Recurrent early pregnancy loss and genetic-related disturbances in folate and homocysteine metabolism

British Journal of Hospital Medicine

Volumn 58, Issue 10, 1997, Pages 511-513

  Nelen, Willianne L D M ^a   Van Der Molen, Elisabeth F ^a   Blom, Henk J ^a   Heil, Sandra G ^a   Steegers, Eric A P ^a   Eskes, Tom Kab ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; BIOLOGICAL MARKER; FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; BLOOD; CASE CONTROL STUDY; ENZYMOLOGY; FEMALE; FOLIC ACID DEFICIENCY; GENETIC MARKER; GENETICS; GENOTYPE; HUMAN; METABOLISM; MUTATION; PREGNANCY; RECURRENT ABORTION; RISK;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ABORTION, HABITUAL; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENETIC MARKERS; GENOTYPE; HOMOCYSTEINE; HUMANS; MUTATION; ODDS RATIO; PREGNANCY;

EID: 0031578472     PISSN: 00071064     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. t'rosst P, Blom HI, Miles R et al (1995) A candidate genetic risk factor for vascular disease: a common mutation in methvlenetetrahydrotolate rcductase [letter]. Nat Genet 10: 111-13
2. Hibbard BM (1964) The role of folic acid in pregnancy. With particular reference to anaemia, abruption and abortion. J Obstet Gynaccol Br Commons 71: 529-42
3. Kluijtmans LAJ, Kastelcin JJP, Lindemansl et al (1997) Thermolabile methylenctetrahyclrofolate reductase in coronary artery disease. Circulation (in press)
4. Nelen WLDM, Steegers EAP, Eskes TKAB, Blorn HJ (1997) Genetic risk factor for unexplained recurrent early pregnancy loss [letter]. Lancet 350: 861
5. Pietrzik K, Prinz R, Reusch K, Bung P, Mallmann P, Chronicles A (1992) Folate status and pregnancy outcome. Ann N Y Acad Sa 669: 371-3
6. Van der Put NM, Steegers-Theunissen RPM, Frosst P et al (1995) Mutated mcthylenetetrahydrofolate rcductase as a risk factor for spinà bifida. Lancet 346: 1070-1
7. Wouters MGAI, Boers GHJ, Blom HJ et al (1993) Hypernoinocysteineinia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Stent 60: 820-5