The hepatitis B virus core promoter is strongly activated by the liver nuclear receptor fetoprotein transcription factor or by ectopically expressed steroidogenic factor 1

Journal of Virology

Volumn 74, Issue 11, 2000, Pages 5032-5039

  Gilbert, STÉPHANE ^a   Galarneau, Luc ^a   Lamontagne, Alain ^a   Sylvie, Roy ^a   Bélanger, Luc ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FETOPROTEIN; NUCLEAR FACTOR I; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR; VIRUS DNA;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION; HEPATITIS B VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL NUCLEUS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; VIRUS CORE; VIRUS GENOME; VIRUS NUCLEOCAPSID;

ALPHA-FETOPROTEINS; BASE SEQUENCE; BINDING SITES; DNA, VIRAL; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); FUSHI TARAZU TRANSCRIPTION FACTORS; HEPATITIS B VIRUS; HOMEODOMAIN PROTEINS; HUMANS; LIVER; MOLECULAR SEQUENCE DATA; NUCLEOCAPSID; NUCLEOCAPSID PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034071385     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.11.5032-5039.2000     Document Type: Article

References (46)

1. Araki, K., J.-I. Miyazaki, O. Hino, N. Tomita, O. Chisaka, K. Matsubara, and K.-I. Yamamura. 1989. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Acad. Sci. USA 86:207-211.
2. Babinet, C., H. Farza, D. Morello, M. Hadchouel, and C. Pourcel. 1985. Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice. Science 230:1160-1163.
3. Beasley, R. P., L. Y. Hwang, C. C. Lin, and C. S. Chien. 1981. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan, Lancet ii:1129-1133.
4. 1 foetoprotein. Nature 256:657-659.
5. 1,-fetoprotein locus. J. Biol. Chem. 269:5481-5484.
6. 1-fetoprotein intergenic enhancer. Mol. Cell. Biol. 13:1619-1633.
7. Blumberg, B. S. 1997. The current state of the prevention of HBV infection, the carrier state and hepatocellular carcinoma. Res. Virol. 148:91-94.
8. Chang, C., K.-S. Jeng, C.-P. Hu, S. J. Lo, T.-S. Su, L.-P. Ting, C-K. Chou, S.-H. Han, E. Pfaff, J. Salfeld, and H. Schaller. 1987. Production of hepatitis B virus in vitro by transient expression of cloned HBV DNA in a hepatoma cell line. EMBO J. 6:675-680.
9. Chang, M. H., C. J. Chen, M. S. Lai, H. M. Hsu, T. C. Wu, M. S. Kong, D. C. Liang, W. Y. Shau, and D. S. Chen. 1997. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan childhood hepatoma study group. N. Engl. J. Med. 336:1855-1859.
10. Choi, B. H., G. T. Park, and H. M. Rho. 1999. Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein α synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. J. Biol. Chem. 274: 2858-2865.
11. Dunsford, H. A., S. Sell, and F. V. Chisari. 1990. Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res. 50:3400-3407.
12. Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3:1314-1322.
13. 1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol. Cell. Biol. 16:3853-3865.
14. Galarneau, L., R. Drouin, and L. Bélanger. 1998. Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization. Cytogenet. Cell Genet. 82:269-270.
15. Günther, S., N. Piwon, A. Iwanska, R. Schilling, H. Meisel, and H. Will. 1996. Type, prevalence, and significance of the core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease. J. Virol. 70:8318-8331.
16. Guo, W., M. Chen, T. S. B. Yen, and J.-H. Ou. 1993. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol. Cell. Biol. 13:443-448.
17. Ikeda, Y., D. S. Lala, X. Luo, E. Kim, M.-P. Moisan, and K. L. Parker. 1993. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol. Endocrinol. 7:852-860.
18. Ishida, H., K. Ueda, K. Ohkawa, Y. Kanazawa, A. Hosui, F. Nakanishi, E. Mita, A. Kasahara, Y. Sasaki, M. Hori, and N. Hayashi. 2000. Identification of multiple transcription factors, HLF, FTF, and E4BP4, controlling hepatitis B virus enhancer II. J. Virol. 74:1241-1251.
19. Jameel, S., and A. Siddiqui. 1986. The human hepatitis B virus enhancer requires trans-acting cellular factor(s) for activity. Mol. Cell. Biol. 6:710-715.
20. Kidd-Ljunggren, K., M. Öberg, and A. H. Kidd. 1997. Hepatitis B virus X gene 1751 to 1764 mutations: implications for HBeAg status and disease. J. Gen. Virol. 78:1469-1478.
21. Knowles, B. B., C. C. Howe, and D. P. Aden. 1980. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497-499.
22. Kusano, N., K. Shiraishi, K. Kubo, A. Oga, K. Okita, and K. Sasaki. 1999. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 29:1858-1862.
23. Larkin, J., M. Clayton, B. Sun, C. E. Perchonock, J. L. Morgan, L. D. Siracusa, F. H. Michaels, and M. A. Feitelson. 1999. Hepatitis B virus transgenic mouse model of chronic liver disease. Nat. Med. 5:907-912.
24. Lee, W. M. 1997. Hepatitis B virus infection. N. Engl. J. Med. 337:1733-1745.
25. Lee, Y.-K., K. L. Parker, H.-S. Choi, and D. D. Moore. 1999. Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers. J. Biol. Chem. 274:20869-20873.
26. Li, J., V. E. Buckwold, M.-W. Hon, and J.-H. Ou. 1999. Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J. Virol. 73:1239-1244.
27. Li, M., Y. Xie, X. Wu, Y. Kong, and Y. Wang. 1995. HNF3 binds and activates the second enhancer, ENII, of hepatitis B virus. Virology 214:371-378.
28. Li, M., Y.-H. Xie, Y.-Y. Kong, X. Wu, L. Zhu, and Y. Wang. 1998. Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J. Biol. Chem. 273:29022-29031.
29. López-Cabrera, M., J. Letovsky, K.-Q. Hu, and A. Siddiqui. 1990. Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein. Proc. Natl. Acad. Sci. USA 87:5069-5073.
30. López-Cabrera, M., J. Letovsky, K.-Q. Hu, and A. Siddiqui. 1991. Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus. Virology 183:825-829.
31. Nitta, M., S. Ku, C. Brown, A. Y. Okamoto, and B. Shan. 1999. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene. Proc. Natl. Acad. Sci. USA 96:6660-6665.
32. Pult, I., T. Chouard, S. Wieland, R. Klemenz, M. Yaniv, and H. E. Blum. 1997. A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. Hepatology 25:1507-1515.
33. Raney, A. K., J. L. Johnson, C. N. A. Palmer, and A. McLachlan. 1997. Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter. J. Virol. 71:1058-1071.
34. Rausa, F., L. Galarneau, L. Bélanger, and R. Costa. 1999. The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3ß in the developing murine liver intestine and pancreas. Mech. Dev. 89:185-188.
35. Shaul, Y., W. J. Rutter, and O. Laub. 1985. A human hepatitis B viral enhancer element. EMBO J. 4:427-430.
36. Su, H., and J.-K. Yee. 1992. Regulation of hepatitis B virus gene expression by its two enhancers. Proc. Natl. Acad. Sci. USA 89:2708-2712.
37. Tognoni, A., R. Cattaneo, E. Serfling, and W. Schaffner. 1985. A novel expression selection approach allows precise mapping of the hepatitis B virus enhancer. Nucleic Acids Res. 13:7457-7472.
38. Wang, Y., P. Chen, X. Wu, A.-L. Sun, H. Wang, Y.-A. Zhu, and Z.-P. Li. 1990. A new enhancer element, ENII, identified in the X gene of hepatitis B virus. J. Virol. 64:3977-3981.
39. Wen, P., N. Crawford, and J. Locker. 1993. A promoter-linked coupling region required for stimulation of α-fetoprotein transcription by distant enhancers. Nucleic Acids Res. 21:1911-1918.
40. Wong, N., P. Lai, S.-W. Lee, S. Fan, E. Pang, C.-T. Liew, Z. Sheng, J. W.-Y. Lau, and P. J. Johnson. 1999. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis. Relationship to disease stage, tumor size, and cirrhosis. Am. J. Pathol. 154:37-43.
41. Yaginuma, K., Y. Shirakata, M. Kobayashi, and K. Koike. 1987. Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc. Natl. Acad. Sci. USA 84:2678-2682.
42. Yee, J. K. 1989. A liver-specific enhancer in the core promoter region of human hepatitis B virus. Science 246:658-661.
43. Yu, X., and J. E. Mertz. 1996. Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated. J. Virol. 70:8719-8726.
44. Yu, X., and J. E. Mertz. 1997. Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily. J. Virol. 71:9366-9374.
45. Yuh, C.-H., and L.-P. Ting. 1991. C/EBP-like proteins binding to the functional box-α and box-β of the second enhancer of hepatitis B virus. Mol. Cell. Biol. 11:5044-5052.
46. Yuh, C.-H., Y.-L. Chang, and L.-P. Ting. 1992. Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J. Virol. 66:4073-4084.