Role of third intracellular loop of galanin receptor type 1 in signal transduction

Neuropeptides

Volumn 34, Issue 1, 2000, Pages 25-31

  Rezaei, K ^a   Saar, K ^a,b   Soomets, U ^a,b   Valkna, A ^a,b   Nasman J ^c   Zorko, M ^a,d   Akerman K ^d   Schroeder, T ^a   Bartfai, T ^a,e   Langel, Ü ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GALANIN RECEPTOR; LEUCINE;

ARTICLE; BINDING AFFINITY; HUMAN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0034066376     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1054/npep.1999.0782     Document Type: Article

References (46)

1. Tatemoto K., Rökaeus Å., Jörnvall H., McDonald T. J., Mutt V. Galanin, a novel biologically active peptide from porcine intestine. FEBS Lett. 164:1983;124-128.
2. Wang S., Parker E. M. Galanin receptor subtypes as potential therapeutic targets. Exp Opin Ther Patents. 8:1998;1225-1235.
3. Ögren S-O., Hökfelt T., Kask K., Langel Ü., Bartfai T. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 51:1992;1-5.
4. Leibowitz S. F., Kim T. Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion. Brain Res. 599:1992;148-152.
5. Benelli A., Arletti R., Bertolini A., Menozzi B., Basaglia R., Poggioli R. Galantide stimulates sexual behaviour in male rats. Eur J Pharmacol. 260:1994;279-282.
6. Bartfai T., Hökfelt T., Langel Ü. Galanin - a neuroendocrine peptide. Crit Rev Neurobiol. 7:1993;229-274.
7. Hökfelt T., Millhorn D., Seroogy K. Coexistence of peptides with classical neurotransmitters. Experientia. 43:1987;768-780.
8. Habert-Ortoli E., Amiranoff B., Loquet I., Laburthe M., Mayaux J. F. Molecular cloning of a functional human galanin receptor. Proc Natl Acad Sci USA. 91:1994;9780-9783.
9. Ross, P. C. Information data base. National center for biotechnology, 1995, gene bank accession no. U23854.1.
10. Lorimer D. D., Benya R. V. Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract. Biochem Biophys Res Commun. 222:1996;379-385.
11. Burgevin M-C., Loquet I., Quarteronet D., Habert-Ortoli E. Cloning, pharmacological characterization, and anatomic distribution of a rat cDNA encoding for a galanin receptor. J Mol Neurosci. 6:1995;1-8.
12. Parker E. M., Izzarelli D. G., Nowak H. P. Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells. Mol Brain Res. 34:1995;179-189.
13. Bloomquist B. T., Beauchamp M. R., Zhelnin L. Cloning and expression of the human galanin receptor GalR2. Biochem Biophys Res Commun. 243:1998;474-479.
14. Howard A. D., Tan C., Shiao L. L. Molecular cloning and characterization of a new receptor for galanin. FEBS Lett. 405:1997;285-290.
15. Smith K. E., Walker M. W., Artymyshyn R. Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels. J Biol Chem. 273:1998;23321-23326.
16. Wang S., He C., Hashemi T., Bayne M. Cloning and expressional characterisation of a novel galanin receptor. J Biol Chem. 272:1997;31949-31952.
17. Amiranoff B., Lorinet A. M., Laburthe M. Galanin receptor in the rat pancreatic beta-cell Line Rin m5F - molecular characterization by chemical cross-linking. J Biol Chem. 264:1989;20714-20717.
18. Jacoby A. S., Webb G. C., Liu M. L. Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. Genomics. 45:1997;496-508.
19. Lorimer D., Matkowskj K., Benya R. Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). Biochem Biophys Res Commun. 241:1997;558-564.
20. Tseng M. J., Coon S., Stuenkel E., Struk V., Logsdon C. D. Influence of second and third cytoplasmic loops on binding, internalization, and coupling of chimeric bombesin/m3 muscarinic receptors. J Biol Chem. 270:1995;17884-17891.
21. Hausdorff W. P., Hnatowich M., O'Dowd B. F., Caron M. G., Lefkowitz R. J. A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. J Biol Chem. 265:1990;1388-1393.
22. Eason M. G., Liggett S. B. Chimeric mutagenesis of putative G-protein coupling domains of the alpha(2A)-adrenergic receptor - Localization of two redundant and fully competent G(1) coupling domains. J Biol Chem. 271:1996;12826-12832.
23. Guiramand J., Montmayeur J. P., Ceraline J., Bhatia M., Borrelli E. Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins. J Biol Chem. 270:1995;7354-7358.
24. Strader C. D., Fong T. M., Tota M., Underwood D., Dixon R. A. F. Structure and function of G protein-coupled receptors. Annu Rev Biochem. 63:1994;101-132.
25. Gudermann T., Schoneberg T., Schultz G. Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci. 20:1997;399-427.
26. Taylor J. M., Neubig R. R. Peptides as probes for G protein signal transduction. Cell Signal. 6:1994;841-849.
27. Konig B., Arendt A., McDowell J. H., Kahlert M., Hargrave P. A., Hofmann K. P. Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci USA. 86:1989;6878-6882.
28. Saar K., Valkna A., Soomets U. Role of third cytoplasmic loop in signal transduction by galanin receptors. Biochem Soc Transactions. 25:1997;1036-1040.
29. Langel U., Land T., Bartfai T. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res. 39:1992;516-522.
30. Nukada T., Tanabe T., Takahashi H. Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 195:1986;220-224.
31. Nukada T., Tanabe T., Takahashi H. Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett. 197:1986;305-310.
32. Nakamura F., Kato M., Kameyama K. Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system. J Biol Chem. 270:1995;6246-6253.
33. McKenzie, F. R. Signal Transduction. Oxford, Oxford University Press, 1992.
34. Kask K., Berthold M., Kahl U., Nordvall G., Bartfai T. Delineation of the peptide binding site of the human galanin receptor. EMBO J. 15:1996;236-244.
35. Merkouris M., Dragatsis I., Megaritis G. Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides. Mol Pharmacol. 50:1996;985-993.
36. Remmers A. E. α2-Adrenergic receptor coupling to G proteins. Roche P. C. G Proteins, Methods in Neurosciences. 1996;101-119 Academic Press, London.
37. Dohlman H. G., Thorner J., Caron M. G., Lefkowitz R. J. Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem. 60:1991;653-688.
38. Varrault A., Le Nguyen D., McClue S., Harris B., Jouin P., Bockaert J. 5-Hydroxytryptamine 1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition. J Biol Chem. 269:1994;16720-16725.
39. Hausdorff W. P., Caron M. G., Lefkowitz R. J. Turning off the signal: desensitization of beta-adrenergic receptor function. Faseb J. 4:1990;2881-2889.
40. Lefkowitz R. J., Cotecchia S., Kjelsberg M. A. Adrenergic receptors: recent insights into their mechanism of activation and desensitization. Adv Second Messenger Phosphoprotein Res. 28:1993;1-9.
41. Lohse M. J. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta. 1179:1993;171-188.
42. Cvejic S., Trapaidze N., Cyr C., Devi L. A. Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulation. J Biol Chem. 271:1996;4073-4076.
43. Trapaidze N., Keith D. E., Cvejic S., Evans C. J., Devi L. A. Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization. J Biol Chem. 271:1996;29279-29285.
44. Takano T., Honda Z., Sakanaka C. Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. J Biol Chem. 269:1994;22453-22458.
45. Pak Y., Kouvelas A., Scheideler M. A., Rasmussen J., Odowd B. F., George S. R. Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein. Mol Pharmacol. 50:1996;1214-1222.
46. Segredo V., Burford N., Lameh J., Sadee W. A constitutively internalizing and recycling mutant of the mu-opioid receptor. J Neurochem. 68:1997;2395-2404.