The management of high-risk lymphoblastic leukaemia in children

British Journal of Haematology

Volumn 108, Issue 2, 2000, Pages 204-216

  Chessells, Judith M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bone marrow transplant; Lymphoblastic leukaemia; Prognostic factors

Indexed keywords

ANTILEUKEMIC AGENT; ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; ETOPOSIDE; METHOTREXATE; PREDNISOLONE; THIOACETAZONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AGE; BONE MARROW TRANSPLANTATION; BRAIN RADIATION; CANCER CHEMOTHERAPY; CLINICAL RESEARCH; DRUG INDUCED DISEASE; HIGH RISK PATIENT; HUMAN; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; TREATMENT INDICATION; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; CHILD; CLINICAL TRIALS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; RISK ASSESSMENT; RISK FACTORS;

EID: 0034011225     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01849.x     Document Type: Review

References (103)

1. Amylon, M.D., Shuster, J., Pullen, J., Berard, C., Link, M.P., Wharam, M., Katz, J., Yu., A., Laver, J., Ravindranath, Y., Kurtzberg, J., Desai, S., Camitta, B. & Murphy, S.B. (1999) Intensive high-dose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advanced stage lymphoblastic lymphoma: a Pediatric Oncology Group study. Leukemia, 13, 335-342.
2. Atra, A., Gerrard, M., Hobson, R., Imeson, J.D., Ashley, S. & Pinkerton, C.R. (1998) Improved cure rate in children with B-cell acute lymphoblastic leukaemia (B-ALL) and stage IV B-cell non-Hodgkin's lymphoma (B-NHL) - results of the UKCCSG 9003 protocol. British Journal of Cancer, 77, 2281-2285.
3. Balis, F.M., Lester, C.M., Chrousos, G.P., Heideman, R.L. & Poplack, D.G. (1987) Differences in cerebrospinal fluid penetration of corticosteroids: possible relationship to the preventing of meningeal leukemia. Journal of Clinical Oncology, 5, 202-207.
4. Biggs, J.C., Horowitz, M.M., Gale, R.P., Ash, R.C., Atkinson, K., Helbig, W., Jacobsen, N., Phillips, G.L., Rimm, A.A. & Ringden, O. (1992) Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy. Blood, 80, 1090-1093.
5. Bordigoni, P., Vernant, J.P., Souillet, G., Gluckman, E., Marininchi, D., Milpied, N., Fischer, A., Benz Lemoine, E., Jouet, J.P. & Reiffers, J. (1989) Allogeneic bone marrow transplantation for children with acute lymphoblastic leukemia in first remission: a cooperative study of the Groupe d'Etude de la Greffe de Moelle Osseuse. Journal of Clinical Oncology, 7, 747-753.
6. Bowman, W.P., Shuster, J.J., Cook, B., Griffin, T., Behm, F., Pullen, J., Link, M., Head, D., Carroll, A., Berard, C. & Murphy, S. (1996) Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study. Journal of Clinical Oncology, 14, 1252-1261.
7. Camitta, B., Mahoney, D., Leventhal, B., Lauer, S.J., Shuster, J.J., Adair, S., Civin, C., Munoz, L., Steuber, P., Strother, D. & Komen, B.A. (1994) Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: a Pediatric Oncology Group study. Journal of Clinical Oncology, 12, 1383-1389.
8. Campana, D. & Pui, C.-H. (1995) Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance. Blood, 85, 1416-1434.
9. Cave, H., Van Der Werff ten Bosch, J., Suciu, S., Guildal, C., Waterkeyn, C., Otten, J., Bakkus, M., Thielemans, K., Grandchamp, B. & Vilmer, E. (1998) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. New England Journal of Medicine, 339, 591-598.
10. Cherlow, J.M., Sather, H., Steinherz, P., Gaynon, P., Tubergen, D., Trigg, M., Novak, L. & Bleyer, W.A. (1996) Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group. International Journal of Radiation Oncology and Biological Physics, 36, 19-27.
11. Chessells, J.M. (1986) Acute leukaemia in children. Clinics in Haematology, 15, 727-753.
12. Chessells, J.M., Bailey, C. & Richards, S.M. (1995b) Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Lancet, 345, 143-148.
13. Chessells, J.M., Bailey, C., Wheeler, K. & Richards, S.M. (1992) Bone marrow transplantation for high-risk childhood lymphoblastic leukaemia in first remission: experience in MRC UKALL X. Lancet, 340, 565-568.
14. Chessells, J.M., Eden, O.B., Bailey, C.C., Lilleyman, J.S. & Richards, S.M. (1994) Acute lymphoblastic leukaemia in infancy: experience in MRC UKALL trials. Report from the Medical Research Council Working Party on childhood leukaemia. Leukemia, 8, 1275-1279.
15. Chessells, J.M., Hall, E., Prentice, H.G., Durrant, J., Bailey, C.C. & Richards, S.M. (1998) The impact of age on outcome in lymphoblastic leukaemia; MRC UKALL X and XA compared. A report from the MRC Paediatric and Adult Working Parties. Leukemia, 12, 463-473.
16. Chessells, J.M., Richards, S.M., Bailey, C.C., Lilleyman, J.S. & Eden, O.B. (1995a) Gender and treatment outcome in childhood lymphoblastic leukaemia: report from the MRC UKALL trials. British Journal of Haematology, 89, 364-372.
17. Chessells, J.M., Swansbury, G.J., Reeves, B., Bailey, C.C. & Richards, S.M. (1997) Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X. British Journal of Haematology, 99, 93-100.
18. Conter, V., Arico, M., Valsecchi, M.G., Rizzari, C., Testi, A.M., Messina, C., Mori, P.G., Miniero, R., Colella, R. & Basso, G. (1995) Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munster-based intensive chemotherapy. Journal of Clinical Oncology, 13, 2497-2502.
19. Conter, V., Arico, M., Valsecchi, M.G., Rizzari, C., Testi, A., Miniero, R., Di-Tullio, M.T., Lo, N.L., Pession, A., Rondelli, R., Messina, C., Santoro, N., Mori, P.G., De-Rossi, G., Tamaro, P., Silvestri, D., Biondi, A., Basso, G. & Masera, G. (1998) Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Haematologica, 83, 791-799.
20. Conter, V., Schrappe, M., Arico, M., Reiter, A., Rizzari, C., Dordelmann, M., Valsecchi, M.G., Zimmermann, M., Ludwig, W.-D., Basso, G., Masera, G. & Riehm, H. (1997) Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Journal of Clinical Oncology, 15, 2786-2791.
21. Coustan-Smith, E., Behm, F.G., Sanchez, J., Torrey Sandland, J., Pui, C.-H. & Campana, D. (1998) Immunological detection of minimal residual disease in children with acute lymphoblastic leukaemia. Lancet, 351, 550-554.
22. Crist, W., Carroll, A., Shuster, J., Jackson, J., Head, D., Borowitz, M., Behm, F., Link, M., Steuber, P., Ragab, A., Hirt, A., Brock, B., Land, V. & Pullen, J. (1990) Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A pediatric oncology group study. Blood, 76, 489-494.
23. Crist, W., Shuster, J., Look, T., Borowitz, M., Behm, F., Bowman, P., Frankel, L., Pullen, J., Krance, P., Steuber, P., Camitta, B., Amylon, M., Link, M. & Land, V. (1992) Current results of studies of immunophenotype-, age-and leukocyte-based therapy for children with acute lymphoblastic leukemia. Leukaemia Supplement, 2, 162-166.
24. Donadieu, J., Auclerc, M.F., Baruchel, A., Leblanc, T., Landman, P.J., Perel, Y., Michel, G., Cornu, G., Bordigoni, P., Sommelet, D., Leverger, G., Hill, C. & Schaison, G. (1998) Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: differences in outcome are poorly explained by the most significant prognostic variables. Fralle group. French Acute Lymphoblastic Leukaemia study group. British Journal of Haematology, 102, 729-739.
25. Dordelmann, M., Harbott, J., Reiter, A., Ludwig, W.D., Welte, K., Gotz, N., Gadner, H., Riehm, H. & Schrappe, M. (1999) Prednisolone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood, 94, 1209-1217.
26. Evans, W.E., Relling, M.V., Rodman, J.H., Crom, W.R., Boyett, J.M. & Pui, C.H. (1998) Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. New England Journal of Medicine, 338, 499-505.
27. Fletcher, J.A., Tu, N., Tantravahi, R. & Sallan, S.E. (1992) Extremely poor prognosis of pediatric acute lymphoblastic leukemia with translocation (9;22): updated experience. Leukemia and Lymphoma, 8, 75-79.
28. Frankel, L.S., Ochs, J., Shuster, J.J., Dubowy, R., Bowman, W.P., Hockenberry, E.M., Borowitz, M., Carroll, A.J., Steuber, C.P. & Pullen, D.J. (1997) Therapeutic trial for infant acute lymphoblastic leukemia: the Pediatric Oncology Group experience (POG 8493). Journal of Pediatric and Hematology/Oncology, 19, 35-42.
29. Gajjar, A., Ribeiro, R., Hancock, M.L., Rivera, G.K., Mahmoud, H., Sandlund, J.T., Crist, W.M. & Pui, C.H. (1995) Persistence of circulating blasts after 1 week of multiagent chemotherapy confers a poor prognosis in childhood acute lymphoblastic leukemia. Blood, 86, 1292-1295.
30. Gaynon, P.S., Desai, A.A., Bostrom, B.C., Hutchinson, R.J., Lange, B.J., Nachman, J.B., Reaman, G.H., Sather, H.N., Steinherz, P.G., Trigg, M.E., Tubergen, D.G. & Uckun, F.M. (1997) Early response to therapy and outcome in childhood acute lymphoblastic leukemia. Cancer, 80, 1717-1726.
31. Gaynon, P.S., Steinherz, P.G., Bleyer, W.A., Ablin, A.R., Albo, V.C., Finklestein, J.Z., Grossman, N.J., Novak, L.J., Pyesmany, A.F., Reaman, G.H., Chappell, R.J., Sather, H.N. & Hammond, G.D. (1993) Improved therapy for children with acute lymphoblastic leukemia and unfavourable presenting features: a follow-up report on the Children's Cancer Group Study CCG-106. Journal of Clinical Oncology, 11, 2234-2242.
32. Gustafsson, G., Kreuger, A., Clausen, N., Garwicz, S., Kristinsson, J., Lie, S.O., Moe, P.J., Perkkio, M., Yssing, M. & Saarinen, P.U. (1998) Intensified treatment of acute childhood lymphoblastic leukaemia has improved prognosis, especially in non-high-risk patients: the Nordic experience of 2648 patients diagnosed between 1981 and 1996. Nordic Society of Paediatric Haematology and Oncology (NOPHO). Acta Paediatrica, 87, 1151-1161.
33. Hardisty, R.M. & Till, M.M. (1968) Acute leukaemia 1959-64: factors affecting prognosis. Archives of Diseases of Childhood, 43, 107-115.
34. Harris, M.B., Shuster, J.J., Pullen, D.J., Borowitz, M.J., Carroll, A.J., Behm, F.G. & Land, V.J. (1998) Consolidation therapy with antimetabolite-based therapy in standard-risk acute lymphocytic leukemia of childhood: a Pediatric Oncology Group Study. Journal of Clinical Oncology, 16, 2840-2847.
35. Henze, G., Fengler, R., Reiter, A., Ritter, J. & Riehm, H. (1990) Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic Leukemia. Haematology and Blood Transfusion, 33, 483-488.
36. Hongeng, S., Krance, R.A., Bowman, L.C., Srivastava, D.K., Cunningham, J.M., Horwitz, E.M., Brenner, M.K. & Heslop, H.E. (1997) Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukaemia. Lancet, 350, 767-771.
37. Hutchinson, R.J., Neerhout, R.C., Bertolone, S., Cooper, H.A., Roskos, R., Tannous, R., Wells, L., Heerema, D., Hummell, D., Sailer, S., Sather, H. & Trigg, M. (1996) Should therapy be intensified for patients with good risk ALL? Blood, 88, Suppl. 1, abstract 2662.
38. Janka-Schaub, G., Harms, D., Goebel, U., Graubner, U., Gutjahr, P., Haas, R.J., Juergens, H., Spaar, H.J. & Winkler, K. (1996) Randomized comparison of rotational chemotherapy in high-risk acute lymphoblastic leukaemia of childhood - follow up after 9 years. CoALL Study Group. European Journal of Pediatrics, 155, 640-648.
39. Johansson, B., Moorman, A.V., Haas, O.A., Watmore, A.E., Cheung, K.L., Swanton, S. & Secker, W.L. (1998) Hematologic malignancies with t(4;11) (q21;q23) - a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants. Leukemia, 12, 779-787.
40. Jones, B., Freeman, A.I., Shuster, J.J., Jacquillat, C., Weil, M., Pochedly, C., Sinks, L., Chevalier, L., Maurer, H.M., Koch, K., Falkson, G., Patterson, R., Seligman, B., Sartorius, J., Kung, F., Haurani, F., Stuart, M., Burgert, E.O., Ruymann, F., Sawitsky, A., Forman, E., Hansjuerg, P., Truman, J., Hakami, N., Glidewell, O., Glicksman, A.S. & Holland, J.F. (1991) Lower incidence of meningeal leukaemia when prednisolone is replaced by dexamethasone in the treatment of acute lymphocytic leukaemia. Medical and Pediatric Oncology, 19, 269-275.
41. Kamps, W.A., Bokkerink, J.P.M., Hahlen, K., Hermans, J., Riehm, H., Gadner, H., Schrappe, M., Slater, R., van den Berg-de Ruiter, E., Smets, L.A., De Vaan, G.A.M., Weening, R.S., van Weerden, J.F., van Wering, E.R., van der Does-van den Berg, A. & Veerman, A. J. (1999) Intensive treatment of children with acute lymphoblastic leukemia according to ALL-BFM-86 without cranial radiotherapy: results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-91). Blood, 94, 1226-1236.
42. Kaspers, G.J., Pieters, R., Van-Zantwijk, C.H., Van-Wering, E.R., van der Does-van den Berg, A. & Veerman, A.J. (1998) Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. Blood, 92, 259-266.
43. Land, V.J., Shuster, J.J., Crist, W.M., Ravindranath, Y., Harris, M.B., Krance, R.A., Pinkel, D. & Pullen, D.J. (1994) Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukaemia: a Pediatric Oncology Group study. Journal of Clinical Oncology, 12, 1939-1945.
44. Lange, B., Sather, H., Weetman, R., Bostrom, B., McGuire, P., Rackoff, W., Arthur, D. & Trigg, M. (1997) Double delayed intensification improves outcome in moderate risk pediatric acute lymphoblastic leukemia: a Childrens Cancer Group study, CCG-1891. Blood, 90, Suppl. 1, abstract 2489.
45. Lauer, S.J., Camitta, B.M., Leventhal, B.G., Mahoney, D.H., Shuster, J.J., Adair, S., Casper, J.T., Civin, C.I., Graham, M., Kiefer, G., Pullen, J., Steuber, C.P. & Kamen, B. (1993) Intensive alternating drug pairs for treatment of high-risk childhood acute lymphoblastic leukemia. Cancer, 71, 2854-2861.
46. Leiper, A.D., Stanhope, R., Kitching, P. & Chessells, J.M. (1987) Precocious and premature puberty associated with the treatment of acute lymphoblastic leukaemia. Archives of Diseases of Childhood, 62, 1107-1112.
47. Littman, P., Coccia, P., Bleyer, W.A., Lukens, J., Siegel, S., Miller, D., Sather, H. & Hammond, D.G. (1987) Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL). International Journal of Radiation Oncology and Biological Physics, 13, 1443-1449.
48. Marks, D.I., Bird, J.M., Cornish, J.M., Goulden, N.J., Jones, C.G., Knechtli, C.J.C., Pamphilon, D.H., Steward, C.G. & Oakhill, A. (1998) Unrelated donor bone marrow transplantation for children and adolescents with Philadelphia-positive acute lymphoblastic leukemia. Journal of Clinical Oncology, 16, 931-936.
49. Martinez-Climent, J.A. (1997) Molecular cytogenetics of childhood hematological malignancies. Leukemia, 11, 1999-2021.
50. Mastrangelo, R., Poplack, D.G., Bleyer, W.A., Riccardi, R., Sather, H. & D'Angio, G. (1986) Report and recommendations of the Rome Workshop concerning poor-prognosis acute lymphoblastic leukemia in children: biologic bases for staging, stratification, and treatment. Medical and Pediatric Oncology, 14, 191-194.
51. Mulhern, R.K., Fairclough, D. & Ochs, J. (1991) A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, 24-Gy, or no cranial irradiation. Journal of Clinical Oncology, 9, 1348-1356.
52. Nachman, J., Sather, H.N., Buckley, J.D., Gaynon, P.S., Steinherz, P.G., Tubergen, D.G., Lampkin, B.C. & Denman Hammond, G. (1993) Young adults 16-21 years of age at diagnosis entered on Children's Cancer Group acute lymphoblastic leukemia and acute myeloblastic leukemia protocols. Cancer, 71, 3377-3385.
53. Nachman, J., Sather, H.N., Cherlow, J.M., Sensel, M.G., Gaynon, P.S., Lukens, J.N., Wolff, L. & Trigg, M.E. (1998b) Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group. Journal of Clinical Oncology, 16, 920-930.
54. Nachman, J.B., Sather, H.N., Sensel, M.G., Trigg, M.E., Cherlow, J.M., Lukens, J.N., Wolff, L., Uckun, F.M. & Gaynon, P.S. (1998a) Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. New England Journal of Medicine, 338, 1663-1671.
55. Neglia, J.P., Meadows, A.T., Robison, L.L., Kim, T.H., Newton, W.A., Ruymann, F.B., Sather, H.N. & Hammond, G.D. (1991) Second neoplasms after acute lymphoblastic leukemia in childhood. New England Journal of Medicine, 325, 1330-1336.
56. Niemeyer, C.M., Gelber, R.D., Tarbell, N.J., Donnelly, M., Clavell, L.A., Blattner, S.R., Donahue, K., Cohen, H.J. & Sallan, S.E. (1991) Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update). Blood, 78, 2514-2519.
57. Nysom, K., Holm, K., Lipsitz, S.R., Mone, S.M., Colan, S.D., Orav, E.J., Sallan, S.E., Olsen, J.H., Hertz, H., Jacobsen, J.R. & Lipshultz, S.E. (1998) Relationship between cumulative anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. Journal of Clinical Oncology, 16, 545-550.
58. Oakhill, A., Pamphilon, D.H., Potter, M.N., Steward, C.G., Goodman, S., Green, A., Goulden, P., Goulden, N.J., Hale, G., Waldmann, H. & Cornish, J.M.M. (1996) Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission. British Journal of Haematology, 94, 574-578.
59. Ochs, J., Mulhern, R., Fairclough, D., Parvey, L., Whitaker, J., Ch'ien, L., Mauer, A. & Simone, J. (1991) Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: a prospective study. Journal of Clinical Oncology, 9, 145-151.
60. Patte, C., Michon, J., Frappaz, D., Leverger, G., Rubie, H., Soussain, C. & Pico, J.L. (1994) Therapy of Burkitt and other B-cell acute lymphoblastic leukaemia and lymphoma: experience with the LMB protocols of the SFOP (French Paediatric Oncology Society) in children and adults. Baillieres Clinical Haematology, 7, 339-348.
61. Pieters, R., den-Boer, M.L., Durian, M., Janka, G., Schmiegelow, K., Kaspers, G.J., Van-Wering, E.R. & Veerman, A.J. (1998) Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia - implications for treatment of infants. Leukemia, 12, 1344-1348.
62. Pieters, R., Huismans, D.R., Loonen, A.H., Hahlen, K., van der Does-van den Berg, A., van Wering, E.R. & Veerman, A.J.P. (1991) Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia. Lancet, 338, 399-403.
63. Pirich, L., Haut, P., Morgan, E., Marymount, M. & Kletzel, M. (1999) Total body irradiation, cyclophosphamide, and etoposide with stem cell transplant as treatment for infants with acute lymphocytic leukemia. Medical and Pediatric Oncology, 32, 1-6.
64. Pui, C.H., Boyett, J.M., Relling, M.V., Harrison, P.L., Rivera, G.K., Behm, F.G., Sandlund, J.T., Ribeiro, R.C., Rubnitz, J.E., Gajjar, A. & Evans, W.E. (1999) Sex differences in prognosis for children with acute lymphoblastic leukemia. Journal of Clinical Oncology, 17, 818-824.
65. Pui, C.H., Kane, J.R. & Crist, W.M. (1995a) Biology and treatment of infant leukemias. Leukemia, 9, 762-769.
66. Pui, C.H., Mahmoud, H.H., Rivera, G.K., Hancock, M.L., Sandlund, J.T., Behm, F.G., Head, D.R., Relling, M.V., Ribeiro, R.C., Rubnitz, J.E., Kun, L.E. & Evans, W.E. (1998) Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia. Blood, 92, 411-415.
67. Pui, C.-H., Relling, M.V., Rivera, G.K., Hancock, M.L., Raimondi, S.C., Heslop, H.E., Santana, V.M., Ribeiro, R.C., Sandlund, J.T., Mahmoud, H.H., Evans, W.E., Crist, W.M. & Krance, R.A. (1995b) Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia, 9, 1990-1996.
68. Pullen, J., Boyett, J., Shuster, J., Crist, W., Land, V., Frankel, L., Iyer, R., Backstrom, L., van Eys, J., Harris, M., Ravindranath, Y. & Sullivan, M. (1993) Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study. Journal of Clinical Oncology, 11, 839-849.
69. Reaman, G.H., Sposto, R., Sensel, M.G., Lange, B.J., Feusner, J.H., Heerema, N.A., Leonard, M., Holmes, E.J., Sather, H.N., Pendergrass, T.W., Johnstone, H.S., O'Brien, R.T., Steinherz, P.G., Zeltzer, P.M., Gaynon, P.S., Trigg, M.E. & Uckun, F.M. (1999) Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group. Journal of Clinical Oncology, 17, 445-455.
70. Reiter, A., Ebell, W., Schrappe, M., Harbott, J., Ludwig, W.-D., Klingebiel, T., Zintl, F., Henze, G., Gadner, H., Welte, K. & Riehm, H. (1997) Benefit of intensified consolidation therapy with and without allogeneic BMT for subsets of high risk ALL in trial ALL-BFM 90. Blood, 90: Abstract 997.
71. Reiter, A., Schrappe, M., Ludwig, W.-D., Hiddemann, W., Sauter, S., Henze, G., Zimmermann, M., Lampert, F., Diethammer, D., Odenwald, E., Ritter, J., Mann, G., Welte, K., Gadner, H. & Riehm, H. (1994) Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients, results and conclusions of the multicenter trial ALL-BFM 86. Blood, 84, 3122-3133.
72. Reiter, A., Schrappe, M., Ludwig, W.-D., Lampert, F., Harbott, C., Henze, G., Niemeyer, C.M., Gadner, H., Muller-Weihrich, S., Ritter, J., Odenwald, E. & Rieder, H. (1992) Favorable outcome of B-cell acute lymphoblastic leukemia in childhood: a report of three consecutive studies of the BFM group. Blood, 80, 2471-2478.
73. Ribeiro, R.C., Broniscer, A., Rivera, G.K., Hancock, M.L., Raimondi, S.C., Sandlund, S.C., Crist, W., Evans, W.E. & Pui, C.-H. (1997) Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts. Leukemia, 11, 1493-1496.
74. Richards, S., Burrett, J., Hann, I., Chessells, J., Hill, F. & Bailey, C. (1998a) Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI. Medical Research Council Working Party on Childhood Leukaemia. Leukemia, 12, 1031-1036.
75. Richards, S., Hann, I.M., Hill, F., Gibson, B., Lilleyman, J., Mitchell, C., Kinsey, S. & Eden, O.B. (1998b) A third intensive block of treatment at 35 weeks improves outcome in childhood ALL: preliminary results from the UKALLXI and ALL97 randomised trials. Blood, 92, Suppl. 1, abstract 1645.
76. Riehm, H., Gadner, H., Henze, G., Kornhuber, B., Lampert, F., Niethammer, D., Reiter, A. & Schellong, G. (1990) Results and significance of six randomized trials in four consecutive ALL-BFM studies. Haematology and Blood Transfusion, 33, 439-450.
77. Riehm, H., Langermann, H.J., Gadner, H., Odenwald, E. & Henze, G. (1980) The Berlin Childhood Acute Lymphoblastic Leukemia Therapy Study, 1970-76. American Journal of Pediatric Hematology/Oncology, 2, 299-306.
78. Rivera, G.K., Pui, C.-H., Santana, V.M., Hancock, M.L., Mahmoud, H., Sandlund, J.T., Ribeiro, R.C., Furman, W., Marina, N. & Crist, W.M. (1993) Progress in the treatment of adolescents with acute lymphoblastic leukemia. Cancer, 71, 3400-3405.
79. Rivera, G.K., Raimondi, S.C., Hancock, M.L., Behm, F.G., Pui, C.-H., Abromowitch, M., Mirro, J. Jr, Ochs, J.S., Look, A.T., Williams, D.L., Murphy, S.B., Dahl, G.V., Kalwinsky, D.K., Evans, W.E., Kun, L.E., Simone, J.V. & Crist, W.M. (1991) Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet, 337, 61-66.
80. Saarinen, U.M., Mellander, L., Nysom, K., Ringden, O., Schroeder, H., Glomstein, A. & Gustafsson, G. (1996) Allogeneic bone marrow transplantation in first remission for children with very high-risk acute lymphoblastic leukemia: a retrospective case-control study in the Nordic countries. Nordic Society for Pediatric Hematology and Oncology (NOPHO). Bone Marrow Transplantation, 17, 357-363.
81. Schaison, G., Sommelet, D., Bancillon, A., Perel, Y., Leblanc, T., Bergeron, C., Lejars, O., Baruchel, A., Lepage, E. & Leverger, G. (1992) Treatment of acute lymphoblastic leukemia French protocol Fralle 83-87. Leukemia, 6, 148-152.
82. Schorin, M.A., Blattner, S., Gelber, R.D., Tarbell, N.J., Donnelly, M., Dalton, V., Cohen, H.J. & Sallan, S.E. (1994) Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01. Journal of Clinical Oncology, 12, 740-747.
83. Schrappe, M., Arico, M., Harbott, J., Biondi, A., Zimmermann, M., Conter, V., Reiter, A., Valsecchi, M.G., Gadner, H., Basso, G., Bartram, C.R., Lampert, F., Riehm, H. & Masera, G. (1998a) Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome. Blood, 92, 2730-2741.
84. Schrappe, M., Reiter, A., Henze, G., Niemeyer, C., Bode, U., Kuhl, J., Gadner, H., Havers, W., Pluss, H., Kornhuber, B., Zintl, F., Ritter, J., Urban, C., Niethammer, D. & Riehm, H. (1998b) Prevention of CNS recurrence in childhood ALL: results with reduced radiotherapy combined with CNS-directed chemotherapy in four consecutive ALL-BFM trials. Klinische Padiatrics, 210, 192-199.
85. Schrappe, M., Reiter, A. & Riehm, H. (1996) Cytoreduction and prognosis in childhood acute lymphoblastic leukemia. Journal of Clinical Oncology, 14, 2403-2406.
86. Schrappe, M., Reiter, A., Sauter, S., Gadner, H., Lampert, F., Ritter, J., Pluess, J., Niethammer, D., Havers, W., Doerffel, W., Zimmermann, M. & Welte, K. (1997) Risk-oriented treatment of childhood ALL: favorable outcome despite reduced intensity of treatment in trial ALL-BFM 90. Blood, 90 (Suppl. 1), abstract 2488.
87. Shuster, J.J., Wacker, P., Pullen, J., Humbert, J., Land, V.J., Mahoney, D.H.J., Lauer, S., Look, A.T., Borowitz, M.J., Carroll, A.J. & Camitta, B. (1998) Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group study. Journal of Clinical Oncology, 16, 2854-2863.
88. Sierra, J., Radich, J., Hansen, J.A., Martin, P.J., Petersdorf, E.W., Bjerke, J., Bryant, E., Nash, R.A., Sanders, J.E., Storb, R., Sullivan, K.M., Appelbaum, F.A. & Anasetti, C. (1997) Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 90, 1410-1414.
89. Silverman, L.B., McLean, T.W., Gelber, R.D., Donnelly, M.J., Gilliland, D.G., Tarbell, N.J. & Sallan, S.E. (1997) Intensified therapy for infants with acute lymphoblastic leukemia: results from the Dana-Farber Cancer Institute Consortium. Cancer, 80, 2285-2295.
90. Silverman, L.B., Gelber, R.D., Young, M.L., Dalton, V.K., Barr, R.D. & Sallan, S.E. (1999) Induction failure in acute lymphoblastic leukemia of childhood. Cancer, 85, 1395-1404.
91. Smith, M., Arthur, D., Camitta, B., Carroll, A.J., Crist, W., Gaynon, P., Gelber, R., Heerema, N., Korn, E.L., Link, M., Murphy, S., Pui, C.H., Pullen, J., Reamon, G., Sallan, S.E., Sather, H., Shuster, J., Simon, R., Trigg, M., Tubergen, D., Uckun, F. & Ungerleider, R. (1996) Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Journal of Clinical Oncology, 14, 18-24.
92. Sorensen, K., Levitt, G., Bull, C., Chessells, J.M. & Sullivan, I. (1997) Anthracycline dose in childhood acute lymphoblastic leukemia: issues of early survival versus late cardiotoxicity. Journal of Clinical Oncology, 15, 61-68.
93. Steinherz, P.G., Gaynon, P.S., Breneman, J.C., Cherlow, J.M., Grossman, N.J., Kersey, J.H., Johnstone, H.S., Sather, H.N., Trigg, M.E., Uckun, F.M. & Bleyer, W.A. (1998) Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: randomized controlled trial from the Children's Cancer Group. Cancer, 82, 600-612.
94. Thyss, A., Suciu, S., Bertrand, Y., Mazingue, F., Robert, A., Vilmer, E., Mechinaud, F., Benoit, Y., Brock, P., Ferster, A., Lutz, P., Boutard, P., Marguerite, G., Plouvier, E., Michel, G., Plantaz, D., Munzer, M., Rialland, X., Chantraine, J.M., Norton, L., Solbu, G., Philippe, N. & Otten, J. (1997) Systemic effect of intrathecal methotrexate during the initial phase of treatment of childhood acute lymphoblastic leukemia. The European Organization for Research and Treatment of Cancer Children's Leukemia Cooperative Group. Journal of Clinical Oncology, 15, 1824-1830.
95. Tubergen, D.G., Gilchrist, G.S., O'Brien, R.T., Coccia, P.F., Sather, H.N., Waskerwitz, M.J. & Denman Hammond, G. (1993a) Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial. Journal of Clinical Oncology, 11, 527-537.
96. Tubergen, D.G., Gilchrist, G.S., O'Brien, R.T., Coccia, P.F., Sather, H.N., Waskerwitz, M.J. & Denman Hammond, G. (1993b) Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: a Children's Cancer Group Report. Journal of Clinical Oncology, 11, 520-526.
97. Uckun, F.M., Nachman, J.B., Sather, H.N., Sensel, M.G., Kraft, P., Steinherz, P.G., Lange, B., Hutchinson, R., Reaman, G.H., Gaynon, P.S. & Heerema, N.A. (1998) Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group. Cancer, 83, 2030-2039.
98. Uckun, F.M., Reaman, G., Steinherez, P.G., Arthur, D.C., Sather, H., Trigg, M., Tubergen, D. & Gaynon, P. (1996) Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study. Leukemia and Lymphoma, 24, 57-70.
99. Uderzo, C., Valsecchi, M.G., Balduzzi, A., Dini, G., Miniero, R., Locatelli, F., Rondelli, R., Pession, A., Arcese, W., Bacigalupo, A., Polchi, P., Andolina, M., Messina, C., Conter, V., Arico, M., Galimberti, S. & Masera, G. (1997) Allogeneic bone marrow transplantation versus chemotherapy in high-risk childhood acute lymphoblastic leukaemia in first remission. British Journal of Haematology, 96, 387-394.
100. van-Dongen, J.J., Seriu, T., Panzer, G.E., Biondi, A., Pongers, W.M., Corral, L., Stolz, F., Schrappe, M., Masera, G., Kamps, W.A., Gadner, H., Van-Wering, E.R., Ludwig, W.D., Basso, G., de-Bruijn, M.A., Cazzaniga, G., Hettinger, K., Van-Der-Does-Van-Den-Berg, A., Hop, W.C., Riehm, H. & Bartram, C.R. (1998) Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet, 352, 1731-1738.
101. van Eys, J., Berry, D., Crist, W., Doering, E., Fernbach, D., Pullen, J., Shuster, J. & Wharam, M. (1989) A comparison of two regimens for high-risk acute lymphocytic leukemia in childhood. A Paediatric Oncology Group study. Cancer, 63, 23-29.
102. Wheeler, K., Richards, S., Bailey, C., Gibson, B., Hann, I.M., Hill, F. & Chessells, J.M. (1998) Comparison of bone marrow transplantation with chemotherapy for high risk childhood acute lymphoblastic leukaemia in first remission. Blood, 92: abstract 1317.
103. Zecca, M., Pession, A., Messina, C., Bonetti, F., Favre, C., Prete, A., Cesaro, S., Porta, F., Mazzarino, I., Giorgiani, G., Rondelli, R. & Locatelli, F. (1999) Total body irradiation, thiotepa, and cyclophosphamide as a conditioning regimen for children with acute lymphoblastic leukemia in first or second remission undergoing bone marrow transplantation with HLA-Identical siblings. Journal of Clinical Oncology, 17, 1838-1846.