Expression of human estrogen sulfotransferase in salmonella typhimurium: Differences between hHST and hEST in the enantioselective activation of 1- hydroxyethylpyrene to a mutagen

Chemico-Biological Interactions

Volumn 109, Issue 1-3, 1998, Pages 249-253

  Hagen, Maria ^a   Pabel, Ulrike ^a   Landsiedel, Robert ^a   Bartsch, Ingrid ^b   Falany, Charles N ^c   Glatt, Hansruedi ^a,b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c University of Alabama at Birmingham   (United States)

Author keywords

Ames test; Benzylic alcohols; Enantioselective metabolism; Heterologous expression; Sulfotransferases

Indexed keywords

1 HYDROXYETHYLPYRENE; 1 PYRENEMETHANOL; BENZYL ALCOHOL DERIVATIVE; ESTROGEN SULFOTRANSFERASE; HYDROXYSTEROID SULFOTRANSFERASE; MUTAGENIC AGENT; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; ENANTIOMER; HUMAN; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM;

ANIMALS; BENZYL ALCOHOLS; BLOTTING, WESTERN; CYTOSOL; HUMANS; MUTAGENICITY TESTS; MUTAGENS; RATS; SALMONELLA TYPHIMURIUM; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

EID: 0032549055     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00136-1     Document Type: Conference Paper

References (7)

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3. Glatt H.R., Bartsch I., Czich A., Seidel A., Falany C.N. Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases. Toxicol. Lett. 82:1995;829-834.
4. Enders N., Seidel A., Monnerjahn S., Glatt H.R. Synthesis of 11 benzylic esters, their bacterial mutagenicity and its modulation by chloride, bromide and acetate anions. Polycycl. Aromat. Comp. 3(Suppl):1993;887-894.
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6. Falany C.N., Krasnykh V., Falany J.L. Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. J. Steroid Biochem. Mol. Biol. 52:1995;529-539.
7. Glatt H.R., Pauly K., Czich A., Falany J.L., Falany C.N. Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli. Eur. J. Pharmacol. 293:1995;123-131.