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Volumn 158, Issue 9, 1997, Pages 4465-4470

A Metabolite of the Lupus-Inducing Drug Procainamide Prevents Anergy Induction in T Cell Clones

Author keywords

[No Author keywords available]

Indexed keywords

PROCAINAMIDE;

EID: 0031135289     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (59)
  • 1
    • 0345605420 scopus 로고
    • Dmg-related lupus: The same as or different from idiopathic disease?
    • R. G. Lahita, ed. Churchill Livingstone, New York
    • Hess, E. V., and A.-B. Mongey. 1993. Dmg-related lupus: the same as or different from idiopathic disease? In Systemic Lupus Erythematosus. R. G. Lahita, ed. Churchill Livingstone, New York, pp. 893-904.
    • (1993) Systemic Lupus Erythematosus , pp. 893-904
    • Hess, E.V.1    Mongey, A.-B.2
  • 3
    • 0002313961 scopus 로고    scopus 로고
    • Drug-induced lupus
    • D. J. Wallace and B. H. Hahn, eds. Williams & Wilkins, Baltimore, MD
    • Rubin, R. L. 1996. Drug-induced lupus. In Dubois' Lupus Erythematosus, 5th Ed. D. J. Wallace and B. H. Hahn, eds. Williams & Wilkins, Baltimore, MD, pp. 871-901.
    • (1996) Dubois' Lupus Erythematosus, 5th Ed. , pp. 871-901
    • Rubin, R.L.1
  • 4
    • 0018099670 scopus 로고
    • Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome
    • Woosley, R. L., D. E. Drayer, M. M. Reidenberg, A. S. Nies, K. Carr, and J. A. Oates. 1978. Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome. N. Engl. J. Med. 298: 1157.
    • (1978) N. Engl. J. Med. , vol.298 , pp. 1157
    • Woosley, R.L.1    Drayer, D.E.2    Reidenberg, M.M.3    Nies, A.S.4    Carr, K.5    Oates, J.A.6
  • 5
    • 0002940768 scopus 로고
    • Autoimmune reactions induced by procainamide and hydralazine
    • M. Kammuller, M. Bloksma, and W. Seimen, eds. Elsevier, Amsterdam
    • Rubin, R. L. 1989. Autoimmune reactions induced by procainamide and hydralazine. In Autoimmunity and Toxicology: Immune Disregulation Induced by Drugs and Chemicals. M. Kammuller, M. Bloksma, and W. Seimen, eds. Elsevier, Amsterdam, pp. 119-150.
    • (1989) Autoimmunity and Toxicology: Immune Disregulation Induced by Drugs and Chemicals , pp. 119-150
    • Rubin, R.L.1
  • 6
  • 7
    • 0028986033 scopus 로고
    • Mechanisms of drug-induced lupus, I: Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo
    • Yung, R. L., J. Quddus, C. E. Chrisp, K. J. Johnson, and B. C. Richardson. 1995. Mechanisms of drug-induced lupus, I: cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J. Immunol. 154: 3025.
    • (1995) J. Immunol. , vol.154 , pp. 3025
    • Yung, R.L.1    Quddus, J.2    Chrisp, C.E.3    Johnson, K.J.4    Richardson, B.C.5
  • 8
    • 0028604320 scopus 로고
    • Role of xenobiotic oxidative metabolism
    • Rubin, R. L. 1994. Role of xenobiotic oxidative metabolism. Lupus 3:479.
    • (1994) Lupus , vol.3 , pp. 479
    • Rubin, R.L.1
  • 9
    • 0024553177 scopus 로고
    • Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro
    • Rubin, R. L., and J. T. Curnutte. 1989. Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro. J. Clin. Invest. 83:1336.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1336
    • Rubin, R.L.1    Curnutte, J.T.2
  • 10
    • 0024458708 scopus 로고
    • Mechanism of hypersensitivity reactions: Proposed involvement of reactive metabolites generated by activated leukocytes
    • Uetrecht, J. 1989. Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes. Trends Pharmacol. Sci. 10:463.
    • (1989) Trends Pharmacol. Sci. , vol.10 , pp. 463
    • Uetrecht, J.1
  • 11
    • 0028063436 scopus 로고
    • Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils
    • Jiang, X., G. Khursigara, and R. L. Rubin. 1994. Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science 266:810.
    • (1994) Science , vol.266 , pp. 810
    • Jiang, X.1    Khursigara, G.2    Rubin, R.L.3
  • 12
    • 0029002554 scopus 로고
    • Characterization of tumour necrosis factor a release by human granulocytes in response to procainamide challenge
    • Hill, C. M., J. Lunec, H. R. Griffiths, and K. E. Herbert. 1995. Characterization of tumour necrosis factor a release by human granulocytes in response to procainamide challenge. Biochem. Pharmacol. 49:1837.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1837
    • Hill, C.M.1    Lunec, J.2    Griffiths, H.R.3    Herbert, K.E.4
  • 13
    • 0027500991 scopus 로고
    • T lymphocytes ignore procainamide but respond to its reactive metabolites in peritoneal cells: Demonstration by the adoptive transfer popliteal lymph node assay
    • Kubicka-Muranyi, M., R. Goebels, C. Goebel, J. Uetrecht, and E. Gleichmann. 1993. T lymphocytes ignore procainamide but respond to its reactive metabolites in peritoneal cells: demonstration by the adoptive transfer popliteal lymph node assay. Toxicol. Appl. Pharmacol. 122:88.
    • (1993) Toxicol. Appl. Pharmacol. , vol.122 , pp. 88
    • Kubicka-Muranyi, M.1    Goebels, R.2    Goebel, C.3    Uetrecht, J.4    Gleichmann, E.5
  • 15
    • 0021915755 scopus 로고
    • Reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide
    • Uetrecht, J. P. 1985. Reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide. J. Pharmacol. Exp. Ther. 232:420.
    • (1985) J. Pharmacol. Exp. Ther. , vol.232 , pp. 420
    • Uetrecht, J.P.1
  • 20
    • 0023682426 scopus 로고
    • Rapid communications: Electrochemical determination of N-oxidized procainamide metabolites and functional assessment of effects on murine cells in vitro
    • Wheeler, J. F., C. E. Lunte, W. R. Heineman, L. Adams, and E. V. Hess. 1988. Rapid communications: electrochemical determination of N-oxidized procainamide metabolites and functional assessment of effects on murine cells in vitro. Proc. Soc. Exp. Biol. Med. 188:381.
    • (1988) Proc. Soc. Exp. Biol. Med. , vol.188 , pp. 381
    • Wheeler, J.F.1    Lunte, C.E.2    Heineman, W.R.3    Adams, L.4    Hess, E.V.5
  • 21
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 22
    • 0345546166 scopus 로고
    • T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells
    • Weaver, C. T., C. M. Hawrylowicz, and E. R. Unanue. 1988. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 85:8181.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8181
    • Weaver, C.T.1    Hawrylowicz, C.M.2    Unanue, E.R.3
  • 23
    • 0026660731 scopus 로고
    • Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones: Correlation with lymphokine secretion patterns
    • Williams, M. E., C. M. Shea, A. H. Lichtman, and A. K. Abbas. 1992. Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones: correlation with lymphokine secretion patterns. J. Immunol. 149:1921.
    • (1992) J. Immunol. , vol.149 , pp. 1921
    • Williams, M.E.1    Shea, C.M.2    Lichtman, A.H.3    Abbas, A.K.4
  • 24
    • 0026562552 scopus 로고
    • Tolerance induction in T helper (Th1) cells by thymic macrophages
    • Jayaraman, S., Y. Luo, and M. E. Dorf. 1992. Tolerance induction in T helper (Th1) cells by thymic macrophages. J. Immunol. 148:2672.
    • (1992) J. Immunol. , vol.148 , pp. 2672
    • Jayaraman, S.1    Luo, Y.2    Dorf, M.E.3
  • 25
    • 0025248038 scopus 로고
    • Th1 and Th2 clones differ in their response to a tolerogenic signal
    • Gilbert, K. M., K. D. Hoang, and W. O. Weigle. 1990. Th1 and Th2 clones differ in their response to a tolerogenic signal. J. Immunol. 144:2063.
    • (1990) J. Immunol. , vol.144 , pp. 2063
    • Gilbert, K.M.1    Hoang, K.D.2    Weigle, W.O.3
  • 26
    • 0028025705 scopus 로고
    • Th2 cell clonal anergy as a consequence of partial activation
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
    • (1994) J. Exp. Med. , vol.180 , pp. 1195
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 27
    • 0027424435 scopus 로고
    • Induction of hyporesponsiveness in human lymphocytes-T despite their expression of both the co-receptor CD28 and its ligand B7
    • Friccius, H., P. Siegels-Hübenthal, A. Rehbein, E. Schlotz, and G. Pawelec. 1993. Induction of hyporesponsiveness in human lymphocytes-T despite their expression of both the co-receptor CD28 and its ligand B7. Cell. Immunol. 151:283.
    • (1993) Cell. Immunol. , vol.151 , pp. 283
    • Friccius, H.1    Siegels-Hübenthal, P.2    Rehbein, A.3    Schlotz, E.4    Pawelec, G.5
  • 28
    • 0028237260 scopus 로고
    • Anergic T cells as suppressor cells in vitro
    • Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587.
    • (1994) Science , vol.264 , pp. 1587
    • Lombardi, G.1    Sidhu, S.2    Batchelor, R.3    Lechler, R.4
  • 29
    • 0028054267 scopus 로고
    • The role of anergy in peripheral T cell unresponsiveness
    • Johnson, J. G., and K. M. Jenkins. 1994. The role of anergy in peripheral T cell unresponsiveness. Life Sci. 55:1767.
    • (1994) Life Sci. , vol.55 , pp. 1767
    • Johnson, J.G.1    Jenkins, K.M.2
  • 30
    • 0025309472 scopus 로고
    • Clonal deletion versus clonal anergy: The role of the thymus in inducing self tolerance
    • Ramsdell, F., and B. J. Fowlkes. 1990. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 248:1342.
    • (1990) Science , vol.248 , pp. 1342
    • Ramsdell, F.1    Fowlkes, B.J.2
  • 31
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
    • (1990) Science , vol.248 , pp. 1349
    • Schwartz, R.H.1
  • 32
    • 0021361235 scopus 로고
    • Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes
    • Uetrecht, J. P., B. J. Sweetman, R. L. Woosley, and J. A. Oates. 1984. Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes. Drug Metab. Dispos. 12:77.
    • (1984) Drug Metab. Dispos. , vol.12 , pp. 77
    • Uetrecht, J.P.1    Sweetman, B.J.2    Woosley, R.L.3    Oates, J.A.4
  • 33
    • 0022645825 scopus 로고
    • High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules
    • Ashwell, J. D., C. Chen, and R. H. Schwartz. 1986. High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules. J. Immunol. 136:389.
    • (1986) J. Immunol. , vol.136 , pp. 389
    • Ashwell, J.D.1    Chen, C.2    Schwartz, R.H.3
  • 34
    • 0021919697 scopus 로고
    • Enzyme amplification-a general method applied to provide an immunoassisted assay for placental alkaline phosphatase
    • Self, C. H. 1985. Enzyme amplification-a general method applied to provide an immunoassisted assay for placental alkaline phosphatase. J. Immunol. Methods 76:389.
    • (1985) J. Immunol. Methods , vol.76 , pp. 389
    • Self, C.H.1
  • 35
    • 0026687519 scopus 로고
    • Reversal of in vitro T cell clonal anergy by IL-2 stimulation
    • Beverly, B., S. Kang, M. J. Lenardo, and R. H. Schwartz. 1991. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4:661.
    • (1991) Int. Immunol. , vol.4 , pp. 661
    • Beverly, B.1    Kang, S.2    Lenardo, M.J.3    Schwartz, R.H.4
  • 36
    • 0025058266 scopus 로고
    • Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
    • Jenkins, M. K., C. Chen, G. Jung, D. L. Mueller, and R. H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144: 16.
    • (1990) J. Immunol. , vol.144 , pp. 16
    • Jenkins, M.K.1    Chen, C.2    Jung, G.3    Mueller, D.L.4    Schwartz, R.H.5
  • 37
    • 0025793148 scopus 로고
    • Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection
    • Wheeler, J. F., L. E. Adams, A.-B. Mongey, S. M. Roberts, W. R. Heineman, and E. V. Hess. 1991. Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection. Drug Metab. Dispos. 19:691.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 691
    • Wheeler, J.F.1    Adams, L.E.2    Mongey, A.-B.3    Roberts, S.M.4    Heineman, W.R.5    Hess, E.V.6
  • 38
    • 0026669383 scopus 로고
    • Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn
    • Quill, H., M. P. Riley, E. A. Cho, J. E. Casnellie, J. C. Reed, and T. Torigoe. 1992. Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn. J. Immunol. 149:2887.
    • (1992) J. Immunol. , vol.149 , pp. 2887
    • Quill, H.1    Riley, M.P.2    Cho, E.A.3    Casnellie, J.E.4    Reed, J.C.5    Torigoe, T.6
  • 39
    • 0027301903 scopus 로고
    • Altered protein tyrosine phosphorylation in anergic Th1 cells
    • Cho, E. A., M. P. Riley, A. L. Sillman, and H. Quill. 1993. Altered protein tyrosine phosphorylation in anergic Th1 cells. J. Immunol. 151:20.
    • (1993) J. Immunol. , vol.151 , pp. 20
    • Cho, E.A.1    Riley, M.P.2    Sillman, A.L.3    Quill, H.4
  • 40
    • 0027967385 scopus 로고
    • Partial T cell signalling: Altered phospho-ζ and lack of ZAP70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signalling: altered phospho-ζ and lack of ZAP70 recruitment in APL-induced T cell anergy. Cell 79:913.
    • (1994) Cell , vol.79 , pp. 913
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 41
    • 0023390431 scopus 로고
    • Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
    • Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, T. M. Chused, and R. H. Schwartz. 1987. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 84:5409.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5409
    • Jenkins, M.K.1    Pardoll, D.M.2    Mizuguchi, J.3    Chused, T.M.4    Schwartz, R.H.5
  • 43
    • 0026583665 scopus 로고
    • Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation
    • Go, C., and J. Miller. 1992. Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation. J. Exp. Med. 175:1327.
    • (1992) J. Exp. Med. , vol.175 , pp. 1327
    • Go, C.1    Miller, J.2
  • 44
    • 0028919204 scopus 로고
    • Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy
    • Wotton, D., J. A. Higgins, R. E. O'Hehir, J. R. Lamb, and R. A. Lake. 1995. Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy. Hum. Immunol. 42:95.
    • (1995) Hum. Immunol. , vol.42 , pp. 95
    • Wotton, D.1    Higgins, J.A.2    O'Hehir, R.E.3    Lamb, J.R.4    Lake, R.A.5
  • 45
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
    • (1994) Cell , vol.76 , pp. 263
    • Weiss, A.1    Littman, D.R.2
  • 46
    • 0023266396 scopus 로고
    • Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of a long-lived state of proliferative nonresponsiveness
    • Quill, H., and R. H. Schwartz. 1987. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J. Immunol. 138:3704.
    • (1987) J. Immunol. , vol.138 , pp. 3704
    • Quill, H.1    Schwartz, R.H.2
  • 48
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke, T. M., and P. A. Sandstrom. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7.
    • (1994) Immunol. Today , vol.15 , pp. 7
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 50
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami, N., P. Marchetti, M. Castedo, C. Zanin, J. Vayssière, P. X. Petit, and G. Kroemer. 1995. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181:1661.
    • (1995) J. Exp. Med. , vol.181 , pp. 1661
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.4    Vayssière, J.5    Petit, P.X.6    Kroemer, G.7
  • 53
    • 0028017808 scopus 로고
    • A differential-avidity model for T-cell selection
    • Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
    • (1994) Immunol. Today , vol.15 , pp. 362
    • Ashton-Rickardt, P.G.1    Tonegawa, S.2
  • 54
    • 0028240799 scopus 로고
    • Selecting the T cell receptor repertoire
    • Bevan, M. J., K. A. Hogquist, and S. C. Jameson. 1994. Selecting the T cell receptor repertoire. Science 264:796.
    • (1994) Science , vol.264 , pp. 796
    • Bevan, M.J.1    Hogquist, K.A.2    Jameson, S.C.3
  • 55
    • 0028839022 scopus 로고
    • Immunological function of a defined T-cell population tolerized to low-affinity self antigens
    • Kawai, K., and P. S. Ohashi. 1995. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 374:68.
    • (1995) Nature , vol.374 , pp. 68
    • Kawai, K.1    Ohashi, P.S.2
  • 56
    • 0024381358 scopus 로고
    • A. nondeletional mechanism of thymic self tolerance
    • Ramsdell, F., T. Lantz, and B. J. Fowlkes. 1989. A. nondeletional mechanism of thymic self tolerance. Science 246:1038.
    • (1989) Science , vol.246 , pp. 1038
    • Ramsdell, F.1    Lantz, T.2    Fowlkes, B.J.3
  • 57
    • 0025320109 scopus 로고
    • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities
    • Roberts, J. L., S. O. Sharrow, and A. Singer. 1990. Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp. Med. 171:935.
    • (1990) J. Exp. Med. , vol.171 , pp. 935
    • Roberts, J.L.1    Sharrow, S.O.2    Singer, A.3
  • 59
    • 0030953630 scopus 로고    scopus 로고
    • Autoimmunity caused by disruption of central T cell tolerance: A murine model of drug-induced lupus
    • In press
    • Kretz-Rommel, A., S. R. Duncan, and R. L. Rubin. 1997. Autoimmunity caused by disruption of central T cell tolerance: a murine model of drug-induced lupus. J. Clin. Invest. In press.
    • (1997) J. Clin. Invest.
    • Kretz-Rommel, A.1    Duncan, S.R.2    Rubin, R.L.3


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