Intrahypothalamic perfusion of KP102 stimulates growth hormone release in goats

Endocrine Journal

Volumn 45, Issue 1, 1998, Pages 53-59

  Hashizume, Tsutomu ^a   Sasaki, Koichi ^a   Kobayashi, Satoko ^a   Nitta, Yumi ^a  

^a IWATE UNIVERSITY   (Japan)

Author keywords

GH; GHRP 2; Goat; Hypothalamus; KP102

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; PRALMORELIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GOAT; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HYPOTHALAMUS; INTRACEREBRAL DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN;

EID: 0031946829     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.45.53     Document Type: Article

References (28)

1. Wu D, Chen C, Katoh K, Zhang J, Clarke IJ (1994) The effect of GH-releasing peptide-2 (GHRP-2 or KP102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. J Endocrinol 140: R9-R13.
2. Hashizume T, Yanagimoto M, Kainuma S, Nagano R, Moriwaki K, Ohtsuki K, Sasaki K, Masuda H, Hirata T (1997) Effects of new growth hormone-releasing peptide (KP102) on the release of growth hormone in vitro and in vivo in cattle. Anim Sci Technol (Jpn) 68: 450-458.
3. Bowers CY (1993) GH releasing peptides - structure and kinetics. J Pediatr Endocrinol 6: 21-31.
4. Pihoker C, Middleton R, Reynolds GA, Bowers CY, Badger TM (1995) Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature. J Clin Endocrinol Metab 80: 2987-2992.
5. 2 (KP-102)] on growth hormone secretion in adult male rats. J Nippon Med Sch 62: 142-149 (In Japanese).
6. Roh S-G, Matsunaga N, Hidaka S, Hidari H (1996) Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves. Endocr J 43: 291-298.
7. Nakagawa T, Ukai K, Ohyama T, Koida M, Okamura H (1996) Effects of the synthesized growth hormone releasing peptide, KP102, on growth hormone release in sodium glutamate monohydrate-treated low growth rats. Life Sci 59: 705-712.
8. Hashizume T, Sasaki K, Sakai M, Tauchi S, Masuda H (1997) The effect of new growth hormone-releasing peptide (KP102) on the release of growth hormone (GH) in goats. Anim Sci Technol (Jpn) 68: 247-256.
9. Laron Z (1995) Growth hormone secretagogues. Clinical experience and therapeutic potential. Drugs 50: 595-601.
10. Korbonits M, Grossman AB (1993) Growth hormone-releasing peptide and its analogues. Novel stimuli to growth hormone release. TEM 6: 43-49.
11. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, Mckee KK, Pong S-S, Chaung L-Y, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji D J S, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LHT (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977.
12. Fairhall KM, Mynett A, Robinson ICAF (1995) Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. J Endocrinol 144: 555-560.
13. 2 on GH release in conscious, freely moving male rats. Neuroendocrinology 63: 198-206.
14. Kasuya E, Hashizume T, Kanematsu S (1995) The effect of pentobarbital sodium on growth hormone release in shiba goats. Anim Sci Technol (Jpn) 66: 854-856.
15. Kasuya E, Hodate K, Matsumoto M, Sakaguchi M, Hashizume T, Kanematsu S (1996) The effects of xylazine on plasma concentrations of growth hormone, insulin-like growth factor-I, glucose and insulin in calves. Endocr J 43: 145-149.
16. 2-adrenergic antagonist, and somatostatin on xylazine-induced growth hormone release in calves. Endocr J 43: 551-556.
17. Hashizume T, Nitta Y, Kasuya K, Kanematsu S (1995) Microdialysis measurement of intracerebral somatostatin in the goat. Domest Anim Endocrinol 12: 363-370.
18. Ungerstedt U (1991) Microdialysis-principles and applications for studies in animals and man. J Intern Med 230: 365-373.
19. Robinson JE (1995) Microdialysis: A novel tool for research in the reproductive system. Biol Reprod 52: 237-245.
20. Hashizume T, Haglof SA, Malven PV (1994) Intracerebral methionine-enkephalin, serum cortisol, and serum β-endorphin during acute exposure of sheep to physical or isolation stress. J Anim Sci 72: 700-708.
21. Johke T (1978) Effects of TRH on circulating growth hormone, prolactin and triiodothyronine levels in the bovine. Endocrinol Japon 25: 19-26.
22. Hashizume T, Kanematsu S (1991) Effects of cholecystokinin octapeptide on the release of growth hormone in perifused pituitary and hypothalamus of the goat. Anim Sci Technol (Jpn) 62: 343-350.
23. Merriam GE, Wachter KW (1982) Algorithms for the study of episodic hormone secretion. Am J Physiol 243: E310-E318.
24. Clarke IJ, Fletcher TP, Pomares CC, Holmes JHG, Dunshea F, Thomas GB, Tilbrook AJ, Walton PE, Galloway DB (1993) Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams. J Endocrinol 138: 421-427.
25. Wakabayashi K (1984) Life Science Personal Computer Series 5, Arrangement of Experimental Data (PC-8801, 9801). Baihukan, Tokyo, 44-57, 90-133.
26. Guillaume V, Magnan E, Cataldi M, Dutour A, Sauze N, Renard M, Razafindraibe H, Conte-Devolx B, Deghenghi R, Lenaerts V, Oliver C (1994) Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology 135: 1073-1076.
27. Dickson SL, Leng G, Dyball REJ, Smith RG (1995) Central actions of peptide and non-peptide growth hormone secretagogues in the rat. Neuroendocrinology 61: 36-43.
28. Fletcher TP, Thomas GB, Clarke IJ (1996) Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. Domest Anim Endocrinol 13: 251-258.