1-Imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: Syntheses and evaluation of dual inhibitors of thromboxane A2 synthase and aromatase

Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2000, Pages 1841-1851

  Jacobs, Christoph ^a   Frotscher, Martin ^a   Dannhardt, Gerd ^b   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 IMIDAZOL 1 YLETHYL) 7,8 DIHYDROQUINOLINE; AMINOGLUTETHIMIDE; AROMATASE INHIBITOR; BENZOFURAN DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; CYTOCHROME P450; DAZOXIBEN; NAPHTHALENE DERIVATIVE; QUINOLINE DERIVATIVE; THROMBOXANE A2; THROMBOXANE B2; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; METASTASIS; NONHUMAN; RAT;

ANIMALS; AROMATASE INHIBITORS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; THROMBOXANE A2; THROMBOXANE B2; THROMBOXANE-A SYNTHASE;

EID: 0034026141     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991180u     Document Type: Article

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