Target-related and intrinsic neuronal death in Lurcher mutant mice are both mediated by caspase-3 activation

Journal of Neuroscience

Volumn 20, Issue 3, 2000, Pages 992-1000

  Selimi, Fekrije ^a,b   Doughty, Martin ^a   Delhaye Bouchaud, Nicole ^a   Mariani, Jean ^a  

^a CNRS   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Apoptosis; Caspase 3; Immunohistochemistry; Lurcher; Neuronal death; Purkinje cells; TUNEL

Indexed keywords

CASPASE 3; CELL DNA; DNA FRAGMENT; ENZYME PRECURSOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVATION; GRANULE CELL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0034143430     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-03-00992.2000     Document Type: Article

References (31)

1. Araki K, Meguro H, Kushiya E, Takayama C, Inoue Y, Mishina M (1993) Selective expression of the glutamate receptor channel δ2 subunit in cerebellar Purkinje cells. Biochem Biophys Res Commun 197:1267-1276.
2. Bailly Y, Kyriakopoulou K, Delhaye-Bouchaud N, Mariani J, Karagogeos D (1996) Cerebellar granule cell differentiation in mutant and X-irradiated rodents revealed by the neural adhesion molecule TAG-1. J Comp Neurol 369:150-161.
3. Caddy KWT, Biscoe TJ (1979) Structural and quantitative studies on the normal C3H and Lurcher mutant mouse. Philos Trans R Soc Lond B Biol Sci 287:167-201.
4. Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, Simon RP (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
5. Du Y, Dodel RC, Bales KR, Jemmerson R, Hamilton-Byrd E, Paul SM (1997) Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J Neurochem 69:1382-1388.
6. Dumesnil-Bousez N, Sotelo C (1992) Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis. J Neurocytol 21:506-529.
7. Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme. J Biol Chem 269:30761-30764.
8. Green D, Kroemer G (1998) The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 8:267-271.
9. Herrup K, Busser JC (1995) The induction of multiple cell cycle events precedes target-related neuronal death. Development 121:2385-2395.
10. Herrup K, Shojaeian-Zanjani H, Panzini L, Sunter K, Mariani J (1996) The numerical matching of source and target populations in the CNS: the inferior olive to Purkinje cell projection. Brain Res Dev Brain Res 96:28-35.
11. Korhonen L, Hamnér S, Olsson P, Lindholm D (1997) Bcl-2 regulates the levels of the cysteine proteases ICH and CPP32/Yama in human neuronal precursor cells. Eur J Neurosci 9:2489-2496.
12. Krajewska M, Wang H, Krajewski S, Zapata JM, Shabaik A, Gascoyne R, Reed JC (1997) Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease. Cancer Res 57:1605-1613.
13. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372.
14. Mancini M, Nicholson DW, Roy S, Thornberry NA, Peterson EP, Casciola-Rosen LA, Rosen A (1998) The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol 140:1485-1495.
15. Marks N, Berg MJ, Guidotti A, Saito M (1998) Activation of caspase-3 and apoptosis in cerebellar granule cells. J Neurosci Res 52:334-341.
16. Namura S, Zhu J, Fink K, Endres M, Srinivasan A, Tomaselli KJ, Yuan J, Moskowitz MA (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 18:3659-3668.
17. Nicholson DW, Thornberry NA (1997) Caspases: killer proteases. Trends Biol Sci 22:299-306.
18. Norman DJ, Feng L, Cheng SS, Gubbay J, Chan E, Heintz N (1995) The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development 121:1183-1193.
19. Rodriguez I. Matsuura K, Ody C, Nagata S, Vassalli P (1996) Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J Exp Med 184:2067-2072.
20. Smeyne RJ, Chu T, Lewin A, Bian F, S-Crisman S. Kunsch C, Lira SA, Oberdick J (1995) Local control of granule cell generation by cerebellar Purkinje cells. Mol Cell Neurosci 6:230-251.
21. Tanabe H, Eguchi Y, Kamada S, Martinou J, Tsujimoto Y (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur J Neurosci 9:848-856.
22. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316.
23. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. J Biol Chem 272:17907-17911.
24. L regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627-637.
25. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL (1996) Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 15:1012-1020.
26. Wetts R, Herrup K (1982b) Interaction of granule, Purkinje and inferior olivary neurons in Lurcher chimeric mice. II. Granule cell death. Brain Res 250:358-362.
27. Wüllner U, Löschmann P-A, Weller M, Klockgether T (1995) Apoptotic cell death in the cerebellum of mutant weaver and lurcher mice. Neurosci Lett 200:109-112.
28. Wullner U, Weller M, Schulz J, Krajewski S, Reed J, Klockgether T (1998) Bcl-2, Bax and Bcl-x expression in neuronal apoptosis: a study of mutant weaver and lurcher mice. Acta Neuropathol (Berl) 96:233-238.
29. Zanjani HS, Vogel MW, Martinou JC, Delhaye-Bouchaud N, Mariani J (1998a) Postnatal expression of Hu-Bcl-2 gene in Lurcher mutant mice fails to rescue Purkinje cells but protects inferior olivary neurons from target-related cell death. J Neurosci 18:319-327.
30. Zanjani H, Rondi-Reig L, Vogel M, Martinou J-C, Delhaye-Bouchaud N, Mariani J (1998b) Overexpression of a Hu-bcl-2 transgene in Lurcher mutant mice delays Purkinje cell death. C R Acad Sci (Paris) 321:633-640.
31. Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N (1997) Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene. Nature 388:769-773.