Cerebral microspokidiosis due to Encephalitozoon cuniculi in a patient with human immunodeficiency virus infection

New England Journal of Medicine

Volumn 336, Issue 7, 1997, Pages 474-478

  Weber, Rainer ^a   Deplazes, Peter ^b   Flepp, Markus ^a   Mathis, Alexander ^b   Baumann, Reinhard ^c   Sauer, Bärbel ^a   Kuster, Herbert ^a   Lüthy, Ruedi ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Diakoniewerk Bethanien   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN INFECTION; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; FECES ANALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MICROSPORA; MICROSPORIDIOSIS; PRIORITY JOURNAL; SPUTUM ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; URINALYSIS; AIDS RELATED COMPLEX; ANIMAL; BRAIN; CEREBROSPINAL FLUID; ELECTRON MICROSCOPY; ENCEPHALITOZOON CUNICULI; FATALITY; ISOLATION AND PURIFICATION; PARASITOLOGY; PATHOLOGY; PROTOZOAL INFECTION; URINE;

ALBENDAZOLE; ANTHELMINTIC AGENT;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; BRAIN; CEREBROSPINAL FLUID; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOONOSIS; FATAL OUTCOME; HUMANS; MALE; MICROSCOPY, ELECTRON; URINE;

EID: 0030614753     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199702133360704     Document Type: Article

References (27)

1. Canning EU, Lom J. The microsporidia of vertebrates. New York: Academic Press, 1986.
2. Wright JH, Craighead EM. Infectious motor paralysis in young adults J Exp Med 1922;36:135-40.
3. Levaditi C, Nicolau S, Schoen R. L'agent étiologique de l'encéphalite épizootique du lapin (Encephalitozoon cuniculi). C R Seances Soc Biol Fil 1923;89:984-6.
4. Matsubayashi H, Koike T, Mikata I, Takei H, Hagiwara S. A case of Encephalitozoon-like body infection in man. Arch Pathol 1959;67:181-7.
5. Bergquist NR, Stintzing G, Smedman L, Waller T, Andersson T. Diagnosis of encephalitozoonosis in man by serological tests. BMJ 1984;288:902.
6. Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev 1994;7:426-61.
7. Deplazes P, Mathis A, Müller C, Weber R. Molecular epidemiology of Encephalitozoon cuniculi and first detection of Enterocytozoon bieneusi in faecal samples of pigs. J Eukaryot Microbiol 1996;43:93S.
8. Orenstein JM, Yachnis A, Didier E, Fishbein M, Mertens R. Microsporidia also infect the brain and heart of AIDS patients. In: Vol. 2 of the 11th International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:265. abstract.
9. Weber R, Bryan RT, Owen RL, et al. Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. N Engl J Med 1992;326:161-6.
10. Weber R, Kuster H, Visvesvara GS, Bryan RT, Schwanz DA, Lüthy R. Disseminated microsporidiosis due to Encephalitozoon hellem: pulmonary colonization, microhematuria, and mild conjunctivitis in a patient with AIDS. Clin Infect Dis 1993;17:415-9.
11. Visvesvara GS, Leitch GJ, Moura HM, Wallace S, Weber R, Bryan T. Culture, electron microscopy, and immunoblot studies on a microsporidian parasite isolated from the urine of a patient with AIDS. J Protozool 1991; 38:105S-111S.
12. Deplazes P, Mathis A, Baumgartner R, Tanner I, Weber R. Immunologic and molecular characteristics of Encephalitozoon-like microsporidia isolated from humans and rabbits indicate that Encephalitozoon cuniculi is a zoonotic parasite. Clin Infect Dis 1996;22:557-9.
13. Mathis A, Michel M, Kuster H, Müller C, Weber R, Deplazes P. Two Encephalitozoon cuniculi subtypes of human origin are infectious to rabbits. Parasitology 1997;114:29-35.
14. Mathis A, Åkerstedt J, Tharaldsen J, Ødegaard Ø, Deplazes P. Isolates of Encephalitozoon cuniculi from farmed blue foxes (Alopex lagopus) from Norway differ from isolates from Swiss domestic rabbits (Oryctolagus cuniculus). Parasitol Res 1996;82:727-30.
15. Katiyar SK, Visvesvara GS, Edlind TD. Comparisons of ribosomal RNA sequences from amitochondrial protozoa: implications for processing, mRNA binding and paromomycin susceptibility. Gene 1995;152:27-33.
16. Katzwinkel-Wladarsch S, Lieb M, Helse W, Löscher T, Rinder H. Direct amplification and species determination of microsporidian DNA from stool specimens. Trop Med Int Health 1996;1:373-8.
17. De Groote MA, Visvesvara G, Wilson ML, et al. Polymerase chain reaction and culture confirmation of disseminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albendazole. J Infect Dis 1995;171:1375-8.
18. Hollister WS, Canning EU, Colbourn NI, Aarons EJ. Encephalitozoon cuniculi isolated from the urine of an AIDS patient, which differs from canine and murine isolates. J Eukaryot Microbiol 1995;42:367-72.
19. Terada S, Reddy KR, Jeffers LJ, Cali A, Schiff ER. Microsporidan hepatitis in the acquired immunodeficiency syndrome. Ann Intern Med 1987; 107:61-2.
20. Zender HO, Arrigoni E, Eckert J, Kapanci Y. A case of Encephalitozoon cuniculi peritonitis in a patient with AIDS. Am J Clin Pathol 1989;92:352-6.
21. Didier ES, Vossbrinck CR, Baker MD, Rogers LB, Bertucci DC, Shadduck JA. Identification and characterization of three Encephalitozoon cuniculi strains. Parasitology 1995;111:411-21.
22. Beauvais B, Sarfati C, Challier S, Derouin F. In vitro model to assess effect of antimicrobial agents on Encephalitozoon cuniculi. Antimicrob Agents Chemother 1994;38:2440-8.
23. Colbourn NI, Hollister WS, Curry A, Canning EU. Activity of albendazole against Encephalitozoon cuniculi in vitro. Eur J Protistol 1994; 30:211-20.
24. Franssen FF, Lumeij JT, van Knapen F. Susceptibility of Encephalitozoon cuniculi to several drugs in vitro. Antimicrob Agents Chemother 1995; 1265-8.
25. Orenstein JM, Dieterich DT, Lew EA, Kotler DP. Albendazole as a treatment for disseminated microsporidiosis due to Septata intestinalis in AIDS patients: a report of four patients. AIDS 1993;7:Suppl 3:S40-S42.
26. Joste NE, Rich JD, Busam KJ, Schwartz DA. Autopsy verification of Encephalitozoon intestinalis (microsporidiosis) eradication following albendazole therapy. Arch Pathol Lab Med 1996;120:199-203.
27. Aarons EJ, Woodrow D, Hollister WS, Canning EU, Francis N, Gazzard BG. Reversible renal failure caused by a microsporidian infection. AIDS 1994;8:1119-21.