HIV-1 and HAART: A time to cure, a time to kill

Nature Medicine

Volumn 5, Issue 6, 1999, Pages 609-611

  Saag, Michael S ^a   Kilby, J Michael ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

CELL SURVIVAL; CYTOPATHOGENIC EFFECT; CYTOTOXIC LYMPHOCYTE; DNA INTEGRATION; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; SHORT SURVEY; VIREMIA; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CLINICAL TRIALS; HIV INFECTIONS; HIV-1; HUMANS; RNA, VIRAL; TREATMENT OUTCOME; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033038485     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/9452     Document Type: Short Survey

References (10)

1. Perelson, A.S. et al. Decay characteristics of HIV-1 infected compartments during combination therapy. Nature 387, 188-191 (1997).
2. Wong, J.K. et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291-1295 (1997).
3. Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295-1300 (1997).
4. + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med 5, 512-517 (1999).
5. Zhang, L. et al. Quantifying residual HIV-1 replication and viral persistence in patients on effective combination antiretroviral therapy. N. Engl. J. Med. (in the press).
6. Hockett, R. et al. Constant mean viral copy number pe infected cell in tissues regardless of high, low, or undectable plasma HIV RNA. J. Exp. Med. (in the press).
7. Chun, T.-W. et al. Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 95, 8869-8873 (1998).
8. Schmitz, J.E. et al. Control of viremia in simian immunodeficiency virus infection by CDB+ lymphocytes. Science 283, 857-859 (1999).
9. Jin, X. et al. Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected Macaques. J. Exp. Med. 189, 991-998 (1999).
10. Bucy, R.P. Immune clearance of HIV Type 1 replication-active cells: A model of two patterns of steady state HIV infection. AIDS Res, Hum. Retroviruses 15, 223-227 (1999).