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Volumn 30, Issue 4, 2000, Pages 357-363

Current status of and future prospects for the medical management of adenocarcinoma of the exocrine pancreas

Author keywords

Cancer treatment; Chemotherapy; Pancreatic cancer

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE; ALPHA INTERFERON; ANTISENSE OLIGODEOXYNUCLEOTIDE; AZATHIOPRINE; CARBOPLATIN; CISPLATIN; DOCETAXEL; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; FLUTAMIDE; FOLINIC ACID; GEMCITABINE; HYDROXYUREA; IFOSFAMIDE; ISOTRETINOIN; LOXIGLUMIDE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; METHOTREXATE; MITOMYCIN C; PACLITAXEL; RALTITREXED; SPARFOSIC ACID; TAXANE DERIVATIVE; TEMOZOLOMIDE; TOPOTECAN; UFT;

EID: 0034088445     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-200006000-00003     Document Type: Review
Times cited : (9)

References (79)
  • 1
    • 0029868667 scopus 로고    scopus 로고
    • National patterns of care for pancreatic cancer. Results of a survey by the Commission on Cancer
    • Janes RH Jr, Niederhuber JE, Chmiel JS, et al. National patterns of care for pancreatic cancer. Results of a survey by the Commission on Cancer. Ann Surg 1996;223:261-72.
    • (1996) Ann Surg , vol.223 , pp. 261-272
    • Janes R.H., Jr.1    Niederhuber, J.E.2    Chmiel, J.S.3
  • 2
    • 0031427541 scopus 로고    scopus 로고
    • Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: Pathology, complications, and outcomes
    • Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 1997;226:248-57.
    • (1997) Ann Surg , vol.226 , pp. 248-257
    • Yeo, C.J.1    Cameron, J.L.2    Sohn, T.A.3
  • 3
    • 0031892666 scopus 로고    scopus 로고
    • Lack of survival benefit of extended lymph node dissection for ductal adenocarcinoma of the head of the pancreas: Retrospective multi-institutional analysis in Japan
    • Mukaiya M, Hirata K, Satoh T, et al. Lack of survival benefit of extended lymph node dissection for ductal adenocarcinoma of the head of the pancreas: retrospective multi-institutional analysis in Japan. World J Surg 1998;22: 248-52.
    • (1998) World J Surg , vol.22 , pp. 248-252
    • Mukaiya, M.1    Hirata, K.2    Satoh, T.3
  • 4
    • 0031860908 scopus 로고    scopus 로고
    • Survival following pancreatico-duodenectomy with resection of the superior mesenteric-portal vein confluence for adenocarcinoma of the pancreatic head
    • Leach SD, Lee JE, Charnsangavej C, et al. Survival following pancreatico-duodenectomy with resection of the superior mesenteric-portal vein confluence for adenocarcinoma of the pancreatic head. Br J Surg 1998;85:611-7.
    • (1998) Br J Surg , vol.85 , pp. 611-617
    • Leach, S.D.1    Lee, J.E.2    Charnsangavej, C.3
  • 5
    • 0031789823 scopus 로고    scopus 로고
    • Intraoperative radiotherapy in the combined-modality management of pancreatic cancer
    • Schuricht AL, Spitz F, Barbot D, Rosato F. Intraoperative radiotherapy in the combined-modality management of pancreatic cancer. Am Surg 1998;64: 1043-9.
    • (1998) Am Surg , vol.64 , pp. 1043-1049
    • Schuricht, A.L.1    Spitz, F.2    Barbot, D.3    Rosato, F.4
  • 6
    • 17144435989 scopus 로고    scopus 로고
    • External and intraoperative radiotherapy for resectable and unresectable pancreatic cancer: Analysis of survival rates and complications
    • Nishimura Y, Hosotani R, Shibamoto Y, et al. External and intraoperative radiotherapy for resectable and unresectable pancreatic cancer: analysis of survival rates and complications. Int J Radiat Oncol Biol Phys 1997;1:39-49.
    • (1997) Int J Radiat Oncol Biol Phys , vol.1 , pp. 39-49
    • Nishimura, Y.1    Hosotani, R.2    Shibamoto, Y.3
  • 7
    • 17544397060 scopus 로고    scopus 로고
    • Intraoperative radiotherapy in resected pancreatic cancer: Feasibility and results
    • Coquard R, Ayzac L, Gilly FN, et al. Intraoperative radiotherapy in resected pancreatic cancer: feasibility and results. Radiother Oncol 1997;44:271-5.
    • (1997) Radiother Oncol , vol.44 , pp. 271-275
    • Coquard, R.1    Ayzac, L.2    Gilly, F.N.3
  • 9
    • 0032421150 scopus 로고    scopus 로고
    • Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma
    • Pisters PW, Abbruzzese JL, Janjan NA, et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol 1998;16: 3843-50.
    • (1998) J Clin Oncol , vol.16 , pp. 3843-3850
    • Pisters, P.W.1    Abbruzzese, J.L.2    Janjan, N.A.3
  • 10
    • 0031750151 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiation for patients with resected pancreatic adenocarcinoma
    • Pendurthi TK, Hoffman JP, Ross E, Johnson DE, Eisenberg BL. Preoperative versus postoperative chemoradiation for patients with resected pancreatic adenocarcinoma. Am Surg 1998;64:686-92.
    • (1998) Am Surg , vol.64 , pp. 686-692
    • Pendurthi, T.K.1    Hoffman, J.P.2    Ross, E.3    Johnson, D.E.4    Eisenberg, B.L.5
  • 11
    • 0030714978 scopus 로고    scopus 로고
    • Adjuvant or neoadjuvant therapy for pancreatic carcinoma?
    • Jeekel J. Adjuvant or neoadjuvant therapy for pancreatic carcinoma? Digestion 1997;58:533-5.
    • (1997) Digestion , vol.58 , pp. 533-535
    • Jeekel, J.1
  • 12
    • 9844264852 scopus 로고    scopus 로고
    • ESPAC-1 trial progress report: The European randomized adjuvant study comparing radiochemotherapy, 6 months chemotherapy and combination therapy versus observation in pancreatic cancer
    • Neoptolemos JP, Kerr DJ, Beger H, et al. ESPAC-1 trial progress report: the European randomized adjuvant study comparing radiochemotherapy, 6 months chemotherapy and combination therapy versus observation in pancreatic cancer. Digestion 1997;58:570-7.
    • (1997) Digestion , vol.58 , pp. 570-577
    • Neoptolemos, J.P.1    Kerr, D.J.2    Beger, H.3
  • 13
    • 0032937302 scopus 로고    scopus 로고
    • Treatment of cancer of the exocrine pancreas
    • Huguier M, Mason NP. Treatment of cancer of the exocrine pancreas. Am J Surg 1999;177:257-65.
    • (1999) Am J Surg , vol.177 , pp. 257-265
    • Huguier, M.1    Mason, N.P.2
  • 14
    • 0032431738 scopus 로고    scopus 로고
    • A prospective randomized study using adjuvant locoregional chemoimmunotherapy in combination with surgery for pancreatic carcinoma
    • Lygidakis NJ, Berberabe AE, Spentzouris N, et al. A prospective randomized study using adjuvant locoregional chemoimmunotherapy in combination with surgery for pancreatic carcinoma. Hepatogastroenterology 1998;45: 2376-81.
    • (1998) Hepatogastroenterology , vol.45 , pp. 2376-2381
    • Lygidakis, N.J.1    Berberabe, A.E.2    Spentzouris, N.3
  • 15
    • 0031972708 scopus 로고    scopus 로고
    • Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: An Eastern Cooperative Oncology Group Study
    • rd. Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study. J Clin Oncol 1998;16:317-23.
    • (1998) J Clin Oncol , vol.16 , pp. 317-323
    • Hoffman, J.P.1    Lipsitz, S.2    Pisansky, T.3    Weese, J.L.4    Solin, L.5    Benson A.B. III6
  • 16
    • 0031963938 scopus 로고    scopus 로고
    • Chemo-radiotherapy for localized pancreatic cancer: Increased dose intensity and reduced acute toxicity with concomitant radiotherapy and protracted venous infusion 5-fluorouracil
    • Poen JC, Collins HL, Niederhuber JE, et al. Chemo-radiotherapy for localized pancreatic cancer: increased dose intensity and reduced acute toxicity with concomitant radiotherapy and protracted venous infusion 5-fluorouracil. Int J Radiat Oncol Biol Phys 1998;40:93-9.
    • (1998) Int J Radiat Oncol Biol Phys , vol.40 , pp. 93-99
    • Poen, J.C.1    Collins, H.L.2    Niederhuber, J.E.3
  • 17
    • 0032009833 scopus 로고    scopus 로고
    • Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole
    • Todd KE, Gloor B, Lane JS, Isacoff WH, Reber HA. Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole. J Gastrointest Surg 1998;2:159-66.
    • (1998) J Gastrointest Surg , vol.2 , pp. 159-166
    • Todd, K.E.1    Gloor, B.2    Lane, J.S.3    Isacoff, W.H.4    Reber, H.A.5
  • 18
    • 0029975668 scopus 로고    scopus 로고
    • high-dose folinic acid and fluorouracil with or without ifosfamide is an inactive combination in advanced pancreatic cancer. A randomized phase II study of the Italian Oncology Group for Clinical Research (G.O.I.R.C.)
    • Di Costanzo F, Tagliaventi M, Carlini P, et al. high-dose folinic acid and fluorouracil with or without ifosfamide is an inactive combination in advanced pancreatic cancer. A randomized phase II study of the Italian Oncology Group for Clinical Research (G.O.I.R.C.). Am J Clin Oncol 1996;19: 307-10.
    • (1996) Am J Clin Oncol , vol.19 , pp. 307-310
    • Di Costanzo, F.1    Tagliaventi, M.2    Carlini, P.3
  • 19
    • 0029561294 scopus 로고
    • Intermittent continuous infusion of ifosfamide and 5-fluorouracil in patients with advanced adenocarcinoma of the pancreas
    • Poorter RL, Bakker PJ, Huizing MT, et al. Intermittent continuous infusion of ifosfamide and 5-fluorouracil in patients with advanced adenocarcinoma of the pancreas. Ann Oncol 1995;6:1048-9.
    • (1995) Ann Oncol , vol.6 , pp. 1048-1049
    • Poorter, R.L.1    Bakker, P.J.2    Huizing, M.T.3
  • 20
    • 0031022310 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic adenocarcinoma with 5-FU, leucovorin, interferon-alpha-2b, and cisplatin
    • Sporn JR, Buzaid AC, Slater D, Cohen N, Greenberg BR. Treatment of advanced pancreatic adenocarcinoma with 5-FU, leucovorin, interferon-alpha-2b, and cisplatin. Am J Clin Oncol 1997;20:81-3.
    • (1997) Am J Clin Oncol , vol.20 , pp. 81-83
    • Sporn, J.R.1    Buzaid, A.C.2    Slater, D.3    Cohen, N.4    Greenberg, B.R.5
  • 21
    • 0031899236 scopus 로고    scopus 로고
    • Continuous venous infusion 5-fluorouracil and interferon-alpha in pancreatic carcinoma
    • John WJ, Flett MQ. Continuous venous infusion 5-fluorouracil and interferon-alpha in pancreatic carcinoma. Am J Clin Oncol 1998;2:147-50.
    • (1998) Am J Clin Oncol , vol.2 , pp. 147-150
    • John, W.J.1    Flett, M.Q.2
  • 22
    • 0029900438 scopus 로고    scopus 로고
    • A phase II study of continuous-infusion 5-fluorouracil with cisplatin and epirubicin in inoperable pancreatic cancer
    • Evans TR, Lofts FJ, Mansi JL, Glees JP, Dalgleish AG, Knight MJ. A phase II study of continuous-infusion 5-fluorouracil with cisplatin and epirubicin in inoperable pancreatic cancer. Br J Cancer 1996;73:1260-4.
    • (1996) Br J Cancer , vol.73 , pp. 1260-1264
    • Evans, T.R.1    Lofts, F.J.2    Mansi, J.L.3    Glees, J.P.4    Dalgleish, A.G.5    Knight, M.J.6
  • 23
    • 13344286320 scopus 로고    scopus 로고
    • Phase II trial of 5-fluorouracil, leucovorin and cisplatin for treatment of advanced pancreatic adenocarcinoma
    • Andre T, Lotz JP, Bouleuc C, et al. Phase II trial of 5-fluorouracil, leucovorin and cisplatin for treatment of advanced pancreatic adenocarcinoma. Ann Oncol 1996;7:173-8.
    • (1996) Ann Oncol , vol.7 , pp. 173-178
    • Andre, T.1    Lotz, J.P.2    Bouleuc, C.3
  • 24
    • 0030210863 scopus 로고    scopus 로고
    • Clinical response to systemic combined chemotherapy with 5-fluorouracil and cisplatin (FP therapy) in patients with advanced pancreatic cancer
    • Okusaka T, Okada S, Ishii H, et al. Clinical response to systemic combined chemotherapy with 5-fluorouracil and cisplatin (FP therapy) in patients with advanced pancreatic cancer. Jpn J Clin Oncol 1996;26:215-20.
    • (1996) Jpn J Clin Oncol , vol.26 , pp. 215-220
    • Okusaka, T.1    Okada, S.2    Ishii, H.3
  • 25
    • 0030433157 scopus 로고    scopus 로고
    • Phase II study of oral L-leucovoin, 120-hour fluorouracil infusion and carboplatin in advanced pancreatic cancer
    • Colleoni M, Nelli P, Vicario G, Pancheri F, Sgarbossa G, Manente P. Phase II study of oral L-leucovoin, 120-hour fluorouracil infusion and carboplatin in advanced pancreatic cancer. Tumori 1996;82:573-5.
    • (1996) Tumori , vol.82 , pp. 573-575
    • Colleoni, M.1    Nelli, P.2    Vicario, G.3    Pancheri, F.4    Sgarbossa, G.5    Manente, P.6
  • 26
    • 0030878120 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic carcinoma with a combination of protracted infusional 5-fluorouracil and weekly carboplatin: A Mid-Atlantic Oncology Program Study
    • Auerbach M, Wampler GL, Lokich JJ, Fryer D, Fryer JG, Ahlgren JD. Treatment of advanced pancreatic carcinoma with a combination of protracted infusional 5-fluorouracil and weekly carboplatin: a Mid-Atlantic Oncology Program Study. Ann Oncol 1997;8:439-44.
    • (1997) Ann Oncol , vol.8 , pp. 439-444
    • Auerbach, M.1    Wampler, G.L.2    Lokich, J.J.3    Fryer, D.4    Fryer, J.G.5    Ahlgren, J.D.6
  • 27
    • 0029808109 scopus 로고    scopus 로고
    • Phase II trials of 5-fluorouracil and leucovorin in patients with metastatic gastric or pancreatic carcinoma
    • Rubin J, Gallagher JG, Schroeder G, et al. Phase II trials of 5-fluorouracil and leucovorin in patients with metastatic gastric or pancreatic carcinoma. Cancer 1996;1:1888-91.
    • (1996) Cancer , vol.1 , pp. 1888-1891
    • Rubin, J.1    Gallagher, J.G.2    Schroeder, G.3
  • 28
    • 9544221631 scopus 로고    scopus 로고
    • Treatment of advanced adenocarcinomas of the exocrine pancreas and the gallbladder with 5-fluorouracil, high dose levofolinic acid and oral hydroxyurea on a weekly schedule. Results of multicenter study of Southern Italy Oncology Group (G.O.I.M.)
    • Gebbia V, Majello E, Testa A, et al. Treatment of advanced adenocarcinomas of the exocrine pancreas and the gallbladder with 5-fluorouracil, high dose levofolinic acid and oral hydroxyurea on a weekly schedule. Results of multicenter study of Southern Italy Oncology Group (G.O.I.M.). Cancer 1996;78:1300-7.
    • (1996) Cancer , vol.78 , pp. 1300-1307
    • Gebbia, V.1    Majello, E.2    Testa, A.3
  • 29
    • 15644362776 scopus 로고    scopus 로고
    • Combined epirubicin, 5-fluorouracil and folinic acid vs no treatment for patients with advanced pancreatic cancer: A prospective comparative study
    • Tsavaris T, Tentas K, Tzivras M, et al. Combined epirubicin, 5-fluorouracil and folinic acid vs no treatment for patients with advanced pancreatic cancer: a prospective comparative study. J Chemother 1998;10:331-7.
    • (1998) J Chemother , vol.10 , pp. 331-337
    • Tsavaris, T.1    Tentas, K.2    Tzivras, M.3
  • 30
    • 0032444972 scopus 로고    scopus 로고
    • A phase II trial of etoposide, folinic acid, fluorouracil and epirubicin in advanced pancreatic carcinoma
    • Maiello E, Gebbia V, Giuliani F, et al. A phase II trial of etoposide, folinic acid, fluorouracil and epirubicin in advanced pancreatic carcinoma. Clin Ter 1998;149:351-5.
    • (1998) Clin Ter , vol.149 , pp. 351-355
    • Maiello, E.1    Gebbia, V.2    Giuliani, F.3
  • 31
    • 0030930136 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic cancer with epirubicin, 5-fluorouracil and 1-leucovorin: A phase II study
    • Raderer M, Kornek, GV, Hejna MH, et al. Treatment of advanced pancreatic cancer with epirubicin, 5-fluorouracil and 1-leucovorin: a phase II study. Ann Oncol 1997;8:797-9.
    • (1997) Ann Oncol , vol.8 , pp. 797-799
    • Raderer, M.1    Kornek, G.V.2    Hejna, M.H.3
  • 32
    • 0030780051 scopus 로고    scopus 로고
    • Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonoacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma
    • Harstick A, Kohne CH, Hiddemann W, et al. Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonoacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma. Ann Oncol 1997;8:917-8.
    • (1997) Ann Oncol , vol.8 , pp. 917-918
    • Harstick, A.1    Kohne, C.H.2    Hiddemann, W.3
  • 33
    • 7844236416 scopus 로고    scopus 로고
    • Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced pancreatic carcinoma: A University of Chicago phase II consortium study
    • Mani S, Kugler JW, Sciortino DF, et al. Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced pancreatic carcinoma: a University of Chicago phase II consortium study. Ann Oncol 1998;9:1035-7.
    • (1998) Ann Oncol , vol.9 , pp. 1035-1037
    • Mani, S.1    Kugler, J.W.2    Sciortino, D.F.3
  • 34
    • 0342276033 scopus 로고    scopus 로고
    • Concomitant intraarterial cisplatin, intravenous 5-fluorouracil, and split-course radiation therapy for locally advanced unresectable pancreatic adenocarcinoma: A phase II study of the Puget Sound Oncology Consortium (PSOC-703)
    • Thomas CR Jr, Weiden PL, Traverso LW, Thompson T. Concomitant intraarterial cisplatin, intravenous 5-fluorouracil, and split-course radiation therapy for locally advanced unresectable pancreatic adenocarcinoma: a phase II study of the Puget Sound Oncology Consortium (PSOC-703). Am J Clin Oncol 1997;20:161-5.
    • (1997) Am J Clin Oncol , vol.20 , pp. 161-165
    • Thomas C.R., Jr.1    Weiden, P.L.2    Traverso, L.W.3    Thompson, T.4
  • 35
    • 0030938059 scopus 로고    scopus 로고
    • Protracted 5-fluorouracil infusion with concurrent radiotherapy as a treatment for locally advanced pancreatic carcinoma
    • Ishii H, Okada S, Tokuuye K, et al. Protracted 5-fluorouracil infusion with concurrent radiotherapy as a treatment for locally advanced pancreatic carcinoma. Cancer 1997;15:1516-20.
    • (1997) Cancer , vol.15 , pp. 1516-1520
    • Ishii, H.1    Okada, S.2    Tokuuye, K.3
  • 36
    • 0030900150 scopus 로고    scopus 로고
    • Phase II trial of paclitaxel and granulocyte colony-stimulating factor inpatients with pancreatic carcinoma: A Southwest Oncology Group study
    • Whitehead RP, Jacobson J, Brown TD, Taylor SA, Weiss GR, Macdonald JS. Phase II trial of paclitaxel and granulocyte colony-stimulating factor inpatients with pancreatic carcinoma: a Southwest Oncology Group study. J Clin Oncol 1997;15:2414-9.
    • (1997) J Clin Oncol , vol.15 , pp. 2414-2419
    • Whitehead, R.P.1    Jacobson, J.2    Brown, T.D.3    Taylor, S.A.4    Weiss, G.R.5    Macdonald, J.S.6
  • 37
    • 18244413657 scopus 로고    scopus 로고
    • Paclitaxel and concurrent radiation for locally advanced pancreatic carcinoma
    • Safran H, Cioffi W, Iannitti D, Mega A, Akerman P. Paclitaxel and concurrent radiation for locally advanced pancreatic carcinoma. Front Biosci 1998; 3:E204-6.
    • (1998) Front Biosci , vol.3
    • Safran, H.1    Cioffi, W.2    Iannitti, D.3    Mega, A.4    Akerman, P.5
  • 38
    • 0032926239 scopus 로고    scopus 로고
    • Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction
    • Safran H, Akerman P, Cioffi W, et al. Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroesophageal junction. Semin Radiat Oncol 1999;9:53:7.
    • (1999) Semin Radiat Oncol , vol.9 , pp. 53
    • Safran, H.1    Akerman, P.2    Cioffi, W.3
  • 39
    • 0029588498 scopus 로고
    • Docetaxel delivers new management opportunities for gastrointestinal carcinomas
    • Rougier P. Docetaxel delivers new management opportunities for gastrointestinal carcinomas. Anticancer Drugs 1995;4:25-29.
    • (1995) Anticancer Drugs , vol.4 , pp. 25-29
    • Rougier, P.1
  • 40
    • 0030870485 scopus 로고    scopus 로고
    • Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer
    • Nobel S, Goa KL. Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drugs 1997; 54:447-72.
    • (1997) Drugs , vol.54 , pp. 447-472
    • Nobel, S.1    Goa, K.L.2
  • 41
    • 8944261362 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
    • Rothenberg ML, Moore MJ, Cripps MC, et al. A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 1996;7:347-53.
    • (1996) Ann Oncol , vol.7 , pp. 347-353
    • Rothenberg, M.L.1    Moore, M.J.2    Cripps, M.C.3
  • 42
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burns H.A. III1    Moore, M.J.2    Andersen, J.3
  • 43
    • 0030964122 scopus 로고    scopus 로고
    • Assessing clinical benefit in the treatment of pancreas cancer: Gemcitabine compared to 5-fluorouracil
    • Burris H, Storniolo AM. Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil. Eur J Cancer 1997; 33:S18-22.
    • (1997) Eur J Cancer , vol.33
    • Burris, H.1    Storniolo, A.M.2
  • 44
    • 0033559213 scopus 로고    scopus 로고
    • An investigational new drug treatment program for patients with gemcitabine: Results for over 3000 patients with pancreatic carcinoma
    • Storniolo AM, Enas NH, Brown CA, Voi M, Rothenberg ML, Schilsky R. An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer 1999; 15:1261-8.
    • (1999) Cancer , vol.15 , pp. 1261-1268
    • Storniolo, A.M.1    Enas, N.H.2    Brown, C.A.3    Voi, M.4    Rothenberg, M.L.5    Schilsky, R.6
  • 45
    • 0030722875 scopus 로고    scopus 로고
    • Clinical response benefit in patients with advanced pancreatic cancer. Role of gemcitabine
    • Carmichael J. Clinical response benefit in patients with advanced pancreatic cancer. Role of gemcitabine. Digestion 1997;58:503-7.
    • (1997) Digestion , vol.58 , pp. 503-507
    • Carmichael, J.1
  • 46
    • 0031855524 scopus 로고    scopus 로고
    • Advances in the treatment of patients with pancreatic cancer: Improvement in symptoms and survival time. The San Antonio Drug Development Team
    • Von Hoff DD, Goodwin AL, Garcia L. Advances in the treatment of patients with pancreatic cancer: improvement in symptoms and survival time. The San Antonio Drug Development Team. Br J Cancer 1998;3:9-13.
    • (1998) Br J Cancer , vol.3 , pp. 9-13
    • Von Hoff, D.D.1    Goodwin, A.L.2    Garcia, L.3
  • 48
    • 0030949235 scopus 로고    scopus 로고
    • Prolonged infusion gemcitabine: A clinical phase I study at low-(300 mg/m2) and high-dose (875 mg/m2) levels
    • Pollera CF, Ceribelli A, Crecco M, Oliva C, Calabresi F. Prolonged infusion gemcitabine: a clinical phase I study at low-(300 mg/m2) and high-dose (875 mg/m2) levels. Invest New Drugs 1997;15:115-21.
    • (1997) Invest New Drugs , vol.15 , pp. 115-121
    • Pollera, C.F.1    Ceribelli, A.2    Crecco, M.3    Oliva, C.4    Calabresi, F.5
  • 49
    • 0031406423 scopus 로고    scopus 로고
    • A phase I trial of weekly gemcitabine administered as a prolonged infusion in patients with pancreatic cancer and other solid tumors
    • Brand R, Capadano M, Tempero M. A phase I trial of weekly gemcitabine administered as a prolonged infusion in patients with pancreatic cancer and other solid tumors. Invest New Drugs 1997;15:331-41.
    • (1997) Invest New Drugs , vol.15 , pp. 331-341
    • Brand, R.1    Capadano, M.2    Tempero, M.3
  • 50
    • 0032146037 scopus 로고    scopus 로고
    • Phase II trial of topotecan as a 21-day continuous infusion in patients with advanced or metastatic adenocarcinoma of the pancreas
    • Stevenson JP, Scher RM, Kosierowski R, et al. Phase II trial of topotecan as a 21-day continuous infusion in patients with advanced or metastatic adenocarcinoma of the pancreas. Eur J Cancer 1998;34:1358-62.
    • (1998) Eur J Cancer , vol.34 , pp. 1358-1362
    • Stevenson, J.P.1    Scher, R.M.2    Kosierowski, R.3
  • 51
    • 0029556666 scopus 로고    scopus 로고
    • Phase II trial of topotecan in advanced or metastatic adenocarcinoma of the pancreas
    • Scher RM, Kosierowski R, Lusch C, et al. Phase II trial of topotecan in advanced or metastatic adenocarcinoma of the pancreas. Invest New Drugs 1996;13:3437-54.
    • (1996) Invest New Drugs , vol.13 , pp. 3437-3454
    • Scher, R.M.1    Kosierowski, R.2    Lusch, C.3
  • 52
  • 53
    • 0029556670 scopus 로고    scopus 로고
    • Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer
    • Pazdur R, Meropol NJ, Casper ES, et al. Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer. Invest New Drugs 1996;13: 355-8.
    • (1996) Invest New Drugs , vol.13 , pp. 355-358
    • Pazdur, R.1    Meropol, N.J.2    Casper, E.S.3
  • 54
    • 0031824186 scopus 로고    scopus 로고
    • Evaluation of pyrazoloacridine in patients with advanced pancreatic carcinoma
    • Zalupski MM, Shields AF, Philip PA, et al. Evaluation of pyrazoloacridine in patients with advanced pancreatic carcinoma. Invest New Drugs 1998;16: 93-6.
    • (1998) Invest New Drugs , vol.16 , pp. 93-96
    • Zalupski, M.M.1    Shields, A.F.2    Philip, P.A.3
  • 55
    • 0031872387 scopus 로고    scopus 로고
    • A phase II study of temozolomide in advanced untreated pancreatic cancer
    • Moore MJ, Feld R, Hedley D, Oza A, Siu LL. A phase II study of temozolomide in advanced untreated pancreatic cancer. Invest New Drugs 1998;16: 77-9.
    • (1998) Invest New Drugs , vol.16 , pp. 77-79
    • Moore, M.J.1    Feld, R.2    Hedley, D.3    Oza, A.4    Siu, L.L.5
  • 56
    • 0030965547 scopus 로고    scopus 로고
    • Clinical evaluation and safety of loxiglumide (CCK-A receptor antagonist) in nonresectable pancreatic cancer patients. Italian Pancreatic Cancer Study Group
    • Militello C, Sperti C, Di Prima F, Pedrazzoli S. Clinical evaluation and safety of loxiglumide (CCK-A receptor antagonist) in nonresectable pancreatic cancer patients. Italian Pancreatic Cancer Study Group. Pancreas 1997;14: 222-8.
    • (1997) Pancreas , vol.14 , pp. 222-228
    • Militello, C.1    Sperti, C.2    Di Prima, F.3    Pedrazzoli, S.4
  • 58
    • 0032572367 scopus 로고    scopus 로고
    • Effect of flutamide on survival in patients with pancreatic cancer: Results of a prospective, randomized, double blind, placebo controlled trial
    • Greenway BA. Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomized, double blind, placebo controlled trial. BMJ 1998;316:1935-8.
    • (1998) BMJ , vol.316 , pp. 1935-1938
    • Greenway, B.A.1
  • 59
    • 0029800623 scopus 로고    scopus 로고
    • A phase II study of weekly oral methotrexate and zidovudine (AZT) in advanced adenocarcinoma of the pancreas and hepatocellular carcinoma
    • Miller KD, Loehrer PJ, Gonin R, et al. A phase II study of weekly oral methotrexate and zidovudine (AZT) in advanced adenocarcinoma of the pancreas and hepatocellular carcinoma. Invest New Drugs 1996;14:207-12.
    • (1996) Invest New Drugs , vol.14 , pp. 207-212
    • Miller, K.D.1    Loehrer, P.J.2    Gonin, R.3
  • 60
    • 0029417248 scopus 로고
    • Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreat adenocarcinoma
    • Moore DF Jr, Pazdur R, Sugarman S, et al. Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreat adenocarcinoma. Am J Clin Oncol 1995;18:525-7.
    • (1995) Am J Clin Oncol , vol.18 , pp. 525-527
    • Moore D.F., Jr.1    Pazdur, R.2    Sugarman, S.3
  • 61
    • 0032400789 scopus 로고    scopus 로고
    • A phase II pilot trial of I3-cis retinoic acid and interferon-alpha in patients with advanced pancreatic carcinoma
    • Brembeck FH, Schoppmeyer K, Leupold U, et al. A phase II pilot trial of I3-cis retinoic acid and interferon-alpha in patients with advanced pancreatic carcinoma. Cancer 1998;83:2317-23.
    • (1998) Cancer , vol.83 , pp. 2317-2323
    • Brembeck, F.H.1    Schoppmeyer, K.2    Leupold, U.3
  • 62
    • 0033126463 scopus 로고    scopus 로고
    • A sudy of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer
    • Stehlin JS, Giovanella BC, Natelson EA, et al. A sudy of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer. Int J Oncol 1999; 14:821-1.
    • (1999) Int J Oncol , vol.14 , pp. 821-821
    • Stehlin, J.S.1    Giovanella, B.C.2    Natelson, E.A.3
  • 64
    • 0030839472 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus an batimastat and marimastat
    • Rasmussen HS, McCann PP. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus an batimastat and marimastat. Pharmacol Ther 1997;75:69-75.
    • (1997) Pharmacol Ther , vol.75 , pp. 69-75
    • Rasmussen, H.S.1    McCann, P.P.2
  • 65
    • 65749308863 scopus 로고    scopus 로고
    • The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application
    • Bramhall SR. The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application. Int J Pancreatol 1997;21:1-12.
    • (1997) Int J Pancreatol , vol.21 , pp. 1-12
    • Bramhall, S.R.1
  • 66
    • 0032233724 scopus 로고    scopus 로고
    • Stromal degradation by the malignant epithelium in pancreatic cancer and the therapeutic potential of proteolytic inhibition
    • Bramhall SR. Stromal degradation by the malignant epithelium in pancreatic cancer and the therapeutic potential of proteolytic inhibition. J Hepatobiliary Pancreat Surg 1998;5:392-401.
    • (1998) J Hepatobiliary Pancreat Surg , vol.5 , pp. 392-401
    • Bramhall, S.R.1
  • 67
    • 0032445725 scopus 로고    scopus 로고
    • Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer
    • Smith JP, Verderame MF, Zagon IS. Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer. Cancer Lett 1999;135:107-12.
    • (1999) Cancer Lett , vol.135 , pp. 107-112
    • Smith, J.P.1    Verderame, M.F.2    Zagon, I.S.3
  • 68
    • 7344229193 scopus 로고    scopus 로고
    • Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides
    • Fiedler A, Knorre C, Franke Y, et al. Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides. Langenbecks Arch Surg 1998;383:269-75.
    • (1998) Langenbecks Arch Surg , vol.383 , pp. 269-275
    • Fiedler, A.1    Knorre, C.2    Franke, Y.3
  • 69
    • 0141586351 scopus 로고    scopus 로고
    • Efficacy of p120 antisense-mediated therapy for pancreatic cancer
    • Freeman JW, Strodel WE, McGrath PC. Efficacy of p120 antisense-mediated therapy for pancreatic cancer. J Gastrointest Surg 1997;1:454-60.
    • (1997) J Gastrointest Surg , vol.1 , pp. 454-460
    • Freeman, J.W.1    Strodel, W.E.2    McGrath, P.C.3
  • 71
    • 0031648811 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer
    • Bouvet M, Bold RJ, Lee J, et al. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 1998;5:681-8.
    • (1998) Ann Surg Oncol , vol.5 , pp. 681-688
    • Bouvet, M.1    Bold, R.J.2    Lee, J.3
  • 72
    • 0031830091 scopus 로고    scopus 로고
    • Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene
    • Hwang RF, Gordon EM, Anderson WF, Parekh D. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery 1998;124:143-50.
    • (1998) Surgery , vol.124 , pp. 143-150
    • Hwang, R.F.1    Gordon, E.M.2    Anderson, W.F.3    Parekh, D.4
  • 73
    • 1842408944 scopus 로고    scopus 로고
    • Active-specific immunotherapy of pancreatic carcinoma: Usefulness of human pancreatic carcinomas in preparing autologous tumor vaccines
    • Grossmann, A, Rameken M, Klapdor R. Active-specific immunotherapy of pancreatic carcinoma: usefulness of human pancreatic carcinomas in preparing autologous tumor vaccines. Anticancer Res 1997;17:3117-9.
    • (1997) Anticancer Res , vol.17 , pp. 3117-3119
    • Rameken, M.1    Klapdor, R.2
  • 74
    • 0032471711 scopus 로고    scopus 로고
    • Moderate activation of the apoptosis inhibitor bel-xL worsens the prognosis in pancreatic cancer
    • Friess H, Lu Z, Andren-Sandberg A, et al. Moderate activation of the apoptosis inhibitor bel-xL worsens the prognosis in pancreatic cancer. Ann Surg 1998;228:780-7.
    • (1998) Ann Surg , vol.228 , pp. 780-787
    • Friess, H.1    Lu, Z.2    Andren-Sandberg, A.3
  • 75
    • 0033134106 scopus 로고    scopus 로고
    • Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells
    • McDade TP, Perugini RA, Vittimberga FJ Jr, Carrigan RC, Callery MP. Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells. J Surg Res 1999;83:56-61.
    • (1999) J Surg Res , vol.83 , pp. 56-61
    • McDade, T.P.1    Perugini, R.A.2    Vittimberga F.J., Jr.3    Carrigan, R.C.4    Callery, M.P.5
  • 76
    • 0032959825 scopus 로고    scopus 로고
    • Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells
    • Fujimoto K, Hosotani R, Doi R, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer 1999;81:637-44.
    • (1999) Int J Cancer , vol.81 , pp. 637-644
    • Fujimoto, K.1    Hosotani, R.2    Doi, R.3
  • 77
    • 0033143029 scopus 로고    scopus 로고
    • Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine
    • Li Y, Singh B, Ali N, Sarkar FH. Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine. Int J Mol Med 1999;3:647-53.
    • (1999) Int J Mol Med , vol.3 , pp. 647-653
    • Li, Y.1    Singh, B.2    Ali, N.3    Sarkar, F.H.4
  • 78
    • 0032976338 scopus 로고    scopus 로고
    • Prognostic significance of angiogenesis in human pancreatic cancer
    • Ikeda N, Adachi M, Taki T, et al. Prognostic significance of angiogenesis in human pancreatic cancer. Br J Cancer 1999;79:1553-63.
    • (1999) Br J Cancer , vol.79 , pp. 1553-1563
    • Ikeda, N.1    Adachi, M.2    Taki, T.3
  • 79
    • 0032213027 scopus 로고    scopus 로고
    • The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
    • Kleeff, J, Ishiwata T, Kumbasar A, et al. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest 1998;102:1662-73.
    • (1998) J Clin Invest , vol.102 , pp. 1662-1673
    • Kleeff, J.1    Ishiwata, T.2    Kumbasar, A.3


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