Synergistic operation of the CAR2 (ornithine transaminase) promoter elements in Saccharomyces cerevisiae

Journal of Bacteriology

Volumn 181, Issue 22, 1999, Pages 7052-7064

  Park, Heui Dong ^a   Scott, Stephanie ^b   Rajendra, Rai ^b   Dorrington, Rosemary ^b,c   Cooper, Terrance G ^b  

^a Kyungpook National University   (South Korea)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c RHODES UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALLANTOIN; ARGININE; BETA GALACTOSIDASE; ORNITHINE OXOACID AMINOTRANSFERASE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0032699003     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.22.7052-7064.1999     Document Type: Article

References (64)

1. Anderson, S. F., C. M. Steber, R. E. Esposito, and J. E. Coleman. 1995. UME6, a negative regulator of meiosis in Saccharomyces cerevisiae, contains a C-terminal Zn2Cys6 binuclear cluster that hinds the URS1 DNA sequence in a zinc-dependent manner. Protein Sci. 4:1832-1843.
2. Bechet, J., M. Grenson, and J.-M. Wiame. 1970. Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae. Eur. J. Biochem. 12:31-39.
3. Bercy, J., E. Dubois, and F. Messenguy. 1987. Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their products. Gene 55:277-285.
4. Bossinger, J., and T. G. Cooper. 1977. Molecular events associated with the induction of arginase in Saccharomyces cerevisiae. J. Bacteriol. 131:163-173.
5. Bricmont, P. A., J. R. Daugherty, and T. G. Cooper. 1991. The DAL81 gene product is required for induced expression of two differently regulated nitrogen catabolic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:1161-1166.
6. Carlson, M., and D. Botstein. 1982. Two differentially regulated mRNAs with different 5' ends encode secreted and intracellular forms of yeast invertase. Cell 28:145-154.
7. Chambers, A., C. Stanway, J. S. H. Tsang, Y. Henry, A. J. Kingsman, and S. M. Kingsman. 1990. ARS binding factor 1 binds adjacent to RAP1 at the UASs of the yeast glycolytic genes PGK and PYK1. Nucleic Acids Res. 18:5393-5399.
8. Coffman. J. A., R. Rai, D. M. Loprete, T. Cunningham, V. Svetlov, and T. G. Cooper. 1997. Cross-regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J. Bacteriol. 179:3416-3229.
9. Cooper, T. G. 1982. Nitrogen metabolism in Saccharomyces cerevisiae, p. 39-99. In J. N. Strathern, E. W. Jones, and J. Broach (ed). The molecular biology of the yeast Saccharomyces: metabolism and gene expression. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
10. Cooper, T. G. 1994. Allantoin degradative system - an integrated transcriptional response to multiple signals, p. 139-169. In G. Marzluf and R. Bambrl (ed.), Mycota III. Springer-Verlag, Berlin, Germany.
11. Crabeel, M., M. de Rijcke, S. Seneca, H. Heimberg, I. Pfeiffer, and A. Matisova. 1995. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Yeast 11:1367-1380.
12. Cunin, R., E. Dubois, G. Vanthienen, K. Tinel, A. Jacobs, and M. Crabeel. 1986. Positive and negative regulation of CAR1 expression in Saccharomyces cerevisiae. Mol. Gen. Genet. 205:170-175.
13. Daugherty, J., R. Rai, T. S. Cunningham, and T. G. Cooper. 1999. Overlapping positive and negative GATA binding sites mediate inducible DAL7 expression in Saccharomyces cerevisiae. J. Biol. Chem. 274:28026-28034.
14. Degols, G. 1987. Functional analysis of the regulatory region adjacent to the cargB gene of Saccharomyces cerevisiae. Eur. J. Biochem. 169:193-200.
15. DeRijcke, M., S. Seneca, B. Punyammalee, N. Glansdorf, and M. Crabeel. 1992. Characterization of the DNA target site for the yeast ARGR regulatory complex: a sequence able to mediate repression or induction by arginine. Mol. Cell. Biol. 12:68-81.
16. Deschamps, J., E. Dubois, and J.-M. Wiame. 1979. L-Ornithine transaminase synthesis in Saccharomvces cerevisiae: regulation by inducer exclusion. Mol. Gen. Genet. 174:225-232.
17. Diffley, J. F. X., and B. Stillman. 1988. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. USA 85:2120-2124.
18. Diffley, J. F. X., and B. Stillman. 1989. Similarity between the transcriptional silencer binding proteins ABF1 and RAP1. Science 246:1034-1038.
19. Dorrington, R., and T. G. Cooper. 1993. The DAL82 protein of Saccharomyces cerevisiae binds to the DAL upstream induction sequence (UIS), Nucleic Acids Res. 21:3777-3784.
20. Dubois, E., J. Bercy, and F. Messenguy. 1987. Characterization of two genes, ARGRI and ARGRIII, required for specific regulation of arginine metabolism in yeast. Mol. Gen. Genet. 207:142-148.
21. Dubois, E., and F. Messenguy. 1985. Isolation and characterization of the yeast ARGRII gene involved in regulating both anabolism and catabolism of arginine. Mol. Gen. Genet. 198:283-289.
22. Guarente, L. 1983. Yeast promoters and lacZ fusion designed to study expression of cloned genes in yeast. Methods Enzymol. 101:181-191.
23. Guarente, L., and T. Mason. 1983. Heme regulatory transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32:1279-1286.
24. Guarente, L., and M. Ptashne. 1981. Fusion of Escherichia coli lacZ to the cytrochrome c gene of Sacchammyces cerevisiae. Proc. Natl. Acad. Sci. USA 78:2199-2230.
25. Hennaut, C. 1981. Ornithine transaminase synthesis in Sacchammyces cerevisiae: induction by allophanate, intermediate and inducer of the urea degradative pathway adds to arginine induction. Curr. Genet. 4:69-72.
26. Henry, Y. A., A. Chambers, J. S. H. Tsang, A. J. Kingsman, and S. M. Kingsman. 1990. Characterization of the DNA binding domain of the yeast RAP1 protein. Nucleic Acids Res. 18:2617-2623.
27. Hoet, P. R., and J. M. Wiame. 1974. On the nature of argR mutations in Sacchammyces cerevisiae. Eur. J. Biochem. 43:87-92.
28. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
29. Kovari, L., R. Sumrada, I. Kovari, and T. G. Cooper. 1990. Multiple positive and negative as-acting elements mediate induced arginase (CAR1) gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:5087-5097.
30. Kovari, L. Z., and T. G. Cooper. 1991. Participation of ABF-1 protein in expression of the Saccharomvces cerevisiae CAR1 gene. J. Bacterial. 173: 6332-6338.
31. Kovari, L. Z., I. Kovari, and T. G. Cooper. 1993. Participation of RAP1 protein in expression of the Saccharomyces cerevisiae arginase (CAR1) gene. J. Bacteriol. 175:941-951.
32. Kurtz, S., and D. Shore. 1991. RAP1 protein activates and silences transcription of mating-type genes in yeast. Genes Dev. 5:616-628.
33. Luche, R. M., R. Sumrada, and T. G. Cooper. 1990. A cis-acting element present in multiple genes serves as a repressor-protein binding site for the yeast CAR1 gene. Mol. Cell. Biol. 10:3884-3995.
34. Lustig, A. J., S. Kurtz, and D. Shore. 1990. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250: 549-553.
35. Mandel, M., and A. Higa. 1970. Calcium-dependent bacteriophagc DNA infection. J. Mol. Biol. 53:159-162.
36. Messenguy, F., and E. Dubois. 1993. Genetic evidence for a role for MCM1 in the regulation of arginine metabolism in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:2586-2592.
37. Messenguy, F., E. Dubois, and C. Boonchird. 1991. Determination of the DNA-binding sequences of ARGR proteins to arginine anabolic and catabolic promoters. Mol. Cell. Biol. 11:2852-2863.
38. Messenguy, F., E. Dubois, and F. Descamps. 1986. Nucleotide sequence of the ARGRII regulatory gene and amino acid sequence homologies between ARGRII, PPR1 and GAL4 regulatory proteins. Eur. J. Biochem. 57:77-81.
39. Middlehoven, W. J. 1964. The pathway of arginine breakdown in Saccharomyces cerevisiae. Biochim. Biophys. Acta 93:650-652.
40. Middlehoven, W. J. 1968. The derepression of arginase and ornithine transaminase in nitrogen-starved baker's yeast. Biochim. Biophys. Acta 156: 440-443.
41. Middlehoven, W. J. 1969. Enzyme repression in the arginine pathway of Saccharomvces cerevisiae. Antonie Leeuwenhoek J. Microbiol. Serol. 35:215-226.
42. Middlehoven, W. J. 1970. Induction and repression of arginase and ornithine transaminase in baker's yeast. Antonie Leeuwenhoek J. Microbiol. Serol. 36:1-19.
43. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
44. Park, H.-D., R. M. Luche, and T. G. Cooper. 1992. The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 represser binding site. Nucleic Acids Res. 20:1909-1915.
45. Qui, H. F., E. Dubois, P. Broen, and F. Messenguy. 1990. Functional analysis of ARGRI and ARGRIII regulatory proteins involved in the regulation of arginine metabolism in Saccharomyces cerevisiae. Mol. Gen. Genet. 222:192-200.
46. NTR functioning in combination with other UAS elements underlies exceptional patterns of nitrogen regulation in Saccharomyces cerevisiae. Yeast 11:247-260.
47. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
48. Shore, D., and K. Nasmyth. 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51:721-732.
49. Smart, W. C., J. A. Coffman, and T. G. Cooper. 1996. Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) gene promoter in response to multiple environmental signals. Mol. Cell. Biol. 16:5876-5887.
50. Strich, R., R. T. Surosky, C. Steber, E. Dubois, F. Messenguy, and R. E. Esposito. 1994. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 8:796-810.
51. Sumrada, R. Personal communication.
52. Sumrada, R., and T. G. Cooper. 1982. Isolation of the CAR1 gene from Saccharomyces cerevisiae and analysis of its expression. Mol. Cell. Biol. 2:1514-1523.
53. Sumrada, R. A., and T. G. Cooper. 1985. Point mutation generates constitutive expression of an inducible eukaryotic gene. Froc. Natl. Acad. Sci. USA 82:643-647.
54. Sumrada, R. A., and T. G. Cooper. 1987. Ubiquitous expression sequences control activation of inducible arginase gene in yeast. Proc. Natl. Acad. Sci. USA 84:3997-4001.
55. Svetlov, V., and T. G. Cooper. 1997. The minimal transactivation region of Saccharomyces cerevisiae Gln3p is localized to 13 amino acids. J. Bacteriol. 179:7644-7652.
56. Tabor, S., and C. C. Richardson. 1987. DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc. Natl. Acad. Sci. USA 84:4767-4771.
57. Taylor, G., M. McPherson, and D. Hames. 1994. PCRII: a practical approach. IRL Press, New York, N.Y.
58. Tschumper, G., and J. Carbon. 1980. Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. Gene 10:1157-1166.
59. Turoscy, V., and T. G. Cooper. 1982. Pleiotropic control of five eucaryotic genes by multiple regulatory elements. J. Bacteriol. 151:1237-1246.
60. van Vuuren, H. J. J., J. R. Daugherty, R. Rai, and T. G. Cooper. 1991. Upstream induction sequence, the cis-acting element required for response to the allantoin pathway inducer and enhancement of operation of the nitrogen-regulated upstream activation sequence in Sacchammyces cerevisiae. J. Bacteriol. 173:7186-7195.
61. Viljoen, M, L. Z. Kovari, I. A. Kovari, H.-D. Park, H. J. J. van Vuuren, and T. G. Cooper. 1992. Tripartite structure of the Saccharomyces cerevisiae arginase (CAR1) gene inducer-responsive upstream activation sequence. J. Bacteriol. 174:6831-6839.
62. Whitney, P. A., and B. Magasanik. 1973. The induction of arginase in Saccharomyces cerevisiae. J. Biol. Chem. 248:6197-6202.
63. Wiame, J.-M. 1971. The regulation of arginine metabolism in Saccharomyces cerevisiae: exclusion mechanism. Curr. Top. Cell. Regul. 4:1-38.
64. Yoo, H.-S., and T. G. Cooper. 1989. The DAL7 promoter consists of multiple elements that cooperatively mediate regulation of the gene's expression. Mol. Cell. Biol. 9:3231-3243.