-
1
-
-
0342309581
-
-
EP 819125, JP 1999507015, WO 9631492
-
Chan, M.F., RaJu, B.G., Kois, A., Verner, E.J., Wu, C., Castillo, R,S., Yalamoori, V., Balaji, V.N. (Texas Biotechnology Corp.). Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivs. thereof that modulate the activity of endothelin. EP 819125, JP 1999507015, WO 9631492.
-
Thienyl-, Furyl-, Pyrrolyl- and Biphenylsulfonamides and Derivs. Thereof That Modulate the Activity of Endothelin
-
-
Chan, M.F.1
Raju, B.G.2
Kois, A.3
Verner, E.J.4
Wu, C.5
Castillo, R.6
Yalamoori, V.7
Balaji, V.N.8
-
2
-
-
0342744530
-
-
US 5783705, WO 9849162
-
Wu, C., Blok, N., Kogan, T., Keller, K., Woodard, P. (Texas Biotechnology Corp.). Sulfonamides for treatment of endothelin-mediated disorders. US 5783705, WO 9849162.
-
Sulfonamides for Treatment of Endothelin-mediated Disorders
-
-
Wu, C.1
Blok, N.2
Kogan, T.3
Keller, K.4
Woodard, P.5
-
3
-
-
0030943903
-
Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-a selective antagonist
-
Wu, C., Chan, M.F., Stavros, F., Raju, B., Okun, I., Mong, S., Keller, K.M., Brock, T., Kogan, T.P., Dixon, R.A.F. Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist, J Med Chem 1997, 40: 1690-7.
-
(1997)
J Med Chem
, vol.40
, pp. 1690-1697
-
-
Wu, C.1
Chan, M.F.2
Stavros, F.3
Raju, B.4
Okun, I.5
Mong, S.6
Keller, K.M.7
Brock, T.8
Kogan, T.P.9
Dixon, R.A.F.10
-
4
-
-
0013543367
-
The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
-
Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto. K., Masaki, T. The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Nail Acad Sci USA 1989, 86: 2863-7.
-
(1989)
Proc Nail Acad Sci USA
, vol.86
, pp. 2863-2867
-
-
Inoue, A.1
Yanagisawa, M.2
Kimura, S.3
Kasuya, Y.4
Miyauchi, T.5
Goto, K.6
Masaki, T.7
-
7
-
-
0000184085
-
TBC11251, a highly selective endothelin-A receptor antagonist, prevents and reverses acute hypoxia-induced pulmonary hypertension in the rat
-
Abst 601
-
Chen, S.J., Brock, T., Stavros, F., Okun, I., Wu, C., Chan, F., Mong, S., Dixon, R.A.F., Oparil, S., Chen, V.F TBC11251, a highly selective endothelin-A receptor antagonist, prevents and reverses acute hypoxia-induced pulmonary hypertension in the rat. FASEB J 1996, 10(3): Abst 601.
-
(1996)
FASEB J
, vol.10
, Issue.3
-
-
Chen, S.J.1
Brock, T.2
Stavros, F.3
Okun, I.4
Wu, C.5
Chan, F.6
Mong, S.7
Dixon, R.A.F.8
Oparil, S.9
Chen, V.F.10
-
8
-
-
0031760395
-
Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: Dose study and review of endothelin-based therapies in the literature on cerebral vasospasm
-
Wanebo, J.E., Arthur, A.S., Louis, H.G., West, K., Kassell, N.R, Lee, K.S., Helm, G.A. Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: Dose study and review of endothelin-based therapies in the literature on cerebral vasospasm. Neurosurgery 1998, 43:1409-17.
-
(1998)
Neurosurgery
, vol.43
, pp. 1409-1417
-
-
Wanebo, J.E.1
Arthur, A.S.2
Louis, H.G.3
West, K.4
Kassell, N.R.5
Lee, K.S.6
Helm, G.A.7
-
9
-
-
0342744529
-
Inhibition of monocyte/macrophage homing to atherosclerotic plaque by treatment with endothelin receptor-A antagonist
-
Abst 66
-
Pasceri, V., Wu, H., Brock, T., Yeh, E.T.H., Willerson, J.T. Inhibition of monocyte/macrophage homing to atherosclerotic plaque by treatment with endothelin receptor-A antagonist. Circulation 1999, 100(18, Suppl. 1): Abst 66.
-
(1999)
Circulation
, vol.100
, Issue.18 SUPPL. 1
-
-
Pasceri, V.1
Wu, H.2
Brock, T.3
Yeh, E.T.H.4
Willerson, J.T.5
-
11
-
-
0004917956
-
A receptor blockade reduces pulmonary vascular resistance in patients with chronic heart failure
-
Abst 3044
-
A receptor blockade reduces pulmonary vascular resistance in patients with chronic heart failure. Circulation 1998, 98(17, Suppl.): Abst 3044.
-
(1998)
Circulation
, vol.98
, Issue.17 SUPPL.
-
-
Givertz, M.M.1
Colucci, W.S.2
Gottlieb, S.S.3
Hare, J.M.4
LeJemtel, T.5
Slawsky, M.T.6
Leier, C.V.7
Loh, E.8
Nicklas, J.M.9
Lewis, B.E.10
-
16
-
-
0343179109
-
-
Texas Biotechnology Company Communication Nov 3
-
TBC-11251 development status. Texas Biotechnology Company Communication Nov 3, 1999.
-
(1999)
TBC-11251 Development Status
-
-
-
18
-
-
0029945669
-
A selective endothelin receptor antagonists. 1. Discovery of A-127722
-
A selective endothelin receptor antagonists. 1. Discovery of A-127722. J Med Chem 1996, 39: 1039-48.
-
(1996)
J Med Chem
, vol.39
, pp. 1039-1048
-
-
Winn, M.1
Von Geldern, T.W.2
Opgenorth, T.J.3
-
19
-
-
0032424117
-
Pharmacological profile of T-0201, a highly potent and orally active endothelin receptor antagonist
-
Hoshino, T., Yamauchi, R., Kikkawa, K., Yabana, H., Murata, S. Pharmacological profile of T-0201, a highly potent and orally active endothelin receptor antagonist. J Pharmacol Exp Ther 1998, 286: 643-9.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 643-649
-
-
Hoshino, T.1
Yamauchi, R.2
Kikkawa, K.3
Yabana, H.4
Murata, S.5
-
21
-
-
0030980244
-
Endothelin receptor antagonists: Effect of serum albumin on potency and comparison of pharmacological characteristics
-
Wu-Wong, J.R., Dixon, D.B., Chiou, W.J., Opgenorth, T.J. Endothelin receptor antagonists: Effect of serum albumin on potency and comparison of pharmacological characteristics. J Pharmacol Exp Ther 1997, 281: 791-8.
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 791-798
-
-
Wu-Wong, J.R.1
Dixon, D.B.2
Chiou, W.J.3
Opgenorth, T.J.4
-
23
-
-
0029551537
-
Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist
-
Williams, D.L. Jr., Murphy. K.L., Nolan, N.A. et al. Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist. J Pharmacol Exp Ther 1995, 275: 1518-26.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1518-1526
-
-
Williams D.L., Jr.1
Murphy, K.L.2
Nolan, N.A.3
-
24
-
-
0032437265
-
Nonpeptide endothelin receptor antagonists XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist
-
Ohlstein, E.H., Nambi, P., Hay, D.W., Gellai, M., Brooks, D.P., Luengo, J., Xiang, J.N., Elliott, J.D. Nonpeptide endothelin receptor antagonists XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist. J Pharmacol Exp Ther 1998, 286: 650-6.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 650-656
-
-
Ohlstein, E.H.1
Nambi, P.2
Hay, D.W.3
Gellai, M.4
Brooks, D.P.5
Luengo, J.6
Xiang, J.N.7
Elliott, J.D.8
-
25
-
-
0028093424
-
SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist
-
Ohlstein, E.H., Nambi, P., Douglas, S.A. et al. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci USA 1994, 91: 8052-6.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8052-8056
-
-
Ohlstein, E.H.1
Nambi, P.2
Douglas, S.A.3
-
26
-
-
0030077787
-
Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist
-
Ohlstein, E.H., Nambi, P., Lago, A., Hay, D.W., Beck, G., Fong, K.L., Eddy, E.P., Smith, P., Ellens, H., Elliott, J.D. Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist. J Pharmacol Exp Ther 1996, 276: 609-15.
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 609-615
-
-
Ohlstein, E.H.1
Nambi, P.2
Lago, A.3
Hay, D.W.4
Beck, G.5
Fong, K.L.6
Eddy, E.P.7
Smith, P.8
Ellens, H.9
Elliott, J.D.10
-
27
-
-
0028113570
-
Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670
-
Ohlstein, E.H., Beck, G.R. Jr., Douglas. S.A., Nambi, P., Lago, M.A., Gleason, J.G., Ruffolo, R.R. Jr., Feuerstein, G., Elliott, J.D. Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670. J Pharmacol Exp Ther 1994, 271: 762-8.
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 762-768
-
-
Ohlstein, E.H.1
Beck G.R., Jr.2
Douglas, S.A.3
Nambi, P.4
Lago, M.A.5
Gleason, J.G.6
Ruffolo R.R., Jr.7
Feuerstein, G.8
Elliott, J.D.9
-
28
-
-
0001271975
-
LU 302872 and its racemate (LU 224332) show balanced endothelin-A/B receptor affinity, high oral activity, and inhibit human prostate tissue contractions
-
Raschack, M., Gock, S., Unger, L., Hahn, A., Amberg, W., Jansen, R., Alken, P., Weber, A., Hergenroder, S. LU 302872 and its racemate (LU 224332) show balanced endothelin-A/B receptor affinity, high oral activity, and inhibit human prostate tissue contractions. J Cardiovasc Pharmacol 1998, 31 (Suppl 1.): S241-4.
-
(1998)
J Cardiovasc Pharmacol
, vol.31
, Issue.SUPPL. 1
-
-
Raschack, M.1
Gock, S.2
Unger, L.3
Hahn, A.4
Amberg, W.5
Jansen, R.6
Alken, P.7
Weber, A.8
Hergenroder, S.9
-
29
-
-
0029896933
-
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists
-
Riechers, H., Albrecht, H.P., Amberg, W. et al. Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J Med Chem 1996, 39: 2123-8.
-
(1996)
J Med Chem
, vol.39
, pp. 2123-2128
-
-
Riechers, H.1
Albrecht, H.P.2
Amberg, W.3
-
30
-
-
0031456079
-
Ro 61-1790, a new hydrosoluble endothelin antagonist: General pharmacology and effects on experimental cerebral vasospasm
-
Roux, S., Breu, V., Giller, T., Neidhart. W., Ramuz, H., Coassolo, P., Clozel, J.P., Clozel, M. Ro 61-1790, a new hydrosoluble endothelin antagonist: General pharmacology and effects on experimental cerebral vasospasm. J Pharmacol Exp Ther 1997, 283: 1110-8.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1110-1118
-
-
Roux, S.1
Breu, V.2
Giller, T.3
Neidhart, W.4
Ramuz, H.5
Coassolo, P.6
Clozel, J.P.7
Clozel, M.8
-
31
-
-
0013460675
-
A receptor antagonist
-
Abst P-143
-
A receptor antagonist. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-143.
-
(1997)
Jpn J Pharmacol
, vol.73
, Issue.SUPPL. 1
-
-
Mihara, S.1
-
32
-
-
0030440925
-
Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 cyclo [D-α-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonytl-L-alanyl-L-α- aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyljdisodium salt], in human endothelinA and endothelinB receptors
-
Masuda, Y., Sugo, T., Kikuchi, T., Kawata, A., Satoh, M., Fujisawa, Y., Itoh, Y., Wakimasu, M., Ohtaki, T Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 [cyclo[D-α-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonytl-L-alanyl-L- α-aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyljdisodium salt], in human endothelinA and endothelinB receptors. J Pharmacol Exp Ther 1996, 279: 675-85.
-
(1996)
J Pharmacol Exp Ther
, vol.279
, pp. 675-685
-
-
Masuda, Y.1
Sugo, T.2
Kikuchi, T.3
Kawata, A.4
Satoh, M.5
Fujisawa, Y.6
Itoh, Y.7
Wakimasu, M.8
Ohtaki, T.9
-
33
-
-
0032766706
-
Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use
-
Clozel, M., Ramuz, H., Clozel, J.P., Breu, V., Hess, P., Loffler, B.M., Coassolo, P., Roux, S. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 1999, 290: 840-6.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 840-846
-
-
Clozel, M.1
Ramuz, H.2
Clozel, J.P.3
Breu, V.4
Hess, P.5
Loffler, B.M.6
Coassolo, P.7
Roux, S.8
|