The antihypertensive effect of garlic (Allium sativum) in the rat two- kidney-one-clip Goldblatt model

Journal of Ethnopharmacology

Volumn 66, Issue 2, 1999, Pages 217-222

  Al Qattan, K K ^a   Alnaqeeb, M A ^a   Ali, M ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

2K 1C Goldblatt model; Antihypertensive; Garlic; Hypertension; Prostaglandins

Indexed keywords

ANGIOTENSIN; ANTIHYPERTENSIVE AGENT; GARLIC EXTRACT; HYPERTENSIVE AGENT; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GARLIC; HERBAL MEDICINE; HYPOTENSION; NONHUMAN; RAT; RENOVASCULAR HYPERTENSION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; FEMALE; GARLIC; HYPERTENSION, RENOVASCULAR; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032985666     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00173-1     Document Type: Article

References (25)

1. Ali M., Mohammad S.Y. Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandins Leukotrienes Med. 25:1986;139-146.
2. Al-Qattan K.K., Johns E.J. A comparison of the actions of cilazapril in normal, dietary sodium-depleted and two kidney, one clip Goldblatt hypertensive anaesthetized rats. J. Hypertens. 10:1992;423-429.
3. Banerjee A. Effect of aqueous extract of garlic on arterial blood pressure of normotensive and hypertensive rats. Artery. 2:1979;369-373.
4. Block E., Ahmad S., Cataflamo J.L., Jian M.K., ApitzCastro R. Antithrombotic organosulfur compounds from garlic: structural mechanistic and synthetic studies. J. Am. Chem. Soc. 108:1986;7045-7048.
5. Bordia A. Effect of garlic on human platelet aggregation in vitro. Atherosclerosis. 29:1978;355-360.
6. Bordia A., Verma S.K., Vyas A.K., Bedi H.K. Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits. Atherosclerosis. 26:1977;379-386.
7. Bordia A., Joshi H.K., Sandhya Y.K., Bhu N. Effects of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery diseases. Atherosclerosis. 28:1978;155-159.
8. Brunner H.R., Gavras H., Laragh J.H., Keenan R. Hypertension in man; Exposure of the renin and sodium component using angiotensin II blockade. Circ. Res. 34(Suppl. I):1974;35-43.
9. Chutani S.K., Bordia A. The effect of fried versus raw garlic on fibrinolytic activity in man. Atherosclerosis. 38:1981;417-421.
10. DeForrest J.M., Knappenberger R.Z., Antonaccio M.J., Ferrone R.A., Creekmore J.S. Angiotensin II is a necessary component for the development of hypertension in the two kidney, one clip rat. Am. J. Cardiol. 49:1982;1515-1517.
11. Dunn, J.M., 1986. The relationship of prostaglandin and thromboxane to the pathophysiology of renal disease and hypertension. In: Fisher, J.W. (Ed.), Kidney Hormones, vol. III. Academic Press, New York, p. 449.
12. Foushee D.B., Ruffin J., Banerjee U. Garlic as a natural agent for the treatment of hypertension: a preliminary report. Cytobios. 34:1982;145-152.
13. Grunwald J. Garlic. Lancet. 335:1990;115.
14. Heinrikson, R.L., Poorman, R.A., 1990. The biochemistry and molecular biology of recombinant human renin and prorenin. In: Laragh, H., Brenner, B.M. (Eds.), Hypertension: Pathophysiology, Diagnosis and Management. Raven Press, New York, p. 1181.
15. Huang W.-C., Ploth D.W., Navar L.C. Effect of saralasin infusion on bilateral renal function in two-kidney one clip Goldblatt hypertensive rats. Clin. Sci. 62:1982;573-579.
16. Kivirata J., Huovinen K., Karppanen H., Kilpelainen M. Effects of onion and garlic extracts on spontaneously hypertensive rats. Phytother. Res. 3:1989;132-135.
17. Makheia A.N., Vanderhock J.Y., Bailey J.M. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. Lancet. 1:1979;781.
18. Marsden, P.A., Brenner, B.M., Ballermann, B.J., 1990. Mechanisms of angiotensin action on vascular smooth muscle. In: Laragh, H., Brenner, B.M. (Eds.), Hypertension: Pathophysiology, Diagnosis and Management. Raven Press, New York, p. 1255.
19. Mohammed S.F., Woodward S.C. Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum. Thromb. Res. 44:1986;793-806.
20. Rashid A., Khan H.H. The mechanism of hypotensive effect of garlic extract. J. Pakistan Med. Assoc. 35:1985;357-362.
21. Ruffin J., Hunter S.A. An evaluation of side effects of garlic as an antihypertensive agent. Cytobios. 37:1983;85-89.
22. Samson R.R. Effects of dietary garlic on temporal drift on platelet aggregation. Atherosclerosis. 44:1982;119-120.
23. Vane J.R., McGiff J.C. Possible contributions of endogenous prostaglandins to the control of blood pressure. Circ. Res. 36(1):1975;1-75.
24. Weber P.C., Siess W., Lorenz R., Scherer B. The role of prostaglandins in essential hypertension. Int. J. Obes. 5(1):1981;125-133.
25. Zheziang Institute of Traditional Chinese Medicine The effect of essential oil of garlic on hyperlipemia and platelet aggregation. J. Trad. Chin. Med. 6:1986;117-120.