Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype

AIDS

Volumn 14, Issue 5, 2000, Pages 483-489

  Martinson, Jeremy J ^c   Hong, Lily ^a   Karanicolas, Rose ^a   Moore, John P ^a   Kostrikis, Leondios G ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

CCR2; CCR5; Co receptors; HIV; Polymorphisms

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; UNCLASSIFIED DRUG;

AFRICA; ARTICLE; ASIA; DNA POLYMORPHISM; EUROPE; GENE FREQUENCY; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION RESISTANCE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE;

ALLELES; GENETIC SCREENING; HAPLOTYPES; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; WORLD HEALTH;

EID: 0034119188     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200003310-00003     Document Type: Article

References (33)

1. 1. Moore JP. Coreceptors: implications for HIV pathogenesis and therapy. Science 1997, 276:51-52.
2. 2. Berger EA, Murphy PM, Farber MT. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease. Ann Rev Immunol 1999, 17:657-700.
3. 3. Fauci AS: Host factors and the pathogenesis of HIV-induced disease. Nature 1996, 384:529-534.
4. 4. O'Brien TR, Goedert JJ. Chemokine receptors and genetic variability: another leap in HIV research. J Am Med Assoc 1998, 279:317-318.
5. 5. Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996, 272:1955-1958.
6. 6. Choe H, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996, 85:1135-1148.
7. 7. Deng HK, Unutmaz D, KewalRamani VN, Liftman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997, 388:296-300.
8. 8. Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996 85:1149-1158.
9. 9. Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4-cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996, 381:667-673.
10. 10. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996, 273:1856-1862.
11. 11. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med 1996, 2:1240-1243.
12. 12. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996, 86:367-377.
13. 13. Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1966, 382:722-725.
14. 14. loannidis JP, O'Brien TR, Rosenberg PS, Contopoulos-loannidis DG, Goedert JJ. Genetic effects on HIV disease progression. Nature Med 1998, 4:536.
15. 15. O'Brien TR, Winkler C, Dean M, et al. HIV-1 infection in a man homozygous for CCR5Δ32. Lancet 1997, 349:1219.
16. 16. Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C. HIV-1 infection in an individual homozygous for CCR5Δ32. Lancet 1997, 349:1219-1220.
17. 17. Biti R, French R, Young J, Bennetts B, Stewart G. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nature Med. 1997, 3:252-253.
18. 18. Michael NL, Chang G, Louie LG, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nature Med 1997, 3:338-340.
19. 19. Misrahi M, Teglas J-P, N'Go N, et al. CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children, J Am Med Assoc 1998, 279:277-280.
20. 20. Zimmerman PA, Buckler-White A, Alkhatib G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997, 3:23-36.
21. 21. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 1997, 277:959-965.
22. 22. Kostrikis L, Huang X, Moore JP, et al. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Med 1998, 4:350-353.
23. 23. Lee B, Doranz BJ, Rana S, et al. Influence of the CCR2-V641 polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J Virol 1998, 72:7450-7458.
24. 24. Mummidi S, Ahuja S, Gonzalez E, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nature Med 1998, 4:786-793.
25. 25. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nature Genet 1997, 16:100-103.
26. 26. Christodoulou C, Poullikas M, Neumann AU, Kostrikis LG. Low frequency of CCR5Δ32 allele among Greeks in Cyprus. AIDS Res Hum Retroviruses 1997, 13:1373-1374.
27. 27. Nasioulas G, Dean M, Koumbarelis E, et al. Allele frequency of the CCR5 mutant chemokine receptor in Greek Caucasians. J Acquir Immune Defic Syndr Hum Retrovirol 1998, 17:181-182.
28. 28. Lucotte G, Mercier G. Distribution of the CCR5 gene 32-bp deletion in Europe. J Acquir Immune Defic Syndr Hum Retrovirol 1998, 19:174-177.
29. 29. Kostrikis LG, Tyagi S, Mhlanga MM, Ho DD, Kramer FR. Spectral genotyping of human alleles. Science 1998, 279: 1228-1229.
30. 30. Stephens JC, Reich DE, Goldstein DB, et al. Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet 1998, 62:1507-1515.
31. 31. Liberi F, Cochaux P, Beckman G, et al. The DCCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum Mol Genet 1998, 7:399-406.
32. 32. Weir BS. Genetic Data Analysis. Sunderland MA: Sinauer; 1990.
33. 33. Flint J, Boyce AJ, Martinson JJ, Clegg JB. Population bottlenecks in Polynesia revealed by minisatellites. Hum Genet 1989, 83:257-263.