The use of newborn rats and an adenoviral gene delivery vector as a model system for wound-healing research

Annals of Plastic Surgery

Volumn 44, Issue 5, 2000, Pages 543-552

  Liu, Wei ^a   Mehrara, Babak J ^a   Chin, Gyu S ^a   Hsu, Meier ^a   Peled, Ziv ^a   Longaker, Michael T ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYTOKINE; GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HISTOLOGY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN INJURY; WOUND HEALING;

EID: 0034122916     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000637-200044050-00014     Document Type: Article

References (39)

1. Longaker MT, Adzick NS. The biology of fetal wound healing: a review. Plast Reconstr Surg 1991;87(4):788-798
2. Bennett NT, Schultz GS. Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 1999;165(6):728-737
3. Lee TY, Chin GS, Kim WJH, et al. Expression of transforming growth factor beta 1,2, and 3 proteins in keloids. Ann Plast Surg 1999;43(2):179-184
4. Chau D, Mancoll JS, Lee S, et al. Tamoxifen downregulates TGF-beta production in keloid fibroblasts. Ann Plast Surg 1998;40(5):490-493
5. Polo M, Smith PD, Kim YJ, et al. Effect of TGF-beta 2 on proliferative scar fibroblast cell kinetics. Ann Plast Surg 1999;43(2):185-190
6. Akimoto S, Ishikawa O, Iijima C, et al. Expression of basic fibroblast growth factor and its receptor by fibroblast, macrophages and mast cells in hypertrophic scar. Eur J Dermatol 1999;9(5):357-362
7. Smith P, Mosiello G, Deluca L, et al. TGF-beta 2 activates proliferative scar fibroblasts. J Surg Res 1999;82(2):319-323
8. Younai S, Venters G, Vu S, et al. Role of growth factors in scar contraction: an in vitro analysis. Ann Plast Surg 1996;36(5):495-501
9. Steinbrech DS, Mehrara BJ, Chau D, et al. Hypoxia upregulates VEGF production in keloid fibroblasts. Ann Plast Surg 1999;42(5):514-519
10. Ghahary A, Shen YJ, Wang R, et al. Expression and localization of insulin-like growth factor-1 in normal and postburn hypertrophic scar tissue in humans. Mol Cell Biochem 1998;183(1-2):1-9
11. Kopp JB. Glomerulosclerosis, tubulointerstitial fibrosis, and obstructive uropathy in PEPCK-TGF-betal transgenic mice. Am J Kidney Dis 1999;34(1):177-183
12. Molotkov A, Satoh M, Tohyama C. Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett 1998;132(1-2):187-192
13. Clark RAF. Wound repair: overview and general considerations. In: Clark RAF, ed. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press, 1996:3-50
14. Bonyadi M, Rusholme SA, Cousins FM, et al. Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Nat Genet 1997;15(2):207-211
15. Borkowski TA, Letterio JJ, Farr AG, et al. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 1996;184(6):2417-2422
16. Khavari PA, Krueger GG. Cutaneous gene therapy. Dermatol Clin 1997;15(1):27-35
17. Slama J, Andree C, Winkler T, et al. Gene transfer. Ann Plast Surg 1995;35:429-439
18. Alexander MY, Akhurst RJ. Liposome-mediated gene transfer and expression via the skin. Hum Mol Genet 1995;4(12):2279-2285
19. Goula D, Benoist C, Mantero S, et al. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 1998;5(9):1291-1295
20. Liptay S, Weidenbach H, Adler G, et al. Colon epithelium can be transiently transfected with liposomes, calcium phosphate precipitation and DEAE dextran in vivo. Digestion 1998;59(2):142-147
21. Andree C, Swain W, Page CP, et al. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A 1994;91:12188-12192
22. Eriksson E, Yao F, Svensjo T, et al. In vivo gene transfer to skin and wound by microseeding. J Surg Res 1998;78(2): 85-91
23. Katsumi A, Emi N, Abe A. Humoral and cellular immunity to an encoded protein induced by direct DNA injection. Hum Gene Ther 1994;5:1335-1339
24. Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990;247: 1465-1468
25. Vanderkwaak TJ, Wang M, Gomez-Navarro J, et al. An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches. Gynecol Oncol 1999;74(2):227-234
26. van der Eb MM, Hoeben RC, van de Velde CJ. Towards gene therapy for colorectal liver metastases. Cancer Res 1998;147:173-186
27. Eisensmith RC, Woo SL. Viral vector-mediated gene therapy for hemophilia B. Thromb Haemost 1997;78(1):24-30
28. Coutelle C, Williamson R. Liposomes and viruses for gene therapy of cystic fibrosis. J Aerosol Med 1996;9(1):79-88
29. Barkats M, Bilang-Bleuel A, Buc-Caron MH, et al. Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseases. Prog Neurobiol 1998;55(4): 333-341
30. Lu B, Federoff HJ, Wang Y, et al. Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol 1997;108(5):803-808
31. Knowles MR, Hohneker KW, Zhou Z, et al. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 1995;333(13):823-831
32. Fang B, Eisensmith RC, Wang H, et al. Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovims-mediated factor IX expression. Hum Gene Ther 1995;6(8):1039-1044
33. Bakker JM, Broug-Holub E, Kroes H, et al. Functional immaturity of rat alveolar macrophages during postnatal development. Immunology 1999;94(3):303-309
34. Sainte-Marie G, Guay G, Peng FS. Association of neutrophils with high endothelial venules in the neonatal rat lymph nodes: a probable relation to immunoincompetence. Acta Anat 1995;152(1):41-48
35. Yang EY, Kim HB, Shaaban AF, et al. Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus. J Pediatr Surg 1999; 34(5):766-772
36. Yamasaki K, Edington HD, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1988;101(5):967-971
37. Liechty KW, Sablich TJ, Adzick NS, et al. Young investigator award: recombinant adenoviral mediated gene transfer in ischemic impaired wound healing. Wound Repair Regen 1999;7(3):148-153
38. Liechty KW, Nesbit M, Herlyn M, et al. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing. J Invest Dermatol 1999;113(3):375-383
39. Mehrara BJ, Saadeh PB, Steinbrech DS, et al. Adenovirus-mediated gene therapy of osteoblasts in vitro and in vivo. J Bone Miner Res 1999;14(8):1290-1301