Role of growth factors in scar contraction: An in vitro analysis

Annals of Plastic Surgery

Volumn 36, Issue 5, 1996, Pages 495-501

  Younai, Soheil ^a   Venters, Gregory ^b   Vu, Steve ^b   Nichter, Larry ^b   Nimni, Marcel E ^b   Tuan, Tai Lan ^b  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BURN; BURN CONTRACTURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; PRIORITY JOURNAL; SKIN FIBROBLAST; WOUND CONTRACTION;

EID: 0029945754     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000637-199605000-00011     Document Type: Article

References (23)

1. Ehrlich HP. Wound closure: evidence of cooperation between fibroblasts and collagen matrix. Eye 1988;2:149-157
2. Ehrlich HP. The modulation of contraction of fibroblast populated collagen lattices by type I, II, and III collagen. Tissue Cell 1988;20:47-50
3. Ehrlich HP, Buttle DJ, Bernanke DH. Physiological variables affecting collagen lattice contraction by human dermal fibroblasts. Exp Mol Pathol 1989;50:220-229
4. Tuan T-L, Grinnell F, Fibronectin and fibrinolysis are not required for fibrin gel contraction by human skin fibroblasts. J Cell Physiol 1989;140:577-583
5. Guidry C, Grirnnell F. Heparin modulates the organization of hydrated collagen gels and inhibits gel contraction by fibroblast. J Cell Biol 1987;104:1097-1103
6. Montesano R, Orci L. Transforming growth factor β stimulated collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A 1988;85:4894-4897
7. Tingstrom A, Heldin CH, Rubin K. Regulation of fibroblast-mediated collagen gel contraction by platelet- derived growth factor, interleukin-1a and transforming growth factor-β1. J Cell Sci 1992;102:315-322
8. Chen JK, Li SR, Tsai RJF. Cyclic AMP-inhibition of collagen lattice contraction by fibroblasts may be attenuated by both cyclic AMP dependent and independent mechanisms. J Cell Physiol 1993;155:8-13
9. Clark RAF, Folkvord JM, Hart CE, et al. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest 1989;84:1036- 1040
10. Guidry C. Extracellular matrix contraction by fibroblasts: peptide promoters and second messengers. Cancer Metastasis Rev 1992;11:45-54
11. Soma Y, Grotendorst GR. TGF-β stimulated primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides. J Cell Physiol 1989;140:246-253
12. Ehrlich HP, Desmouliere A, Diegelmann RF, et al. Morphological and immunological differences between keloid and hypertrophic scar. Am J Pathol 1994;145:105-113
13. Roberts AB, Sporn MB, eds. Peptide growth factors and their receptors. Handbook of experimental pharmacology. Heidelberg: Springer-Verlag, 1990
14. Ross R, Raines EW, Browen-Pope DF. The biology of platelet-derived growth factor. Cell 1986;45:155-169
15. 1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993;122:103-111
16. Leof EB, Proper JA, Goustin AS, et al. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: a proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci U S A 1986;83:2453-2457
17. Messadi DV, Bertolami CN. CD44 and hyaluronan expression in human cutaneous scar fibroblasts. Am J Pathol 1993;142:1041-1049
18. Russell SB, Trupin KM, Rodriguez-Eaton S, et al. Reduced growth factor requirement of keloid-derived fibroblasts may account for tumor growth. Proc Natl Acad Sci U S A 1988;85:587-593
19. Garner WL, Karmiol S, Rodriguez JL, et al. Phenotypic differences in cytokine responsiveness of hypertrophic scar versus dermal fibroblasts. J Invest Dermatol 1993;101:875-879
20. Younai S, Nichter LS, Wellisz T, et al. Modulation of collagen synthesis by TGF-β in keloid and hypertrophic scar fibroblasts. Ann Plast Surg 1994;33:148-151
21. Wrana JL, Attisano L, Wieser R, et al. Mechanism of activation of the TGF-beta receptor. Nature 1994;370:341-347
22. Nathan C, Sporn M. Cytokines in context. J Cell Biol 1991;113:981-986
23. Tuan TL, Song A, Chang S, et al. In vitro fibroplasia: matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels. Exp Cell Res 1996;223:127-134