New insights into the thyroid-stimulating hormone receptor: The major antigert of Graves' disease

Endocrinology and Metabolism Clinics of North America

Volumn 29, Issue 2, 2000, Pages 267-286

  Graves, Peter N ^b   Davies, Terry F ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; COMPLEMENTARY DNA; MESSENGER RNA; RECEPTOR SUBUNIT; T LYMPHOCYTE ANTIGEN; THYROTROPIN; THYROTROPIN RECEPTOR;

BINDING SITE; GLYCOPROTEIN SYNTHESIS; GRAVES DISEASE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; RNA SPLICING; T LYMPHOCYTE;

EID: 0034130131     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70131-6     Document Type: Article

References (65)

1. D.D. Adams H.D. Purvis Abnormal responses in the assay of thyrotropin Proceedings of the University of Otago Medical School 34 1956 11 12
2. A. Allgeier S. Offermanns J. Van Sande The human TSH receptor activates G-proteins Gs and Gq/11 J Biol Chem 269 1994 13733 13735
3. C.A. Alvarez P. Narayan J. Huang Characterization of a region of the LH receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling Endocrinology 140 1999 1775 1782
4. R.S. Bahn C.M. Dutton N. Natt Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: Potential autoantigen in Graves' ophthalmopathy J Clin Endocrinol Metab 83 1998 998 1002
5. S. Costagliola P. Rodien M.C. Many Genetic immunization against the TSH receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor J Immunol 160 1998 1458 1465
6. J. Couet S. Sar A. Jolivet Shedding of human TSH receptor ectodomain: Involvement of a matrix metalloprotease J Biol Chem 271 1996 4545 4552
7. T.F. Davies The pathogenesis of Graves' disease L.E. Braverman R.D. Utiger The Thyroid: A Fundamental Text 1996 Lippincott Philadelphia 525 536
8. T.F. Davies Y. Bobovnikova M. Weiss Development and characterization of monoclonal antibodies specific for the murine TSH receptor Thyroid 8 1998 693 701
9. T.F. Davies A. Martin E.S. Concepcion Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease N Engl J Med 325 1991 238 244
10. T.F. Davies H. Vlase M. Kita The search for an animal model for Graves' disease Y. Schoenfeld The Decade of Autoimmunity 1999 Elsevier Amsterdam 43 50
11. S. de Bernard M. Misrahi J.C. Huet Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain J Biol Chem 274 1999 101 107
12. S. Dirmikis D.S. Munro Studies on the binding activity for the long-acting thyroid stimulator J Endocrinol 58 1973 577 590
13. M.L. Dufau T. Minegishi E. Buczko Characterization and structure of ovarian and testicular LH/hCG receptors J Steroid Biochem 33 1989 715 720
14. L. Duprez J. Parma S. Costagliola Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain FEBS Lett 409 1997 469 474
15. J.-L. Fan R.K. Desai J.S. Dallas Heterogenity in cellular and antibody responses against thyrotropin receptor in patients with Graves' disease detected using synthetic peptides J Autoimmunol 6 1993 799 808
16. A. Feliciello A. Porcellini I. Ciullo Expression of thyrotropin-receptor specific mRNA in healthy and Graves' disease retroorbital tissue Lancet 342 1993 337 338
17. P. Graves A. Pritsker T.F. Davies Post-translational processing of the natural human TSH receptor: Demonstration of more than two cleavage sites Endocrinology 84 1999 2177 2181
18. P.N. Graves H. Vlase Y. Bobovnikova Multimeric complex formation by the natural TSH receptor Endocrinology 137 1996 3915 3920
19. P.N. Graves H. Vlase T.F. Davies Folding of the recombinant hTSH receptor extracellular domain: Identification of folded monomeric and tetrameric complexes which bind TSH receptor autoantibodies Endocrinology 136 1995 521 527
20. P.N. Graves Y. Tomer T.F. Davies Cloning and sequencing of a 1.3 kb variant of human thyrotropin receptor mRNA lacking the transmembrane domain Biochem Biophys Res Commun 187 1992 1135 1143
21. X. Jiang M. Dreano D.R. Buckler Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions Structure 3 1995 1341 1353
22. M. Kita L. Ahmad R.C. Marians Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease Endocrinology 140 1999 1392 1398
23. L.D. Kohn H. Shimula Y. Shimula The thyrotropin receptor Vitam Horm 50 1995 287 384
24. P. Kopp J.L. Jameson T.F. Roe Congenital nonautoimmune hyperthyroidism in a nonidentical twin caused by a sporadic germline mutation in the thyrotropin receptor gene Thyroid 7 1997 765 770
25. P. Kopp J. Van Sande J. Parma Brief report: Congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene [see comments] N Engl J Med 332 1995 150 154
26. Z. Kraiem N. Lahat B. Glaser Thyrotropin receptor blocking antibodies: Incidence, characterization and in vitro synthesis Clin Endocrinol 27 1987 409 421
27. F. Libert A. Lefort C. Gerard Cloning, sequencing and expression of the human TSH receptor: Evidence for binding of autoantibodies Biochem Biophys Res Commun 165 1989 1250 1255
28. H. Loosfelt C. Pichon A. Jolivet Two-subunit structure of the human thyrotropin receptor Proc Natl Acad Sci USA 89 1992 3765 3769
29. M. Ludgate M. Crisp C. Lane The thyrotropin receptor in thyroid eye disease [In Process Citation] Thyroid 8 1998 411 413
30. M.C. Many S. Costagliola M. Detrait Development of an animal model of autoimmune thyroid eye disease J Immunol 162 1999 4966 4974
31. A. Martin M. Nakashima A. Zhou Detection of major T-cell epitopes on the human TSH receptor by overriding immune heterogeneity in patients with Graves' disease J Clin Endocrinol Metab 82 1997 3361 3366
32. M. Misrahi N. Ghinea S. Sar Processing of precursors of the human TSH receptor in various eukaryotic cells Eur J Biochem 222 1994 711 719
33. R.J. Mullins Y. Chernajovsky C. Dayan Transfection of thyroid autoantigens into EBV-transformed B cell lines J Immunol 152 1994 5572 5580
34. Y. Nagayama K.D. Kaufman P. Seto Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor Biochem Biophys Res Commun 165 1989 1184 1190
35. Y. Nagayama D. Russo G.D. Chazenbalk Extracellular domain chimeras of the TSH and LH/CG receptors reveal the mid-region (amino acids 171–260) to play a vital role in high affinity TSH binding Biochem Biophys Res Commun 173 1990 1150 1156
36. M. Nakashima A. Martin T.F. Davies Intrathyroidal T cell accumulation in Graves' disease: Delineation of mechanisms based on in situ T cell receptor analysis J Clin Endocrinol Metab 81 1996 3346 3351
37. J. Parma L. Duprez J. Van Sande Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas J Clin Endocrinol Metab 82 1997 2695 2701
38. J. Parma L. Duprez J. Van Sande Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas Nature 365 1993 649 651
39. M. Parmentier F. Libert C. Maenhaut Molecular cloning of the TSH receptor Science 246 1989 1620 1622
40. Paschke R, Center for Internal Medicine, University of Leipzig. TSH Receptor Database. Available at: http://www.uni-leipzig.de/~innere/TSH/frame_en.htm . Accessed March 2, 2000
41. R. Paschke M. Ludgate The thyrotropin receptor in thyroid diseases N Engl J Med 337 1997 1675 1681
42. B. Rapoport G.D. Chazenbalk J.C. Jaume The thyrotropin (TSH) receptor: Interaction with TSH and autoantibodies [published erratum appears in Endocr Rev 1999 Feb;20(1):100] Endocr Rev 19 1998 673 716
43. B. Rees Smith S.M. McLachlan J. Furmaniak Autoantibodies to the thyrotropin receptor Endocr Rev 9 1988 106 121
44. D. Russo G.D. Chazenbalk Y. Nagayama A new structural model for the TSH receptor, as determined by covalent cross-linking of TSH to the recombinant receptor in intact cells: Evidence for a single polypeptide chain Mol Endocrinol 5 1991 1607 1612
45. D. Russo G.D. Chazenbalk Y. Nagayama Site-directed mutagenesis of the human TSH receptor: Role of aspiragine-linked oligosaccharides in the expression of a functional receptor Mol Endocrinol 5 1991 29 33
46. J. Sanders Y. Oda S.A. Roberts Understanding the TSH receptor function-structure relationship Balliere's Clin Endocrinol Metab 11 1997 451 480
47. N. Shimojo Y. Kohno K.-I. Yamaguchi Induction of Graves'-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule Proc Natl Acad Sci USA 93 1996 11074 11079
48. M. Soliman E. Kaplan M.-E. Fisfalen T-cell reactivity to recombinant human thyrotropin receptor extracellular domain and thyroglobulin in patients with autoimmune and non-autoimmune thyroid diseases J Clin Endocrinol Metab 80 1995 206 213
49. M. Soliman E. Kaplan V. Guimaraes T-cell recognition of residue 158-176 in thyrotropin receptor confers risk for development of thyroid autoimmunity in siblings in a family with Graves' disease Thyroid 6 1996 545 551
50. W. Stadlmayr C. Spitzweg A.M. Bichlmair TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema Thyroid 7 1997 3 12
51. T. Sunthornthepvarakul Y. Hayashi S. Refetoff Polymorphisms of a variant TSH receptor gene Thyroid 4 1994 147 149
52. A. Takeshita Y. Nagayama K. Fujiyama Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript Biochem Biophys Res Commun 188 1992 1214 1219
53. K. Tanaka G.D. Chazenbalk S.M. McLachlan The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit Mol Cell Endocrinol 150 1999 113 119
54. K. Tanaka G.D. Chazenbalk S.M. McLachlan Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion J Biol Chem 274 1999 2093 2096
55. N. Tandon M.A. Freeman A.P. Weetman T cell response to synthetic TSH receptor peptides in Graves' disease Clin Exp Immunol 89 1992 468 473
56. M. Tonacchera J. Van Sande J. Parma TSH receptor and disease Clin Endocrinol 44 1996 621 633
57. B. Trultzsch T. Nebel R. Paschke The TSH receptor mutation database Eur J Endocrinol 140 1999 VII
58. J. Van Sande J. Parma M. Tonacchera Somatic and germline mutations of the TSH receptor gene in thyroid diseases J Clin Endocrinol Metab 80 1995 2577 2585
59. G. Vassart TSHR mutations. Symposium on TSH Receptor in Thyroid Disease 1999 72nd Annual Meeting of the American Thyroid Association Palm Beach, Florida
60. H. Vlase N. Matsuoka P.N. Graves Folding-dependent binding of thyrotropin (TSH) and TSH receptor autoantibodies to the murine TSH receptor ectodomain Endocrinology 138 1997 1658 1666
61. H. Vlase M. Nakashima P.N. Graves Defining the major antibody epitopes on the human TSH receptor in immunized mice Endocrinology 136 1995 4415 4423
62. H. Vlase M. Weiss P.N. Graves Characterization of the murine immune response to the murine TSH receptor ectodomain: Induction of hypothyroidism and TSH receptor antibodies Clin Exp Immunol 113 1998 111 118
63. H.L. Wadsworth G.D. Chazenbalk Y. Nagayama An insertion in the human thyrotropin receptor critical for high affinity hormone binding Science 249 1990 1423 1425
64. H.L. Wadsworth D. Russo Y. Nagayama Studies on the role of amino acids 38-45 in the expression of a functional thyrotropin receptor Mol Endocrinol 6 1992 394 398
65. M. Zakarija J.M. McKenzie M.S. Eidson Transient neonatal hypothyroidism: Characterization of maternal antibodies to the thyrotropin receptor J Clin Endocrinol Metab 70 1990 1239 1246