메뉴 건너뛰기




Volumn 21, Issue 6, 1997, Pages 487-499

Immunologic aspects of osteoporosis

Author keywords

Aging; Estrogen; Interleukin 6; Osteoclast; Osteoporosis

Indexed keywords

ANDROGEN; ESTROGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH HORMONE; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; SOMATOMEDIN C;

EID: 0031446261     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-305X(97)00029-3     Document Type: Article
Times cited : (66)

References (127)
  • 1
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodelling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas, S. C.; Jilka, R. L. Bone marrow, cytokines, and bone remodelling. Emerging insights into the pathophysiology of osteoporosis. N. Engl. J. Med. 332(5):305-311; 1995.
    • (1995) N. Engl. J. Med. , vol.332 , Issue.5 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 2
    • 0027174296 scopus 로고
    • Cytokines and estrogen in bone: Anti-osteoporotic effects
    • Horowitz, M. C. Cytokines and estrogen in bone: Anti-osteoporotic effects. Science 260:626-627; 1993.
    • (1993) Science , vol.260 , pp. 626-627
    • Horowitz, M.C.1
  • 4
    • 0028799124 scopus 로고
    • The worldwide problem of osteoporosis: Insights afforded by epidemiology
    • Riggs, B. L.; Melton, L. Jr. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17(5):505S-511S; 1995.
    • (1995) Bone , vol.17 , Issue.5
    • Riggs, B.L.1    Melton L., Jr.2
  • 8
    • 0029761456 scopus 로고    scopus 로고
    • Factors associated with bone mineral density in middle-aged men
    • Bendavid, E. J.; Shan, J.; Barrett-Conor, E. Factors associated with bone mineral density in middle-aged men. J. Bone Miner. Res. 11:1185-1190; 1996.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 1185-1190
    • Bendavid, E.J.1    Shan, J.2    Barrett-Conor, E.3
  • 9
    • 0028151410 scopus 로고
    • Epidemiology of bone loss with aging
    • Gunby, M. C.; Morley, J. E. Epidemiology of bone loss with aging. Clin. Geriatr. Med. 10:557-574; 1994.
    • (1994) Clin. Geriatr. Med. , vol.10 , pp. 557-574
    • Gunby, M.C.1    Morley, J.E.2
  • 11
    • 0029873379 scopus 로고    scopus 로고
    • Epidemiology of hip fractures: Implications of the exponential increase with age
    • Melton, L. Jr. Epidemiology of hip fractures: implications of the exponential increase with age. Bone 18(3):121S-125S; 1996.
    • (1996) Bone , vol.18 , Issue.3
    • Melton L., Jr.1
  • 13
    • 0023581926 scopus 로고
    • Rate of mortality for elderly patients after fractures of the hip in the 1980's
    • White, B. L.; Fisher, W. D.; Laurin, C. A. Rate of mortality for elderly patients after fractures of the hip in the 1980's. J. Bone Joint Surgery 69A:1335-1340; 1987.
    • (1987) J. Bone Joint Surgery , vol.69 A , pp. 1335-1340
    • White, B.L.1    Fisher, W.D.2    Laurin, C.A.3
  • 14
    • 0023701496 scopus 로고
    • The care of elderly patients with hip fractures. Changes since implementation of the prospective payment system
    • Fitzgerald, J. F.; Moore, P. S.; Dittus, R. S. The care of elderly patients with hip fractures. Changes since implementation of the prospective payment system. N. Engl. J. Med. 319:1392-1397; 1988.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1392-1397
    • Fitzgerald, J.F.1    Moore, P.S.2    Dittus, R.S.3
  • 15
    • 0028963784 scopus 로고
    • The dilemma of osteoporosis in men
    • Seeman, E. The dilemma of osteoporosis in men. Am. J. Med. 98(2A):76S-88S; 1995.
    • (1995) Am. J. Med. , vol.98 , Issue.2 A
    • Seeman, E.1
  • 16
    • 0025329007 scopus 로고
    • Osteoporosis in men: Diagnosis, pathophysiology, and prevention
    • Jackson, H. A.; Kleerkoper, M. Osteoporosis in men: Diagnosis, pathophysiology, and prevention. Medicine 69:137-152; 1990.
    • (1990) Medicine , vol.69 , pp. 137-152
    • Jackson, H.A.1    Kleerkoper, M.2
  • 18
    • 0029897405 scopus 로고    scopus 로고
    • Prevalent vertebral deformities: Relationship to bone mineral density and spinal osteophytosis in elderly men and women
    • Jones, G., White, C., Nguyen, T., Sambrook, P. N., Kelly, P. J. and Eisman, J. A. Prevalent vertebral deformities: relationship to bone mineral density and spinal osteophytosis in elderly men and women. Osteoporos. Int. 6:233-239; 1996.
    • (1996) Osteoporos. Int. , vol.6 , pp. 233-239
    • Jones, G.1    White, C.2    Nguyen, T.3    Sambrook, P.N.4    Kelly, P.J.5    Eisman, J.A.6
  • 19
    • 0029003159 scopus 로고
    • Risk of vertebral fractures in men: Relationship to mineral density of the vertebral body
    • Resch, A.; Schneider, B.; Bernecker, P. Risk of vertebral fractures in men: relationship to mineral density of the vertebral body. Am. J. Roentgenol. 164(6):1447-1450; 1995.
    • (1995) Am. J. Roentgenol. , vol.164 , Issue.6 , pp. 1447-1450
    • Resch, A.1    Schneider, B.2    Bernecker, P.3
  • 20
  • 22
    • 0028919301 scopus 로고
    • Relations between histoloic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis
    • Parfitt, A. M.; Villanueva, A. R.; Foldes, J.; Sudhaker, R. D. Relations between histoloic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis. J. Bone Miner. Res. 10:466-473; 1995.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 466-473
    • Parfitt, A.M.1    Villanueva, A.R.2    Foldes, J.3    Sudhaker, R.D.4
  • 23
    • 0018222773 scopus 로고
    • Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age
    • Lips, P.; Courpron, P.; Meunier, P. Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age. Calcif. Tissue Int. 26:13-17; 1978.
    • (1978) Calcif. Tissue Int. , vol.26 , pp. 13-17
    • Lips, P.1    Courpron, P.2    Meunier, P.3
  • 24
  • 25
    • 0029030042 scopus 로고
    • Femoral peak bone mass and osteoclast number in an animal model of age-related spontaneous osteopenia
    • Okamoto, Y.; Takahashi, K.; Toriyama, K.; Takeda, N.; Kitagawa, K.; Hosokawa, M.; Takeda, T. Femoral peak bone mass and osteoclast number in an animal model of age-related spontaneous osteopenia. Anat. Record 242:21-28; 1995.
    • (1995) Anat. Record , vol.242 , pp. 21-28
    • Okamoto, Y.1    Takahashi, K.2    Toriyama, K.3    Takeda, N.4    Kitagawa, K.5    Hosokawa, M.6    Takeda, T.7
  • 26
    • 0029928698 scopus 로고    scopus 로고
    • Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence
    • Jilka, R. L.; Weinstein, R. S.; Takahashi, K.; Parfitt, A. M.; Manolagas, S. C. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J. Clin. Invest. 97(7):1732-1740; 1996.
    • (1996) J. Clin. Invest. , vol.97 , Issue.7 , pp. 1732-1740
    • Jilka, R.L.1    Weinstein, R.S.2    Takahashi, K.3    Parfitt, A.M.4    Manolagas, S.C.5
  • 28
    • 85190502357 scopus 로고    scopus 로고
    • Generation of human osteoclasts from peripheral blood hematopoietic precursors cells in absence of stromal cells: Effects of estrogen and aging
    • Abs M401
    • Matayoshi, A., Brown, C. and Pacifici, R. Generation of human osteoclasts from peripheral blood hematopoietic precursors cells in absence of stromal cells: Effects of estrogen and aging. J. Bone Miner. Res. 1996, 11(1), S282 (Abs M401).
    • (1996) J. Bone Miner. Res. , vol.11 , Issue.1
    • Matayoshi, A.1    Brown, C.2    Pacifici, R.3
  • 29
    • 0029148659 scopus 로고
    • Modulation of osteoclast differentiation by local factors
    • Suda, T.; Udagawa, N.; Nakamura, I.; Miyaura, C.; Takahashi, N. Modulation of osteoclast differentiation by local factors. Bone 17(2):87S-91S; 1995.
    • (1995) Bone , vol.17 , Issue.2
    • Suda, T.1    Udagawa, N.2    Nakamura, I.3    Miyaura, C.4    Takahashi, N.5
  • 31
    • 0028201425 scopus 로고
    • Macrophage colony-stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hrmone or 1,25-dihydroxyvitamin D3
    • Morohashi, T.; Corboz, V. A.; Fleisch, H.; Cecchinin, M. G.; Felix, R. Macrophage colony-stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hrmone or 1,25-dihydroxyvitamin D3. J. Bone Miner. Res. 9:401-407; 1994.
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 401-407
    • Morohashi, T.1    Corboz, V.A.2    Fleisch, H.3    Cecchinin, M.G.4    Felix, R.5
  • 33
    • 0023855354 scopus 로고
    • Comparison of the effects of lung cancer, benign lung disease, and normal aging on pituitary-gonadal function in men
    • Blackman, M. R.; Weintraub, B. D.; Rosen, S. W.; Harman, S. M. Comparison of the effects of lung cancer, benign lung disease, and normal aging on pituitary-gonadal function in men. J. Clin. Endocrinol. Metab. 66:88-95; 1988.
    • (1988) J. Clin. Endocrinol. Metab. , vol.66 , pp. 88-95
    • Blackman, M.R.1    Weintraub, B.D.2    Rosen, S.W.3    Harman, S.M.4
  • 34
    • 0018950079 scopus 로고
    • Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone and leydig cell response to human chorionic gonadotropin
    • Harman, S. M.; Tsitouras, P. D. Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin. J. Clin. Endocrinol. Metab. 51:35-41; 1980.
    • (1980) J. Clin. Endocrinol. Metab. , vol.51 , pp. 35-41
    • Harman, S.M.1    Tsitouras, P.D.2
  • 36
    • 0026070170 scopus 로고
    • Clinical review 24: Androgens in the aging male
    • Vermeulen, A. Clinical review 24: Androgens in the aging male. J. Clin. Endocrinol. Metab. 73:221-224; 1991.
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 221-224
    • Vermeulen, A.1
  • 37
    • 0023550187 scopus 로고
    • The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: Response to clomiphene citrate
    • Tenover, J. S.; Matsumoto, A. M.; Plymate, S. R.; Bremner, W. J. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: Response to clomiphene citrate. J. Clin. Endocrinol. Metab. 65:1118-1126; 1987.
    • (1987) J. Clin. Endocrinol. Metab. , vol.65 , pp. 1118-1126
    • Tenover, J.S.1    Matsumoto, A.M.2    Plymate, S.R.3    Bremner, W.J.4
  • 38
    • 0023000708 scopus 로고
    • Decreased bioavailable testosterone in aging normal and impotent men
    • Nankin, H. R.; Calkins, J. H. Decreased bioavailable testosterone in aging normal and impotent men. J. Clin. Endocrinol. Metab. 63:1418-1420; 1986.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 1418-1420
    • Nankin, H.R.1    Calkins, J.H.2
  • 39
    • 0025137930 scopus 로고
    • Age related decline of plasma bioavailable testosterone in adult men
    • Nahoul, K.; Roger, M. Age related decline of plasma bioavailable testosterone in adult men. J. Steroid Biochem. Molec. Biol. 35:293-299; 1990.
    • (1990) J. Steroid Biochem. Molec. Biol. , vol.35 , pp. 293-299
    • Nahoul, K.1    Roger, M.2
  • 41
    • 0015431771 scopus 로고
    • Age-related changes in the twenty-four hour spontaneous secretion of growth hormone in normal individuals
    • Finkelstein, J.; Roffwarg, H.; Boyar, P.; Kream, J.; Hellman, L. Age-related changes in the twenty-four hour spontaneous secretion of growth hormone in normal individuals. J. Clin. Endocrinol. Metab. 35:665-670; 1972.
    • (1972) J. Clin. Endocrinol. Metab. , vol.35 , pp. 665-670
    • Finkelstein, J.1    Roffwarg, H.2    Boyar, P.3    Kream, J.4    Hellman, L.5
  • 42
    • 0021928693 scopus 로고
    • The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals
    • Zadik, Z.; Chalew, S. A.; McCarter, R. J.; Meistas, M.; Kowarski, A. A. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J. Clin. Endocrinol. Metab. 60:513-516; 1985.
    • (1985) J. Clin. Endocrinol. Metab. , vol.60 , pp. 513-516
    • Zadik, Z.1    Chalew, S.A.2    McCarter, R.J.3    Meistas, M.4    Kowarski, A.A.5
  • 43
    • 0023098492 scopus 로고
    • Effects of sex and age on 24-hour profile of growth hormone secretion in men: Importance of endogenous estradiol concentrations
    • Ho, K. Y.; Evans, W. S.; Blizzard, R. M. Effects of sex and age on 24-hour profile of growth hormone secretion in men: Importance of endogenous estradiol concentrations. J. Clin. Endocrinol. Metab. 64:51-58; 1987.
    • (1987) J. Clin. Endocrinol. Metab. , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 44
    • 0023181868 scopus 로고
    • Nyctohemoral growth hormone profiles in young and aged men: Correlations with somatomedin-C levels
    • Vermeulen, A. Nyctohemoral growth hormone profiles in young and aged men: Correlations with somatomedin-C levels. J. Clin. Endocrinol. Metab. 64:884-888; 1987.
    • (1987) J. Clin. Endocrinol. Metab. , vol.64 , pp. 884-888
    • Vermeulen, A.1
  • 46
  • 47
    • 0026066023 scopus 로고
    • Effects of progestin-opposed transdermal estrogen administration on GH and IGF-I in postmenopausal women of different ages
    • Bellantoni, M. F.; Harman, S. M.; Cho, D.; Blackman, M. R. Effects of progestin-opposed transdermal estrogen administration on GH and IGF-I in postmenopausal women of different ages. J. Clin. Endocrinol. Metab. 72:172-178; 1991.
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 172-178
    • Bellantoni, M.F.1    Harman, S.M.2    Cho, D.3    Blackman, M.R.4
  • 48
    • 0021334604 scopus 로고
    • Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man
    • Shibasaki, T.; Shizume, K.; Nakahara, M. Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J. Clin. Endocrinol. Metab. 58:212-214; 1984.
    • (1984) J. Clin. Endocrinol. Metab. , vol.58 , pp. 212-214
    • Shibasaki, T.1    Shizume, K.2    Nakahara, M.3
  • 49
    • 0024446258 scopus 로고
    • Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH releasing hormone testing in normal aging
    • Iovino, M.; Monteleone, P.; Steardo, L. Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH releasing hormone testing in normal aging. J. Clin. Endocrinol. Metab. 69:910-913; 1989.
    • (1989) J. Clin. Endocrinol. Metab. , vol.69 , pp. 910-913
    • Iovino, M.1    Monteleone, P.2    Steardo, L.3
  • 50
    • 0026069703 scopus 로고
    • Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline
    • Coiro, V.; Volpi, R.; Cavazzini, U. Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline. J. Gerontol. 46:M155-158; 1991.
    • (1991) J. Gerontol. , vol.46
    • Coiro, V.1    Volpi, R.2    Cavazzini, U.3
  • 51
    • 0027473333 scopus 로고
    • Continuous subcutaneous infusions of GHRH 1-44 for 14 days increase GH and IGF-I levels in old men
    • Corpas, E.; Harman, S. M.; Piñeyro, M. A.; Roberson, R.; Blackman, M. R. Continuous subcutaneous infusions of GHRH 1-44 for 14 days increase GH and IGF-I levels in old men. J. Clin. Endocrinol. Metab. 76:134-138; 1993.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 134-138
    • Corpas, E.1    Harman, S.M.2    Piñeyro, M.A.3    Roberson, R.4    Blackman, M.R.5
  • 53
    • 0021049966 scopus 로고
    • Risk factors for spinal osteoporosis in men
    • Seeman, E.; Melton, I. E. J. Risk factors for spinal osteoporosis in men. Am. J. Med. 75:977-983; 1983.
    • (1983) Am. J. Med. , vol.75 , pp. 977-983
    • Seeman, E.1    Melton, I.E.J.2
  • 54
    • 0025329007 scopus 로고
    • Osteoporosis in men: Diagnosis, pathophysiology, and prevention
    • Jackson, J. A.; Kleerekoper, M. Osteoporosis in men: diagnosis, pathophysiology, and prevention. Medicine 69:137-152; 1990.
    • (1990) Medicine , vol.69 , pp. 137-152
    • Jackson, J.A.1    Kleerekoper, M.2
  • 56
    • 0026342804 scopus 로고
    • Does hypogonadism contribute to the occurrence of minimal trauma hip fracture in elderly men?
    • Stanley, H. L.; Schmitt, B. P.; Poses, R. M.; Deiss, W. P. Does hypogonadism contribute to the occurrence of minimal trauma hip fracture in elderly men? J. Am. Geriatr. Soc. 39:766-771; 1991.
    • (1991) J. Am. Geriatr. Soc. , vol.39 , pp. 766-771
    • Stanley, H.L.1    Schmitt, B.P.2    Poses, R.M.3    Deiss, W.P.4
  • 57
    • 0018345196 scopus 로고
    • Estrogen replacement therapy I: A 10-year study in the relationship to osteoporosis
    • Nachtigall, L. E.; Nachtigall, R. H.; Nachtigall, R. D.; Beckman, E. M. Estrogen replacement therapy I: A 10-year study in the relationship to osteoporosis. Obstetr. Gynecol. 53:277-281; 1979.
    • (1979) Obstetr. Gynecol. , vol.53 , pp. 277-281
    • Nachtigall, L.E.1    Nachtigall, R.H.2    Nachtigall, R.D.3    Beckman, E.M.4
  • 58
    • 0026014689 scopus 로고
    • Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy
    • Prince, R. L., Smith, M., Dick, I. M., et al. Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. N. Engl. J. Med. 325:1189-1195; 1991.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1189-1195
    • Prince, R.L.1    Smith, M.2    Dick, I.M.3
  • 60
    • 0021964389 scopus 로고
    • Long-term estrogen replacement therapy prevents bone loss and fractures
    • Ettinger, B.; Genant, H. K.; Cann, C. E. Long-term estrogen replacement therapy prevents bone loss and fractures. Ann. Intern. Med. 102:319-324; 1985.
    • (1985) Ann. Intern. Med. , vol.102 , pp. 319-324
    • Ettinger, B.1    Genant, H.K.2    Cann, C.E.3
  • 61
    • 0019208916 scopus 로고
    • Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen
    • Weiss, N. S.; Ure, C. L.; Ballard, J. H.; Williams, A. R.; Daling, J. R. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N. Engl. J. Med. 303:1195-1198; 1980.
    • (1980) N. Engl. J. Med. , vol.303 , pp. 1195-1198
    • Weiss, N.S.1    Ure, C.L.2    Ballard, J.H.3    Williams, A.R.4    Daling, J.R.5
  • 63
    • 0024461620 scopus 로고
    • Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism
    • Finkelstein, J. S.; Klibanski, A.; Neer, R. M. Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism. J. Clin. Endocrinol. Metab. 69:776-783; 1989.
    • (1989) J. Clin. Endocrinol. Metab. , vol.69 , pp. 776-783
    • Finkelstein, J.S.1    Klibanski, A.2    Neer, R.M.3
  • 64
    • 0026078286 scopus 로고
    • Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis
    • Diamond, T.; Stiel, D.; Posen, S. Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis. J. Bone Miner. Res. 6:39-43; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 39-43
    • Diamond, T.1    Stiel, D.2    Posen, S.3
  • 66
    • 0026742706 scopus 로고
    • Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study
    • Devogelaer, J. P.; DeCooman, S.; Nagant de Deuxchaisnes, C. Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study. Maturitas 15:17-23; 1992.
    • (1992) Maturitas , vol.15 , pp. 17-23
    • Devogelaer, J.P.1    Decooman, S.2    Nagant de Deuxchaisnes, C.3
  • 67
    • 0029132158 scopus 로고
    • Short-term effect of testosterone treatment on reduced bone density in boys with constitutional delay of puberty
    • Bertelloni, D.; Baroncelli, G. I.; Battini, R.; Perii, G.; Saggese, G. Short-term effect of testosterone treatment on reduced bone density in boys with constitutional delay of puberty. J. Bone Miner. Res. 10:1488-1495; 1995.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 1488-1495
    • Bertelloni, D.1    Baroncelli, G.I.2    Battini, R.3    Perii, G.4    Saggese, G.5
  • 68
    • 10244222400 scopus 로고    scopus 로고
    • Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men-a clinical research center study
    • Wang, C.; Eyre, D. R.; Clark, R. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men-a clinical research center study. J. Clin. Endocrinol. Metab. 81:3654-3662; 1996.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3654-3662
    • Wang, C.1    Eyre, D.R.2    Clark, R.3
  • 72
    • 0029812889 scopus 로고    scopus 로고
    • Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency
    • Johannson, G.; Rosen, T.; Bosaeus, I.; Sjostrom, L.; Bengtsson, B.-A. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J. Clin. Endocrinol. Metab. 81:2865-2873; 1996.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2865-2873
    • Johannson, G.1    Rosen, T.2    Bosaeus, I.3    Sjostrom, L.4    Bengtsson, B.-A.5
  • 73
    • 0025368959 scopus 로고
    • Effect of human growth hormone in men over 60 years old
    • Rudman, D.; Feller, A. G.; Nagraj, H. S. Effect of human growth hormone in men over 60 years old. N. Engl. J. Med. 323:1-6; 1990.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 1-6
    • Rudman, D.1    Feller, A.G.2    Nagraj, H.S.3
  • 74
    • 0028146277 scopus 로고
    • Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women
    • Holloway, L.; Butterfield, G.; Hintz, R.; Geusundheit, N.; Marcus, R. Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J. Clin. Endocrinol. Metab. 79:470-479; 1994.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 470-479
    • Holloway, L.1    Butterfield, G.2    Hintz, R.3    Geusundheit, N.4    Marcus, R.5
  • 76
    • 0024435582 scopus 로고
    • Interleukin 2, interleukin 2 receptor and interferon g synthesis and mRNA expression in phorbol myrisate acetate and calcium ionophore A23187 stimulated T cells from elderly humans
    • Chopra, R. K.; Powers, D. C.; Kendig, N. E.; Adler, W. H.; Nagel, J. E. Interleukin 2, interleukin 2 receptor and interferon g synthesis and mRNA expression in phorbol myrisate acetate and calcium ionophore A23187 stimulated T cells from elderly humans. Clin. Immunol. Immunopathol. 53:297-308; 1989.
    • (1989) Clin. Immunol. Immunopathol. , vol.53 , pp. 297-308
    • Chopra, R.K.1    Powers, D.C.2    Kendig, N.E.3    Adler, W.H.4    Nagel, J.E.5
  • 78
    • 0027480306 scopus 로고
    • Serum soluble interleukin-6 receptor in MRL/1pr mice is elevated with age and mediates the interleukin-6 signal
    • Suzuki, H.; Yasukawa, K.; Saito, T.; Narazaki, M.; Hasegawa, A.; Taga, T.; Kishimoto, T. Serum soluble interleukin-6 receptor in MRL/1pr mice is elevated with age and mediates the interleukin-6 signal. Eur. J. Immunol. 23:1078-1082; 1993.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1078-1082
    • Suzuki, H.1    Yasukawa, K.2    Saito, T.3    Narazaki, M.4    Hasegawa, A.5    Taga, T.6    Kishimoto, T.7
  • 79
    • 0025827542 scopus 로고
    • Influence of age and caloric restriction on macrophage IL-6 and TNF production
    • Effros, R. B.; Svoboda, K.; Walford, R. L. Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res. 10(5):347-351; 1991.
    • (1991) Lymphokine Cytokine Res. , vol.10 , Issue.5 , pp. 347-351
    • Effros, R.B.1    Svoboda, K.2    Walford, R.L.3
  • 81
    • 0026550820 scopus 로고
    • Fever, tumor necrosis factor, and interlukin-6 in young, mature, and aged fischer 344 rats
    • Foster, K. D.; Conn, C. A.; Kluger, M. J. Fever, tumor necrosis factor, and interlukin-6 in young, mature, and aged Fischer 344 rats. Am. J. Physiol. 262:R211-R215; 1992.
    • (1992) Am. J. Physiol. , vol.262
    • Foster, K.D.1    Conn, C.A.2    Kluger, M.J.3
  • 82
    • 0026497223 scopus 로고
    • Increase of plasma IL-6 concentration with age in healthy subjects
    • Wei, J.; Xu, H.; Davies, J. L.; Hemmings, G. P. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sciences 51:1953-1956; 1992.
    • (1992) Life Sciences , vol.51 , pp. 1953-1956
    • Wei, J.1    Xu, H.2    Davies, J.L.3    Hemmings, G.P.4
  • 84
    • 0027162602 scopus 로고
    • Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
    • Daynes, R. A.; Araneo, B. A.; Ershler, W. B.; Maloney, C.; Li, G. Z.; Ryu, S. Y. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J. Immunol. 150:5219-5230; 1993.
    • (1993) J. Immunol. , vol.150 , pp. 5219-5230
    • Daynes, R.A.1    Araneo, B.A.2    Ershler, W.B.3    Maloney, C.4    Li, G.Z.5    Ryu, S.Y.6
  • 85
  • 91
    • 0010279734 scopus 로고
    • Demonstration of estrogen receptors by western blot analysis in bone marrow stromal cells and osteoblasts: Correlation with interleukin-6 regulation by estrogens and antiestrogens
    • Bellido, T.; Girasole, G.; Passeri, G.; Yu, X. P.; Jilka, R. L.; Boder, G.; Williams, D. C.; Boswell, S.; Notides, A.; Manolagas, S. C. Demonstration of estrogen receptors by western blot analysis in bone marrow stromal cells and osteoblasts: Correlation with interleukin-6 regulation by estrogens and antiestrogens. J. Bone Miner. Res. 6(1):S88; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.1
    • Bellido, T.1    Girasole, G.2    Passeri, G.3    Yu, X.P.4    Jilka, R.L.5    Boder, G.6    Williams, D.C.7    Boswell, S.8    Notides, A.9    Manolagas, S.C.10
  • 92
    • 0026516415 scopus 로고
    • 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens
    • Girasole, G.; Jilka, R. L.; Passeri, G.; Boswell, G.; Boder, G.; Williams, D. C.; Manolagas, S. C. 17β-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89:883-891; 1992.
    • (1992) J. Clin. Invest. , vol.89 , pp. 883-891
    • Girasole, G.1    Jilka, R.L.2    Passeri, G.3    Boswell, G.4    Boder, G.5    Williams, D.C.6    Manolagas, S.C.7
  • 93
    • 0010281795 scopus 로고
    • Upregulation of osteoclastogenic potential of the marrow is induced by orchiectomy and is reversed by testosterone replacement in the mouse
    • Girasole, G.; Passeri, G.; Knutson, S.; Manolagas, S. C.; Jilka, R. L. Upregulation of osteoclastogenic potential of the marrow is induced by orchiectomy and is reversed by testosterone replacement in the mouse. J. Bone Miner. Res. 7(1):596; 1992.
    • (1992) J. Bone Miner. Res. , vol.7 , Issue.1 , pp. 596
    • Girasole, G.1    Passeri, G.2    Knutson, S.3    Manolagas, S.C.4    Jilka, R.L.5
  • 94
    • 0000726129 scopus 로고
    • 17β estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures
    • Passeri, G.; Girasole, G.; Markus, T.; Abrams, J. S.; Manolagas, S. C.; Jilka, R. L. 17β estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures. J. Bone Miner. Res. 6(1):S263; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.1
    • Passeri, G.1    Girasole, G.2    Markus, T.3    Abrams, J.S.4    Manolagas, S.C.5    Jilka, R.L.6
  • 96
    • 0029662224 scopus 로고    scopus 로고
    • Inhibition of NFκB activity through maintenance of IkBa levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
    • Keller, E. T.; Chang, C.; Ershler, W. B. Inhibition of NFκB activity through maintenance of IkBa levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J. Biol. Chem. 271:26267-26275; 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26267-26275
    • Keller, E.T.1    Chang, C.2    Ershler, W.B.3
  • 97
    • 0026546227 scopus 로고
    • IL-6 receptor and mechanism of signal transduction
    • Kishimoto, T.; Akira, S.; Taga, T. IL-6 receptor and mechanism of signal transduction. Int. J. Immunopharmac. 14:431-438; 1992.
    • (1992) Int. J. Immunopharmac , vol.14 , pp. 431-438
    • Kishimoto, T.1    Akira, S.2    Taga, T.3
  • 98
    • 0027048936 scopus 로고
    • Cytokine receptors and signal transduction
    • Taga, T.; Kishimoto, T. Cytokine receptors and signal transduction. FASEB J. 7:3387-3396; 1993.
    • (1993) FASEB J. , vol.7 , pp. 3387-3396
    • Taga, T.1    Kishimoto, T.2
  • 99
    • 0024458160 scopus 로고
    • Soluble cytokine receptors are present in normal human urine
    • Novick, D.; Englmann, H.; Wallach, D.; Rubinstein, M. Soluble cytokine receptors are present in normal human urine. J. Expl. Med. 170:1409-1414; 1989.
    • (1989) J. Expl. Med. , vol.170 , pp. 1409-1414
    • Novick, D.1    Englmann, H.2    Wallach, D.3    Rubinstein, M.4
  • 100
    • 0026321453 scopus 로고
    • The role of cytokines in the regulation of local bone resorption
    • Lorenzo, J. A. The role of cytokines in the regulation of local bone resorption. Crit. Rev. Immunol. 11:195-213; 1991.
    • (1991) Crit. Rev. Immunol. , vol.11 , pp. 195-213
    • Lorenzo, J.A.1
  • 101
    • 0013681969 scopus 로고
    • Sex steroids regulate the expression of the gp130 transduction pathway by bone marrow and bone cells
    • Bellido, T.; Girasole, G.; Passeri, G.; Jilka, R. L.; Manolagas, S. C. Sex steroids regulate the expression of the gp130 transduction pathway by bone marrow and bone cells. Bone Miner. 25(S1):S39; 1994.
    • (1994) Bone Miner. , vol.25 , Issue.S1
    • Bellido, T.1    Girasole, G.2    Passeri, G.3    Jilka, R.L.4    Manolagas, S.C.5
  • 102
    • 0025965312 scopus 로고
    • Effects of interleukin-6 on cellular function in UMR-106-01 osteoblast-like cells
    • Fang, M. A.; Hahn, T. J. Effects of interleukin-6 on cellular function in UMR-106-01 osteoblast-like cells. J. Bone Miner. Res. 6:133-139; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 133-139
    • Fang, M.A.1    Hahn, T.J.2
  • 105
    • 0028291884 scopus 로고
    • Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells
    • Green, H.; Schotland, S.; Sella, Z.; Kleeman, C. R. Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells. J. Clin. Invest. 93:2340-2350; 1994.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2340-2350
    • Green, H.1    Schotland, S.2    Sella, Z.3    Kleeman, C.R.4
  • 107
    • 0024365860 scopus 로고
    • Interleukin-6 is produced by bone and modulated by parathyroid hormone
    • Feyen, H. J. M.; Elford, P.; Ki Padova, F. E.; Trechsel, U. Interleukin-6 is produced by bone and modulated by parathyroid hormone. J. Bone Miner. Res. 4:633-638; 1989.
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 633-638
    • Feyen, H.J.M.1    Elford, P.2    Ki Padova, F.E.3    Trechsel, U.4
  • 108
    • 0027493864 scopus 로고
    • In vitro PTH increases both mRNA expression and IL-6 secretion from both osteoblast like cells and rat osteoblasts
    • Greenfield, E. M.; Gornik, S. A.; Horowitz, M. C.; Donahue, H. J.; Shaw, S. M. In vitro PTH increases both mRNA expression and IL-6 secretion from both osteoblast like cells and rat osteoblasts. J. Bone Miner. Res. 8:1163-1171; 1993.
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 1163-1171
    • Greenfield, E.M.1    Gornik, S.A.2    Horowitz, M.C.3    Donahue, H.J.4    Shaw, S.M.5
  • 109
    • 0024404268 scopus 로고
    • Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis
    • Löwik, C. W. G. M.; van der Pluijm, G.; Bloys, H.; Hoekman, K.; Bijvoet, O. L. M.; Asrden, L. A.; Papapoulos, S. E. Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis. Biochem. Biophys. Res. Comm. 162:1546-1552; 1989.
    • (1989) Biochem. Biophys. Res. Comm. , vol.162 , pp. 1546-1552
    • Löwik, C.W.G.M.1    Van der Pluijm, G.2    Bloys, H.3    Hoekman, K.4    Bijvoet, O.L.M.5    Asrden, L.A.6    Papapoulos, S.E.7
  • 111
    • 0027993620 scopus 로고
    • Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-b1 genes in normal human osteoblast-like cells
    • Zheng, M. H.; Wood, D. J.; Wysocki, S.; Papadimitriou, J. M.; Wang, E. A. Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-b1 genes in normal human osteoblast-like cells. J. Cell Physiol. 159:76-82; 1994.
    • (1994) J. Cell Physiol. , vol.159 , pp. 76-82
    • Zheng, M.H.1    Wood, D.J.2    Wysocki, S.3    Papadimitriou, J.M.4    Wang, E.A.5
  • 113
    • 0029144320 scopus 로고
    • The effect of interleukin-6 and soluble interleukin-6 receptor protein on the bone resorptive activity of human osteoclasts generated in vitro
    • Flanagan, A. M.; Stow, M. D.; Williams, R. The effect of interleukin-6 and soluble interleukin-6 receptor protein on the bone resorptive activity of human osteoclasts generated in vitro. J. Pathol. 176:289-297; 1995.
    • (1995) J. Pathol. , vol.176 , pp. 289-297
    • Flanagan, A.M.1    Stow, M.D.2    Williams, R.3
  • 114
    • 0025313227 scopus 로고
    • IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
    • Kurihara, N.; Bertolini, D.; Suda, T.; Akiyama, Y.; Roodman, G. D. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J. Immunol. 144:4226-4230; 1990.
    • (1990) J. Immunol. , vol.144 , pp. 4226-4230
    • Kurihara, N.1    Bertolini, D.2    Suda, T.3    Akiyama, Y.4    Roodman, G.D.5
  • 117
    • 0010388158 scopus 로고
    • Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro
    • Black, K. S.; Mundy, G. R.; Garrett, I. R. Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro. J. Bone Miner. Res. 6(1):S271; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.1
    • Black, K.S.1    Mundy, G.R.2    Garrett, I.R.3
  • 118
    • 0026516415 scopus 로고
    • 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens
    • Girasole, G.; Jilka, R. L.; Passeri, F.; Boswell, S.; Boder, G.; Williams, D. C.; Manologas, S. C. 17β-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89:883-891; 1992.
    • (1992) J. Clin. Invest. , vol.89 , pp. 883-891
    • Girasole, G.1    Jilka, R.L.2    Passeri, F.3    Boswell, S.4    Boder, G.5    Williams, D.C.6    Manologas, S.C.7
  • 119
    • 0026437455 scopus 로고
    • Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone
    • Ohsaki, Y.; Takahashi, S.; Scarcez, T.; Demulder, A.; Nishihara, T.; Williams, R.; Roodman, G. D. Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology 131:2229-2234; 1992.
    • (1992) Endocrinology , vol.131 , pp. 2229-2234
    • Ohsaki, Y.1    Takahashi, S.2    Scarcez, T.3    Demulder, A.4    Nishihara, T.5    Williams, R.6    Roodman, G.D.7
  • 122
    • 0023946662 scopus 로고
    • Multiple actions of interleukin-6 within a cytokine network
    • Wong, G. G.; Clark, S. C. Multiple actions of interleukin-6 within a cytokine network. Immunol. Today 9:137-139; 1988.
    • (1988) Immunol. Today , vol.9 , pp. 137-139
    • Wong, G.G.1    Clark, S.C.2
  • 123
    • 0025930702 scopus 로고
    • Letter to the editor the bone-resorbing activity of interleukin-6
    • Bataille, R.; Klein, B. Letter to the editor The bone-resorbing activity of interleukin-6. J. Bone Miner. Res. 6:1143-1144; 1991.
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 1143-1144
    • Bataille, R.1    Klein, B.2
  • 124
    • 84991186971 scopus 로고
    • Reply: The bone-resorbing activity of interleukin-6
    • Gowen, M. Reply: The bone-resorbing activity of interleukin-6 J. J. Bone Miner. Res. 6:1145-1146; 1991.
    • (1991) J. J. Bone Miner. Res. , vol.6 , pp. 1145-1146
    • Gowen, M.1
  • 125
    • 0026863763 scopus 로고
    • Perspectives interleukin-6: An osteotrophic factor?
    • Roodman, G. D. Perspectives Interleukin-6: An osteotrophic factor? J. Bone Miner. Res. 7:475-478; 1992.
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 475-478
    • Roodman, G.D.1
  • 126
    • 0028245512 scopus 로고
    • Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis
    • Ralston, S. H. Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis. J. Bone Min. Res. 9:883-890; 1994.
    • (1994) J. Bone Min. Res. , vol.9 , pp. 883-890
    • Ralston, S.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.