Garlic extract therapy in children with hypercholesterolemia

Archives of Pediatrics and Adolescent Medicine

Volumn 152, Issue 11, 1998, Pages 1089-1094

  McCrindle, Brian W ^a   Helden, Elizabeth ^b   Conner, William T ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GARLIC EXTRACT; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FAMILIAL HYPERLIPEMIA; FEMALE; GARLIC; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; OUTCOMES RESEARCH; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PAIN;

EID: 0031769890     PISSN: 10724710     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpedi.152.11.1089     Document Type: Article

References (21)

1. Anonymous. National Cholesterol Education Program: report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics. 1994;89: 525-584.
2. Newman TB, Garber AM, Holtzman NA, Hulley SB. Problems with the report of the Expert Panel on blood cholesterol levels in children and adolescents. Arch Pediatr Adolesc Med. 1995;149:241-247.
3. Dennison BA, Jenkins PL, Pearson TA. Challenges to implementing the current pediatric cholesterol screening guidelines into practice. Pediatrics. 1994;94: 296-302.
4. Anonymous. Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). The Writing Group for the DISC Collaborative Research Group. JAMA. 1995;273:1429-1435.
5. McCrindle BW, O'Neill MB, Cullen-Dean G, Helden E. Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: a randomized, crossover trial. J Pediatr. 1997;130:266-273.
6. Silagy C, Neil A. Garlic as a lipid lowering agent - a meta-analysis. J R Coll Physicians Lond. 1994;28:39-45.
7. Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med. 1993;119:599-560.
8. Silagy CA, Neil HAW. A meta-analysis of the effect of garlic on blood pressure. J Hypertension. 1994;12:463-468.
9. Neil HA, Silagy CA, Lancaster T, et al. Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J R Coll Phys London. 1996;30:329-334.
10. Kendler BS. Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Prev Med. 1987;16:670-685.
11. Auer W, Eiber A, Hertkorn E, et al. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Prac. 1990;69:3-6.
12. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets: evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung. 1990;40:1111-1116.
13. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? a controlled clinical study. Am J Med. 1993;94:632-635.
14. Kenzelmann R, Kade F. Limitation of the deterioration of lipid parameters by a standardized garlic-ginkgo combination product. A multicenter placebo-controlled double-blind study. Arzneimittelforschung. 1993;43:978-981.
15. Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr. 1996;64:866-870.
16. McMahon FG, Vargas R. Can garlic lower blood pressure? a pilot study. Pharmacotherapy. 1993;13:406-407.
17. Kiesewetter H, Jung F, Mrowietz C, et al. Effect of garlic therapy on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharm Ther Tox. 1991;29:151-155.
18. Kiesewetter H, Jung F, Mrowietz C, Pindur G, Heiden M, Wenzel E. Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study. Br J Clin Prac. 1990;44:24-29.
19. Simons LA, Balasubramaniam S, von Konigsmark M, Parfitt A, Simons J, Peters W. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis. 1995;113:219-225.
20. Estrada CA, Young MJ. Patient preferences for novel therapy: an N-of-1 trial of garlic in the treatment for hypertension. J Gen Int Med. 1993;8:619-621.
21. Lautier R, Wendt V. Kontackallergie aus Alliaceae. Dermatosen. 1985;33:213-215.