Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon γ, indomethacin, and phenylbutyrate

Cancer Research

Volumn 60, Issue 12, 2000, Pages 3200-3206

  Huang, Yicong ^b   Horvath, Curt M ^a   Waxman, Samuel ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Rochelle Belfer Chemother Found L   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLBUTYRIC ACID DERIVATIVE; FLUOROURACIL; GAMMA INTERFERON; INDOMETACIN; PROTEIN P21;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG MIXTURE; DRUG SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL DIVISION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYCLOOXYGENASE 2; DNA FRAGMENTATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROURACIL; HUMANS; INDOMETHACIN; INTERFERON TYPE II; ISOENZYMES; MEMBRANE PROTEINS; NEOPLASM RECURRENCE, LOCAL; PHENYLBUTYRATES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; RECURRENCE; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0034124452     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Bruckner, H. W., and Mortwani, B. T. Chemotherapy of advanced cancer of the colon and rectum. Semin. Oncol., 18: 443-461, 1991.
2. Moertel, C. G., and Reitemeier, R. J. Advanced Gastrointestinal Cancer-Clinical Management and Chemotherapy. New York: Harper & Row, 1969.
3. Northover, J. Colorectal cancer. Eur. J. Gastroenterol. Hepatol., 11: 37-39, 1999.
4. Waxman, S., Bruckner, H., Wagle, A., and Schreiber, C. Potentiation of 5-fluorouracil antimetabolic effect by leucovorin. Proc. Am. Assoc. Cancer Res., 19: 1949, 1978.
5. Evans, R. M., Laskin, J. D., and Hakala, M. T. Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res., 41: 3288-3294, 1981.
6. The Advanced Colorectal Cancer Meta-Analysis Project, Piedbois, P., Buyse, M., Rustum, Y., Machover, D., Erlichman, C., Carlson, R. W., Valone, F., Labianca, R., Doroshow, J. H., and Petrelli, N. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidance in terms of response rate. J. Clin. Oncol., 10: 896-903, 1992.
7. Wadler, S., Schwartz, E. L., Goldman, M., Lyver, A., Rader, M., Zimmerman, M., Itri, L., Weinberg, V., and Wiernik, P. H. Fluorouracil and recombinant α-2a-interferon: an active regimen against advanced colorectal carcinoma. J. Clin. Oncol., 7: 1769-1775, 1989.
8. Huang, Y., and Waxman, S. Enhanced growth inhibition and differentiation of fluorodeosyuridine-treated human colon carcinoma cells by phenylbutyrate. Clin. Cancer Res., 4: 2503-2509, 1998.
9. WAF1/CIP1 mediated by STAT1. Science (Washington DC), 272: 719-722, 1996.
10. Wong, L. H., Hatzinisiriou, I., Devenish, R. J., and Ralph, S. J. IFN-γ priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type 1 IFNs. J. Immunol., 160: 5475-5484, 1998.
11. Levy, G. N. Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB J., 11: 234-247, 1997.
12. Thun, M. J., Namboodiri, M. M., and Heath, C. W., Jr. Aspirin use and-reduced risk of fatal colon cancer. N. Engl. J. Med., 325: 1593-1596, 1991.
13. Giardieno, F. M., Hamilton, S. R., Krush, A. J., Piantadosi, S., Hylind, L. M., Celano, P., Booker, S. V., Robinson, C. R., and Offerhaus, J. A. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med., 328: 1313-1316, 1993.
14. Shiff, S. J., Koutsos, M. I., Qiao, L., and Rigas, B. Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Exp. Cell Res., 222: 179-188, 1996.
15. Giardina, C., and Inan, M. S. Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells. Biochim. Biophys. Acta, 1401: 277-288, 1998.
16. Melchior, S. W., Brown, L. G., Figg, W. D., Quinn, J. E., Santucci, R. A., Brunner, J., Thuroff, J. W., Lange, P. H., and Vessella, R. L. Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo. Int. J. Oncol., 14: 501-508, 1999.
17. Pelidis, M. A., Carducci, M. A., and Simons, J. W. Cytotoxic effects of sodium phenylbutyrate on human neuroblastoma cell lines. Int. J. Oncol., 12: 889-893, 1998.
18. Carducci, M. A., Nelson, J. B., Chan-Tack, K. M., Ayyagari, S. R., Sweatt, W. H., Campbell, P. A., Nelson, W. G., and Simons, J. W. Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate. Clin. Cancer Res., 2: 379-387, 1996.
19. Engelhard, H. H., Homer, R. J., Duncan, H. A., and Rozental, J. Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J. Neuro-Oncol., 37: 97-108, 1998.
20. Samid, D. Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers. Adv. Exp. Med. Biol., 400A: 501-505, 1997.
21. Goldwasser, F., Bae, I., Valenti, M., Torres, K., and Pommier, Y. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res., 55: 2116-2121, 1995.
22. Huang, Y., and Waxman, S. Enhanced apoptosis in leukemia cells following treatment with combination fluoropyrimidines and differentiation inducers. Mol. Cell. Differ., 2: 83-100, 1994.
23. Horvath, C. M., Wen, Z., and Darnell, J. E., Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev., 9: 984-994, 1995.
24. Heerdt, B. G., Houston, M. A., and Augenlicht, L. H. Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Res., 54: 3288-3294, 1994.
25. van der Wilt, C. L., Smid, K., Aherne, G. W., Noordhuis, P., and Peters, G. J. Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells. Eur. J. Cancer, 33: 471-478, 1997.
26. Chu, E., Zinn, S., Boarman, D., and Allegra, C. J. Interaction of γ interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res., 50: 5834-5840, 1990.
27. Tillman, D. M., Petak. I., and Houghton, J. A. A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin. Cancer Res., 5: 425-430, 1999.
28. Xu, X., Fu, X., Plate, J., and Chong, A. S. IFN-γ induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res., 58: 2832-2837, 1998.
29. Chen, A., Licht, J. D., Wu, Y., Hellinger, N., Scher, W., and Waxman, S. Retinoic acid is required for and potentiates differentiation of acute promyelocytic leukemia cells by nonretinoid agents. Blood. 84: 2122-2129, 1994.
30. Jing, Y., Dai, J., Chalmers-Redman, R. M. E., Tatton, W. G., and Waxman, S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94: 2102-2111, 1999.
31. Shirasawa S., Furuse, M., Yokoyama, N., and Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (Washington DC), 260: 85-88, 1993.
32. H oncogene. Cell Growth Differ., 4: 341-347, 1993.
33. Sechler J. M. G., Malech, H. L., White, L. J., and Gallin, J. I. Recombination human interferon-γ reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood. Proc. Natl. Acad. Sci. USA, 85: 4874-4878, 1988.
34. Kopp, W. C., Smith, J. W., II, Ewel, C. H., Alvord, W. G., Main, C., Guyre, P. M., Steis, R. G., Longo, D. L., and Urba, W. J. Immunomodulatory effects of interferon γ in patients with metastatic malignant melanoma. J. Immunother., 13: 181-190, 1993.
35. Bonnem, E. C., and Oldham, R. K. γ-Interferon: physiology and speculation on its role in medicine. J. Biol. Response Modif., 6: 275-301, 1987.
36. Namba, M., Miyoshi, T., Kanamori, T., Nobuhara, M., Kimoto, T., and Ogawa, S. Combined effects of 5-fluorouracil and interferon on proliferation of human neoplastic cells in culture. Gann, 73: 819-824, 1982.
37. Stadler, M., Chelbi-Alix, M. K., Koken, M. H. M., Venturini, L., Lee, C., Saib, A., Quignon, F., Pelicano, L., Guillemin, M. C., Schindler, C., and de The, H. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene, 11: 2565-2573, 1995.
38. Pine, R., Canova, A., and Schindler, C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFNα and IFNγ, and is likely to autoregulate the p91 gene. EMBO J., 13: 158-167, 1994.
39. L716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 87: 803-809, 1996.
40. Narisawa, T., Sato, M., Tani, M., Kudo, T., Takahashi, T., and Goto, A. Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. Cancer Res., 41: 1954-1957, 1981.
41. Metzger, U., Meier, J., Uhlschmid, G., and Weihe, H. Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer. Dis. Colon Rectum, 27: 366-369, 1984.
42. Boolbol, S. K., Dannenberg, A. J., Chadurn, A., Martucci, C., Guo, X. J., Ramonetti, J. T., Abteu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., and Bertagnolli, M. M. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res., 56: 2556-2560, 1996.
43. Dubois, R. N., Radhika, A., Reddy, B. S., and Entingh, A. J. Increased cyclooxygenase-2 levels in carcingen-induced rat colonic tumors. Gastroenterology, 110: 1259-1262, 1996.
44. Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano-Coico, L., Shiff, S. I., and Rigas, B. Effects of nonsteroid anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol., 52: 237-245, 1996.
45. Chan, T. A., Morin, P. J., Vogelstein, B., and Kinzler, K. W. Mechanisms underlying nonsteroid antiinflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 95: 681-686, 1998.
46. Giardina, C., Boulares, H., and Inan, M. S. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-α and Fas ligation: the role of reactive oxygen species. Biochim. Biophys. Acta, 1448: 425-438, 1999.
47. Sung, M. W., and Waxman, S. Chemodifferentiation theraphy with fluorouracil (FU) and phenylbutyrate (PB) in advanced colorectal cancer: a Phase 1 trial. Proc. Am. Assoc. Cancer Res., 40: A2245, 1999.