Unbiased determination of cytokine localization in bone: Colocalization of interleukin-6 with osteoblasts in serial sections from monkey vertebrae

Bone

Volumn 26, Issue 5, 2000, Pages 461-467

  Johnson, C S ^a   Jerome, C P ^a   Brommage, R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Colocalization; Histomorphometry; Interleukin 6 (IL 6); Osteoblasts; Osteoclasts

Indexed keywords

ALKALINE PHOSPHATASE; CYTOKINE; INTERLEUKIN 6;

ANIMAL TISSUE; ARTICLE; FEMALE; HISTOCHEMISTRY; MONKEY; MORPHOMETRICS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; VERTEBRA;

ANIMALS; BONE AND BONES; FEMALE; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; MACACA FASCICULARIS; OSTEOBLASTS; THORACIC VERTEBRAE;

EID: 0034114307     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00244-1     Document Type: Article

References (54)

1. Ballanti P., Minisola S., Pacitti M.T., Scarnecchia L., Rosso R., Mazzuoli G.F., Bonucci E. Tartrate-resistant acid phosphate activity as osteoclastic marker Sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry . Osteopor Int. 7:1997;39-43.
2. Bismar H., Diel I., Ziegler R., Pfeilschifter J. Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. J Clin Endocrin Metab. 80:1995;3351-3355.
3. Boyce B.F., Hughes D.E., Wright K.R., Xing L., Dai A. Recent advances in bone biology provide insight into the pathogenesis of bone diseases. Lab Invest. 79:1999;83-94.
4. Bradbeer J.N., Zanelli J.M., Lindsay P.C., Pearson J., Reeve J. Relationship between the location of osteoblastic alkaline phosphatase activity and bone formation in human iliac crest bone. J Bone Miner Res. 7:1992;905-912.
5. Devlin R.D., Bone H.G. III, Roodman G.D. Interleukin-6 A potential mediator of the massive osteolysis in patients with Gorham-Stout disease . J Clin Endocrinol Metab. 81:1996;1893-1897.
6. Dodds R.A., Merry K., Littlewood A., Gowen M. Expression of mRNA for IL 1β, IL6 and TGFβ1 in developing human bone and cartilage. J Histochem Cytochem. 42:1994;733-744.
7. Eriksen E.F. Normal and pathological remodeling of human trabecular bone Three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease . Endocrine Rev. 7:1986;379-408.
8. Ershler W.B., Harman S.M., Keller E.T. Immunologic aspects of osteoporosis. Devel Compar Immunol. 21:1997;487-499.
9. Gao Y., Morita I., Maruo N., Kubota T., Murota S., Aso T. Expression of IL-6 receptor and gp130 in mouse bone marrow cells during osteoclast differentiation. Bone. 22:1998;487-493.
10. Greenfield E.M. ODF/OPGL expression is increased by IL-1 and IL-6. J Bone Miner Res. 14:(Suppl.):1999;S361.
11. Grey, A., Mitnick, M. A., Masiukiewicz, U., Sun, B. H., Rudikoff, S., Jilka, R. L., Manolagas, S. C., and Insogna, K. A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo. Endocrinology 140:4863-4690; 1999.
12. Grey A., Mitnick M.A., Shapses S., Ellison A., Gundberg C., Insogna K. Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption - a clinical research center study. J Clin Endocrinol Metab. 81:1996;3450-3454.
13. Holt I., Davie M.W.J., Marshall M.J. Osteoclasts are not the major source of interleukin-6 in mouse parietal bones. Bone. 18:1996;221-226.
14. Horwood N.J., Elliot J., Martin T.J., Gillespie M.T. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology. 139:1998;4743-4746.
15. Hsu H., Lacey D.L., Dunstan C.R., Solovyev I., Colombero A., Timms E., Tan H.-L., Elliott G., Kelley M.J., Sarosi I., Wang L., Xia X.-Z., Elliot R., Chiu L., Black T., Scully S., Capparelli C., Morony S., Shimamoto G., Bass M.B., Boyle W.J. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA. 96:1999;3540-3545.
16. Hughes D.E., Boyce B.F. Apoptosis in bone physiology and disease. J Clin Pathol Clin Mol Pathol. 50:1997;132-137.
17. Jerome C.P., Power R.A., Obasanjo I.O., Register T.C., Guidry M., Carlson C.S., Weaver D.S. The androgenic anabolic steroid nandrolone decanoate prevents osteopenia and inhibits bone turnover in ovariectomized monkeys. Bone. 20:1997;355-364.
18. Jerome C.P., Vafai H.T., Minetti K.L., Kaplan K. Structural histomorphometric analysis of cortical, transitional, and cancellous vertebral bone in intact, ovariectomized, and nandrolone-treated cynomolgus monkeys (Macaca fascicularis). J Histotechnol. 20:1997;191-198.
19. Jilka R.L. Cytokines, bone remodeling, and estrogen deficiency A 1998 update . Bone. 23:1998;75-81.
20. Kaye M. When is it an osteoclast? J Clin Pathol. 17:1984;398-400.
21. Kong Y.-Y., Yoshida H., Sarosi I., Tan H.-L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A.J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C.R., Lacey D.L., Mak T.W., Boyle W.J., Penninger J.M. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:1999;315-323.
22. Langub M.C., Koszewski N.J., Turner H.V., Monier-Faugere M.C., Geng Z., Malluche H.H. Bone resorption and mRNA expression of IL-6 and IL-6 receptor in patients with renal osteodystrophy. Kidney Int. 50:1996;515-520.
23. Lin S.C., Yamate T., Taguchi Y., Borba V.Z., Girasole G., O'Brien C.A., Bellido T., Abe E., Manolagas S.C. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J Clin Invest. 100:1997;1980-1990.
24. Manolagas S.C. The role of IL-6 type cytokines and their receptors in bone. Ann NY Acad Sci. 840:1998;194-204.
25. Manolagas S.C. Pathophysiologic role of interleukin-6 in osteoporosis and other bone diseases. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 128:1998;127-137.
26. Martin T.J., Romas E., Gillespie M.T. Interleukins in the control of osteoclast differentiation. Crit Rev Eukary Gene Expr. 8:1998;107-123.
27. Mills B.G., Frausto A. Cytokines expressed in multinucleated cells Paget's disease and giant cell tumors versus normal bone . Calcif Tissue Int. 61:1997;16-21.
28. Miyaura C., Kusano K., Masuzawa T., Chaki O., Onoe Y., Aoyagi M., Sasaki T., Tamura T., Koshihara Y., Ohsugi Y., Suda T. Endogenous bone-resorbing factors in estrogen deficiency Cooperative effects of IL-1 and IL-6 . J Bone Miner Res. 10:1995;1365-1373.
29. Montalbán C., García-Unzeuta M.T., De Francisco A.L.M., Amado J.A. Serum interleukin-6 in renal osteodystrophy Relationship with serum PTH and bone remodeling markers . Horm Metab Res. 31:1999;14-17.
30. Most W., Schot I., Ederveen A., van der Wee-Pals L., Papapoulos S., Löwik C. In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis. J Bone Miner Res. 10:1995;1523-1530.
31. Obasanjo I.O., Clarkson T.B., Weaver D.S. Effects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgus monkeys. Metabolism. 45:1996;463-468.
32. 3 or parathyroid hormone. J Biol Chem. 274:1999;19301-19308.
33. O'Keefe R.J., Teot L.A., Singh D., Puzas J.E., Rosier R.N., Hicks D.G. Osteoclasts constitutively express regulators of bone resorption An immunohistochemical and in situ hybridization study . Lab Invest. 76:1997;457-465.
34. Parfitt A.M. Stereologic basis of bone histomorphometry; theory of quantitative microscopy and reconstruction of the third dimension. Recker R.R. Bone Histomorphometry Techniques and Interpretation . 1983;53-87 CRC, Boca Raton.
35. Parfitt A.M. Osteonal and hemi-osteonal remodeling The spatial and temporal framework for signal traffic in adult human bone . J Cell Biochem. 55:1994;273-286.
36. Parfitt A.M. Bone histomorphometry The only window on the BMU, the only tool of in vivo bone cell biology . Bone. 19:(Suppl.):1996;158S.
37. Passeri G., Girasole G., Jilka R.L., Manolagas S.C. Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. Endocrinology. 133:1993;822-828.
38. Poli V., Balena R., Fattori E., Markatos A., Yamamoto M., Tanaka H., Ciliberto G., Rodan G.A., Costantini F. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. Eur Med Biol Org J. 13:1994;1189-1196.
39. Pollock J.H., Blaha M.J., Lavish S.A., Stevenson S., Greenfield E.M. In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor. J Bone Miner Res. 11:1996;754-759.
40. Ralston S.H. Analysis of gene expression in human bone biopsies by polymerase chain reaction Evidence for enhanced cytokine expression in postmenopausal osteoporosis . J Bone Miner Res. 9:1994;883-890.
41. Rifas L. Bone and cytokines Beyond IL-1, IL-6 and TNFα Calcif Tissue Int. 64:1999;1-7.
42. Romas E., Udagawa N., Zhou H., Tamura T., Saito M., Hilton D.J., Suda T., Ng K.W., Martin T.J. The role of gp130-mediated signals in osteoclast development Regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures . J Exp Med. 183:1996;2581-2591.
43. Roodman G.D. Role of cytokines in the regulation of bone resorption. Calcif Tissue Int. 53:(Suppl.):1993;S94-S98.
44. Roodman G.D. Paget's disease and osteoclast biology. Bone. 19:1996;209-212.
45. Roodman G.D. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer. 80:1997;1557-1563.
46. Rosner B. Fundamentals of Biostatistics. 3rd ed. 1990;PWS-Kent, Boston.
47. Simon, J. L. and Bruce, P. The new biostatistics of resampling. MD Comput 12:115-121; 141; 1995.
48. Suda T., Udagawa N., Nakamura I., Miyaura C., Takahashi N. Modulation of osteoclast differentiation by local factors. Bone. 17:(Suppl.):1995;87S-91S.
49. Takahashi N., Akatsu T., Udagawa N., Sasaki T., Yamaguchi A., Moseley J.M., Suda T. Osteoblastic cells are involved in osteoclast formation. Endocrinology. 123:1988;2600-2602.
50. Takahashi N., Udagawa N., Suda T. A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem Biophys Res Commun. 256:1999;449-455.
51. Tanaka H., Barnes J., Liang C.T. Effect of age on the expression of insulin-like growth factor-I, interleukin-6, and transforming growth-β mRNAs in rat femurs following marrow ablation. Bone. 18:1996;473-478.
52. Udagawa N., Takashi N., Katagiri T., Tamura T., Wada S., Findlay D.M., Martin T.J., Horota H., Taga T., Kismimoto T., Suda T. Interleukin-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med. 182:1995;1461-1468.
53. van Bezooijen R.L., Farih-Sips H.C.M., Papapoulos S.E., Lowik C.W.G.M. IL-1α, IL-1β, IL-6, and TNF-α steady-state mRNA levels analyzed by reverse transcription-competitive PCR in bone marrow of gonadectomized mice. J Bone Miner Res. 13:1998;185-194.
54. Vidal N.A.O., Sjögren K., Eriksson B.I., Ljunggren O., Ohlsson C. Osteoprotegerin mRNA is increased by interleukin-1α in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. Biochem Biophys Res Commun. 248:1998;696-700.