Encephalitozoon cuniculi microsporidiosis: Infection of the brain, heart, kidneys, trachea, adrenal glands, and urinary bladder in a patient with AIDS

Modern Pathology

Volumn 10, Issue 1, 1997, Pages 68-77

  Mertens, Richard B ^a   Didier, Elizabeth S ^b   Fishbein, Michael C ^a   Bertucci, Donna C ^b   Rogers, Linda B ^b   Orenstein, Jan Marc ^c  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

adrenal glands; AIDS; brain; Encephalitozoon cuniculi; heart; kidneys; microsporidia

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADRENAL GLAND; ARTICLE; AUTOPSY; BLADDER; BRAIN; CASE REPORT; FEMALE; HEART; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KIDNEY; MICROSPORIDIOSIS; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; TRACHEA; ULTRASTRUCTURE;

ADRENAL GLANDS; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANIMALS; BRAIN; ENCEPHALITOZOON CUNICULI; ENCEPHALITOZOONOSIS; FATAL OUTCOME; FEMALE; HUMANS; KIDNEY; LYMPH NODES; MYOCARDIUM; SPLEEN; TRACHEA; URINARY BLADDER;

EID: 0031040281     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Desportes I, Le Charpentier Y, Galian A, Bernard F, Cochand-Priollet B, Lavergne A, et al. Occurrence of a new microsporidan: Enterocytozoon bieneusi n.g., n.sp., in the enterocytes of a human patient with AIDS. J Protozool 1985; 32:250-4.
2. Cali A, Owen RL. Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. J Protozool 1990;37:145-55.
3. Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev 1994;7:426-61.
4. Schwartz DA, Sobottka I, Leitch GJ, Cali A, Visvesvara GS. Pathology of microsporidiosis: emerging parasitic infections in patients with acquired immunodeficiency syndrome. Arch Pathol Lab Med 1996;120:173-88.
5. Orenstein JM, Chiang J, Steinberg W, Smith PD, Rotterdam H, Kotler DP. Intestinal microsporidiosis as a cause of diarrhea in human immunodeficiency virus-infected patients: a report of 20 cases. Hum Pathol 1990;21:475-81.
6. Orenstein JM. Intestinal microsporidiosis. Adv Anat Pathol 1996;3:46-58.
7. French AL, Beaudet LM, Benator DA, Levy CS, Kass M, Orenstein JM. Cholecystectomy in 136 patients with human immunodeficiency virus infection. J Infect Dis 1995;21:852-8.
8. Pol S, Romana CA, Richard S, Amouyal P, Desportes-Livage I, Carnot F, et al. Microsporidia infection in patients with the human immunodeficiency virus and unexplained cholangitis. N Engl J Med 1993;328:95-9.
9. Orenstein JM, Dieterich DT, Kotler DP. Systemic dissemination by a newly recognized microsporidia species in AIDS. AIDS 1992;6:1143-50.
10. Orenstein JM, Tenner M, Cali A, Kolter DP. A microsporidian previously undescribed in humans, infecting enterocytes and macrophages and associated with diarrhea in an AIDS patient. Hum Pathol 1992;23:722-8.
11. Cali A, Kotler DP, Orenstein JM. Septata intestinalis, n.g., n.sp., an intestinal microsporidian associated with chronic diarrhea and dissemination in AIDS patients. J Eukaryot Microbiol 1993;40:101-12.
12. Canning EU, Lom J. The microsporidia of vertebrates. Orlando, FL: Academic Press, 1986.
13. Wilson JM. The biology of Encephalitozoon cuniculi. Med Biol 1979;57:84-101.
14. Cox J, Hamilton R, Attwood H. An investigation of the route and progression of Encephalitozoon cuniculi infection in adult rabbits. J Protozool 1979;26:260-5.
15. Shadduck JA, Watson WT, Pakes SP, Cali A. Animal infectivity of Encephalitozoon cuniculi. J Parasitol 1979;65:123-9.
16. Koller LD. Spontaneous Nosema cuniculi infection in laboratory rabbits. J Am Vet Med Assoc 1969;155:1108-14.
17. Gannon J. The course of infection of Encephalitozoon cuniculi immunodeficient and immunocompetent mice. Lab Anim 1980;14:189-92.
18. Terada S, Reddy KR, Jeffers LJ, Cali A, Schiff ER. Microsporidian hepatitis in the acquired immunodeficiency syndrome. Ann Intern Med 1987;107:61-2.
19. Zender HO, Arrigoni E, Eckert J, Kapanci Y. A case of Encephalitozoon cuniculi peritonitis in a patient with AIDS. Am J Clin Pathol 1989;92:352-6.
20. Hollister WS, Canning EU, Colbourn NI, Aarons EJ. Encephalitozoon cuniculi isolated from the urine of an AIDS patient, which differs from canine and murine isolates. J Eukaryot Microbiol 1955;42:367-72.
21. de Groote MA, Visvesvara G, Wilson ML, Pieniazek NJ, Slemenda SB, daSilva AJ, et al. Polymerase chain reaction and culture confirmation of disseminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albendazole. J Infect Dis 1995;171:1375-8.
22. Didier ES, Didier PJ, Friedberg DN, Stenson SM, Orenstein JM, Yee RW, et al. Isolation and characterization of a new microsporidian, Encephalitozoon hellem (n.sp.) from corneas of three AIDS patients. J Infect Dis 1991;163:617-21.
23. Didier PJ, Didier ES, Orenstein JM, Shadduck JA. Fine structure of a new human microsporidian, Encephalitozoon hellem, in culture. J Protozool 1991;38:502-7.
24. Schwartz DA, Bryan RT, Hewan-Lowe KO, Visvesvara GS, Webber R, Cali A, et al. Disseminated microsporidiosis (Encephalitozoon hellem) and acquired immunodeficiency syndrome. Autopsy evidence for respiratory acquisition. Arch Pathol Lab Med 1992;116:660-8.
25. Orenstein JM. The role of electron microscopy in infectious disease diagnosis. J Histotechnol 1995;18:211-24.
26. Aldras AM, Orenstein JM, Kotler DP, Shadduck JA, Didier ES. Detection of microsporidia by indirect immunofluorescence antibody test using polyclonal and monoclonal antibodies. J Clin Microbiol 1994;32:608-12.
27. Vossbrinck CR, Baker M, Didier ES, Debrunner-Vossbrinck B, Shadduck JA. Ribosomal DNA sequences of Encephalitozoon hellem and Encephalitozoon cuniculi: species identification and phylogenetic construction. J Eukaryot Microbiol 1993;40:354-62.
28. Didier ES, Vossbrinck CR, Baker MD, Rogers LB, Bertucci DC, Shadduck JA. Identification and characterization of three Encephalitozoon cuniculi strains. Parasitology 1995; 111:411-22.
29. Didier ES, Rogers LB, Orenstein JM, Baker MD, Vossbrinck CR, van Gool T, et al. Characterization of Encephalitozoon (Septata) intestinalis isolates cultured from nasal mucosa and bronchoalveolar lavage fluids of two AIDS patients. J Eukaryot Microbiol 1996;43:34-43.
30. Sambrook J, Fritsch EF, Maniatis T. Enzymes used in molecular chemistry. In Ford N, Nolan C, Ferguson M, editors. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989:5.0-5.95.
31. Soto D, Sukumar S. Improved detection of mutations in the p53 gene in human tumors as single-stranded conformation polymorphs and double-stranded heteroduplex DNA. PCR Methods Appl 1992;2:96-8.
32. Orenstein JM. Diagnosis of gastrointestinal disease in AIDS. Adv Pathol Lab Med 1995;8:453-77.
33. Field AS, Hing MC, Milliken ST, Marriott DJ. Microsporidia in the small intestine of HIV-infected patients: a new diagnostic technique and a new species. Med J Aust 1993;158: 390-4.
34. Tiner JD. Birefringent spores differentiate Encephalitozoon and Microsporidia from Coccidia. Vet Pathol 1988;25:227-30.
35. Stewart CG, Van Dellen AF, Botha WS. Canine encephalitozoonosis in kennels and the isolation of Encephalitozoon in tissue culture. J S Afr Vet Assoc 1979;50:165-8.
36. Freda PU, Wardlaw SL, Brudney K, Goland RS. Clinical case seminar: primary adrenal insufficiency in patients with the acquired immunodeficiency syndrome: a report of five cases. J Clin Endocrinol Metab 1994;79:1540-5.
37. Travis WD, Schmidt K, MacLowry JD, Masur H, Condron KS, Fojo AT. Respiratory cryptosporidiosis in a patient with malignant lymphoma. Arch Pathol Lab Med 1990; 114:519-22.
38. Didier ES, Rogers LB, Brush AD, Wong S, Traina-Dorge V, Bertucci D. Diagnosis of disseminated microsporidian Encephalitozoon hellem infection by PCR-Southern analysis and successful treatment with albendazole and fumagillin. J Clin Microbiol 1996; 34:947-52.
39. Orenstein JM, Dieterich DT, Lew EA, Kotler DP. Albendazole as a treatment for intestinal and disseminated microsporidiosis due to Septata intestinalis in AIDS patients: a report of four patients. AIDS 1993;7(suppl 3):S40-S42.
40. Franzen C, Schwartz DA, Visvesvara GS, Muller A, Schwenk A, Salzberger B, et al. Immunologically confirmed disseminated asymptomatic Encephalitozoon cuniculi infection of the gastrointestinal tract in a patient with AIDS. Clin Infect Dis 1995;21:1480-4.