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Volumn 278, Issue 2 47-2, 2000, Pages

Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state

Author keywords

Insulin resistance; Leptin; Neuroendocrine; Obesity; Respiratory quotient; Ventromedial hypothalamus

Indexed keywords

FAT; GLUCAGON; GLUCOSE; INSULIN; LEPTIN; NORADRENALIN; TRIACYLGLYCEROL;

EID: 0034099771     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.278.2.r435     Document Type: Article
Times cited : (36)

References (51)
  • 1
    • 0025267399 scopus 로고
    • Intra-ventromedial hypothalamic injection of glutamate stimulates brown adipose tissue thermogenesis in the rat
    • Amir, S. Intra-ventromedial hypothalamic injection of glutamate stimulates brown adipose tissue thermogenesis in the rat. Brain Res. 511: 341-344, 1990.
    • (1990) Brain Res. , vol.511 , pp. 341-344
    • Amir, S.1
  • 2
    • 0024992019 scopus 로고
    • Insulin co-injection suppresses the thermogenic response to glutamate microinjection into the VMH in rats
    • Amir, S., A. Schiavetto, and R. Pollock. Insulin co-injection suppresses the thermogenic response to glutamate microinjection into the VMH in rats. Brain Res. 527: 326-329, 1990.
    • (1990) Brain Res. , vol.527 , pp. 326-329
    • Amir, S.1    Schiavetto, A.2    Pollock, R.3
  • 3
    • 0022368396 scopus 로고
    • Photoperiodic control of seasonal body weight cycles in hamsters
    • Bartness, T. J., and G. N. Wade. Photoperiodic control of seasonal body weight cycles in hamsters. Neurosci. Biobehav. Rev. 9: 599-612, 1995.
    • (1995) Neurosci. Biobehav. Rev. , vol.9 , pp. 599-612
    • Bartness, T.J.1    Wade, G.N.2
  • 4
    • 0032191009 scopus 로고    scopus 로고
    • Insulin resistance in obesity: Metabolic mechanisms and measurement methods
    • Belfiore, F., and S. Iannello. Insulin resistance in obesity: metabolic mechanisms and measurement methods. Mol. Genet. Metab. 65: 121-128, 1998.
    • (1998) Mol. Genet. Metab. , vol.65 , pp. 121-128
    • Belfiore, F.1    Iannello, S.2
  • 5
    • 4244190785 scopus 로고    scopus 로고
    • Norepinephrine mediates the increase in GABA activity in VMH after 2-DG in rats
    • Beverly, J. L., L. Arseneau, and M. Devries. Norepinephrine mediates the increase in GABA activity in VMH after 2-DG in rats (Abstract). Diabetes 47, Suppl. 1: A294, 1998.
    • (1998) Diabetes , vol.47 , Issue.SUPPL. 1
    • Beverly, J.L.1    Arseneau, L.2    Devries, M.3
  • 6
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 7
    • 4243801718 scopus 로고    scopus 로고
    • Hypothalamic adrenergic receptor changes in the metabolic syndrome of ob/ob mice
    • Boundy, V. A., and A. H. Cincotta. Hypothalamic adrenergic receptor changes in the metabolic syndrome of ob/ob mice. Diabetes 48, Suppl. 1: A285, 1999.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Boundy, V.A.1    Cincotta, A.H.2
  • 8
    • 0027468108 scopus 로고
    • Bromocriptine redirects metabolism and prevents seasonal onset of obese hyperinsulinemic state in Syrian hamsters
    • Cincotta, A. H., T. A, MacEachern, and A. H. Meier. Bromocriptine redirects metabolism and prevents seasonal onset of obese hyperinsulinemic state in Syrian hamsters. Am. J. Physiol. Endocrinol. Metab. 264: E285-E293, 1993.
    • (1993) Am. J. Physiol. Endocrinol. Metab. , vol.264
    • Cincotta, A.H.1    MacEachern, T.A.2    Meier, A.H.3
  • 10
    • 77049299397 scopus 로고
    • A relation between nonesterified fatty acids plasma and the metabolism of glucose
    • Dole, V. P. A relation between nonesterified fatty acids plasma and the metabolism of glucose. J. Clin. Invest. 35: 150-154, 1956.
    • (1956) J. Clin. Invest. , vol.35 , pp. 150-154
    • Dole, V.P.1
  • 12
    • 0031846461 scopus 로고    scopus 로고
    • How to measure insulin sensitivity
    • Ferrannini, E., and A. Mari. How to measure insulin sensitivity. J. Hypertens. 16: 895-906, 1998.
    • (1998) J. Hypertens , vol.16 , pp. 895-906
    • Ferrannini, E.1    Mari, A.2
  • 13
    • 0343815310 scopus 로고
    • Seasonal variations in carbohydrate metabolism in mammalian hibernators: Insulin and body weight changes
    • edited by T. B. Van Itallie and J. Hirsch. London: Liberty
    • Florant, G. L., and W. A. Bauman. Seasonal variations in carbohydrate metabolism in mammalian hibernators: insulin and body weight changes. In: Recent Advances in Obesity Research, edited by T. B. Van Itallie and J. Hirsch. London: Liberty, 1984, vol. 4, p 57-64.
    • (1984) Recent Advances in Obesity Research , vol.4 , pp. 57-64
    • Florant, G.L.1    Bauman, W.A.2
  • 14
    • 0000572760 scopus 로고
    • Hypothalamic control of metabolism
    • edited by P. J. Morgane and J. Panksepp. New York: Dekker
    • Frohman, L. A. Hypothalamic control of metabolism. In: Handbook of the Hypothalamus. Physiology of the Hypothalamus, edited by P. J. Morgane and J. Panksepp. New York: Dekker, 1980, vol. 2, p. 519-555.
    • (1980) Handbook of the Hypothalamus. Physiology of the Hypothalamus , vol.2 , pp. 519-555
    • Frohman, L.A.1
  • 15
    • 0028892579 scopus 로고
    • Developmental and regional changes in brain norepinephrine levels in diabetic C57BL/KsJ mice: Effects of estradiol and progesterone
    • Garris, D. R. Developmental and regional changes in brain norepinephrine levels in diabetic C57BL/KsJ mice: effects of estradiol and progesterone. Brain Res. 89: 314-319, 1995.
    • (1995) Brain Res. , vol.89 , pp. 314-319
    • Garris, D.R.1
  • 16
    • 0032567996 scopus 로고    scopus 로고
    • Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome
    • Grundy, S. M. Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am. J. Cardiol. 81: 18B-25B, 1998.
    • (1998) Am. J. Cardiol. , vol.81
    • Grundy, S.M.1
  • 17
    • 84981834057 scopus 로고
    • The relation of various hypothalamic lesions to adiposity in the rat
    • Hetherington, A. W., and S. W. Ranson. The relation of various hypothalamic lesions to adiposity in the rat. J. Comp. Neurol. 76: 475-499, 1942.
    • (1942) J. Comp. Neurol. , vol.76 , pp. 475-499
    • Hetherington, A.W.1    Ranson, S.W.2
  • 19
    • 0028788998 scopus 로고
    • Central command neurons of the sympathetic nervous system: Basis of the fight-or-flight response
    • Jansen, A. S. P., X. V. Nguyen, V. Karpitskiy, T. C. Metenleiter, and A. D. Loewy. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 270: 644-646, 1995.
    • (1995) Science , vol.270 , pp. 644-646
    • Jansen, A.S.P.1    Nguyen, X.V.2    Karpitskiy, V.3    Metenleiter, T.C.4    Loewy, A.D.5
  • 20
    • 0029116485 scopus 로고
    • Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring
    • Jones, A. P., E. N. Pothos, P. Rada, D. H. Olster, and B. G. Hoebel. Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring. Dev. Brain Res. 88: 127-131, 1995.
    • (1995) Dev. Brain Res. , vol.88 , pp. 127-131
    • Jones, A.P.1    Pothos, E.N.2    Rada, P.3    Olster, D.H.4    Hoebel, B.G.5
  • 21
    • 0030720085 scopus 로고    scopus 로고
    • Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity
    • Koyama, K., G. Chen, Y. Lee, and R. H. Unger. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am. J. Physiol. Endocrinol. Metab. 273: E708-E713, 1997.
    • (1997) Am. J. Physiol. Endocrinol. Metab. , vol.273
    • Koyama, K.1    Chen, G.2    Lee, Y.3    Unger, R.H.4
  • 22
    • 0342944308 scopus 로고
    • Effect of monoamine iontophoresis on neuronal activity in ventromedial hypothalamus of lean and obese mice
    • Kraszewski, K., and A. H. Cincotta. Effect of monoamine iontophoresis on neuronal activity in ventromedial hypothalamus of lean and obese mice. Soc. Neurosci. Abstr. 23: 1794, 1977.
    • (1977) Soc. Neurosci. Abstr. , vol.23 , pp. 1794
    • Kraszewski, K.1    Cincotta, A.H.2
  • 24
    • 0031791129 scopus 로고    scopus 로고
    • Dopamine agonist treatment ameliorates hyperglcemia hyperlipidemia and the elevated basal insulin release from islets of ob/ob mice
    • Liang, Y., M. Lubkin, H. Sheng, and A. H. Cincotta. Dopamine agonist treatment ameliorates hyperglcemia hyperlipidemia and the elevated basal insulin release from islets of ob/ob mice. Biochim. Biophys. Acta 1404: 1-13, 1998.
    • (1998) Biochim. Biophys. Acta , vol.1404 , pp. 1-13
    • Liang, Y.1    Lubkin, M.2    Sheng, H.3    Cincotta, A.H.4
  • 25
    • 0032745617 scopus 로고    scopus 로고
    • Chronic infusion of norepinephrine plus serotonin into the VMH impairs pancreatic islet function
    • Liang, Y., S. Luo, and A. H. Cincotta. Chronic infusion of norepinephrine plus serotonin into the VMH impairs pancreatic islet function. Metabolism 48: 1287-1289, 1999.
    • (1999) Metabolism , vol.48 , pp. 1287-1289
    • Liang, Y.1    Luo, S.2    Cincotta, A.H.3
  • 26
    • 0023269739 scopus 로고
    • The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism
    • Luiten, P. G. M., G. J. Ter Horst, and A. B. Steffens. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog. Neurobiol. 28: 1-54, 1987.
    • (1987) Prog. Neurobiol. , vol.28 , pp. 1-54
    • Luiten, P.G.M.1    Ter Horst, G.J.2    Steffens, A.B.3
  • 27
    • 0033429422 scopus 로고    scopus 로고
    • Chronic ventromedial hypothalamic infusion of norepinephrine and serotonin promotes insulin resistance and glucose intolerance
    • Luo, S., J. Luo, and A. H. Cincotta. Chronic ventromedial hypothalamic infusion of norepinephrine and serotonin promotes insulin resistance and glucose intolerance. Neuroendocrinology 70: 460-465, 1999.
    • (1999) Neuroendocrinology , vol.70 , pp. 460-465
    • Luo, S.1    Luo, J.2    Cincotta, A.H.3
  • 28
    • 0033551594 scopus 로고    scopus 로고
    • Suprachiasmatic nuclei monoamine metabolism of glucose tolerant versus intolerant hamsters
    • Luo, S., J. Luo, and A. H. Cincotta. Suprachiasmatic nuclei monoamine metabolism of glucose tolerant versus intolerant hamsters. Neuroreport 10: 2073-2077, 1999.
    • (1999) Neuroreport , vol.10 , pp. 2073-2077
    • Luo, S.1    Luo, J.2    Cincotta, A.H.3
  • 29
    • 0001308196 scopus 로고    scopus 로고
    • Increased daily turnover of noradrenaline and serotonin in ventral medial hypothalamus (VMH) of obese versus lean Zucker rats assessed by in vivo microdialysis
    • Luo, S., J. Luo, S. Hodge, and A. H. Cincotta. Increased daily turnover of noradrenaline and serotonin in ventral medial hypothalamus (VMH) of obese versus lean Zucker rats assessed by in vivo microdialysis. Soc. Neurosci. Abstr. 22: 605, 1996.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , pp. 605
    • Luo, S.1    Luo, J.2    Hodge, S.3    Cincotta, A.H.4
  • 30
    • 0030663631 scopus 로고    scopus 로고
    • Dopaminergic neurotoxin administration to the area of the suprachiasmatic nuclei induces insulin resistance
    • Luo, S., J. Luo, A. H. Meier, and A. H. Cincotta. Dopaminergic neurotoxin administration to the area of the suprachiasmatic nuclei induces insulin resistance. Neuroreport 8: 3495-3499, 1997.
    • (1997) Neuroreport , vol.8 , pp. 3495-3499
    • Luo, S.1    Luo, J.2    Meier, A.H.3    Cincotta, A.H.4
  • 31
    • 0031807188 scopus 로고    scopus 로고
    • Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters
    • Luo, S., A. H. Meier, and A. H. Cincotta. Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters. Neuroendocrinology 68: 1-10, 1998.
    • (1998) Neuroendocrinology , vol.68 , pp. 1-10
    • Luo, S.1    Meier, A.H.2    Cincotta, A.H.3
  • 33
    • 0030445765 scopus 로고    scopus 로고
    • Circadian rhythms regulate the expression of the thrifty genotype/phenotype
    • Meier, A. H., and A. H. Cincotta. Circadian rhythms regulate the expression of the thrifty genotype/phenotype. Diabetes Rev. 4: 464-487, 1996.
    • (1996) Diabetes Rev. , vol.4 , pp. 464-487
    • Meier, A.H.1    Cincotta, A.H.2
  • 34
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • Minokoshi, Y., M. S. Haque, and R. Shimazu. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 48: 287-291, 1999.
    • (1999) Diabetes , vol.48 , pp. 287-291
    • Minokoshi, Y.1    Haque, M.S.2    Shimazu, R.3
  • 35
    • 0006814670 scopus 로고
    • Cyclical obesity in hibernators: The search for the adjustable regulator
    • edited by T. B. Van Itallie and J. Hirsch. London: Liberty
    • Mrosovsky, N. Cyclical obesity in hibernators: the search for the adjustable regulator. In: Recent Advances in Obesity Research, edited by T. B. Van Itallie and J. Hirsch. London: Liberty, 1984, vol. 4, p. 45-56.
    • (1984) Recent Advances in Obesity Research , vol.4 , pp. 45-56
    • Mrosovsky, N.1
  • 37
    • 0020627013 scopus 로고
    • Norepinephrine and dopamine levels in hypothalamic nuclei of the genetically obese mouse (ob/ob)
    • Oltmans, G. A. Norepinephrine and dopamine levels in hypothalamic nuclei of the genetically obese mouse (ob/ob). Brain Res. 273: 369-373, 1983.
    • (1983) Brain Res. , vol.273 , pp. 369-373
    • Oltmans, G.A.1
  • 38
    • 0030696968 scopus 로고    scopus 로고
    • The deadly quartet - The insulin resistance syndrome
    • Opara, J. U., and J. H. Levine. The deadly quartet - the insulin resistance syndrome. South Med. J. 90: 1162-1168, 1997.
    • (1997) South Med. J. , vol.90 , pp. 1162-1168
    • Opara, J.U.1    Levine, J.H.2
  • 40
    • 0031957844 scopus 로고    scopus 로고
    • Role of nonesterified fatty acids in the pathogenesis of type 2 diabetes mellitus
    • Paolisso, G., and B. V. Howard. Role of nonesterified fatty acids in the pathogenesis of type 2 diabetes mellitus. Diabetes Med. 15: 360-366, 1998.
    • (1998) Diabetes Med. , vol.15 , pp. 360-366
    • Paolisso, G.1    Howard, B.V.2
  • 43
    • 0023579701 scopus 로고
    • Effect of age and sex on rat endocrine pancreas
    • Reaven, E. P., D. L. Curry, and G. M. Reaven. Effect of age and sex on rat endocrine pancreas. Diabetes 36: 1397-1400, 1987.
    • (1987) Diabetes , vol.36 , pp. 1397-1400
    • Reaven, E.P.1    Curry, D.L.2    Reaven, G.M.3
  • 44
    • 0030025673 scopus 로고    scopus 로고
    • Hypertension and associated metabolic abnormalities: The role of insulin resistance and the sympathoadrenal system
    • Reaven, G. M., H. Lithell, and L. Landsberg. Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. New Engl. J. Med. 334: 374-381, 1996.
    • (1996) New Engl. J. Med. , vol.334 , pp. 374-381
    • Reaven, G.M.1    Lithell, H.2    Landsberg, L.3
  • 46
    • 0032913283 scopus 로고    scopus 로고
    • Attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists
    • Scislowski, P. W. D., E. Tozzo, Y. Zhang, and A. H. Cincotta. Attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists. Int. J. Obesity 23: 425-431, 1999.
    • (1999) Int. J. Obesity , vol.23 , pp. 425-431
    • Scislowski, P.W.D.1    Tozzo, E.2    Zhang, Y.3    Cincotta, A.H.4
  • 47
    • 0023129641 scopus 로고
    • Neuronal regulation of hepatic glucose metabolism in mammals
    • Shimazu, T. Neuronal regulation of hepatic glucose metabolism in mammals. Diabetes Metab. Rev. 3: 185-206, 1987.
    • (1987) Diabetes Metab. Rev. , vol.3 , pp. 185-206
    • Shimazu, T.1
  • 48
    • 0022551156 scopus 로고
    • Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats
    • Shimazu, T., M. Noma, and M. Saito. Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats. Brain Res. 369: 215-233, 1986.
    • (1986) Brain Res. , vol.369 , pp. 215-233
    • Shimazu, T.1    Noma, M.2    Saito, M.3
  • 49
    • 0021665552 scopus 로고
    • Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats
    • Steffens, A. B., G. Damsma, J. van der Gugten, and P. G. M. Luiten. Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats. Am. J. Physiol. Endocrinol. Metab. 247: E765-E771, 1984.
    • (1984) Am. J. Physiol. Endocrinol. Metab. , vol.247
    • Steffens, A.B.1    Damsma, G.2    Van Der Gugten, J.3    Luiten, P.G.M.4
  • 50
    • 0027502495 scopus 로고
    • Sympathetic nerve activity after discrete hypothalamic injections of L-glutamate
    • Yoshimatsu, H., M. Egawa, and G. A. Bray. Sympathetic nerve activity after discrete hypothalamic injections of L-glutamate. Brain Res. 601: 121-128, 1993.
    • (1993) Brain Res. , vol.601 , pp. 121-128
    • Yoshimatsu, H.1    Egawa, M.2    Bray, G.A.3
  • 51
    • 0000375768 scopus 로고
    • Fat, energy and mammalian survival
    • Young, R. A. Fat, energy and mammalian survival. Am. Zool. 16: 699-710, 1976.
    • (1976) Am. Zool. , vol.16 , pp. 699-710
    • Young, R.A.1


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