Non-PCR-dependent detection of the Factor V Leiden mutation from genomic DNA using a homogeneous invader microtiter plate assay

Molecular Diagnosis

Volumn 4, Issue 2, 1999, Pages 135-144

  Ryan, Daniel ^a   Nuccie, Bonnie ^a   Arvan, Dean ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Cleavase enzyme; Factor V Leiden; Invader assay; Polymorphism detection; Signal amplification

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ARTICLE; DNA TEMPLATE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0032793539     PISSN: 10848592     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-8592(99)80037-X     Document Type: Article

References (3)

1. Dahlback B: Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene. Haemostasis 1994;24:139-151
2. Dahlbäck B, Hildebrand B: Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci USA 1994;91:1396-1400
3. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67