Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: An update and practical considerations

Critical Reviews in Toxicology

Volumn 30, Issue 3, 2000, Pages 287-306

  Kranendonk, Michel ^a,b   Laires, António ^a,c   Rueff, José ^a   Estabrook, Ronald W ^d   Vermeulen, Nico P E ^b  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bioactivation; Biotransformation; E. coli; Heterologous expression; Mutagenicity; S. typhimurium

Indexed keywords

ACYLTRANSFERASE; COMPLEMENTARY DNA; CYTOCHROME P450; GENE PRODUCT; GLUTATHIONE TRANSFERASE; SULFOTRANSFERASE; XENOBIOTIC AGENT;

ANALYTIC METHOD; BACTERIAL METABOLISM; BIOTRANSFORMATION; DRUG ACTIVATION; ENZYME ANALYSIS; ESCHERICHIA COLI; GENETIC TRANSFECTION; GENOTOXICITY; MUTAGENICITY; NONHUMAN; PLASMID; PROTEIN EXPRESSION; REVIEW; SALMONELLA TYPHIMURIUM; TOXICOKINETICS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LONCHOCARPUS GLAUCIFOLIUS; MAMMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034080524     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/10408440091159211     Document Type: Review

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