Gabapentin use in neuropathic pain syndromes

Acta Neurologica Scandinavica

Volumn 101, Issue 6, 2000, Pages 359-371

  Nicholson, Bruce ^a  

^a Pain Specialists of Greater Lehigh Valley   (United States)

Author keywords

Gabapentin; Neuropathic pain

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; CALCIUM ION; CARBAMAZEPINE; FELBAMATE; GABAPENTIN; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROKININ; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE; PHENYTOIN; PHOSPHOLIPASE C; PROTEIN KINASE C;

CALCIUM TRANSPORT; CLINICAL TRIAL; DIABETIC NEUROPATHY; GENE EXPRESSION; HUMAN; HYPERALGESIA; NEURALGIA; NEUROPATHY; NOCICEPTION; NONHUMAN; POSTHERPETIC NEURALGIA; PROTO ONCOGENE; REVIEW; SECOND MESSENGER; SOMNOLENCE; VERTIGO;

ACETIC ACIDS; AMINES; ANALGESICS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HUMANS; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; SYNDROME;

EID: 0034094949     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0404.2000.0006a.x     Document Type: Review

References (81)

1. 1. MACFARLANE BV, WRIGHT A, O'CALLAGHAN J, BENSON HAE. Chronic neuropathic pain and its control by drugs. Pharmacol Ther 1997;75:1-19.
2. 2. MCQUAY H, CARROLL D, JADAD AR, WIFFEN P, MOORE A. Anticonvulsant drugs for management of pain: a systematic review. Br Med J 1995;311:1047-52.
3. 3. RULL J, QUIBRERA R, GONZALEZ-MILLAN H, LOZANOCASTENADA O. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine: double-blind crossover study. Diabetologia 1969;5:215-20.
4. 4. LEIJON G, BOIVIE J. Central post-stroke pain-controlled trial of amitriptyline and carbamazepine. Pain 1989;36:27-36.
5. 5. CHADDA VS, MATHUR MS. Double blind study of the effects of diphenylhydantoin sodium on diabetic neuropathy. J Assoc Physicians India 1978;26:403-6.
6. 6. SAUDEK CD, WERNS S, REIDENBERG MM. Phenytoin in the treatment of diabetic symmetrical polyneuropathy. Clin Pharmacol Ther 1977;22:196-9.
7. 7. EISENBERG E, ALON N, ISHAY A, DAOUD D, YARNITSKY D. Lamotrigine in the treatment of painful diabetic neuropathy. Eur J Neurol 1998;5:167-73.
8. 8. CHESHIRE WP. Felbamate relieved trigeminal neuralgia. Clin J Pain 1995;11:139-42.
9. 9. FIELD MJ, OLES RJ, LEWIS AS, MCCLEARY S, HUGHES J, SINGH L. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. J Pharmacol 1997;121:1513-22.
10. 10. SIDDALL PJ, COUSINS MJ. Spine update: spinal pain mechanisms. Spine 1997;22:98-104.
11. 11. WOOLF CJ, CHONG M-S. Preemptive analgesia: treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg 1993;77:1-18.
12. 12. WILLIS WD JR. Summary and overview. In: WILLIS WD JR, ed. Hyperalgesia and allodynia. New York: Raven Press, 1992;5.
13. 13. HOGAN QH, ABRAM SE. Diagnostic and prognostic neural blockade. In: COUSINS MJ, BRIDENBAUGH PO, eds. Neural blockade in clinical anesthesia and management of pain. Third ed. Philadelphia: Lippincott-Raven, 1998:837-45.
14. 14. WALL PD, GUTNICK M. Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma. Exp Neurol 1974;43:580-93.
15. 15. GOVRIN-LIPPMAN R, DEVOR M. Ongoing activity in severed nerves. Source and variation with time. Brain Res 1978;159:406-10.
16. 16. LADURON PM. Axonal transport of presynaptic receptors. In: SMITH RS, BISBY M, eds. Axonal transport. New York: Liss, 1987:347-63.
17. 17. KARLSTEN R, GORDH T. How do drugs relieve neurogenic pain? Drugs & Aging 1997;11:398-412.
18. 18. OMANA-ZAPATA I, KHABBAZ MA, HUNTER JC, CLARKE DE, BLEY KR. Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons. Pain 1997;72:41-9.
19. 19. MCLACHLAN EM, JANIG W, DEVOR M, MICHAELIS M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature 1993;363:543-6.
20. 20. WOOLF CJ. Evidence for central component of post-injury pain. Nature 1983;306:686-8.
21. 21. SCADDING JW. The development of ongoing activity, mechanosensitivity and adrenaline sensitivity in severed peripheral nerve axons. J Exp Neurol 1981;43:580-93.
22. 22. WILCOX GL. Proceedings of the VIth World Congress on Pain. Amsterdam: Elsevier, 1990;97.
23. 23. WOOLF CJ, DOUBELL TP. The pathophysiology of chronic pain - increased sensitivity to low threshold. A beta-fibre inputs. Curr Opin Neurobiol 1994;4:525-34.
24. 24. CARR DB. Oncogenes analgesia and the fuss over fos. IASP Newsletter (1990) (March/April) 3-5.
25. 25. CHI SI, LEVINE JD, BASBAUM AI. Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat. Brain Res 1993;617:225-37.
26. 26. TRUJILLO KA, AKIL H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 1991;251:85-7.
27. 27. WOOLF CJ, SHORTLAND P, COGGESHALL E. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 1992;355:75-8.
28. 28. SINGH L, FIELD MJ, FERRIS P et al. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology 1996;127:1-9.
29. 29. JENSEN TS, LENZ FA. Central post-stroke pain: a challenge for the scientist and the clinician. Pain 1995;61:161-4.
30. 30. GEBHART GF. Mechanisms of central changes produced by peripheral damage: overview. In: WILLIS WD JR, ed. Hyperalgesia and allodynia. New York: Raven Press, 1992:265.
31. 31. TAYLOR CP. Gabapentin: mechanisms of action. In: LEVY RH, MATTSON RH, MELDRUM BS, eds. Antiepileptic drugs. New York: Raven Press, 1995:829-41.
32. 32. PETROFF OA, ROTHMAN DI, BEHAR KL, LAMOUREUX D, MATTSON RH. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 1996;39:95-9.
33. 33. TAYLOR CP, VARTANIAN MG, ANDRUSZKIEWIEWICZ R, SILVERMAN RB. 3-alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Epilepsy Res 1992;11:103-10.
34. 34. SUMAN CHAUHAN N, WEBDALE L, HILL DR, WOODRUFF GN. Characterisation of [PH]-gabapentin binding to a novel site in rat brain: homogenate binding studies. Eur J Pharmacol 1993;244:293-301.
35. 35. THURLOW RJ, BROWN JP, GEE NS, HILL DR, WOODRUFF GN. [PH]-gabapentin binding may label a system-L like neutral amino acid carrier in brain. Eur J Pharmacol 1993;247: 341-5.
36. 36. HILL DR, SUTMAN CHAUHAN N, WOODRUFF GN. Localization of (PH)-gabapentin to a novel site in rat brain: autoradiographic studies. Eur J Pharmacol 1993;244:303-9.
37. 37. SU T, LUNNEY E, CAMPBELL G, OXENDER DL. Transport of gabapentin, a γ-amino acid drug, by system L α-amino acid transporters: a comparative study in astrocytes, synaptosomes and CHO cells. J Neurochem 1995;64:2125-31.
38. 38. WELTY DF, SCHIELKE GP, VARTANIAN MG, TAYLOR CP. Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentration in plasma and brain micro-dialysate. Epilepsy Res 1993;16:175-81.
39. 39. TAYLOR CP, GEE NS, SU T-Z et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29:233-49.
40. 40. HAMILTON SI, HAWKES MJ, BRUSH K, COOK R, CHANG RJ, SMILOWITZ HM. Subunit composition of the purified dihydropyridine binding protein from skeletal muscle. Biochemistry 1989;28:7820-8.
41. + channels in a voltage-dependent manner but gabapentin does not. Soc Neurosci 1993;23:1631. Abstract.
42. 42. ROCK DM, KELLY KM, MACDONALD RL. Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons. Epilepsy Res 1993;16:89-98.
43. 43. WAMILL AW, MCLEAN MJ. Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture. Epilepsy Res 1994;17:1-11.
44. 44. FIELD MJ, HOLLOMAN EF, MCCLEARY S, HUGHES J, SINGH L. Evaluation of gabapentin and S-(+)-3-Isobutylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther 1997; 282:1242-6.
45. 45. HWANG JH, YAKSH TL. Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth 1997;22:249-56.
46. 46. SHIMOYAMA N, SHIMOYAMA M, DAVIS AM, INTURRISI CE, ELLIOTT KJ. Spinal gabapentin is antinociceptive in the rat formalin test. Neurosci Lett 1997;222:65-7.
47. 47. CODERRE TJ, VACCARINO AL, MELZACK R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res 1990;535:155-8.
48. 48. MELLER ST, PECHMAN PS, GEBHART GF, MAVES TJ. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat. Neuroscience 1992;50:7-10.
49. 49. MELLER ST, GEBHART GF. Spinal mediators of hyperalgesia. Drugs 1994;47:10-20.
50. 50. KIM SH, CHUNG JM. An experimental model of peripheral neuropathy produced by segmental spinal nerve ligation. Pain 1992;50:355-63.
51. 51. HUNTER JC, GOGAS KR, HEDLEY LR et al. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol 1997;324:153-60.
52. 52. CHAPMAN V, SUZUKI R, CHAMARETTE HL, RYGH LJ, DICKENSON AH. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain 1998;75:261-72.
53. 53. FIELD MJ, MCCLEARY S, SINGH L. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain 1999;80:391-8.
54. 54. ATTAL N, PARKER F, BRASSEUR L, CHAUVIN M, BOUHASSIRA D. Efficacy of gabapentin on neuropathic pain: a pilot study. Presented at the 16th Annual Scientific Meeting of the American Pain Society; October 23-26, 1997; New Orleans, LA.
55. 55. MACKIN GA. Medical and pharmacologic management of upper extremity neuropathic pain syndromes. J Hand Therapy 1997;10:96-109.
56. 56. NESS TJ, CRIMALDI JC, MCDANAL JT. Case report on gabapentin. Reg Anesth Pain Med 1998;23:110-11.
57. 57. ROSENBERG JM, HARRELL C, RISTIC H, WERNER RA, DE ROSAYRO AM. The effect of gabapentin on neuropathic pain. Clin J Pain 1997;13:251-5.
58. 58. ROSNER H, RUBIN L, KESTENBAUM A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain 1996;12: 56-8.
59. 59. SIST TC, FILADORA VA II, MINER M, LEMA M. Experience with gabapentin for neuropathic pain in the head and neck: report of ten cases. Reg Anesth 1997;22:473-8.
60. 60. SEGAL AZ, RORDORF G. Gabapentin as a novel treatment for postherpetic neuralgia. Neurology 1996;46:1175. Letter.
61. 61. DALLOCCHIO C, BUFFIA C, LlGURE N, MAZZARELLO P, CHIROLI S. Gabapentin versus amitriptyline in painful diabetic neuropathy of the elderly. Neurology 1998;50:A102. Abstract.
62. 62. GORSON KC, SCHOTT C, RAND WM, HERMAN R, ROPPER AH. Gabapentin in the treatment of painful diabetic neuropathy: a placebo-controlled, double-blind, crossover trial. Neurology 1998;50:A103. Abstract.
63. 63. HOUTCHENS MK, RICHERT JR, SAMI A, ROSE JW. Open label gabapentin treatment for pain in multiple sclerosis. Multiple Sclerosis 1997;3:250-3.
64. 64. SOLARO C, UCCELLI A, INGLESE M et al. Gabapentin is effective in treating paroxysmal symptoms in multiple sclerosis. Neurology 1998;50:A147. Abstract.
65. 65. SAMKOFF LM, DARAS M, TUCHMAN AJ, KOPPEL BS. Amelioration of refractory dysesthetic limb pain in multiple sclerosis by gabapentin. Neurology 1997;49:304-5.
66. 66. KHATRI A, PEARLSTEIN L. Pain in Guillain-Barré syndrome. Neurology 1997;49:1474. Letter.
67. 67. GATTI A, JANN S, SANDRO B, MANUELA B. Gabapentin in the treatment of distal symmetric axonopathy in HIV infected patients. Neurology 1998;50:A216. Abstract.
68. 68. LUCIER E. Use of gabapentin in a case of facial neuritis. Anesth Analg 1997;85:1410.
69. 69. VALZANIA F, STRAFELLA AP, NASSETTI SA, TROPEANI A, TASSINARI CA. Gabapentin in idiopathic trigeminal neuralgia. Neurology 1998;50:A379. Abstract.
70. 70. SIST T, FILADORA V, MINER M, LEMA M. Gabapentin for idiopathic trigeminal neuralgia: report of two cases. Neurology 1997;48:1467-71.
71. 71. SCHACHTER SC, SAUTER MK. Treatment of central pain with gabapentin: case reports. J Epilepsy 1996;9:223-6. Letter.
72. 72. MATHEW NT, LUCKER C. Gabapentin in migraine prophylaxis: a preliminary open label study. Neurology 1996;50: A169. Abstract.
73. 73. ZAPP JJ. Postpoliomyelitis pain treated with gabapentin. Am Fam Physician 1996;53:2442-5. Letter.
74. 74. MELLICK GA, MELLICK LB. Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil 1997; 78:98-105.
75. 75. WACKIM ME, ZELTZER L, ROBERTS RL, WEIGENSBERG M. Management of erythromelalgia with epidural bupivicaine and fentanyl and oral gabapentin. J Invest Med 1997;45:138A. Abstract.
76. 76. MCGRAW T, KOSEK P. Erythromelalgia pain managed with gabapentin. Anesthesiology 1997;86:988-90.
77. 77. CHEVILLE A, NARCESSIAN E, ELLIOT K. Neuropathic pain in radiation myelopathy: a case report. Proceedings of the 14th Annual Scientific Meeting of the American Pain Society, November 9-12, 1995; Los Angeles, CA:A115. Abstract.
78. 78. MERCADANTE S. Gabapentin in spinal cord injury pain. Pain Clinic 1998;10:203-6.
79. 79. ROWBOTHAM M, HARDEN N, STACEY B, PODOLNICK P, MAGNUS-MILLER L. Gabapentin for the treatment of post-herpetic neuralgia: a multicenter, double-blind, placebo-controlled study. JAMA 1998;280:1837-42.
80. 80. BACKONJA M, BEYDOUN A, EDWARDS KR et al. Gabapentin monotherapy for the treatment of painful neuropathy: a multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus. JAMA 1998;280:1831-6.
81. 81. MAX MB, LYNCH SA, MUIR J, SHOAF SE, SMOLLER B, DUBNER R. Effects of Desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326: 1250-6.