Phospholipid metabolism and nuclear envelope signaling

Advances in Enzyme Regulation

Volumn 40, Issue , 2000, Pages 97-123

  Raben, Daniel M ^a   Baldassare, Joseph J ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; DIACYLGLYCEROL; PHOSPHOLIPID; PROTEIN KINASE; RAS PROTEIN; THROMBIN; TRANSDUCIN;

ANIMAL; ANIMAL CELL; CELL NUCLEUS MEMBRANE; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GOLGI COMPLEX; HAMSTER; HYDROLYSIS; METABOLISM; MITOGENESIS; NONHUMAN; PHOSPHOLIPID METABOLISM; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

ANIMALS; CRICETINAE; CRICETULUS; NUCLEAR ENVELOPE; PHOSPHOLIPIDS; SIGNAL TRANSDUCTION;

ANIMALIA; CRICETINAE;

EID: 0034086184     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(99)00023-0     Document Type: Conference Paper

References (113)

1. M. KARIN and T. SMEAL, Control of transcription factors by signal transduction pathways: the beginning of the end, Trends. Biochem. Sci. 17, 418-422 (1992).
2. M. KARIN, The regulation of AP-1 activity by mitogen-activated protein kinases, Philos. Trans. R. Soc. Lond. B Biol. Sci. 351, 127-134[Review] [60 refs] (1996).
3. B. SU and M. KARIN, Mitogen-activated protein kinase cascades and regulation of gene expression, Curr. Opin. Immunol. 8, 402-411[Review] [95 refs] (1996).
4. T. M. WRIGHT, L. A. RANGAN, H. S. SHIN and D. M. RABEN, Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by α-thrombin and epidermal growth factor, J. Biol. Chem. 263, 9374-9380 (1988).
5. J. CHENG, J. D. WEBER, J. J. BALDASSARE and D. M. RABEN, Ablation of Go α-subunit results in a transformed phenotype and constitutively active phosphatidylcholine-specific phospholipase C, J. Biol. Chem. 272, 17312-17319 (1997).
6. J. D. WEBER, J. CHENG, D. M. RABEN, A. GARDNER and J. J. BALDASSARE, Ablation of Gοα overrides G1 restriction point control through Ras/ ERK/cyclin D1-CDK activities, J. Biol. Chem. 272, 17320-17326 (1997).
7. B. STOYANOV, S. VOLINIA, T. HANCK, I. RUBIO, M. LOUBTCHENKOV, D. MALEK, S. STOYANOVA, B. VANHAESEBROECK, R. DHAND and B. NURNBERG, Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase, Science 269, 690-693 (1995).
8. D. M. RABEN, K. M. YASUDA and D. D. CUNNINGHAM, Relationship of thrombin-stimulated arachidonic acid release and metabolism to mitogenesis and phosphatidylinositol synthesis, J. Cell Physiol. 130, 466-473 (1987).
9. L. A. RANGAN, T. M. WRIGHT and D. M. RABEN, Differential dependence of early and late increases in 1,2-diacylglycerol on the presence of catalytically active alpha-thrombin: evidence for regulation at the level of 1,2-diacylglycerol generation, Cell Regul. 2, 311-316 (1991).
10. T. M. WRIGHT, H. S. SHIN and D. M. RABEN, Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis, Biochem. J. 267, 501-507 (1990).
11. T. M. WRIGHT, S. WILLENBERGER and D. M. RABEN, Activation of phospholipase D by alpha-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol, Biochem. J. 285, 395-400 (1992).
12. H. ISHIHARA, A. J. CONNOLLY, D. ZENG, M. L. KAHN, Y. W. ZHENG, C. TIMMONS, T. TRAM and S. R. COUGHLIN, Protease-activated receptor 3 is a second thrombin receptor in humans, Nature 386, 502-506 (1997).
13. S. NYSTEDT, K. EMILSSON, C. WAHLESTEDT and J. SUNDELIN, Molecular cloning of a potential proteinase activated receptor, Proc. Natl Acad. Sci. USA 91, 9208-9212[see comments] (1994).
14. T. K. VU, D. T. HUNG, V. I. WHEATON and S. R. COUGHLIN, Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation, Cell 64, 1057-1068 (1991).
15. W. F. XU, H. ANDERSEN, T. E. WHITMORE, S. R. PRESNELL, D. P. YEE, A. CHING, T. GILBERT, E. W. DAVIE and D. C. FOSTER, Cloning and characterization of human protease-activated receptor 4, Proc. Natl. Acad. Sci. USA 95, 6642-6646 (1998).
16. D. T. HUNG, T. K. VU, V. I. WHEATON, K. ISHII and S. R. COUGHLIN, Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation, J. Clin. Invest. 89, 1350-1353 (1992).
17. R. COLLU, C. BOUVIER, G. LAGACE, C. G. UNSON, G. MILLIGAN, P. GOLDSMITH and A. M. SPIEGEL, Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors, Endocrinology 122, 1176-1178 (1988).
18. D. M. RABEN, K. YASUDA and D. D. CUNNINGHAM, Modulation of thrombin-stimulated lipid responses in cultured fibroblasts. Evidence for two coupling mechanisms, Biochemistry 26, 2759-2765 (1987).
19. M. S. PESSIN and D. M. RABEN, Molecular species analysis of 1,2-diglycerides stimulated by α-thrombin in cultured fibroblasts, J. Biol. Chem. 264, 8729-8738 (1989).
20. C. D. SMITH and W. W. WELLS, ]Phosphorylation of rat liver nuclear envelopes. II. Characterization of in vitro lipid phosphorylation, J. Biol. Chem. 258, 9368-9373 (1983).
21. J. H. EXTON, Signaling through phosphatidylcholine breakdown, J. Biol. Chem. 265, 1-4[Review] (1990).
22. D. P. SIEGEL, J. BANSCHBACH, D. ALFORD, H. ELLENS, L. J. LIS, P. J. QUINN, P. L. YEAGLE and J. BENTZ, Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases, Biochemistry 28, 3703-3709 (1989).
23. T. F. MARTIN, K. P. HSIEH and B. W. PORTER, The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells, J. Biol. Chem. 265, 7623-7631 (1990).
24. M. B. JARPE, K. L. LEACH and D. M. RABEN, Alpha-thrombin-induced nuclear sn-1,2-diacylglycerols are derived from phosphatidylcholine hydrolysis in cultured fibroblasts, Biochemistry 33, 526-534 (1994).
25. N. DIVECHA, H. BANFIC and R. F. IRVINE, The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus, EMBO J. 10, 3207-3214 (1991).
26. N. DIVECHA, H. BANFIC and R. F. IRVINE, Inositides and the nucleus and inositides in the nucleus, Cell 74, 405-407[Review] (1993).
27. A. CATALDI, S. MISCIA, R. LISIO, R. RANA and L. COCCO, Transient shift of diacylglycerol and inositol lipids induced by interferon in Daudi cells. Evidence for a different pattern between nuclei and intact cells, FEBS Lett. 269, 465-468 (1990).
28. L. COCCO, A. M. MARTELLI, R. S. GILMOUR, A. OGNIBENE, F. A. MANZOLI and R. F. IRVINE, Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I, Biochem. Biophys. Res. Commun. 154, 1266-1272 (1988).
29. L. COCCO, A. M. MARTELLI, R. S. GILMOUR, A. OGNIBENE, F. A. MANZOLI and R. F. IRVINE, Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I, Biochem. Biophys. Res. Commun. 159, 720-725 (1989).
30. L. COCCO, A. M. MARTELLI, R. S. GILMOUR, R. A. RANA, O. BARNABEI and F. A. MANZOLI, Changes in inositol lipid metabolism and protein kinase C translocation in nuclei of mitogen stimulated Swiss 3T3 cells, Advan. Enzyme Regul. 32, 91-103 (1992).
31. N. DIVECHA, H. BANFIC and R. F. IRVINE, Inositides and the nucleus and inositides in the nucleus, Cell 74, 405-407 (1993).
32. K. L. LEACH, V. A. RUFF, M. B. JARPE, L. D. ADAMS, D. FABBRO and D. M. RABEN, Alpha-thrombin stimulates nuclear diglyceride levels and differential nuclear localization of protein kinase C isozymes in IIC9 cells, J. Biol. Chem. 267, 21816-21822 (1992).
33. M. S. PESSIN, J. J. BALDASSARE and D. M. RABEN, Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor, J. Biol. Chem. 265, 7959-7966 (1990).
34. M. S. PESSIN, J. G. ALTIN, M. JARPE, F. TANSLEY, R. A. BRADSHAW and D. M. RABEN, Carbachol stimulates a different phospholipid metabolism than nerve growth factor and basic fibroblast growth factor in PC12 cells, Cell Regul. 2, 383-390 (1991).
35. G. AUGERT, S. B. BOCCKINO, P. F. BLACKMORE and J. H. EXTON, Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown, J. Biol. Chem. 264, 21689-21698 (1989).
36. P. G. HOLBROOK, L. K. PANNELL, Y. MURATA and J. W. DALY, Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells, J. Biol. Chem. 267, 16834-16840 (1992).
37. C. LEE, S. K. FISHER, B. W. AGRANOFF and A. K. HAJRA, Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells, J. Biol. Chem. 266, 22837-22846 (1991).
38. C. S. D'SANTOS, J. H. CLARKE, R. F. IRVINE and N. DIVECHA, Nuclei contain two differentially regulated pools of diacylglycerol, Curr. Biol. 9, 437-440[In Process Citation] (1999).
39. C. S. D'SANTOS, J. H. CLARKE, R. F. IRVINE and N. DIVECHA, Nuclei contain two differentially regulated pools of diacylglycerol, Curr. Biol. 9, 437-440 (1999).
40. N. DIVECHA, J. TREAGUS, L. VANN and C. D'SANTOS, Phospholipases in the nucleus, Semin. Cell Dev. Biol. 8, 323-331 (1997).
41. N. DIVECHA, H. BANFIC, J. E. TREAGUS, L. VANN, R. F. IRVINE and C. D'SANTOS, Nuclear diacylglycerol, the cell cycle, the enzymes and a red herring (or how we came to love phosphatidylcholine), Biochem. Soc. Trans. 25, 571-575 (1997).
42. B. PAYRASTRE, M. NIEVERS, J. BOONSTRA, M. BRETON, A. J. VERKLEIJ VAN and P. M. BERGEN EN HENEGOUWEN, A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix, J. Biol. Chem. 267, 5078-5084 (1992).
43. C. L. CARPENTER and L. C. CANTLEY, Phosphoinositide kinases, Curr. Opin. Cell Biol. 8, 153-158 (1996).
44. S. CORVERA and M. P. CZECH, Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction, Trends. Cell Biol. 8, 442-446 (1998).
45. A. TOKER and L. C. CANTLEY, Signalling through the lipid products of phosphoinositide-3-OH kinase, Nature 387, 673-676 (1997).
46. L. M. NERI, D. MILANI, L. BERTOLASO, M. STROSCIO, V. BERTAGNOLO and S. CAPITANI, Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor, Cell Mol. Biol. (Noisy.-le.-grand.) 40, 619-626 (1994).
47. L. M. NERI, M. MARCHISIO, M. L. COLAMUSSI and V. BERTAGNOLO, Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms, Biochem. Biophys. Res. Commun. 259, 314-320 (1999).
48. Y. WANG, T. D. SWEITZER, P. A. WEINHOLD and C. KENT, Nuclear localization of soluble CTP:phosphocholine cytidylyltransferase, J. Biol. Chem. 268, 5899-5904 (1993).
49. C. KENT, Regulation of phosphatidylcholine biosynthesis, Prog. Lipid Res. 29, 87-105 (1990).
50. R. N. KOLESNICK and M. R. HEMER, Physiologic 1,2-diacylglycerol levels induce protein kinase C-independent translocation of a regulatory enzyme, J. Biol. Chem. 265, 10900-10904 (1990).
51. I. C. NORTHWOOD, A. H. TONG, B. CRAWFORD, A. E. DROBNIES and R. B. CORNELL, Shuttling of CTP:phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(O) - → G(1) transition, J. Biol. Chem. 274, 26240-26248 (1999).
52. S. JACKOWSKI, Cell cycle regulation of membrane phospholipid metabolism, J. Biol. Chem. 271, 20219-20222 (1996).
53. L. M. NERI, P. BORGATTI, S. CAPITANI and A. M. MARTELLI, Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha, J. Biol. Chem. 273, 29738-29744 (1998).
54. A. M. MARTELLI, R. S. GILMOUR, L. M. NERI, L. MANZOLI, A. N. CORPS and L. COCCO, Mitogen-stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein kinase C requirement and the onset of DNA synthesis, FEBS Lett. 283, 243-246 (1991).
55. M. K. TOPHAM, M. BUNTING, G. A. ZIMMERMAN, T. M. MCINTYRE, P. J. BLACKSHEAR and S. M. PRESCOTT, Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta, Nature 394, 697-700[see comments] (1998).
56. R. ZIDOVETZKI, L. LAPTALO and J. CRAWFORD, Effect of diacylglycerols on the activity of cobra venom, bee venom, and pig pancreatic phospholipases A2, Biochemistry 31, 7683-7691 (1992).
57. D. J. UHLINGER, D. N. BURNHAM and J. D. LAMBETH, Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C, J. Biol. Chem. 266, 20990-20997 (1991).
58. P. BURN, A. ROTMAN, R. K. MEYER and M. M. BURGER, Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets, Nature 314, 469-472 (1985).
59. J. H. EXTON, Phospholipase D: enzymology, mechanisms of regulation, and function, Physiol. Rev. 77, 303-320[Review] [231 refs] (1997).
60. J. H. EXTON, Phospholipase D, Biochim. Biophys. Acta 1436, 105-115 (1998).
61. A. J. MORRIS, S. M. HAMMOND, C. COLLEY, T. C. SUNG, J. M. JENCO, V. A. SCIORRA, S. A. RUDGE and M. A. FROHMAN, Regulation and functions of phospholipase D, Biochem. Soc. Trans. 25, 1151-1157[In Process Citation] (1997).
62. M. KOBAYASHI and J. N. KANFER, Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D, J. Neurochem. 48, 1597-1603 (1987).
63. S. M. HAMMOND, Y. M. ALTSHULLER, T. C. SUNG, S. A. RUDGE, K. ROSE, J. ENGEBRECHT, A. J. MORRIS and M. A. FROHMAN, Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family, J. Biol. Chem. 270, 29640-29643 (1995).
64. A. J. MORRIS, J. ENGEBRECHT and M. A. FROHMAN, Structure and regulation of phospholipase D, Trends. Pharmacol. Sci. 17, 182-185[Review] (1996).
65. S. M. HAMMOND, J. M. JENCO, S. NAKASHIMA, K. CADWALLADER, Q-M. GU, S. COOK, Y. NOZAWA, G. D. PRESTWICH, M. A. FROHMAN and A. J. MORRIS, Characterization of two alternatively spliced forms of phospholipase D1: Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-α, J. Biol. Chem. 272, 3860-3868 (1997).
66. W. C. COLLEY, T. C. SUNG, R. ROLL, J. JENCO, S. M. HAMMOND, Y. ALTSHULLER, D. BAR-SAGI, A. J. MORRIS and M. A. FROHMAN, Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization, Curr. Biol. 7, 191-201 (1997).
67. J. H. EXTON, New developments in phospholipase D, J. Biol. Chem. 272, 15579-15582[Review] [77 refs] (1997).
68. J. J. BALDASSARE, M. B. JARPE, L. ALFERES and D. M. RABEN, Nuclear translocation of RhoA mediates the mitogen-induced activation of phospholipase D involved in nuclear envelope signal transduction, J. Biol. Chem. 272, 4911-4914 (1997).
69. H. A. BROWN, S. GUTOWSKI, C. R. MOOMAW, C. SLAUGHTER and P. C. STERNWEIS, ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity, Cell 75, 1137-1144[see comments] (1993).
70. I. N. FLEMING, C. M. ELLIOTT and J. H. EXTON, Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor, J. Biol. Chem. 271, 33067-33073 (1996).
71. J. H. EXTON, S. J. TAYLOR, J. S. BLANK and S. B. BOCCKINO, Regulation of phosphoinositide and phosphatidylcholine phospholipases by G proteins, Ciba. Found. Symp. 164, 36-42[Review] (1992).
72. J. H. EXTON, Phosphoinositide phospholipases and G proteins in hormone action, Annu. Rev. Physiol. 56, 349-369 (1994).
73. J. H. EXTON, Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins, Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).
74. A. CARNERO, F. DOLFI and J. C. LACAL, ras-p21 activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis oocytes, J. Cell Biochem. 54, 478-486 (1994).
75. A. CARNERO, A. CUADRADO, L. DEL PESO and J. C. LACAL, Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells, Oncogene 39, 1387-1395 (1994).
76. J. PREISS, C. R. LOOMIS, W. R. BISHOP, R. STEIN, J. E. NIEDEL and R. M. BELL, Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells, J. Biol. Chem. 261, 8597-8600 (1986).
77. R. W. TITBALL, Bacterial phospholipases C, Microbiol. Rev. 57, 347-366 (1993).
78. H. CAI, P. ERHARDT, J. TROPPMAIR, M. T. DIAZ-MECO, G. SITHANANDAM, U. R. RAPP, J. MOSCAT and G. M. COOPER, Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction, Mol. Cell Biol. 13, 7645-7651 (1993).
79. J. H. EXTON, S. J. TAYLOR, G. AUGERT and S. B. BOCCKINO, Cell signalling through phospholipid breakdown, Mol. Cell Biochem. 104, 81-86[Review] (1991).
80. H. R. IRVING and J. H. EXTON, Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists, J. Biol. Chem. 262, 3440-3443 (1987).
81. P. LARRODERA, M. E. CORNET, M. T. DIAZ-MECO, M. LOPEZ-BARAHONA, I. DIAZ-LAVIADA, P. H. GUDDAL, T. JOHANSEN and J. MOSCAT, Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis, Cell 61, 1113-1120 (1990).
82. I. D. LAVIADA, C. BAUDET, I. GALVE-ROPERH, P. NAVEILHAN and P. BRACHET, Phosphatidylcholine-phospholipase C mediates the induction of nerve growth factor in cultured glial cells, FEBS Lett. 364, 301-304 (1995).
83. W. LI, X. LIU and M. YANOFF, Phosphatidylcholine hydrolysis and DNA synthesis in cultured retinal capillary pericytes, Microvasc. Res. 49, 350-363 (1995).
84. D. BUSCHER, R. A. HIPSKIND, S. KRAUTWALD, T. REIMANN and M. BACCARINI, Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages, Mol. Cell Biol. 15, 466-475 (1995).
85. J. HALSTEAD, K. KEMP and R. A. IGNOTZ, Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-beta signaling, J. Biol. Chem. 270, 13600-13603 (1995).
86. S. SCHUTZE, K. POTTHOFF, T. MACHLEIDT, D. BERKOVIC, K. WIEGMANN and M. KRONKE, TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown, Cell 71, 765-776 (1992).
87. C. LUBERTO and Y. A. HANNUN, Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?, J. Biol. Chem. 273, 14550-14559 (1998).
88. I. G. MACARA, Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown, Mol. Cell Biol. 9, 325-328 (1989).
89. I. B. WEINSTEIN, The role of protein kinase C in growth control and the concept of carcinogenesis as a progressive disorder in signal transduction, Advanced Second Messenger Phosphoprotein Res. 24, 307-316[Review] (1990).
90. M. D. WATERFIELD, Altered growth regulation in cancer, Brit. Med. Bull. 45, 570-581[Review] (1989).
91. J. H. EXTON, Phosphatidylcholine breakdown and signal transduction, Biochim. Biophys. Acta 1212, 26-42[Review] (1994).
92. K. SEUWEN and J. POUYSSEGUR, G protein-controlled signal transduction pathways and the regulation of cell proliferation, Advanced Cancer Res. 58, 75-94[Review] (1992).
93. D. Y. NOH, S. H. SHIN and S. G. RHEE, Phosphoinositide-specific phospholipase C and mitogenic signaling, Biochim. Biophys. Acta 1242, 99-113[Review] (1995).
94. V. VOURET-CRAVIARI, E. VAN OBBERGHEN-SCHILLING, J. C. SCIMECA, E. VAN OBBERGHEN and J. POUYSSEGUR, Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist, Biochem. J. 289, 209-214 (1993).
95. C. ALBANESE, J. JOHNSON, G. WATANABE, N. EKLUND, D. VU, A. ARNOLD and R. G. PESTELL, Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions, J. Biol. Chem. 270, 23589-23597 (1995).
96. X. GRANA and E. P. REDDY, Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs), Oncogene 11, 211-219 (1995).
97. P. W. HINDS, S. F. DOWDY, E. N. EATON, A. ARNOLD and R. A. WEINBERG, Function of a human cyclin gene as an oncogene, Proc. Natl. Acad. Sci. USA 91, 709-713 (1994).
98. Y. C. LI and M. W. LIEBERMAN, Two genes associated with liver cancer are regulated by different mechanisms in rasT24 transformed liver epithelial cells, Oncogene 4, 795-798 (1989).
99. H. LOVEC, A. SEWING, F. C. LUCIBELLO, R. MULLER and T. MOROY, Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation, Oncogene 9, 323-326 (1994).
100. H. MATSUSHIME, M. F. ROUSSEL, R. A. ASHMUN and C. J. SHERR, Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle, Cell 65, 701-713 (1991).
101. J. KATO, H. MATSUSHIME, S. W. HIEBERT, M. E. EWEN and C. J. SHERR, Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4, Genes Dev. 7, 331-342 (1993).
102. D. RESNITZKY, M. GOSSEN, H. BUJARD and S. I. REED, Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system, Mol. Cell Biol. 14, 1669-1679 (1994).
103. C. J. SHERR and J. M. ROBERTS, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev. 9, 1149-1163 (1995).
104. C. L. CARPENTER and L. C. CANTLEY, Phosphoinositide 3-kinase and the regulation of cell growth, Biochim. Biophys. Acta 1288, M11-M16 (1996).
105. D. A. FRUMAN, R. E. MEYERS and L. C. CANTLEY, Phosphoinositide kinases, Annu. Rev. Biochem. 67, 481-507 (1998).
106. D. E. CLAPHAM and E. J. NEER, New roles for G-protein beta gamma-dimers in transmembrane signalling, Nature 365, 403-406[Review] (1993).
107. E. J. NEER, G proteins: critical control points for transmembrane signals, Protein Sci. 3, 3-14[Review] (1994).
108. P. CRESPO, N. XU, W. F. SIMONDS and J. S. GUTKIND, Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits, Nature 369, 418-420[see comments] (1994).
109. C. KLEUSS, H. SCHERUBL, J. HESCHELER, G. SCHULTZ and B. WITTIG, Different beta-subunits determine G-protein interaction with transmembrane receptors, Nature 358, 424-426[see comments] (1992).
110. C. KLEUSS, H. SCHERUBL, J. HESCHELER, G. SCHULTZ and B. WITTIG, Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins, Science 259, 832-834 (1993).
111. D. WU, A. KATZ and M. I. SIMON, Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein, Proc. Natl. Acad. Sci. USA 90, 5297-5301 (1993).
112. Y. DAAKA, J. A. PITCHER, M. RICHARDSON, R. H. STOFFEL, J. D. ROBISHAW and R. J. LEFKOWITZ, Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases, Proc. Natl. Acad. Sci. USA 94, 2180-2185 (1997).
113. K. YAN, V. KALYANARAMAN and N. GAUTAM, Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families, J. Biol. Chem. 271, 7141-7146 (1996).