The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine

Domestic Animal Endocrinology

Volumn 18, Issue 3, 2000, Pages 279-291

  Phung, L T ^a   Inoue, H ^a   Nou, V ^a   Lee, H G ^a   Vega, R A ^a   Matsunaga, N ^a   Hidaka, S ^a   Kuwayama, H ^a   Hidari, H ^a  

^a OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

GH; GHRP 2; Growth performance; Swine

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HORMONE DERIVATIVE; OLIGOPEPTIDE; PRALMORELIN;

ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD; BODY GROWTH; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; FOOD INTAKE; GROWTH CURVE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; GROWTH, DEVELOPMENT AND AGING; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHYSIOLOGY; RADIOIMMUNOASSAY; RANDOMIZATION; SECRETION; STATISTICAL MODEL; SUBCUTANEOUS DRUG ADMINISTRATION; SWINE; WEIGHT GAIN;

ANIMALS; AREA UNDER CURVE; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HORMONES; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LINEAR MODELS; MALE; OLIGOPEPTIDES; RADIOIMMUNOASSAY; RANDOM ALLOCATION; SWINE; WEIGHT GAIN;

ANIMALIA; SUS SCROFA;

EID: 0034062706     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0739-7240(00)00050-3     Document Type: Article

References (37)

1. Momany F.A., Bowers C.Y., Reynolds G.A., Hong A., Newlander K. Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology. 114:1984;1531-1536.
2. Bowers C.Y., Momany F.A., Reynolds G.A., Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114:1984;1537-1545.
3. 2 in rats, dogs and monkeys. Life Sci. 47:1990;29-36.
4. Korbonists M., Grossman A.B. Growth hormone-releasing peptide and its analogues. TEM. 6:1993;43-49.
5. Wu D., Chen C., Katoh K., Zhang J., Clarke I.J. The effect of GH-releasing peptide-2 (GHRP-2 or KP102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. J Endocrinol. 140:1994;R9-R13.
6. Hashizume T., Yanagimoto M., Kainuma S., Nagano R., Moriwaki K., Ohtsuki K., Sasaki K., Masuda H., Hirata T. Effect of new growth hormone-releasing peptide (KP102) on the release of growth hormone in vitro and in vivo in cattle. Anim Sci Technol (Jpn). 68:1997;450-458.
7. Roh S.G., He M.L., Matsunaga N., Hidaka S., Hidari H. Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J Anim Sci. 75:1997;2744-2748.
8. Roh S.G., Matsunaga N., Hidaka S., Hidari H. Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocrine J. 43:1996;291-298.
9. Hashizume T., Sasaki K., Sakai M., Tauchi S., Masuda H. The effect of new growth hormone-releasing peptide (KP102) on the release of growth hormone in goats. Anim Sci Technol (Jpn). 68:1997;247-256.
10. Hashizume T., Sasaki K., Kobayashi S., Nitta Y. Intrahypothalamic perfusion of KP102 stimulates growth hormone release in goats. Endocrine J. 45:1998;53-59.
11. Roh S.G., He M.L., Matsunaga N., Hidaka S., Hidari H. No desensitization of the Growth hormone (GH) response between GH-releasing peptide-2 and GH-releasing factor in calves. J Anim Sci. 75:1997;2749-2753.
12. Hashizume T., Kawai M., Ohtsuki K., Ishii A., Numata M. Oral administration of peptidergic growth hormone (GH) secretagogue KP102 stimulates GH release in goats. Domest Anim Endocrinol. 16:1999;31-39.
13. Sawada H., Sugihara H., Onose H., Minami S., Shibasaki T., Wakabayashi I. Effect of D-Ala-D-β Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats. Regul Peptides. 53:1994;195-201.
14. Bowers C.Y. GH releasing peptides-structure and kinetics. J Prediatr Endocrinol. 6:1993;21-31.
15. Nijland E.A., Strasburger C.J., Popp-Snijders C., Van der Wal P.S., Van der Veen E.A. A five day treatment with daily s.c. injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-1 secretion in healthy young men. Eur J Endocrinol. 139:1998;395-401.
16. Van den Berghe G., Wouters P., Bowers C.Y., de Zegher F., Bouillon R. Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness. Eur J Endocrinol. 140:1999;17-22.
17. Smith C.A., Ficken M.D. Non-surgical cannulation of the vena cava for chronic blood collection in mature swine. Lab Anim Sci. 41:1991;274-287.
18. Chang C.H., Rickes E.L., Larsen J.G., Trimboli W.A., Seward R.L., Taylor J.E., Chen H.Y. Effects of chronic repeated injection with GHRP-6 and porcine somatotropin (SPT) on GH response, and plasma IGF-1 and BUN levels in swine (Abstract). J Anim Sci. 68:(suppl 1):1990;316.
19. Rickes E.L., Chang C.H., Larsen J.G., Trimboli W.A., Seward R.L., Taylor J.E., Chen H.Y., Hickey G.J. Effects of GHRP-6 or porcine somatotropin (PST) on plasma GH, IGF-1, BUN, insulin and glucose in swine during repeated administration over 72 h (Abstract). J Anim Sci. 69:(suppl 1):1991;313.
20. 2 in the rat. Endocrinology. 117:1985;1441-1447.
21. Badger T.M., Millard W.J., McCormick G.F., Bowers C.Y., Martin J.B. The effects of growth hormone (GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats. Endocrinology. 115:1984;1432-1438.
22. 2 in rat primary pituitary cell monolayer culture. Endocrinology. 116:1985;952-957.
23. Cheng K., Chan W.W.S., Barreto A., Convey E.M., Smith R.G. The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor stimulated GH release and intracellular adenosine 3′, 5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology. 124:1989;2791-2798.
24. Bowers C.Y., Sator A.O., Reynolds G.A., Badger T.M. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology. 128:1991;2027-2035.
25. 2 stimulate growth hormone release through distinct receptor sites. J Endocrinol. 129:1991;11-19.
26. Goth M.I., Lyons C.E., Canny B.J., Thorner M.O. Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct pituitary receptors. Endocrinology. 130:1992;939-944.
27. Ghigo E., Arvat E., Muccioli G., Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol. 136:1997;445-460.
28. Camanni F., Ghigo E., Arvat E. Growth hormone-releasing peptides and their analogs. Front Neuroendocrinol. 19:1998;47-72.
29. Casanueva F.F., Dieguez C. Growth hormone secretagogues Physiological role and clinical utility . TEM. 10:1999;30-38.
30. Locke W., Kirgis H.D., Bower C.Y., Abdoh A.A. Intracerebroventricular growth hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. Life Sci. 56:1995;1347-1352.
31. Okada K., Ishii S., Minami S., Shibasaki T., Wakabayashi I. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology. 137:1996;5155-5158.
32. Toisello A., Luoni M., Schweiger F., Grilli R., Guidi M., Bresciani E., et al. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Eur J Pharmacol. 360:1998;123-129.
33. Rigamonti A.E., Cella S.G., Marazzi N., Muller E.E. Six-week treatment with hexarelin in young dogs evaluation of the GH responsiveness to acute hexarelin or GHRH administration, and of the orexigenic effect of hexarelin . Eur J Endocrinol. 141:1999;313-320.
34. Chung C.S., Etherton T.D., Wiggins J.P. Stimulation of swine growth by porcine growth hormone. J Anim Sci. 60:1985;118-130.
35. Etherton T.D., Wiggins J.P., Chung C.S., Evock C.M., Rebhun J.F., Walton P.E. Stimulation of pig growth performance by porcine growth hormone and growth hormone-releasing factor. J Anim Sci. 63:1986;1389-1399.
36. Van den Berghe G., de Zegher F., Veldhuis J.D., Wouters P., Awouters M., Verbruggen W., Schets M., Verwaest C., Lauwers P., Bouillon R., Bowers C.Y. The somatotropic axis in critical illness Effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion . J Clin Endocrinol Metab. 82:1997;590-599.
37. 2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men. Endocrinol Jpn. 38:1991;15-21.