Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 5, 2000, Pages 829-833

  Takagi, Yasushi ^a,b,c   Hattori, Itaro ^a,b   Nozaki, Kazuhiko ^a   Mitsui, Akira ^d   Ishikawa, Masatsune ^c   Hashimoto, Nobuo ^a   Yodoi, Junji ^b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Kitano Hospital   (Japan)

^d AJINOMOTO CO INC   (Japan)

Author keywords

Excitotoxicity; Hippocampus; Oxidative stress; Redox regulation; Thioredoxin

Indexed keywords

THIOREDOXIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; HIPPOCAMPUS; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SCORING SYSTEM; TRANSGENIC MOUSE;

EID: 0034075443     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200005000-00009     Document Type: Article

References (36)

1. Abate C, Patel L, Rauscher FJ III, Curran T (1990) Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249:1157-1161
2. Ayata C, Ayata G, Hara H, et al (1997) Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci 17:6908-6917
3. Beal MF (1992) Mechanism of excitotoxicity in neurologic disease. FASEB J 6:3338-3344
4. Cheng Y, Sun AY (1994) Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons. Neurochem Res 19:1557-1564
5. Choi DW (1989) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634
6. Dugan LL, Sensi SL, Canzoniero LM, et al (1995) Mitchondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci 15:6377-6388
7. Endoh M, Kunishita T, Tabira T (1993) Thioredoxin from activated macrophages as a trophic factor for central cholinergic neurons in vitro. Biochem Biophys Res Comm 192:760-765
8. Gary DS, Bruce-Keller AJ, Kindy MS, Mattson MP (1998) Ischemie and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J Cereb Blood Flow Metab 18: 1283-1287
9. Goillot E, Raingeaud J, Ranger A, et al (1997) Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci USA 94:3302-3307
10. Hirata H, Cadet JL (1997) Kainate-induced hippocampal DNA damage is attenuated in Superoxide dismutase transgenic mice. Brain Res Mol Brain Res 48:145-148
11. Hirota K, Matsui M, Iwata S, et al (1997) AP-1 transcriptional activity regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci USA 94:3633-3638
12. Holmgren A (1985) Thioredoxin. Annu Rev Biochem 54:237-271
13. Holmgren A (1989) Thioredoxin and glutaredoxin systems. J Biol Chem 264:13963-13966
14. Hori K, Katayama M, Sano N, et al (1994) Neuroprotection by glial cells through adult T-cell leukemia-derived factor/human thioredoxin (ADF/thioredoxin). Brain Res 652:304-310
15. Kondo T, Sharp FR, Honkaniemi J, et al (1997) DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp 70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase. J Cereb Blood Flow Metab 17:241-256
16. Lafon-Cazal M, Pietri S, Culcasi M, Bockaen J (1993) NMDA-dependent Superoxide production and neurotoxicity. Nature 364:535-537
17. Lippoldt A, Padilla CA, Gerst H, et al (1995) Localization of thioredoxin in the rat brain and functional implications. J Neurosci 15: 6747-6756
18. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87:565-576
19. London ED, Coyle JT (1979) Specific binding of [3H]-kainic acid to receptor sites in rat brain. Mol Pharmacol 15:492-505
20. 2 and antioxidants have opposite effects on activation of NF-kB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 12: 2005-2015
21. Mielke K, Brecht S, Dorst A, Herdegen T (1999) Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures. Neuroscience 91:471-483
22. Mitsui A, Hirakawa T, Yodoi J (1992) Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/ human thioredoxin. Biochem Biophys Res Commun 186:1220-1226
23. Nakamura H, Matsuda M, Furuke K, et al (1994) Adult T-cell leukemia derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunol Lett 42:75-80
24. Natoli G, Costanzo A, lanni A, et al (1997) Activation of SAPK/JNK by TNF receptor 1 through a non cytotoxic TRAF2-dependent pathway. Science 275:200-203
25. Regan RF, Guo YP (1999) Potentiation of excitotoxic injury by high concentrations of extracellular reduced glutathione. Neuroscience 92:463-470
26. Saitoh M, Nishitoh H, Fujii M, et al (1998) Mammalial thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17:2596-2606
27. Schenk H, Klein M, Erdbrugger W, et al (1994) Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kB and AP-1. Proc Natl Acad Sci USA 91:1672-1676
28. Shultz JB, Henshaw DR, Siwek D, et al (1995) Involvement of free radicals in excitotoxicity in vivo. J Neurochem 64:2239-2247
29. Tagaya Y, Okada M, Sugie K, et al (1988) IL-2 receptor (p55)/Tac inducing factor: purification and characterization of ATL-derived factor (ADF). J Immunol 140:2613-2620
30. Tagaya Y, Maeda Y, Mitsui A, et al (1989) ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin: possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J 8:757-764
31. Takagi Y, Mitsui A, Nishiyama A, et al (1999) Overexpression of thioredoxin transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci USA 96:4131-1136
32. Takagi Y, Tokime T, Gon Y, et al (1998) Redox control of neuronal damage during brain ischemia following middle cerebral artery occlusion in the rat: immunohistochemical and hybridization studies of thioredoxin. J Cereb Blood Flow Metab 18:206-214
33. Uz T, Giusti P, Franceschini D, Kharlamov A, Manev H (1996) Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats. Neuroscience 73:631-636
34. Xu X, Raber J, Yang D, Su B, Mucke L (1997) Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc Natl Acad Sci USA 94:12655-12660
35. Yang DD, Kuan CY, Whitmarsh AJ, et al (1997) Absence of excito-toxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389:865-870
36. Yodot J, Uchiyama T (1992) Diseases associated with HTLV-1: virus, IL-2 receptor dysregulation and redox regulation. Immunol Today 13:405-411