Application of genetics and genomics in drug development

Drug Development Research

Volumn 49, Issue 1, 2000, Pages 43-45

  Polymeropoulos, Mihael H ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

DNA; EST; Expressed sequence tag; Human Genome Project; Pharmacogenetics; Polymorphism

Indexed keywords

DNA; DRUG;

ARTICLE; DNA POLYMORPHISM; DNA SEQUENCE; DRUG DEVELOPMENT; DRUG TARGETING; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENE TECHNOLOGY; GENETICS; GENOTYPE; METABOLISM; MOLECULAR CLONING; PHARMACOGENETICS;

EID: 0034105415     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(200001)49:1<43::AID-DDR7>3.0.CO;2-V     Document Type: Article

References (15)

1. Aarbakke J, Janka-Schaub G, Elion GB. 1997. Thiopurine biology and pharmacology. Trends Pharmacol Sci 18:3-7.
2. Debouck C, Goodfellow PN. 1999. DNA microarrays in drug discovery and development. Nat Genet 21:48-50.
3. Donger C, Denjoy I, Berthet M, Neyroud N, Cruaud C, Bennaceur M, Chivoret G, Schwartz K, Coumel P, Guicheney P. 1997. KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome. Circulation 96:2778-2781.
4. Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM. 1999. Expression profiling using cDNA microarrays. Nat Genet 21:10-14.
5. Evans WE, Relling MV. 1999. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487-491.
6. Griffin TJ, Hall JG, Prudent JR, Smith LM. 1999. Direct genetic analysis by matrix-assisted laser desorption/ionization mass spectrometry. Proc Natl Acad Sci USA 96:6301-6306.
7. Lee CK, Klopp RG, Weindruch R, Prolla TA. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science 285:1390-1393.
8. Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM. 1987. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 41:18-25.
9. Lennon G, Auffray C, Polymeropoulos M, Soares MB. 1996. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 33:151-152.
10. Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ. 1999. High density synthetic oligonucleotide arrays. Nat Genet 21:20-24.
11. Lyamichev V, Mast AL, Hall JG, Prudent JR, Kaiser MW, Takova T, Kwiatkowski RW, Sander, TJ, de Arruda M, Arco DA, Neri BP, Brow MA. 1999. Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes. Nat Biotechnol 17:292-296.
12. Nakano Y, Oshima T, Watanabe M, Matsuura H, Kajiyama G, Kambe M. 1997. Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension. Am J Hypertens 10:1064-1068.
13. Priori SG, Barhanin J, Hauer RN, Haverkamp W, Jongsma HJ, Kleber AG, McKenna WJ, Roden DM, Rudy Y, Schwartz K, Schwartz PJ, Towbin JA, Wilde AM. 1999. Genetic and molecular basis of cardiac arrhythmias: impact on clinical management, III. Circulation 99:674-681.
14. Ryan D, Nuccie B, Arvan D. 1999. Non-PCR-dependent detection of the factor V Leiden mutation from genomic DNA using a homogeneous invader microtiter plate assay. Mol Diagn 4: 135-144.
15. Southern E, Mir K, Shchepinov M. 1999. Molecular interactions on microarrays. Nat Genet 21:5-9.