Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes mellitus

Brain Research

Volumn 706, Issue 2, 1996, Pages 313-317

  Kumagai, Arno K ^a   Vinores, Stanley A ^b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood retinal barrier; Glucose transporter; GLUT1; Retinal microvasculature; Retinopathy

Indexed keywords

GLUCOSE TRANSPORTER;

ADULT; AGED; ARTICLE; BLOOD RETINA BARRIER; CAPILLARY; CASE REPORT; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; ULTRASTRUCTURE;

EID: 0030051444     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01335-0     Document Type: Article

References (20)

1. Bell, G.I., Kayano, T., Buse, J.B., Burant, C.F., Takeda, J., Lin, D., Fukumoto, H. and Seino, S., Molecular biology of mammalian glucose transporters, Diabetes Care, 13 (1990) 198-208.
2. Betz, A.L. and Goldstein, G.W., Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries, Science, 202 (1978) 225-227.
3. Brownlee, M., The role of non-enzymatic glycosylation in the pathogenesis of diabetic angiopathy. In B. Draznin, S. Melmed and D. LeRoith (Eds.), Molecular and Cellular Biology of Diabetes Mellitus, Vol. 3, Alan R. Liss, New York, 1989, pp. 9-17.
4. Cagliero, E., Maiello, M., Boeri, D., Roy, S. and Lorenzi, M., Increased expression of basement membrane components in human endothelial cells cultured in high glucose, J. Clin. Invest., 82 (1988) 735-738.
5. Cogan, D.G., Aldose reductase and the complications of diabetes, Ann. Int. Med., 101 (1991) 82-91.
6. Cornford, E.M., Hyman, S. and Pardridge, W.M., An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter, J. Cereb. Blood Flow Metab., 13 (1993) 841-854.
7. Cunha-Vaz, J.G., The blood-retinal barriers, Doc. Ophthalmol., 41 (1976) 287-327.
8. Cunha-Vaz, J., Faria de Abreu, J.R., Campos, A.J. and Figo, G.M., Early breakdown of the blood-retinal barrier in diabetes, Br. J. Ophthal., 59 (1975) 649-656.
9. Farrell, C.L. and Pardridge, W.M., Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study, Proc. Natl. Acad. Sci. USA, 88 (1991) 5779-5783.
10. Ferris, F.L., Diabetic retinopathy, Diabetes Care, 16 (supp. 1) (1993) 322-325.
11. Harik, S.I., Kalaria, R.N., Whitney, P.M., Andersson, L., Lundahl, P., Ledbetter, S.R. and Perry, G., Glucose transporters are abundant in cells with 'occluding' junctions at the blood-eye barriers, Proc. Natl. Acad. Sci. USA, 87 (1990) 4261-4264.
12. Kumagai, A.K., Glasgow, B.J. and Pardridge, W.M., GLUT1 glucose transporter expression in the human diabetic and non-diabetic eye. Invest, Ophthalmol. Vis. Sci., 35 (1994) 2887-2894.
13. Lorenzi, M., Cagliero, E. and Toledo, S., Glucose toxicity for human endothelial cells in culture: delayed replication, disturbed cell cycle and accelerated death, Diabetes, 34 (1985) 621-627.
14. Lorenzi, M., Glucose toxicity in the vascular complications of diabetes: the cellular perspective, Diab. Metab. Rev., 8 (1992) 85-103.
15. Merimee, T.J., Diabetic retinopathy: a synthesis of perspectives, N. Engl. J. Med., 322 (1990) 978-983.
16. Pardridge, W.M., Boado, R.J. and Farrell, C.R., Brain-type glucose transporter (GLUT1) is selectively localized to the blood-brain barrier. Studies with quantitative Western blotting and in situ hybridization, J. Biol. Chem., 265 (1990) 18035-18040.
17. Roy, S., Sala, R., Cagliero, E. and Lorenzi, M., Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory, Proc. Natl. Acad. Sci. USA, 87 (1990) 404-408.
18. Takata, K., Kasahara, T., Kasahara, M., Ezaki, O. and Hirano, H., Erythrocyte/Hep G2 type glucose transporter is concentrated in cells of blood-tissue barriers, Biochem. Biophys. Res. Commun., 173 (1990) 67-73.
19. Vinores, S.A., Van Neil, E., Swerdloff, J.L. and Campochiaro, P.A., Electron microscopic immunocytochemical demonstration of blood-retinal barrier breakdown in human diabetics and its association with aldose reductase in retinal vascular endothelium and retinal pigment epithelium, Histochem. J., 25 (1993) 648-663.
20. Waltman, S.R., Oestrich, C., Krupin, T., Hanish, S., Ratzan, S., Santiago, J. and Kilo, C., Quantitative Vitreous Fluorophotometry. A sensitive technique for measuring early breakdown of the blood-retinal barrier in young diabetic patients, Diabetes, 27 (1978) 85-87.