Effects of transforming growth factor β1 released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(propylene fumarate) substrates

Journal of Biomedical Materials Research

Volumn 50, Issue 3, 2000, Pages 452-462

  Peter, Susan J ^a   Lu, Lichun ^a   Kim, Daniel J ^a   Stamatas, Georgios N ^a   Miller, Michael J ^b   Yaszemski, Michael J ^c   Mikos, Antonios G ^a  

^a RICE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Biodegradable polymers; Bone tissue engineering; Growth factor delivery; Marrow stromal cells; Poly(propylene fumarate); Transforming growth factor 1

Indexed keywords

ANIMAL CELL CULTURE; BIODEGRADATION; CARBOXYLIC ACIDS; CATALYST ACTIVITY; ENZYMES; POLYETHYLENE GLYCOLS; POLYMER BLENDS; POLYPEPTIDES; POLYPROPYLENES;

POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYPROPYLENE FUMARATE; TRANSFORMING GROWTH FACTOR;

BIOMATERIALS;

ALKALINE PHOSPHATASE; OSTEOCALCIN; POLYMER; POLYPROPYLENE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DEGRADATION; ENZYME ACTIVITY; MALE; NONHUMAN; OSTEOBLAST; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; STROMA CELL;

NON-PROGRAMMATIC;

ANIMALS; BIOCOMPATIBLE MATERIALS; CAPSULES; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FUMARATES; HUMANS; LACTIC ACID; OSTEOBLASTS; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; POLYPROPYLENES; RATS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034027888     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(20000605)50:3<452::AID-JBM20>3.0.CO;2-0     Document Type: Article

References (31)

1. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/ glycolic acid) microspheres. Pharm Res 1991;8:713-720.
2. Anderson JM, Shive MS. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997; 28:5-24.
3. Crotts G, Park TG. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues. J Microencapsul 1998;15:699-713.
4. Hollinger JO, Leong K. Poly(α-hydroxy acids): carriers for bone morphogenetic proteins. Biomaterials 1996;17:187-194.
5. Mooney DJ, Kaumann PM, Sano K, Schwendeman SP, Majahod K, Schloo B, Vacanti JP, Langer R. Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes. Biotech Bioeng 1996;50:422-429.
6. Cao X, Shoichet MS. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders. Biomaterials 1999;20:329-339.
7. Cleek RL, Ting KC, Eskin SG, Mikos AG. Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. J Control Release 1997;48:259-268.
8. Hock JM, Canalis E, Centrella M. Transforming growth factor-β stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae. Endocrinology 1990;126: 491-426.
9. Joyce M, Roberts A, Sporn M, Bolander M. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 1990;110:2195-2207.
10. Spargo BJ, Cliff RO, Rollwagen FM, Rudolph AS. Controlled release of transforming growth factor-β from lipid-based microcylinders. J Microencapsul 1995;12:247-254.
11. Linkhart TA, Mohan S, Baylink DJ. Growth factors for bone growth and repair: IGF, TGFβ, and BMP1. Bone 1996;19:1S-12S.
12. Sandberg MM, Aro HT, Vuorio EI. Gene expression during bone repair. Clin Orthop Rel Res 1993;289:292-312.
13. Sumner DR, Turner TM, Purchio AF, Gombotz WR, Urban RM, Galante JO. Enhancement of bone ingrowth by transforming growth factor-β. J Bone Joint Surg 1995;77A:1135-1147.
14. Lu L, Stamatas GN, Mikos AG. Controlled release of transforming growth factor β1 from biodegradable polymer microparticles. J Biomed Mater Res, to appear.
15. Peter SJ, Suggs LJ, Yaszemski MJ, Engel PS, Mikos AG. Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger. J Biomater Sci Polym Ed 1999;10:363-373.
16. Yaszemski MJ, Payne RG, Hayes WC, Langer RS, Aufdemorte TB, Mikos AG. The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold. Tissue Eng 1995;1:41-52.
17. Peter SJ, Kim P, Yasko AW, Yaszemski MJ, Mikos AG. Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. J Biomed Mater Res 1999;44:314-321.
18. Peter SJ, Lu L, Kim DJ, Mikos AG. Marrow stromal osteoblast function on a poly(propylene fumarate)/β-tricalcium phosphate biodegradable orthopaedic composite. Biomaterials, to appear.
19. Lu L, Garcia CA, Mikos AG. In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. J Biomed Mater Res 1999; 46:236-244.
20. Cleek RL, Rege AA, Denner LA, Eskin SG, Mikos AG. Inhibition of smooth muscle cell growth in vitro by an antisense oligodeoxynucleotide released from poly(DL-lactic-co-glycolic acid) microparticles. J Biomed Mater Res 1997;35:525-530.
21. Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997;36:17-28.
22. Maniatopoulos C, Sodek J, Melcher A. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 1988;254:317-330.
23. Jaiswal N, Bruder SP. The pleiotropic effects of dexamethasone on osteoblast differentiation depend on the developmental state of the responding cells. J Bone Miner Res 1996;11:S259.
24. Peter SJ, Liang CR, Kim DJ, Widmer MS, Mikos AG. Osteoblastic phenotype of rat marrow stromal cells cultured in the presence of dexamethasone, β-glycerolphosphate, and L-ascorbic acid. J Cell Biochem 1998;71:55-62.
25. Krewson CE, Dause R, Mak M, Saltzman WM. Stabilization of nerve growth factor in controlled release polymers and in tissue. J Biomater Sci Polym Ed 1996; 8:103-117.
26. Schwendeman SP, Cardamone M, Klibanov A, Langer R, Brandon MR. Stability of proteins and their delivery from biodegradable polymer microspheres. In: Cohen S, Bernstein H, editors. Microparticulate systems for the delivery of proteins and vaccines. New York: Marcel Dekker; 1996. p 1-19.
27. Ishaug SL, Yaszemski MJ, Bizios R, Mikos AG. Osteoblast function on synthetic biodegradable polymers. J Biomed Mater Res 1994;28:1445-1453.
28. Ishaug-Riley SL, Crane-Kruger GM, Yaszemski MJ, Mikos AG. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 1998;19:1405-1412.
29. Wake MC, Gerecht PD, Lu L, Mikos AG. Effects of biodegradable polymer particles on rat marrow-derived stromal osteoblasts in vitro. Biomaterials 1998;19:1255-1268.
30. Puleo DA, Huh WW, Duggirala SS, DeLuca PP. In vitro cellular responses to bioerodible particles loaded with recombinant human bone morphogenetic protein-2. J Biomed Mater Res 1998; 41:104-110.
31. 3 on function, cytochemistry and morphology of normal human osteoblast-like cells. Differentiation 1994;55:153-163.