Preoperative versus postoperative chemoradiation for patients with resected pancreatic adenocarcinoma

American Surgeon

Volumn 64, Issue 7, 1998, Pages 686-692

  Pendurthi, Tribhuvan K ^a   Hoffman, John P ^a   Ross, Eric ^a   Johnson, Dennis E ^a   Eisenberg, Burton L ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; GEMCITABINE; MITOMYCIN C;

ADULT; AGED; ARTICLE; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NAUSEA; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; SURVIVAL TIME; TREATMENT OUTCOME; VOMITING;

ADENOCARCINOMA; AGED; CHEMOTHERAPY, ADJUVANT; COHORT STUDIES; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; POSTOPERATIVE CARE; PREOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 0031750151     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Pilepich MV, Miller HH. Preoperative irradiation in carcinoma of the pancreas. Cancer 1980;46:1945-9.
2. Kopelson G. Curative surgery for adenocarcinoma of the pancreas/ampulla of Vater: The role of adjuvant pre- or postoperative radiation therapy. Int J Radiat Oncol Biol Phys 1983;9: 911-5.
3. Ishikawa O, Ohhigashi H, Teshima T, et al. Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region. J Surg Oncol 1989; 40:143.
4. Weese JL, Nussbaum ML, Paul AR, et al. Increased resect-ability of locally advanced pancreatic and periampullary carcinoma with neoadjuvant chemoradiotherapy. Int J Pancreatol 1990; 7:177-85.
5. Evans DB, Byrd DR, Mansfield PF. Preoperative chemoradiotherapy for adenocarcinoma of the pancreas: Rationale and techniques. Am J Clin Oncol 1991;14:359-64.
6. Hoffman JP, Weese JL, Solin LJ, Agarwal P, Engstrom P, Scher R, et al. A single institutional experience with preoperative chemoradiotherapy for stage I-III pancreatic adenocarcinoma. Am Surg 1993;59:772-81.
7. Evans DB, Rich TA, Byrd DR, et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 1992:127;1335.
8. Huffman JP, Weese JL, Solin LJ. Engstrom P, Agarwal P, Barber LW, Guttmann MC, Litwin S, Salazar H, Eisenberg BL. A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg 1995;169:71-8.
9. Hoffman JP, Weese JL, Lipsitz S, Solin LJ, et al. Preoperative chemoradiation for patients with resectable pancreatic adeno-carcinoma: An Eastern Cooperative Oncology Group (ECOG) Phase II study (Abstract). Proc Am Soc Clin Oncol 1995;14:201.
10. Ishikawa O, Ohigashi H, Imaoka S, et al. Preoperative indications for extended pancreatectomy for locally advanced pancreas cancer involving the portal vein. Ann Surg 1992;215:231-6.
11. Pendurthi TK, Cooper HS, Young NA, Hoffman JP, Litwin S, Watts P, Johnson DE, Eisenberg BL. Histopathologic effects of preoperative chemoradiotherapy on pancreatic carcinoma (A-271). Am Gastroenterol Assn Abstr 1996;91:1082.
12. Spitz FR, Abbruzzese JL, Lee JE, et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreatoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 1997;15:928-37.
13. Hoffman JP, O'Dwyer P, Agarwal P, et al. Preoperative chemoradiotherapy for localized pancreatic carcinoma: A perspective. Cancer (Suppl) 1996;78:592-7.