Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. J Protozool 37:145-155, 1990
20. Candy DJ, Becker A, Wegener G: Coordination and integration of metabolism in insect flight. Comp Biochem Physiol 117:497-512, 1997
21. Canning EU, Lom J: The Microsporidia of Vertebrates. Harcourt Brace Jovanovich, New York, NY, 1986
22. Chalifoux LV, MacKey J, Carville A, Shvetz D, Lin KC, Lackner A, Mansfield KG: Ultrastructural morphology of Enterocytozoon bieneusi in biliary epithelium of rhesus macaques (Macaca mulatto). Vet Pathol 35:292-296, 1998
23. Chioralia G, Trammer T, Kampen H, Seitz HM: Relevant criteria for detecting microsporidia in stool specimens. J Clin Microbiol 36:2279-2283, 1998
24. Chupp GL, Alroy J, Adelman LS, Breen JC, Skolnik PR: Myositis due to Pleistophora (Microsporidia) in a patient with AIDS. Clin Infect Dis 16:15-21, 1993
25. Cox JC, Gallichio HA: Serological and histological studies on adult rabbits with recent, naturally acquired encephalitozoonosis. Res Vet Sci 24:260-261, 1978
26. Cox JC, Gallichio HA, Pye D, Walden NB: Application of immunofluorescence to the establishment of an Encephalitozoon cuniculi-free rabbit colony. Lab Anim Sci 27:204-209, 1977
27. Cox JC, Hamilton RC, Attwood HD: An investigation of the route and progression of Encephalitozoon cuniculi infection in adult rabbits. J Protozool 26:260-265, 1979
28. Coyle C, Kent M, Tanowitz HB, Wittner M, Weiss LM: TNP-470 is an effective antimicrosporidial agent. J Infect Dis 177:515-518, 1998
29. De Groote MA, Visvesvara GS, Wilson ML, Pieniazek NJ, Slemenda SB, da Silva AJ, Leitch GJ, Bryan RT, Reves R: Polymerase chain reaction and culture confirmation of disseminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albendazole. J Infect Dis 171:1375-1378, 1995
30. del Aguila C, Lopez-Velez R, Fenoy S, Turrientes C, Cobo J, Navajas R, Visvesvara GS, Croppo GP, da Silva AJ, Pieniazek NJ: Identification of Enterocytozoon bieneusi spores in respiratory samples from an AIDS patient with a 2-year history of intestinal microsporidiosis. J Clin Microbiol 35:1862-1866, 1997
31. Delbac F, Duffieux F, David D, Metenier G, Vivares C: Immunocytochemical identification of spore proteins in two microsporidia, with emphasis on extrusion apparatus. J Eukaryot Microbiol 45:224-231, 1998
32. Delbac F, Peyret P, Metenier G, David D, Danchin A, Vivares CP: On proteins of the microsporidian invasive apparatus: complete sequence of a polar tube protein of Encephalitozoon cuniculi. Mol Microbiol 29:825-834, 1998
33. Deplazes P, Mathis A, Baumgartner R, Tanner I, Weber R: Immunologic and molecular characteristics of Encephalitozoon-like microsporidia isolated from humans and rabbits indicate that Encephalitozoon cuniculi is a zoonotic parasite. Clin Infect Dis 22:557-559, 1996
34. Deplazes P, Mathis A, Muller C, Weber R: Molecular epidemiology of Encephalitozoon cuniculi and first detection of Enterocytozoon bieneusi in faecal samples of pigs. J Eukaryot Microbiol 43:93S, 1996
35. Desportes I, Le Charpentier Y, Galian A, Bernard F, Cochand-Proillet B, Lavergne A, Ravisse P, Modigliani R: Occurrence of a new microsporidian: Enterocytozoon bieneusi n. g., n. sp., in the enterocytes of a human patient with AIDS. J Protozool 32:250-254, 1985
36. Dick EJ, Kittell CL, Meyer H, Farrar PL, Ropp SL, Esposito JJ, Buller RML, Neubauer H, Kang YH, McKee AE: Mousepox outbreak in a laboratory mouse colony. Lab Anim Sci 46:602-611, 1996
37. Didier ES: Effects of albendazole, fumagillin, and TNP-470 on miciosporidial replication in vitro. Antimicrob Agents Chemother 47:1541-1546, 1997
38. Didier ES, Didier PJ, Friedberg DN, Stenson SM, Orenstein JM, Yee RW, Tio FO, Davis RM, Vossbrinck C, Millichamp N, Shadduck JA: Isolation and characterization of a new human microsporidian, Encephalitozoon hellem (n. sp.), from three AIDS patients with keratoconjunctivitis. J Infect Dis 163:617-621, 1991
39. Didier ES, Orenstein JM, Aldras A, Bertucci D, Rogers LB, Janney FA: Comparison of three staining methods for detecting rnicrosporidia in fluids. J Clin Microbiol 33:3138-3145, 1995
40. Didier ES, Rogers LB, Brush AD, Wong S, Traina-Dorge V, Bertucci D: Diagnosis of disseminated microsporidian Encephalitozoon hellem infection by PCR-Southern analysis and successful treatment with albendazole and fumagillin. J Clin Microbiol 34:947-952, 1996
41. Didier ES, Snowden K, Shadduck JA: Biology of microsporidian species infecting mammals. In: Advances in Parasitolcgy, ed. Baker JR, Muller R, and Rollinson D, pp. 283-320. Academic Press, San Diego, CA, 1998
42. Didier ES, Varner PW, Didier PJ, Aldras A, Millichamp NJ, Murphey-Corb M, Bohm R, Shadduck JA: Experimental microsporidiosis in immunocompetent and immunodeficient mice and monkeys. Folia Parasitol 41: 1-11, 1994
43. Didier ES, Visvesvara GS, Baker MD, Rogers LB, Bertucci D, De Groote MA, Vossbrinck CR: A microsporidian isolated from an AIDS patient corresponds to Encephalitozoon cuniculi III, originally isolated from domestic dogs. J Clin Microbiol 34:2835-2837, 1996
44. Didier PJ, Didier ES, Orenstein JM, Shadduck JA: Fine structure of a new human microsporidian, Encephalitozoon hellem, in culture. J Protozool 38:502-507, 1991
45. Dieterich DT, Lew EA, Kolter DP, Poles MA, Orenstein JM: Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS. J Infect Dis 169:178-183, 1994
46. DiGiacomo RF, Garlinghouse LE, Giddens WE, Dennis MB: Outbreaks of salmonellosis in mice. Lab Anim Sci 33:496, 1983 [abstract]
47. Dionisio D, Manneschi LI, Di Lollo S, Orsi A, Sterrantino G, Meli M, Gabbrielle M, Tani A, Papucci A, Leoncini F: Enterocytozoon bieneusi in AIDS: symptomatic relief and parasite changes after furazolidone. J Clin Pathol 50:472-476, 1997
48. Dore GJ, Marriott DJ, Hing MC, Harkness JL, Field AS: Disseminated microsporidiosis due to Septata intestinalis in nine patients infected with the human immunodeficiency virus: response to therapy with albendazole. Clin Infect Dis 21:70-76, 1995
49. Fakhry YE, Achbarou A, Desportes-Livage I, Mazier D: Encephalitozoon intestinalis: humoral responses in interferon-δ receptor knockout mice infected with a microsporidium pathogenic in AIDS patients. Exp Parasitol 89:113-121, 1998
50. Flatt RE, Jackson SJ: Renal nosematosis in young rabbits. Vet Pathol 7:492-497, 1970
51. Franzen C, Schwartz DA, Visvesvara GS, Muller A, Schwenk A, Salzberger B, Fatkenheuer G, Hartmann P, Mahrle G, Diehl V, Schrappe M: Immunologicaliy confirmed disseminated, asymptomatic Encephalitozoon cuniculi infection of the gastrointestinal tract in a patient with AIDS. Clin Infect Dis 21:1480-1484, 1995
52. Frenkel JK Pathogenesis of toxoplasmosis and of infections with organisms resembling Toxoplasma. Ann NY Acad Sci 64:215-231, 1956
53. Fuentealba IC, Mahoney NT, Shadduck JA, Harvill J, Wicher V, Wicher K: Hepatic lesions in rabbits infected with Encephalitozoon cuniculi administered per rectum. Vet Pathol 29:536-540, 1992
54. Ganaway JR, Allen AM, Moore TD: Tyzzer's disease. Am J Pathol 64: 717-732, 1971
55. Gannon J: The course of infection of Encephalitozoon cuniculi in immunodeficient and immunocompetent mice. Lab Anim 14:189-192, 1980
56. Gardiner CH, Fayer R, Dubey JP: An Atlas of Protozoan Parasites in Animal Tissues, 2nd ed. American Registry of Pathology, Washington, DC, 1998
57. Gardner MB, Henderson BE, Rongey RW, Estes JD, Huebner RJ: Spontaneous tumors of aging wild house mice: incidence, pathology, and C-type virus expression. J Natl Cancer Inst 50:719-734, 1973
58. Glaser CA, Angulo FJ, Rooney JA: Animal-associated opportunist c infections among persons infected with the human mmunodeficiency virus. Clin Infect Dis 18: 14-24, 1994
59. Goodpasture EW: Spontaneous encephalitis in rabbits. J Infect Dis 34:428-432, 1924
60. Hermanek J, Koudela B, Kucerova Z, Ditrich O, Travnicek J: Prophylactic and therapeutic immune reconstitution of SCID mice infected with Encephalitozoon cuniculi. Folia Parasitol 40:287-291, 1993
61. Hollister WS, Canning EU, Weidner E, Field AS, Kench J, Marriott DJ: Development and ultrastructure of Trachipleistophora hominis n.g., n.sp. after in vitro isolation from an AIDS patient and inoculation into athymic mice. Parasitology 112:143-154, 1996
62. Homberger FR, Zhang-LiNong, Barthold SW: Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies. Lab Anim Sci 48:50-54, 1998
63. Innes JRM, Zeman W, Frenkel JK: Occult endemic encephalitozoonosis of the central nervous system of mice. J Neuropathol Exp Neurol 21:519-533, 1962
64. Jordan J, Mirick GS: An infectious hepatitis of undetermined origin in mice: I. Description of the disease. J Exp Med 102:601-616, 1965
65. Jordan J, Mirick GS: An infectious hepatitis of undetermined origin in mice: II. Characteristics of the infective agent. J Exp Med 102:617-630, 1965
66. Jorge JA, De-Lourdes M, Polizeli TM, Thevelein JM, Terenzi HF: Trehalases and trehalose hydrolysis in fungi. FEMS Microbiol Lett 154:165-171, 1997
67. Joste NE, Rich JD, Busam KJ, Schwartz DA: Autopsy verification of Encephalitozoon intestinalis (microsporidiosis) eradication following albendazole therapy. Arch Pathol Lab Med 120:199-203, 1996
68. Katzwinkel -Wladarsch S, Lieb M, Heise W, Loscher T, Rinder H: Direct amplification and species determination of microsporidian DNA from stool specimens. Trop Med Int Health 1:373-378, 1996
69. Keeling PJ, McFadden GI: Origins of microsporidia. Trends Microbiol 6:19-23, 1998
70. Kellett BS, Bywater JEC: A modified india-ink immunoreaction for the detection of encephalitozoonosis. Lab Anim 12:59-60, 1978
71. Kemp RL, Kluge JP: Encephalitozoon sp. in the blue-masked lovebird, Agapornis personata (Reichenow): first confirmed report of microsporidian infection in birds. J Protozool 22:489-491, 1975
72. Kester KE, Turiansky GW, McEvoy PL: Nodular cutaneous microsporidiosis in a patient with AIDS and successful treatment with long-term oral clindamycin therapy. Ann Intern Med 128:911-914, 1998
73. Khan IA, Moretto M: Role of gamma interferon in cellular immune response against murine Encephalitozoon cuniculi infection. Infect Immun 67:1887-1893, 1999
74. Kolter D, Orenstein JM: Clinical syndromes associated with microsporidiosis. In: Advances in Parasitology, ed. Baker JR, Muller R, and Rollinson D, pp. 321-349. Academic Press, San Diego, CA, 1998
75. Kondova I, Mansfield K, Buckholt MA, Stein B, Widmer G, Carville A, Lackner A, Tzipori S: Transmission and serial propagation of Enterocytozoon bieneusi from humans and rhesus macaques in gnotobiotic piglets. Infect Immun 66:5515-5519, 1998
76. Koudela B, Vitovec J, Kucerova Z, Ditrich O, Travnicek J: The severe combined immunodeficient mouse as a model for Encephalitozoon cuniculi microsporidiosis. Folia Parasitol 40:279-285, 1993
77. Kunstyr I, Naumann S: Head tilt in rabbits caused by pasteurellosis and encephalitozoonosis. Lab Anim 19: 208-213, 1985
78. Leitch GJ, He Q, Wallace S, Visvesvara GS: Inhibition of the spore polar filament extrusion of the microsporidium Encephalitozoon hellem, isolated from an AIDS patient. J Eukaryot Microbiol 40:711-717, 1993
79. Leitch GJ, Scanlon M, Visvesvara GS, Wallace S: Calcium and hydrogen ion concentrations in the parasitophorous vacuoles of epithelial cells infected with the microsporidian Encephalitozoon hellem. J Eukaryot Microbiol 42:445-451, 1995
80. Lowder CY, McMahon JT, Meisler DM, Dodds EM, Calabrese LH, Didier ES, Cali A: Microsporidial keratoconjunctivitis caused by Septata intestinalis in a patient with acquired immunodeficiency syndrome. Am J Ophthalmol 121:715-717, 1996
81. Luna V, Stewart BK, Bergeron DL, Clausen CR, Plorde JJ, Fritsche TR: Use of the fluorochrome calcofluor white in the screening of stool specimens for spores of microsporidia. Am J Clin Pathol 103:656-659, 1995
82. Mansfield KG, Carville A, Hebert D, Chalifoux L, Shvetz D, Lin KC, Tzipori S, Lackner AA: Localization of persistent Enterocytozoon bieneusi infection in normal rhesus macaques (Macaca mulatto) to the hepatobiliary tree. J Clin Microbiol 36:2336-2338, 1998
83. Mansfield KG, Carville A, Shvetz D, MacKey J, Tzipori S, Lackner AA: Identification of an Enterocytozoon bieneusi-like microsporidian parasite in simian-immunodeficiency-virus-inoculated macaques with hepatobiliary disease. Am J Pathol 150:1395-1405, 1997
84. Margileth AM, Strano AJ, Chandra R, Neafie R, Blum M, McCully RM: Disseminated nosematosis in an immunologically compromised infant. Arch Pathol 95: 145-150, 1973
85. Mathis A, Michel M, Kuster H, Muller C, Weber R, Deplazes P: Two Encephalitozoon cuniculi strains of human origin are infectious to rabbits. Parasitol 114: 29-36, 1997
86. Matsubyashi M, Kioke T, Mikata I, Takei H, Hagiwara S: A case of encephalitozoon-like body infection in man. Arch Pathol 67:73-79, 1959
87. McInnes EF, Stewart CG: The pathology of subclinical infection of Encephalitozoon cuniculi in canine dams producing pups with over encephalitozoonosis. J S Afr Vet Med Assoc 62:51-54, 1991
88. Mertens RB, Didier ES, Fishbein MC, Bertucci D, Rogers LB, Orenstein JM: Encephalitozoon cuniculi microsporidiosis: infection of the brain, heart, kidneys, trachea, adrenal glands, and urinary bladder in a patient with AIDS. Mod Pathol 10:68-77, 1997
89. Mohn SF, Nordstoga K, Krogsrud J, Helgebostad A: Transplacental transmission of Nosema cuniculi in the blue fox (Alopex lagopus). Acta Pathol Microbiol Scand 82:299-300, 1974
90. Molina J, Goguel J, Sarfati C, Chastang C, DesportesLivage I, Michiels J, Maslo C, Katlama C, Cotte L, Leport C, Raffi F, Derouin F, Modai J: Potential efficacy of fumagillin in intestinal microsporidiosis due to Enterocytozoon bieneusi in patients with HIV infection: results of a drug screening study. AIDS 11:1603-1610, 1997
91. Molina J, Oksenhendler E, Beauvais B, Sarfati C, Jaccard A, Derouin F, Modai J: Disseminated microsporidiosis due to Septata intestinalis in patients with AIDS: clinical features and response to albendazole therapy. J Infect Dis 171:245-249, 1995
92. Morris JA, McCown JM, Blount RE: Ascites and hepatosplenomegaly in mice associated with protozoan-like cytoplasmic structures. J Infect Dis 98:306-311, 1956
93. Moura H, Sodre FC, Bornay-Llinares F, Leitch GJ, Navin T, Wahlquist SP, Bryan RT, Meseguer I, Visvesvara GS: Detection by an immunofluorescence of Encephalitozoon intestinalis spores in routinely formalin-fixed stool samples stored at room temperature. J Clin Microbiol 37:2317-2322, 1999
94. Muller C, Fatzer RS, Beck K, Vandevelde M, Zurbriggen A: Studies on canine distemper virus persistence in the central nervous system. Acta Neuropathol 89:438-445, 1995
95. Nordstoga K, Westbye K: Polyarteritis nodosa associated with nosematosis in blue foxes. Acta Pathol Microbiol Scand 84:291-296, 1976
96. Norton JH, Prior HC: Microsporidiosis in a peach-faced lovebird (Agapornis roseicollis). Aust Vet J 71:23-24, 1994
97. Orenstein JM: Microsporidiosis. In: Pathology of Infectious Diseases, ed. Connor DH, Chandler FW, Schwartz DA, Manz HJ, and Lack EE, pp. 1223-1239. Appleton & Lange, Stamford, CT, 1997
98. Orenstein JM, Tenner M, Call A, Kolter DP: A microsporidian previously undescribed in humans, infecting enterocytes and macrophages, and associated with diarrhea in an acquired immunodeficiency syndrome patient. Hum Pathol 23:722-728, 1992
99. Pakes SP, Gerrity LW: Protozoal diseases. In: The Biology of the Laboratory Rabbit, ed. Manning PJ, Ringler DH, and Newcomer CE, 2nd ed., pp. 205-229. Academic Press, San Diego, CA, 1994
100. Pakes SP, Shadduck JA, Cali A: Fine structure of Encephalitozoon cuniculi from rabbits, mice and hamsters. J Protozool 22:481-488, 1975
101. Percy DH, Barthold SW: Pathology of Laboratory Rodents and Rabbits. Iowa State University Press, Ames, IA, 1993
102. Perrin TL: Spontaneous and experimental encephalitozoon infection in laboratory animals. Arch Pathol 36: 559-567, 1943
103. Perrin TL: Toxoplasma and encephalitozoon in spontaneous and in experimental infections of animals. Arch Pathol 36:568-578, 1943
104. Petri M: A cytolytic parasite in the cells of transplantable, malignant tumors. Nature 205:302-303, 1965
105. Peyretaillade E, Broussolle V, Peyret P, Metenier G, Gouy M, Vivares C: Microsporidia, amitochondrial protists, posses a 70-kDa heat shock protein gene of mitochondrial origin. Mol Biol Evol 15:683-689, 1998
106. Plowright W, Yeoman G: Probable encephalitozoon infection of the dog. Vet Rec 64:381-383, 1952
107. Pol S, Romana C, Richard S, Carnot F, Dumont J, Bouche H, Pialoux G, Stern M, Pays J, Berthelot P: Enterocytozoon bieneusi infection in acquired immunodeficiency syndrome-related sclerosing cholangitis. Gastroenterology 102:1778-1781, 1992
108. Pulparampil N, Grahm D, Phalen D, Snowden K: Encephalitozoon hellem in two eclectus parrots (Eclectus roratus): idenlification from archival tissues. J Eukaryot Microbiol 45:651-655, 1998
109. Raynaud L, Delbac F, Broussolle V, Rabodonirina M, Girault V, Wallon M, Cozon G, Vivares CP, Peyron F: Identification of Encephalitozoon intestinalis in travelers with chronic diarrhea by specific PCR amplification. J Clin Microbiol 36:37-40, 1998
110. Ridoux O, Drancourt M: In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolites. Antimicrob Agents Chemother 42:3301-3303, 1998
111. Robinson JJ: Common infectious disease of laboratory rabbits questionably attributed to Encephalitozoon cuniculi. Arch Pathol 58:71-84, 1954
112. Ruehlmann D, Podell M, Oglesbee M, Dubey JP: Canine neosporosis: a case report and literature review. J Am Anim Hosp Assoc 31:174-183, 1995
113. Sabin AB, Wright AM: Acute ascending myelitis following a monkey bite, with the isolation of a virus capable of reproducing the disease. J Exp Med 59:115-136, 1934
114. Scaglia M, Gatti S, Sacchi L, Corona S, Chichino G, Bernuzzi AM, Barbarini G, Croppo GP, Da Silva A, Pieniazek NJ, Visvesvara GS: Asymptomatic respiratory tract microsporidiosis due to Encephalitozoon hellem in three patients with AIDS. Clin Infect Dis 26: 174-176, 1998
115. Schmidt EC, Shadduck JA: Murine encephalitozoonosis model for studying the host-parasite relationship of a chronic infection. Infect Immun 40:936-942, 1983
116. Schmidt EC, Shadduck JA: Mechanisms of resistance to the intracellular protozoan Encephalitozoon cuniculi in mice. J Immunol 133:2712-2719, 1984
117. Schwartz DA, Sobottka I, Leitch GJ, Cali A, Visvesvara GS: Pathology of microsporidiosis. Arch Pathol Lab Med 120:173-188, 1996
118. Schwartz DA, Visvesvara GS, Leitch GJ, Tashjian L, Pollack M, Holden J, Bryan RT: Pathology of symptomatic microsporidial (Encephalitozoon hellem) bronchiolitis in the acquired immunodeficiency syndrome: a new respiratory pathogen diagnosed from lung biopsy, bronchoalveolar lavage, sputum, and tissue culture. Hum Pathol 24:937-943, 1993
119. Schwartz DA, Visvesvara GS, Weber R, Bryan RT: Male genital tract microsporidiosis and AIDS: prostatic abscess due to Encephalitozoon hellem. J Eukaryot Microbiol 41:61S, 1994
120. Seibold HR, Fussell EN: Intestinal microsporidiosis in Callicebus moloch. Lab Anim Sci 23:115-118, 1973
121. Shadduck JA: Nosema cuniculi: in vitro isolation. Science 166:516-517, 1969
122. Shadduck JA, Baskin G: Serologic evidence of Encephalitozoon cuniculi infection in a colony of squirrel monkeys (Saimiri sciureus). Lab Anim Sci 39:328-330, 1989
123. Shadduck JA, Bendele R, Robinson GT: Isolation of the causative organism of canine encephalitozoonosis. Vet Pathol 15:449-460, 1978
124. Shadduck JA, Pakes SP: Encephalitozoonosis (nose-matosis) and toxoplasmosis. Am J Pathol 64:657-671, 1971
125. Sharpstone D, Rowbottom A, Nelson M, Gazzard B: The treatment of microsporidial diarrhoea with thalidomide. AIDS 9:658-659, 1995
126. Shell LG: The differential diagnosis of seizures. Vet Med 88:629-640, 1993
127. Shimi A, Keyhani M, Hedayati K: Studies on salmonellosis in the house mouse, Mus musculus. Lab Anim 13:33-34, 1979
128. Silveira H. Canning EU: Vittaforma corneae n. comb. for the human microsporidium Nosema corneum Shadduck, Meccoli, Davis & Font, 1990, based on its ultrastructure in the liver of experimentally infected athymic mice. J Eukaryot Microbiol 42:158-165, 1995
129. Sobottka I, Albrecht H, Schafer H, Schottelius J, Visvesvara GS, Laufs R, Schwartz DA: Disseminated Encephalitozoon (Septata) intestinalis infection in a patient with AIDS: novel diagnostic approaches and autopsy-confirmed parasitological cure following treatment with albendazole. J Clin Microbiol 33:2948-2952, 1995
130. Soule JB, Halverson AL, Becker RB, Pistole MC, Orenstein JM: A patient with acquired immunodeficiency syndrome and untreated Encephalitozoon (Septata) intestinalis microsporidiosis leading to small bowel perforation: response to albendazole. Arch Pathol 121: 880-887, 1997
131. Stiles J, Didier ES, Ritchie B, Greenacre C, Willis M, Martin C: Encephalitozoon cuniculi in the lens of a rabbit with phacoclastic uveitis: confirmation and treatment. Vet Comp Ophthalmol 7:233-238, 1997
132. Szabo JR, Shadduck JA: Experimental encephalitozoonosis in neonatal dogs. Vet Pathol 24:99-108, 1987
133. Thomas WB, Sorjonen DC, Steiss JE: A retrospective evaluation of 38 cases of canine distemper encephalomyelitis. J Am Anim Hosp Assoc 29:129-133, 1993
134. Tzipori S, Carville A, Widmer G, Kotler D, Mansfield K, Lackner A: Transmission and establishment of a persistent infection of Enterocytozoon bieneusi, derived from a human with AIDS, in simian immunodeficiency virus-infected rhesus monkeys. J Infect Dis 175:1016-1020, 1997
135. Undeen A, Frixione E: The role of osmotic pressure in the germination of Nosema algerae spores. J Protozool 37:561-567, 1990
136. Undeen A, Vander Meer RK: The effect of ultraviolet radiation on the germination of Nosema algerae Vávra and Undeen (Microsporida: Nosematidae) spores. J Protozool 37:194-199, 1990
137. Van Dellen AF, Stewart CG, Botha WS: Studies of encephalitozoonosis in vervet monkeys (Cercopithecus pygerythrus) orally inoculated with spores of Encephalitozoon cuniculi isolated from dogs (Canis familiaris). Onderstepoort J Vet Res 56:1-22, 1989
138. Vavra J, Yachnis AT, Shadduck JA, Orenstein JM: Microsporidia of the genus Trachipleistophora - causative agents of human microsporidiosis: description of Trachipleistophora anthropophthera n.sp. (Protozoa: Microsporidia). J Eukaryot Microbiol 45:271-283, 1998
139. Visvesvara GS, Leitch GJ, Pieniazek NJ, da Silva AJ, Wallace S, Slemenda SB, Weber R, Schwartz DA, Gorelkin L, Wilcox CM, Bryan RT: Short-term in vitro culture and molecular analysis of the microsporidian, Enterocytozoon bieneusi, J Eukaryot Microbiol 42: 506-510, 1995
140. Viting AI: [On the etiology of multiple sclerosis in the light of data on the morphological study of the central nervous system (preliminary report)]. Zh Nevropatol Psikhiatr Im S S Korsakova 65:1641-1645, 1965
141. Vossbrinck CR, Baker MD, Didier ES, Debrunner-Vossbrinck BA, Shadduck JA: Ribosomal DNA sequences of Encephalitozoon hellem and Encephalitozoon cuniculi: species identification and phylogenetic construction. J Eukaryot Microbiol 40:354-362, 1993
142. Wan C, Franklin C, Riley LK, Hook RR, Besch-Williford C: Diagnostic exercise: granulomatous encephalitis in guinea pigs. Lab Anim Sei 46:228-230, 1996
143. Wasson K, Snowden K, Didier ES, Shadduck JA, Gelberg HB: Rabbit intestinal xenograft model for human encephalitozoon infection in mice. Lab Anim Sci 49: 189-196, 1999
144. Watson GL, Evans MG: Listeriosis in a rabbit. Vet Pathol 22:191-193, 1985
145. Weber R, Bryan RT, Owen RL, Wilcox CM, Gorelkin L, Visvesvara GS: Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. N Engl J Med 326:161-166, 1992
146. Weber R, Deplazes P, Flepp M, Mathis A, Baumann R, Sauer B, Kuster H, Luthy R: Cerebral microsporidiosis due to Encephalitozoon cuniculi in a patient with human immunodeficiency virus infection. N Engl J Med 336:474-478, 1997
147. Weber R, Kuster H, Visvesvara GS, Bryan RT, Schwanz DA, Luthy R: Disseminated microsporidiosis due to Encephalitozoon hellem: pulmonary colonization, microhematuria, and mild conjunctivitis in a patient with AIDS. Clin Infect Dis 17:415-419, 1993
148. Weidner E: Ultrastructural study of microsporidian invasion into cells. Z Parasitenkd 40:227-242, 1972
149. Weiss LM, Vossbrinck CR: Microsporidiosis: molecular and diagnostic aspects. In: Advances in Parasitology, ed. Baker JR, Muller R, and Rollinson D, pp. 351-395. Academic Press, San Diego, CA, 1998
150. Wicher V, Baughn RE, Fuentealba IC, Shadduck JA, Abbruscato F, Wicher K: Enteric infection with an obligate intracellular parasite, Encephalitozoon cuniculi, in an experimental model. Infect Immun 59:2225-2231, 1991
151. Willson R, Harrington R, Stewart B, Fritsche T: Human immunodeficiency virus 1-associated necrotizing cholangitis caused by infection with Septata intestinalis. Gastroenterology 108:247-251, 1995
152. Wright JH, Craighead EM: Infectious motor paralysis in young rabbits. J Exp Med 36:135-140, 1922
153. Yee RW, Tio FO, Martinez JA, Held KS, Shadduck JA, Didier ES: Resolution of microsporidial epithelial keratopathy in a patient with AIDS. Ophthalmology 98: 196-201, 1991
154. Zeman DH, Baskin G: Encephalitozoonosis in squirrel monkeys (Saimiri sciureus). Vet Pathol 22:24-31, 1985