Effect of TGF-β2 on proliferative scar fibroblast cell kinetics

Annals of Plastic Surgery

Volumn 43, Issue 2, 1999, Pages 185-190

  Polo, Max ^a,b   Smith, Paul D ^a   Kim, Y J ^a   Wang, Xue ^a   Ko, Francis ^a   Robson, Martin C ^a,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b MAIMONIDES MEDICAL CENTER   (United States)

^c Bay Pines VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA2; ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BURN SCAR; CELL PROLIFERATION; COLLAGEN SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; KELOID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCAR; SCAR FORMATION; SKIN FLAP; ANIMAL; CELL CULTURE; CELL DIVISION; DRUG EFFECT; NUDE RAT; PATHOLOGY; PLASTIC SURGERY;

ANIMALS; CELL DIVISION; CELLS, CULTURED; CICATRIX, HYPERTROPHIC; FIBROBLASTS; HUMANS; KELOID; PROTEIN ISOFORMS; RATS; RATS, NUDE; SURGICAL FLAPS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032587390     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000637-199943020-00014     Document Type: Article

References (20)

1. Ernst H, Konturek P, Hahn EG, et al. Acceleration of wound healing in gastric ulcers by local injection of neutralizing antibody to transforming growth factor β1. Gut 1996;39:172-175
2. Shaw M, Foreman DM, Ferguson MWJ. Neutralizing antibody to TGF-β1, 2 reduces cutaneous scarring in adult rodents. J Cell Sci 1994;107:1137-1157
3. Hayward PG, Linares HA, Evans MH, et al. A model of human keloid using the nude (athymic) rat. Surg Forum 1991;42:612-614
4. Polo M, Kim YJ, Kucukcelebi A, et al. Special article: an in vivo model of human proliferative scar. J Surg Res 1998; 74:187-195
5. Berman B, Bieley HC. Adjunct therapies to surgical management of keloids. Dermatol Surg 1996;22:126-130
6. Kischer CW, Shetlar MR, Chvapil M. Hypertrophic scars and keloids: a review and new concept concerning their origin. Scanning Microsc 1982;4:1699-1713
7. Khalil N, O'Connor RN, Unruh HW, et al. Increased production and immunohistochemical localization of transforming growth factor in idiopathic pulmonary fibrosis. Am J Resp Cell Mol Biol 1991;5:155-162
8. Polo M, Ko F, Busillo BS, et al. The 1997 Moyer Award: cytokine production in patients with hypertrophic burn scars. J Burn Care Rehabil 1997;18:477-482
9. Wu L, Siddiqui A, Morris DE, et al. Transforming growth factor beta 3 (TGF beta 3) accelerates wound healing without alteration of scar prominence. Histologic and competitive reverse-transcription-polymerase chain reaction studies. Arch Surg 1997;132:753-760
10. Cromack DT, Porras-Reyes B, Purdy JA, et al. Acceleration of tissue repair by transforming growth factor beta 1: identification of in vivo mechanism of action with radiotherapy-induced specific healing deficits. Surgery 1993; 113:36-42
11. Chau D, Mancoll JS, Lee S, et al. Tamoxifen downregulates TGF-beta production in keloid fibroblasts. Ann Plast Surg 1998;40:490-493
12. Aiba S, Tagami H. Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. J Cutan Pathol 1997;24:65-69
13. Polo M, Kim YJ, Wang X, et al. Effects of exogenous TGF-b2 on human proliferative scar xenografts in nude rats. Surg Forum 1997;48:669-671
14. Datubo-Brown DD. Keloids: a review of the literature. Br J Plast Surg 1990;43:70-77
15. Muir IF. On the nature of keloid and hypertrophic scars. Br J Plast Surg 1990;43:61-69
16. Lawrence WT. In search of the optimal treatment of keloids: report of a series and a review of the literature. Ann Plast Surg 1991;27:164-178
17. Robb EC, Wayrnack JP, Warden GO, et al. A new model for studying the development of human hypertrophic burn scar formation. J Burn Care Rehabil 1987;8:371-375
18. Bettinger DA, Yager DR, Diegelmann RF, Cohen IK. The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis. Plast Reconstr Surg 1996;98:827-833
19. Roberts AB, Sporn MB, Assoin RK, et al. Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986;83:4167-4171
20. Wassermann RJ, Polo M, Smith PD, et al. Differential production of apoptosis modulating proteins in patients with hypertrophic burn scar. J Surg Res 1998;75:187-195