Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats

Endocrinology

Volumn 137, Issue 11, 1996, Pages 5155-5158

  Okada, Kenmei ^a   Ishii, Shinya ^a   Minami, Shiro ^a   Sugihara, Hitoshi ^a   Shibasaki, Tamotsu ^a   Wakabayashi, Ichiji ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; PRALMORELIN; SERMORELIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; HORMONAL REGULATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY;

EID: 0029806442     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895390     Document Type: Article

References (14)

1. Bowers CY, Momany F, Reynolds GA, Chang D, Hong A, Chang K 1980 Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology 106:663-667.
2. Bowers CY, Momany FA, Reynolds GA, Hong A 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114:1537-1545.
3. Bowers CY, Sartor AO, Reynolds GA, Badger TM 1991 On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 128:2027-2035.
4. Bowers CY 1993 GH releasing peptides-structure and kinetics. J Pediatr Endocrinol 6:21-31.
5. Smith RG, Cheng K, Schoen WR, Pong S-S, Hickey G, Jacks T, Butler B, Chan WW-S, Chaung L-YP, Judith F, Taylor J, Wyvratt MJ, Fisher MH 1993A nonpeptidyl growth hormone secretagogue. Science 260:1640-1643.
6. Patchett AA, Nargund RP, Tata JR, Chen MH , Barakat KJ, Johnston DBR, Cheng K, Chan WW-S, Butler B, Hickey G, Jacks T, Schleim K, Pong S-S, Chaung L-YP, Chen HY, Frazier E, Leung KH, Chiu S-HL, Smith RG 1995 Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA 92:7001-7005.
7. Pong S-S, Chaung L-YP, Dean DC, Nargund RP, Patchett AA, Smith RG 1996 Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol 10:57-61.
8. Van der Ploeg LHT, Howard AD, Feighner SD, Cully DF, Liberator PA, Arena JP, Rosenblum CI, Hamelin MJ, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu K, Kulju K, Pong S-S, Chaung L-Y, Elbrecht A, Schaeffer JM, Smith RG 1996 Cloning of a G-protein coupled receptor for the growth hormone releasing peptide (GHRP-6) and non-peptidyl growth hormone secretagogues. 10th Int Congr Endocrinol OR39-4 (Abstract).
9. Vaccarino FJ, Bloom FE, Rivier J, Vale W, Koob GF 1985 Stimulation of food intake in rats by centrally administered hypothalamic growth hormone-releasing factor. Nature 314:167-168.
10. Vaccarino FJ, Feifel D, Rivier J, Vale W, Koob GF 1988 Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats. Peptides 9 (Suppl 1):35-38.
11. Lumpkin MD, McDonald JK 1989 Blockade of growth hormone-releasing factor (GRF) activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist. Endocrinology 124:1522-1531.
12. Dickson SL, Leng G, Robinson ICAF 1993 Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons. Neuroscience 53:303-306.
13. Guillaume V, Magnan E, Cataldi M, Dutour A, Sauze N, Renard M, Razafindraibe H, Conte-Devolx B, Deghenghi R, Lenaerts V, Oliver C 1994 Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology 135:1073-1076.
14. Kamegai J, Hasegawa O, Minami S, Sugihara H, Wakabayashi I 1996 The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus. Mol Brain Res 39:153-159