Oral administration of peptidergic growth hormone (GH) secretagogue KP102 stimulates GH release in goats

Domestic Animal Endocrinology

Volumn 16, Issue 1, 1999, Pages 31-39

  Hashizume, T ^a   Kawai, M ^a   Ohtsuki, K ^a   Ishii, A ^a   Numata, M ^a  

^a IWATE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; OLIGOPEPTIDE; PRALMORELIN;

AGE DISTRIBUTION; AGING; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GOAT; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; SECRETION;

AGING; ANIMALS; FEMALE; GOATS; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; KINETICS; MALE; OLIGOPEPTIDES;

EID: 0032973875     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0739-7240(98)00048-4     Document Type: Article

References (33)

1. Ghigo E., Arvat E., Muccioli G., Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol. 136:1997;445-460.
2. Pong S.S., Chaung L.Y.P., Dean D.C., Nargund R.P., Patchett A.A., Smith R.G. Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol. 10:1996;57-61.
3. Howard A.D., Feighner S.D., Cully D.F., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 273:1996;974-977.
4. Wu D., Chen C., Katoh K., Zhang J., Clarke I.J. The effect of GH-releasing peptide-2 (GHRP-2 or KP102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. J Endocrinol. 140:1994;R9-R13.
5. Hashizume T., Yanagimoto M., Kainuma S., Nagano R., Moriwaki K., Ohtsuki K., Sasaki K., Masuda H., Hirata T. Effects of new growth hormone-releasing peptide (KP102) on the release of growth hormone in vitro and in vivo in cattle. Anim Sci Technol (Jpn). 68:1997;450-458.
6. Cheng J., Wu T.-J., Butler B., Cheng K. Growth hormone releasing peptide A comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells . Life Sci. 60:1997;1385-1392.
7. Roh S.G., He M.L., Matsunaga N., Hidaka S., Hidari H. Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J Anim Sci. 75:1997;2744-2748.
8. Hashizume T, Soliman EB, Ohtsuki K, et al. The effects of growth hormone-releasing hormone (GRF) and growth hormone-releasing peptide (KP102) on growth hormone release in ruminants. In: Reproductive Biology Update-Novel Tools for Assessment-Shoukadoh Booksellers Company, Kyoto, pp. 305-313, 1998.
9. Bowers C.Y. GH releasing peptides - structure and kinetics. J Pediatr Endocrinol. 6:1993;21-31.
10. Pihoker C., Middleton R., Reynolds G.A., Bowers C.Y., Badger T.M. Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature. J Clin Endocrinol Metab. 80:1995;2987-2992.
11. 2 (KP-102)] on growth hormone secretion in adult male rats. J Nippon Med Sch 62:142-149, 1995 (in Japanese).
12. Argente J., Garcia-Segura L.M., Pozo J., Chowen J.A. Growth hormone-releasing peptides Clinical and basic aspects . Neuroendocrinology. 46:1996;155-159.
13. Roh S.-G., Matsunaga N., Hidaka S., Hidari H. Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocrine J. 43:1996;291-298.
14. Nakagawa T., Ukai K., Ohyama T., Koida M., Okamura H. Effects of the synthesized growth hormone releasing peptide, KP102, on growth hormone release in sodium glutamate monohydrate-treated low growth rats. Life Sci. 59:1996;705-712.
15. Hashizume T., Sasaki K., Sakai M., Tauchi S., Masuda H. The effect of new growth hormone-releasing peptide (KP102) on the release of growth hormone (GH) in goats. Anim Sci Technol (Jpn). 68:1997;247-256.
16. Arvat E., Di Vito L., Maccagno B., Broglio F., Boghen M.F., Deghenghi R., Camanni F., Ghigo E. Effects of GHRP-2 and Hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Peptides. 18:1997;885-891.
17. Van den Berghe G., de Zegher F., Veldhuis J.D., Wouters P., Awouters M., Verbruggen W., Schetz M., Verwaest C., Lauwers P., Bouillon R., Bowers C.Y. The somatotropic axis in critical illness Effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion . J Clin Endocrinol Metab. 82:1997;590-599.
18. Roh S.G., He M.L., Matsunaga N., Hidaka S., Hidari H. No desensitization of growth hormone (GH) response between GH-releasing peptide-2 and GH-releasing factor in calves. J Anim Sci. 75:1997;2749-2753.
19. Hashizume T., Sasaki K., Kobayashi S., Nitta Y. Intrahypothalamic perfusion of KP102 stimulates growth hormone release in goats. Endocrin J. 45:1998;53-59.
20. Chang C.H., Rickes E.L., McGuire L., Frazier E., Chen H., Barakat K., Nargund R., Patchett A., Smith R.G., Hickey G.J. Growth hormone (GH) and insulin-like growth factor-I responses after treatments with an orally active GH secretagogue L-163,255 in swine. Endocrinology. 137:1996;4851-4856.
21. Jacks T., Smith K.R., Judith F., Schleim K., Frazier E., Chen H., Krupa D., Hora D., Nargund R., Patchett A.A., Hickey G. MK-0677, a potent novel, orally active growth hormone (GH) secretagogue GH, insulin-like growth factor-I and other hormonal responses in beagles . Endocrinology. 137:1966;5284-5289.
22. Bowers C.Y., Alster D.K., Frentz J.M. The GH releasing activity of a synthetic hexapeptide in normal men and short stature children after oral administration. J Clin Endocrinol Metab. 74:1992;292-298.
23. Hartman M.L., Farello G., Pezzoli S.S., Thorner M.O. Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. J Clin Endocrinol Metab. 74:1992;1378-1384.
24. Bellone J., Ghizzoni L., Aimaretti G., Volta C., Boghen M.F., Bernasconi S., Ghigo E. Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature. Eur J Endocrinol. 133:1995;425-429.
25. 2 in rats, dogs and monkeys. Life Sci. 47:1990;29-36.
26. Church D.C. Chapter 3 - Growth and development of the ruminant stomach. Digestive Physiology and Nutrition of Ruminants. 1979;34-45 Oxford Press, Portland.
27. 2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men. Endocrinol Japon. 38:1991;15-21.
28. Laron Z. Growth hormone secretagogues. Clinical experience and therapeutic potential. Drugs. 50:1995;595-601.
29. Johke T. Effects of TRH on circulating growth hormone, prolactin and triiodothyronine levels in the bovine. Endocrinol Japon. 25:1978;19-26.
30. Hashizume T., Kanematsu S. Effects of cholecystokinin octapeptide on the release of growth hormone in perifused pituitary and hypothalamus of the goat. Anim Sci Technol (Jpn). 62:1991;343-350.
31. Ozawa A., Hodate K., Miyamoto S., Ohtani F., Tsushima T., Johke T. Plasma profiles of insulin-like growth factor-I for 24 hours and after injection of bovine growth hormone in dairy heifers. Anim Sci Technol (Jpn). 62:1991;933-938.
32. Daughaday W.H., Mariz I.K., Blethen S.L. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum . J Clin Endocr Metab. 51:1980;781-788.
33. Reid A.M., Titchen D.A. Gastric electromyographic activity in the milk-fed lamb. J Physiol. 396:1988;25-39.