Relationship of telomeres and p53 in aging bovine corneal endothelial cell cultures

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 5, 2000, Pages 1070-1075

  Whikehart, David R ^a   Register, Shilpa J ^a   Chang, Qing ^a   Montgomery, Brodrick ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATTLE; CELL CULTURE; CELL CYCLE S PHASE; CELL DIVISION; CORNEA ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYEBANK; NONHUMAN; PENETRATING KERATOPLASTY; PRIORITY JOURNAL; SKIN FIBROBLAST; TELOMERE;

ANIMALS; BETA-GALACTOSIDASE; CATTLE; CELL AGING; CELLS, CULTURED; DNA; ENDOTHELIUM, CORNEAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034126888     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Pepose JS, Ubels JL. The cornea. In: Hart WM, ed. Adler's Physiology of the Eye. 9th ed., St. Louis: Mosby; 1992:29-70.
2. Joyce NC, Harris DL, Zieske JD. Mitotic inhibition of corneal endothelium in neonatal rats. Invest Ophthalmol Vis Sci. 1998;39: 2572-2583.
3. Wilson SE, Lloyd SA, He Y-G, McCash CS. Extended life of human corneal endothelial cells transfected with the SV40 large T antigen. Invest Ophthalmol Vis Sci. 1993;34:2112-2123.
4. Whikehart DR, Montgomery B, Wells JD. Age as a function of ATPase activity in cultured corneal endothelial cells. Invest Ophthalmol Vis Sci. 1989;30:335-338.
5. Register SJ, Coston TS, Blake DA, Whikehart DR. Bovine corneal endothelial cell p53 levels increase with culture age as the cellular telomeres shorten [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1999;40(4):S366. Abstract nr 1942.
6. Harley CB. Telomeres and aging. In: Blackburn EH, Greider CW, eds. Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1995:247-263.
7. Olovnikov A. A theory of marginotomy: the incomplete copying of template margininenzymatic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor Biol. 1973;41: 181-190.
8. Chiu CP, Harley CB. Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc Soc Exp Biol Med. 1997;214:99-106.
9. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998; 279:349-352.
10. Levine AJ, Chang A, Dittmer D, et al. The p53 tumor suppressor gene. J Lab Clin Med. 1993;123:817-823.
11. Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997;90:809-819.
12. Kulju KS, Lehman JM. Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res. 1995;217:336-345.
13. Vaziri H, Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol. 1996;31:295-301.
14. Sugre MM, Shin DY, Lee SW, Aaronson SA. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking func-tional p53. Proc Natl Acad Sci USA. 1997;94:9648-9653.
15. Higgins P, Helms C, Liu L, et al. Genlink 1996 genome screen maps with 9 telomere microsatellite markers (abstract). Am J Hum Genet. 1996; 59(suppl):A221.
16. Kip1. In: The Genome Database. Baltimore: Johns Hopkins University School of Medicine; 1999.
17. INK4. In: The Genome Database. Baltimore: Johns Hopkins University School of Medicine; 1999.
18. INK4B) In: The Genome Database. Baltimore: Johns Hopkins University School of Medicine; 1999.
19. Zagrod ME, Whikehart DR. Null effect of adenosine on cyclic nucleotides of the corneal endothelium: possible implications for adenosine-stimulated corneal deturgescence. Curr Eye Res. 1984; 3:293-298.
20. Perlman M, Baum JL. The mass culture of rabbit corneal endothelial cells. Arch Ophthalmol. 1974;92:235-237.
21. Harley CB. Aging of cultured human skin fibroblasts. Methods Mol Biol. 1990;5:25-32.
22. Harley CB, Futcher AB, Greider CW. Telomeres shorten during aging of human fibroblasts. Nature. 1990;345:458-460.
23. Whikehart DR, Blake DA, Chang Q, Montgomery B. Telomeres in human corneal endothelial cells [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1997;38(4):S399. Abstract nr 1883.
24. Sambrook J, Fritsch EF, Maniatis T, eds. Molecular Cloning, A laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989;9:14-9.19,B.5.
25. Bartek J, Bartkova J, Vojesek B. et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991;6:1699-1703.
26. Crowther JR. ELISA, Theory and Practice. Totowa, NJ: Humana Press; 1995:39-41.
27. Dequiedt F, Willems L, Burny A, Kettmann R. Nucleotide sequence of the bovine p53 tumor-suppressor cDNA: DNA sequence. DNA Seq. 1995;5:261-264.
28. Sanes JR, Rubenstein JL, Nicholas J-F. Use of a recombinant retrovirus to study post-implantation cell linkage in mouse embryos. EMBO J 1986;5:3133-3142.
29. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 1995;92:9363-9367.
30. Vaziri H, West MD, Allsopp RC, et al. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly-(ADP-ribose) polymerase. EMBO J. 1997;16:6018-6033.
31. Egan CA, Savre-Train I, Shay JW, Wilson SE, Bourne WM. Analysis of telomere lengths in human corneal endothelial cells from donors of different ages. Invest Ophthalmol Vis Sci 1998;38:648-653.
32. Strahl-Bolsinger S, Hecht A. Luo K, Grunstein M. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev 1997;11:83-93.
33. Bianchi A, Smith S, Chong L, Elias P, de Lange T. TRF1 is a dimer and bends telomeric DNA. EMBO J 1997;16:1785-794.
34. Brown SW. Heterochromatin. Science. 1966:151:417-425.
35. Hennig W. Heterochromatin. Chromosoma. 1999;108:1-9.
36. Braunstein M, Rose AB, Holmes SG, Allis CD, Broach JR. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 1993;7:592-604.
37. van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998;92:401-413.