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Volumn 15, Issue 3, 2000, Pages 244-253

Pathophysiology of the intrahepatic biliary epithelium

Author keywords

Apoptosis; Cholangiocytes; Cholestasis; Cystic fibrosis; Cytokines

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GASTROINTESTINAL HORMONE; IMMUNOGLOBULIN A; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROPEPTIDE; NEUROTRANSMITTER; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034076048     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2000.02091.x     Document Type: Review
Times cited : (77)

References (86)
  • 1
    • 0030725082 scopus 로고    scopus 로고
    • New insights into cholangiocyte physiology
    • Strazzabosco M. New insights into cholangiocyte physiology. J. Hepatol. 1997; 27: 945-52.
    • (1997) J. Hepatol. , vol.27 , pp. 945-952
    • Strazzabosco, M.1
  • 2
    • 0023611354 scopus 로고
    • The intrahepatic biliary epithelium: An area of growing interest in hepatology
    • Tavoloni N. The intrahepatic biliary epithelium: An area of growing interest in hepatology. Semin. Liver Dis. 1987; 7: 280-92.
    • (1987) Semin. Liver Dis. , vol.7 , pp. 280-292
    • Tavoloni, N.1
  • 3
    • 0026072857 scopus 로고
    • Mechanisms and regulation of bile secretion
    • Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. Hepatology 1991; 14: 551-66.
    • (1991) Hepatology , vol.14 , pp. 551-566
    • Nathanson, M.H.1    Boyer, J.L.2
  • 4
    • 0030760489 scopus 로고    scopus 로고
    • Bile acid stimulates proliferative and secretory events in large but not small cholangiocytes
    • Alpini G, Glaser S, Robertson W et al. Bile acid stimulates proliferative and secretory events in large but not small cholangiocytes. Am. J. Physiol. 1997; 273: G518-29.
    • (1997) Am. J. Physiol. , vol.273
    • Alpini, G.1    Glaser, S.2    Robertson, W.3
  • 6
    • 0030020196 scopus 로고    scopus 로고
    • Bile duct epithelium: Frontiers in transport physiology
    • Boyer JL. Bile duct epithelium: Frontiers in transport physiology. Am. J. Physiol. 1996; 270: G1-5.
    • (1996) Am. J. Physiol. , vol.270
    • Boyer, J.L.1
  • 7
    • 0025809102 scopus 로고
    • Intracellular pHi regulation in bile ductular cells isolated from bile duct ligated rats
    • Strazzabosco M, Mennone A, Boyer JL. Intracellular pHi regulation in bile ductular cells isolated from bile duct ligated rats. J. Clin. Invest. 1991; 87: 1503-12.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1503-1512
    • Strazzabosco, M.1    Mennone, A.2    Boyer, J.L.3
  • 9
    • 0343306676 scopus 로고    scopus 로고
    • +-2Cl cotransport participates in stimulated fluid secretion in isolated polarized bile duct units from rat liver
    • Abstract
    • +-2Cl cotransport participates in stimulated fluid secretion in isolated polarized bile duct units from rat liver. Hepatology 1996; 26: 279A (Abstract).
    • (1996) Hepatology , vol.26
    • Singh, S.K.1    Mennone, A.2    Boyer, J.L.3
  • 10
    • 0027134853 scopus 로고
    • Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells
    • Cohn JA, Strong TV, Picciotto MR, Nairn AC, Collins FS, Fitz JG. Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. Gastroenterology 1993; 105: 1857-64.
    • (1993) Gastroenterology , vol.105 , pp. 1857-1864
    • Cohn, J.A.1    Strong, T.V.2    Picciotto, M.R.3    Nairn, A.C.4    Collins, F.S.5    Fitz, J.G.6
  • 11
    • 0027287975 scopus 로고
    • GTP-binding proteins regulate high conductance anion channels in rat bile duct epithelial cells
    • McGill JM, Gettys TW, Basavappa S, Fitz JG. GTP-binding proteins regulate high conductance anion channels in rat bile duct epithelial cells. J. Membr. Biol. 1993; 133: 253-61.
    • (1993) J. Membr. Biol. , vol.133 , pp. 253-261
    • McGill, J.M.1    Gettys, T.W.2    Basavappa, S.3    Fitz, J.G.4
  • 13
    • 0030918556 scopus 로고    scopus 로고
    • Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes
    • Lazaridis KN, Pham L, Vroman B, de Groen PC, LaRusso NF. Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. Am. J. Physiol. 1997; 272: G1168-74.
    • (1997) Am. J. Physiol. , vol.272
    • Lazaridis, K.N.1    Pham, L.2    Vroman, B.3    De Groen, P.C.4    LaRusso, N.F.5
  • 14
    • 0026337224 scopus 로고
    • Glutamate uptake in primary cultures of biliary epithelial cells from normal rat liver
    • Eisemann-Tappe I, Wizigmann S, Gebhardt R. Glutamate uptake in primary cultures of biliary epithelial cells from normal rat liver. Cell Biol. Toxicol. 1991; 7: 315-25.
    • (1991) Cell Biol. Toxicol. , vol.7 , pp. 315-325
    • Eisemann-Tappe, I.1    Wizigmann, S.2    Gebhardt, R.3
  • 15
    • 0031467883 scopus 로고    scopus 로고
    • Rat cholangiocytes adsorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
    • Lazaridis KN, Pham L, Tiets P et al. Rat cholangiocytes adsorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J. Clin. Invest. 1997; 100: 2714-21.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2714-2721
    • Lazaridis, K.N.1    Pham, L.2    Tiets, P.3
  • 16
    • 0031011414 scopus 로고    scopus 로고
    • Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membranes. Evidence for a secretin-induced vesicular translocation of aquaporin-1
    • Marinelli RA, Pham L, Agre P, LaRusso NF. Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membranes. Evidence for a secretin-induced vesicular translocation of aquaporin-1. J. Biol. Chem. 1997; 272: 12 984-8.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12984-12988
    • Marinelli, R.A.1    Pham, L.2    Agre, P.3    LaRusso, N.F.4
  • 18
    • 0026787649 scopus 로고
    • Secretin stimulates bile ductular secretory activity through the cAMP system
    • Lenzen R, Alpini G, Tavoloni N. Secretin stimulates bile ductular secretory activity through the cAMP system. Am. J. Physiol. 1992; 263: G527-32.
    • (1992) Am. J. Physiol. , vol.263
    • Lenzen, R.1    Alpini, G.2    Tavoloni, N.3
  • 19
    • 84895708032 scopus 로고    scopus 로고
    • VIP stimulates bile secretion in cholangiocytes by cAMP-PKA independent mechanisms
    • Abstract
    • Cho WK, Mennone A, Boyer JL. VIP stimulates bile secretion in cholangiocytes by cAMP-PKA independent mechanisms. Hepatology 1997; 26: 397A (Abstract).
    • (1997) Hepatology , vol.26
    • Cho, W.K.1    Mennone, A.2    Boyer, J.L.3
  • 20
    • 0030979612 scopus 로고    scopus 로고
    • Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion
    • Cho WK, Mennone A, Rydberg SA, Boyer JL. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion. Gastroenterology 1997; 113: 311-21.
    • (1997) Gastroenterology , vol.113 , pp. 311-321
    • Cho, W.K.1    Mennone, A.2    Rydberg, S.A.3    Boyer, J.L.4
  • 21
    • 0020011703 scopus 로고
    • Gastrointestinal peptide hormones as modulators of bile secretion
    • Glass GB. Gastrointestinal peptide hormones as modulators of bile secretion. Prog. Liver Dis. 1982; 7: 243-60.
    • (1982) Prog. Liver Dis. , vol.7 , pp. 243-260
    • Glass, G.B.1
  • 22
    • 0021024496 scopus 로고
    • Peptide immunoreactive nerves and cells of the guinea pig gallbladder and biliary pathways
    • Cai W, Gu J, Huang W et al. Peptide immunoreactive nerves and cells of the guinea pig gallbladder and biliary pathways. Gut 1983; 24: 1186-93.
    • (1983) Gut , vol.24 , pp. 1186-1193
    • Cai, W.1    Gu, J.2    Huang, W.3
  • 23
    • 0032939341 scopus 로고    scopus 로고
    • Biliary epithelium: A new chapter in cell biology
    • Alvaro D. Biliary epithelium: A new chapter in cell biology. Ital. J. Gastroenterol. Hepatol. 1999; 31: 78-83.
    • (1999) Ital. J. Gastroenterol. Hepatol. , vol.31 , pp. 78-83
    • Alvaro, D.1
  • 25
    • 0029815856 scopus 로고    scopus 로고
    • Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides
    • Schlosser SF, Burgstahler AD, Nathanson MH. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc. Natl Acad. Sci. USA 1996; 63: 9948-53.
    • (1996) Proc. Natl Acad. Sci. USA , vol.63 , pp. 9948-9953
    • Schlosser, S.F.1    Burgstahler, A.D.2    Nathanson, M.H.3
  • 26
    • 0030669806 scopus 로고    scopus 로고
    • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes
    • Schlenker T, Roman JMJ, Sharara AC et al. Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. Am. J. Physiol. 1997; 273: G1108-17.
    • (1997) Am. J. Physiol. , vol.273
    • Schlenker, T.1    Roman, J.M.J.2    Sharara, A.C.3
  • 27
    • 0031681245 scopus 로고    scopus 로고
    • Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines
    • Zsembery A, Spirli C, Granato A et al. Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines. Hepatology 1998; 28: 914-20.
    • (1998) Hepatology , vol.28 , pp. 914-920
    • Zsembery, A.1    Spirli, C.2    Granato, A.3
  • 28
    • 0030832592 scopus 로고    scopus 로고
    • +-dependent bile acid transporter in large but not small rat cholangiocytes
    • +-dependent bile acid transporter in large but not small rat cholangiocytes. Gastroenterology 1997; 113: 1734-40.
    • (1997) Gastroenterology , vol.113 , pp. 1734-1740
    • Alpini, G.1    Glaser, S.S.2    Rodgers, R.3
  • 29
    • 0031793050 scopus 로고    scopus 로고
    • Advances in hepatic transport: Molecular mechanisms, genetic disorders and treatment. A summmary of the 1998 AASLD single topic conference
    • Wolkoff AW, Suchy FJ, Moseley RH et al. Advances in hepatic transport: Molecular mechanisms, genetic disorders and treatment. A summmary of the 1998 AASLD single topic conference. Hepatology 1998; 28: 1713-19.
    • (1998) Hepatology , vol.28 , pp. 1713-1719
    • Wolkoff, A.W.1    Suchy, F.J.2    Moseley, R.H.3
  • 30
    • 0027932181 scopus 로고
    • Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro
    • Matsumoto K, Fujii H, Michalopoulos G, Fung JJ, Demetris AJ. Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. Hepatology 1994; 20: 376-82.
    • (1994) Hepatology , vol.20 , pp. 376-382
    • Matsumoto, K.1    Fujii, H.2    Michalopoulos, G.3    Fung, J.J.4    Demetris, A.J.5
  • 31
    • 0026320289 scopus 로고
    • Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease
    • Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease. Am. J. Pathol. 1991; 139: 1221-9.
    • (1991) Am. J. Pathol. , vol.139 , pp. 1221-1229
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Stein, H.4    Surrenti, C.5
  • 32
    • 0031722948 scopus 로고    scopus 로고
    • Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes
    • Caligiuri A, Glaser S, Rodgers RE et al. Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. Am. J. Physiol. 1998; 275: G835-46.
    • (1998) Am. J. Physiol. , vol.275
    • Caligiuri, A.1    Glaser, S.2    Rodgers, R.E.3
  • 33
    • 0031883173 scopus 로고    scopus 로고
    • Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: Correlation with monocyte infiltration
    • Marra F, De Franco R, Grappone C et al. Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: Correlation with monocyte infiltration. Am. J. Pathol. 1998; 152: 423-30.
    • (1998) Am. J. Pathol. , vol.152 , pp. 423-430
    • Marra, F.1    De Franco, R.2    Grappone, C.3
  • 34
    • 0030791506 scopus 로고    scopus 로고
    • Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro
    • Morland CM, Fear J, McNab G et al. Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro. Proc. AAP 1997; 109: 372-82.
    • (1997) Proc. AAP , vol.109 , pp. 372-382
    • Morland, C.M.1    Fear, J.2    McNab, G.3
  • 35
    • 0031883604 scopus 로고    scopus 로고
    • Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: In situ and culture study
    • Yasoshima M, Kono N, Sugawara H, Katayanagi K, Harada K, Nakanuma Y. Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: In situ and culture study. Lab. Invest. 1998; 78: 89-100.
    • (1998) Lab. Invest. , vol.78 , pp. 89-100
    • Yasoshima, M.1    Kono, N.2    Sugawara, H.3    Katayanagi, K.4    Harada, K.5    Nakanuma, Y.6
  • 36
    • 0030829599 scopus 로고    scopus 로고
    • Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats
    • Vos TA, Gouw ASH, Klok PA et al. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology 1997; 113: 1323-33.
    • (1997) Gastroenterology , vol.113 , pp. 1323-1333
    • Vos, T.A.1    Ash, G.2    Klok, P.A.3
  • 38
    • 0027424160 scopus 로고
    • Disappearing intrahepatic bile ducts: The syndromes and their mechanisms
    • Woolf GM, Vierling JM. Disappearing intrahepatic bile ducts: The syndromes and their mechanisms. Semin. Liver Dis. 1993; 13: 261-75.
    • (1993) Semin. Liver Dis. , vol.13 , pp. 261-275
    • Woolf, G.M.1    Vierling, J.M.2
  • 39
    • 0032985306 scopus 로고    scopus 로고
    • Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    • Sakamoto T, Liu Z, Murase N et al. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology 1999; 29: 403-11.
    • (1999) Hepatology , vol.29 , pp. 403-411
    • Sakamoto, T.1    Liu, Z.2    Murase, N.3
  • 40
    • 0032794576 scopus 로고    scopus 로고
    • Cytokines and fibrogenesis
    • Friedman SL. Cytokines and fibrogenesis. Semin. Liver Dis. 1999; 19: 129-40.
    • (1999) Semin. Liver Dis. , vol.19 , pp. 129-140
    • Friedman, S.L.1
  • 41
    • 0027254763 scopus 로고
    • Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: Effect of proinflammatory cytokines
    • Ayres RCS, Neuberger JM, Shaw J, Adams DH. Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: Effect of proinflammatory cytokines. Gut 1993; 34: 1245-9.
    • (1993) Gut , vol.34 , pp. 1245-1249
    • Ayres, R.C.S.1    Neuberger, J.M.2    Shaw, J.3    Adams, D.H.4
  • 42
    • 0028816320 scopus 로고
    • Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development
    • Terada T, Nakanuma Y. Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development. Am. J. Pathol 1995; 146: 67-74.
    • (1995) Am. J. Pathol , vol.146 , pp. 67-74
    • Terada, T.1    Nakanuma, Y.2
  • 43
    • 0022335290 scopus 로고
    • Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus
    • Bhathal PS, Gall JA. Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus. Liver 1985; 5: 311-25.
    • (1985) Liver , vol.5 , pp. 311-325
    • Bhathal, P.S.1    Gall, J.A.2
  • 44
    • 0031702777 scopus 로고    scopus 로고
    • Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism
    • Chen XM, Levine SA, Tietz P et al. Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism. Hepatology 1998; 28: 907-13.
    • (1998) Hepatology , vol.28 , pp. 907-913
    • Chen, X.M.1    Levine, S.A.2    Tietz, P.3
  • 45
    • 0032883236 scopus 로고    scopus 로고
    • Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism
    • Chen XM, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. Am. J. Physiol. 1999; 277: G599-608.
    • (1999) Am. J. Physiol. , vol.277
    • Chen, X.M.1    Gores, G.J.2    Paya, C.V.3    LaRusso, N.F.4
  • 46
    • 0030003081 scopus 로고    scopus 로고
    • Effect of tumor necrosis factor alpha on intrahepatic bile duct epithelial cell of rat liver
    • Mano Y, Ishii M, Okamoto H, Igarashi T, Kobayashi K, Toyota T. Effect of tumor necrosis factor alpha on intrahepatic bile duct epithelial cell of rat liver. Hepatology 1996; 23: 1602-7.
    • (1996) Hepatology , vol.23 , pp. 1602-1607
    • Mano, Y.1    Ishii, M.2    Okamoto, H.3    Igarashi, T.4    Kobayashi, K.5    Toyota, T.6
  • 47
    • 4243553412 scopus 로고    scopus 로고
    • IL-6 suppresses cholangiocyte apoptosis by down-regulation of Bax
    • Abstract
    • Patel T, LaRusso NF, Gores JG. IL-6 suppresses cholangiocyte apoptosis by down-regulation of Bax. Hepatology 1997; 26: 226A (Abstract).
    • (1997) Hepatology , vol.26
    • Patel, T.1    LaRusso, N.F.2    Gores, J.G.3
  • 48
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • Rodrigues CMP, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J. Clin. Invest. 1998; 101: 2790-9.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.P.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 49
    • 0040284751 scopus 로고    scopus 로고
    • Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
    • De Vree JML, Jacquemin E, Sturm E et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc. Natl Acad. Sci. USA 1998; 95: 282-7.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 282-287
    • De Vree, J.M.L.1    Jacquemin, E.2    Sturm, E.3
  • 50
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • Smit JJ, Schinkel AH, Oude Elferink RP et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993; 75: 451-62.
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.1    Schinkel, A.H.2    Oude Elferink, R.P.3
  • 51
    • 0031005366 scopus 로고    scopus 로고
    • Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
    • Koga H, Sakisaka S, Ohishi M, Sata M, Tanikawa K. Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 1997; 25: 1077-84.
    • (1997) Hepatology , vol.25 , pp. 1077-1084
    • Koga, H.1    Sakisaka, S.2    Ohishi, M.3    Sata, M.4    Tanikawa, K.5
  • 52
    • 0026529198 scopus 로고
    • Membrane dihydrolipoamideacetyltransferase (E2) on human biliary cirrhosis
    • Joplin R, Lindsay JG, Johnson GD, Strain A, Neuberger J. Membrane dihydrolipoamideacetyltransferase (E2) on human biliary cirrhosis. Lancet 1992; 339: 93-4.
    • (1992) Lancet , vol.339 , pp. 93-94
    • Joplin, R.1    Lindsay, J.G.2    Johnson, G.D.3    Strain, A.4    Neuberger, J.5
  • 54
    • 0032191314 scopus 로고    scopus 로고
    • Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis
    • Malborg AC, Schultz DB, Luton F et al. Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J. Autoimmun. 1998; 11: 573-80.
    • (1998) J. Autoimmun. , vol.11 , pp. 573-580
    • Malborg, A.C.1    Schultz, D.B.2    Luton, F.3
  • 56
    • 0025202418 scopus 로고
    • Neuroendocrine features of reactive bile ductules in cholestatic liver diseases
    • Roskams T, van Der Oord JJ, DeVos R, Desmet V. Neuroendocrine features of reactive bile ductules in cholestatic liver diseases. Am. J. Pathol. 1990; 137: 1019-25.
    • (1990) Am. J. Pathol. , vol.137 , pp. 1019-1025
    • Roskams, T.1    Van Der Oord, J.J.2    DeVos, R.3    Desmet, V.4
  • 57
    • 0032899948 scopus 로고    scopus 로고
    • Bile acid feeding induces cholangiocytes proliferation and secretion: Evidence for bile acid-regulated ductal secretion
    • Alpini G, Glaser SS, Ueno Y et al. Bile acid feeding induces cholangiocytes proliferation and secretion: Evidence for bile acid-regulated ductal secretion. Gastroenterology 1999; 116: 179-86.
    • (1999) Gastroenterology , vol.116 , pp. 179-186
    • Alpini, G.1    Glaser, S.S.2    Ueno, Y.3
  • 58
    • 0028815893 scopus 로고
    • Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis
    • Martinez OM, Villanueva JC, Gershwin ME, Krams SM. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 1995; 21: 113-19.
    • (1995) Hepatology , vol.21 , pp. 113-119
    • Martinez, O.M.1    Villanueva, J.C.2    Gershwin, M.E.3    Krams, S.M.4
  • 59
    • 0030961762 scopus 로고    scopus 로고
    • In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of Th1 subset
    • Harada K, Van de Water J, Leung PSC et al. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of Th1 subset. Hepatology 1997; 25: 791-6.
    • (1997) Hepatology , vol.25 , pp. 791-796
    • Harada, K.1    Van De Water, J.2    Leung, P.S.C.3
  • 60
  • 61
    • 0030339857 scopus 로고    scopus 로고
    • Biliary epithelial cells: Innocent victims or active participants in immune-mediated liver disease?
    • Adams DH. Biliary epithelial cells: Innocent victims or active participants in immune-mediated liver disease? J. Lab Clin. Med. 1996; 128: 528-30.
    • (1996) J. Lab Clin. Med. , vol.128 , pp. 528-530
    • Adams, D.H.1
  • 62
    • 0020082099 scopus 로고
    • Bile ductular cholestasis: An ominous histopathologic sign related to sepsis and 'cholangitis lenta'
    • Lefkovitch JH. Bile ductular cholestasis: An ominous histopathologic sign related to sepsis and 'cholangitis lenta'. Human Pathol. 1981; 13: 19-24.
    • (1981) Human Pathol. , vol.13 , pp. 19-24
    • Lefkovitch, J.H.1
  • 63
    • 0031930768 scopus 로고    scopus 로고
    • Signal transduction in hepatic stellate cells
    • Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver 1998; 18: 2-13.
    • (1998) Liver , vol.18 , pp. 2-13
    • Pinzani, M.1    Marra, F.2    Carloni, V.3
  • 64
    • 0030959190 scopus 로고    scopus 로고
    • Heterogeneity of liver cells expressing procollagen type I and IV in vivo
    • Herbst H, Frey A, Heinrichs O et al. Heterogeneity of liver cells expressing procollagen type I and IV in vivo. Histochem. Cell Biol. 1997; 107: 399-409.
    • (1997) Histochem. Cell Biol. , vol.107 , pp. 399-409
    • Herbst, H.1    Frey, A.2    Heinrichs, O.3
  • 65
    • 0028128269 scopus 로고
    • Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and intrahepatic cholangiocarcinoma
    • Terada T, Nakanuma Y. Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and intrahepatic cholangiocarcinoma. Histopathology 1994; 25: 143-50.
    • (1994) Histopathology , vol.25 , pp. 143-150
    • Terada, T.1    Nakanuma, Y.2
  • 66
    • 0028580429 scopus 로고
    • Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphate activity
    • Green RM, Whiting JF, Rosenbluth AB, Beier D, Gollan JL. Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphate activity. Am. J. Physiol. 1994; 267: G1094-100.
    • (1994) Am. J. Physiol. , vol.267
    • Green, R.M.1    Whiting, J.F.2    Rosenbluth, A.B.3    Beier, D.4    Gollan, J.L.5
  • 69
    • 0025277595 scopus 로고
    • Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat
    • Slott PA, Liu MH, Tavoloni N. Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat. Gastroenterology 1990; 99: 466-77.
    • (1990) Gastroenterology , vol.99 , pp. 466-477
    • Slott, P.A.1    Liu, M.H.2    Tavoloni, N.3
  • 70
    • 0032508289 scopus 로고    scopus 로고
    • New genetics of inheritable jaundice and cholestatic liver disease
    • Arias IM. New genetics of inheritable jaundice and cholestatic liver disease. Lancet 1998; 352: 82-3.
    • (1998) Lancet , vol.352 , pp. 82-83
    • Arias, I.M.1
  • 72
    • 0028982894 scopus 로고
    • CFTR as a cAMP-dependent regulator of sodium channels
    • Stutts MJ, Canessa CM, Olsen JC. CFTR as a cAMP-dependent regulator of sodium channels. Science 1995; 269: 847-50.
    • (1995) Science , vol.269 , pp. 847-850
    • Stutts, M.J.1    Canessa, C.M.2    Olsen, J.C.3
  • 73
    • 0029826866 scopus 로고    scopus 로고
    • + channel (ROMK2) to the inhibitory sulfonylurea compound glybenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis trans-membrane regulator
    • + channel (ROMK2) to the inhibitory sulfonylurea compound glybenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis trans-membrane regulator. Proc. Natl Acad. Sci. USA 1996; 93: 8083-8.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 8083-8088
    • McNicholas, C.M.1    Guggino, W.B.2    Schwiebert, E.M.3    Hebert, S.C.4    Giebish, G.5    Egan, M.E.6
  • 74
    • 0026687233 scopus 로고
    • Defective regulation of outwardly rectifiying Cl channels by protein kinase A corrected by insertion of CFTR
    • Egan M, Flotte T, Afion S. Defective regulation of outwardly rectifiying Cl channels by protein kinase A corrected by insertion of CFTR. Nature 1992; 358: 581-4.
    • (1992) Nature , vol.358 , pp. 581-584
    • Egan, M.1    Flotte, T.2    Afion, S.3
  • 75
    • 0023719216 scopus 로고
    • Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid and secretory defect in the cystic fibrosis pancreas
    • Kopelman HR, Corey M, Gaskin KJ, Durie P, Forstner GG. Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid and secretory defect in the cystic fibrosis pancreas. Gastroenterology 1988; 98: 349-55.
    • (1988) Gastroenterology , vol.98 , pp. 349-355
    • Kopelman, H.R.1    Corey, M.2    Gaskin, K.J.3    Durie, P.4    Forstner, G.G.5
  • 76
    • 0028980536 scopus 로고
    • CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
    • Schwiebert EM, Egan E, Hwang TH. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995; 81: 1063-73.
    • (1995) Cell , vol.81 , pp. 1063-1073
    • Schwiebert, E.M.1    Egan, E.2    Hwang, T.H.3
  • 78
    • 0028007980 scopus 로고
    • Role of membrane trafficking in plasma membrane solute transport
    • Bradbury NA, Bridges RJ. Role of membrane trafficking in plasma membrane solute transport. Am. J. Physiol. 1994; 267: C1-24.
    • (1994) Am. J. Physiol. , vol.267
    • Bradbury, N.A.1    Bridges, R.J.2
  • 80
    • 0032906408 scopus 로고    scopus 로고
    • The innate immune system in cystic fibrosis lung disease
    • Bals R, Weiner DJ, Wilson JM. The innate immune system in cystic fibrosis lung disease. J. Clin. Invest. 1999; 103: 303-7.
    • (1999) J. Clin. Invest. , vol.103 , pp. 303-307
    • Bals, R.1    Weiner, D.J.2    Wilson, J.M.3
  • 81
    • 0004569590 scopus 로고    scopus 로고
    • 2+-activated Cl channels can substitute for CFTR in stimulation of anion-exchanger in human isolated CF cholangiocytes
    • Abstract
    • 2+-activated Cl channels can substitute for CFTR in stimulation of anion-exchanger in human isolated CF cholangiocytes. J. Hepatol. 1999; 30: 141 (Abstract).
    • (1999) J. Hepatol. , vol.30 , pp. 141
    • Zsembery, A.1    Spirli, C.2    Sitter, G.3
  • 82
    • 0027325467 scopus 로고
    • Abnormal expression of anion exchanger genes in primary biliary cirrhosis
    • Prieto J, Qian C, Garcia N, Diez J, Medina JF. Abnormal expression of anion exchanger genes in primary biliary cirrhosis. Gastroenterology 1993; 105: 572-8.
    • (1993) Gastroenterology , vol.105 , pp. 572-578
    • Prieto, J.1    Qian, C.2    Garcia, N.3    Diez, J.4    Medina, J.F.5
  • 83
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger-2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • Medina JF, Martinez A, Vasquez JJ, Prieto J. Decreased anion exchanger-2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 1997; 25: 12-17.
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vasquez, J.J.3    Prieto, J.4
  • 84
    • 0028069352 scopus 로고
    • Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
    • Balfour Sartor R. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations. Gastroenterology 1994; 106: 533-9.
    • (1994) Gastroenterology , vol.106 , pp. 533-539
    • Balfour Sartor, R.1


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