메뉴 건너뛰기




Volumn 11, Issue 2, 2000, Pages 141-147

Endothelial lipase: A new member of the triglyceride lipase gene family

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LIPASE; LIPOPROTEIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

EID: 0034007631     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200004000-00006     Document Type: Review
Times cited : (91)

References (47)
  • 1
    • 0032901331 scopus 로고    scopus 로고
    • A novel endothelial-derived lipase that modulates HDL metabolism
    • 1 Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, et al. A novel endothelial-derived lipase that modulates HDL metabolism. Nature Genet 1999; 21:424-428. This paper was the first report of the discovery of EL and its homology to other members of the triglyceride lipase gene family. It reported the expression of EL messenger RNA and protein by cultured endothelial cells and the different pattern of tissue expression of EL compared with LPL. The production of two major EL protein bands, 68 and 40 kDa, by endothelial cells was noted. In addition, this paper provided in-vivo evidence for the concept the EL can influence lipoprotein metabolism. Overexpression of EL in mice resulted in marked reduction in HDL-cholesterol and apolipoprotein A-I levels and modest reduction in non-HDL-cholesterol levels.
    • (1999) Nature Genet , vol.21 , pp. 424-428
    • Jaye, M.1    Lynch, K.J.2    Krawiec, J.3    Marchadier, D.4    Maugeais, C.5    Doan, K.6
  • 2
    • 0033553565 scopus 로고    scopus 로고
    • Cloning of a unique lipase from endothelial cells extends the lipase gene family
    • 2 Hirata K, Diechek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, et al. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 1999; 274:14170-14175. This paper independently reported the discovery of EL, which was found using subtractive suppression hybridization to isolate genes preferentially expressed in HUVECs undergoing tube formation compared with monolayers. Both the human and murine EL sequences were reported. A variety of human and mouse cell lines, as well as human and mouse embryonic and adult tissues were tested for their ability to express EL messenger RNA. In-situ hybridization indicated EL expression in placenta, lung, corpus luteum of the ovary, and liver.
    • (1999) J Biol Chem , vol.274 , pp. 14170-14175
    • Hirata, K.1    Diechek, H.L.2    Cioffi, J.A.3    Choi, S.Y.4    Leeper, N.J.5    Quintana, L.6
  • 3
    • 0030056398 scopus 로고    scopus 로고
    • Molecular pathobiology of the human lipoprotein lipase gene
    • 3 Murthy V, Julien P, Gagne C. Molecular pathobiology of the human lipoprotein lipase gene. Pharmacol Ther 1996; 70:101-135.
    • (1996) Pharmacol Ther , vol.70 , pp. 101-135
    • Murthy, V.1    Julien, P.2    Gagne, C.3
  • 4
    • 0031019017 scopus 로고    scopus 로고
    • Serine phospholipid-specific phospholipase A that is secreted from activated platelets
    • 4 Sato T, Aok J, Nagai Y, Dohmae N, Takio K, Doi T, et al. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. J Biol Chem 1997; 272:2192-2198.
    • (1997) J Biol Chem , vol.272 , pp. 2192-2198
    • Sato, T.1    Aok, J.2    Nagai, Y.3    Dohmae, N.4    Takio, K.5    Doi, T.6
  • 5
    • 0031037217 scopus 로고    scopus 로고
    • nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases
    • 5 van Groningen JJ, Egmond MR, Bloemers HP, Swart QW. nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases. FEBS Let 1997; 404:82-86.
    • (1997) FEBS Let , vol.404 , pp. 82-86
    • Van Groningen, J.J.1    Egmond, M.R.2    Bloemers, H.P.3    Swart, Q.W.4
  • 6
    • 0033574428 scopus 로고    scopus 로고
    • An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans
    • 6 Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H, Inoue K. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. J Biol Chem 1999; 274:11053-11059.
    • (1999) J Biol Chem , vol.274 , pp. 11053-11059
    • Nagai, Y.1    Aoki, J.2    Sato, T.3    Amano, K.4    Matsuda, Y.5    Arai, H.6    Inoue, K.7
  • 8
    • 0026687923 scopus 로고
    • Structure of the pancreatic lipase-procolipase complex
    • 8 van Tilbeurgh H, Sarda L, Verger R, Cambillau C. Structure of the pancreatic lipase-procolipase complex. Nature 1992; 359:159-162.
    • (1992) Nature , vol.359 , pp. 159-162
    • Van Tilbeurgh, H.1    Sarda, L.2    Verger, R.3    Cambillau, C.4
  • 12
    • 0030951329 scopus 로고    scopus 로고
    • A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipase
    • 12 Wong H, Yang D, Hill JS, Davis RC, Nikazy J, Schotz MC. A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipase. Proc Natl Acad Sci USA 1997; 94:5594-5598.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5594-5598
    • Wong, H.1    Yang, D.2    Hill, J.S.3    Davis, R.C.4    Nikazy, J.5    Schotz, M.C.6
  • 13
    • 0027401019 scopus 로고
    • Chymotryptic cleavage of lipoprotein lipase. Identification of cleavage sites and functional studies of the truncated molecule
    • 13 Lookene A, Bengtsson-Olivecrona G. Chymotryptic cleavage of lipoprotein lipase. Identification of cleavage sites and functional studies of the truncated molecule. Eur J Biochem 1993; 213:185-194.
    • (1993) Eur J Biochem , vol.213 , pp. 185-194
    • Lookene, A.1    Bengtsson-Olivecrona, G.2
  • 14
    • 0028556785 scopus 로고
    • Lipoprotein lipase deficiency due to a 3′ splice site mutation in intron 6 of the lipoprotein lipase gene
    • 14 Holzl B, Huber R, Paulweber B, Patsch JR, Sandhofer F. Lipoprotein lipase deficiency due to a 3′ splice site mutation in intron 6 of the lipoprotein lipase gene. J Lipid Res 1994; 35:2161-2169.
    • (1994) J Lipid Res , vol.35 , pp. 2161-2169
    • Holzl, B.1    Huber, R.2    Paulweber, B.3    Patsch, J.R.4    Sandhofer, F.5
  • 15
    • 0028875755 scopus 로고
    • Human hepatic and lipoprotein lipase: The loop covering the catalytic site mediates lipase substrate specificity
    • 15 Dugi KA, Dichek HL, Santamarina-Fojo S. Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity. J Biol Chem 1995; 270:25396-25401.
    • (1995) J Biol Chem , vol.270 , pp. 25396-25401
    • Dugi, K.A.1    Dichek, H.L.2    Santamarina-Fojo, S.3
  • 17
    • 0026667238 scopus 로고
    • Genetic dyslipoproteinemias: Role of lipoprotein lipase and apolipoprotein C-II
    • 17 Santamarina-Fojo S. Genetic dyslipoproteinemias: role of lipoprotein lipase and apolipoprotein C-II. Curr Opin Lipidol 1992; 3:186-195.
    • (1992) Curr Opin Lipidol , vol.3 , pp. 186-195
    • Santamarina-Fojo, S.1
  • 18
    • 0029079312 scopus 로고
    • COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity
    • 18 Coleman T, Seip RL, Gimble JM, Lee D, Maeda N, Semenkovich CF. COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity. J Biol Chem 1995; 270:12518-12525.
    • (1995) J Biol Chem , vol.270 , pp. 12518-12525
    • Coleman, T.1    Seip, R.L.2    Gimble, J.M.3    Lee, D.4    Maeda, N.5    Semenkovich, C.F.6
  • 19
    • 0028819754 scopus 로고
    • Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice
    • 19 Weinstock PH, Bisgaier CL, Aalto-Setala K, Radner H, Ramakrishnan R, Levak-Frank S, et al. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. J Clin Invest 1995; 96:2555-2568.
    • (1995) J Clin Invest , vol.96 , pp. 2555-2568
    • Weinstock, P.H.1    Bisgaier, C.L.2    Aalto-Setala, K.3    Radner, H.4    Ramakrishnan, R.5    Levak-Frank, S.6
  • 20
    • 0030745465 scopus 로고    scopus 로고
    • Lipoprotein lipase gene variants and risk of coronary disease: A quantitative analysis of population-based studies
    • 20 Hokanson JE. Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies. Int J Clin Lab Res 1997; 27:24-34.
    • (1997) Int J Clin Lab Res , vol.27 , pp. 24-34
    • Hokanson, J.E.1
  • 21
    • 0027220709 scopus 로고
    • Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol
    • 21 Blades B, Vega GL, Grundy SM. Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thromb Vasc Biol 1993; 13:1227-1235.
    • (1993) Arterioscler Thromb Vasc Biol , vol.13 , pp. 1227-1235
    • Blades, B.1    Vega, G.L.2    Grundy, S.M.3
  • 22
    • 14444272749 scopus 로고    scopus 로고
    • Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: Modulation by cholesteryl ester transfer protein and dietary status
    • 22 Clee SM, Zhang H, Bissada N, Miao L, Ehrenborg E, Benlian P, et al. Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status. J Lipid Res 1997; 38:2079-2089.
    • (1997) J Lipid Res , vol.38 , pp. 2079-2089
    • Clee, S.M.1    Zhang, H.2    Bissada, N.3    Miao, L.4    Ehrenborg, E.5    Benlian, P.6
  • 23
    • 0030757251 scopus 로고    scopus 로고
    • Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma
    • 23 Levak-Frank S, Weinstock PH, Hayek T, Verdery R, Hofmann W, Ramakrishnan R, et al. Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. J Biol Chem 1997; 272:17182-17190.
    • (1997) J Biol Chem , vol.272 , pp. 17182-17190
    • Levak-Frank, S.1    Weinstock, P.H.2    Hayek, T.3    Verdery, R.4    Hofmann, W.5    Ramakrishnan, R.6
  • 24
    • 0033021140 scopus 로고    scopus 로고
    • Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels
    • 24 Levak-Frank S, Hofmann W, Weinstock PH, Radner H, Sattler W, Breslow J, Zechner R. Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. Proc Natl Acad Sci USA 1999; 96:3165-3170.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3165-3170
    • Levak-Frank, S.1    Hofmann, W.2    Weinstock, P.H.3    Radner, H.4    Sattler, W.5    Breslow, J.6    Zechner, R.7
  • 25
    • 0029920693 scopus 로고    scopus 로고
    • Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
    • 25 Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 1996; 37:693-707.
    • (1996) J Lipid Res , vol.37 , pp. 693-707
    • Goldberg, I.J.1
  • 26
    • 0032506219 scopus 로고    scopus 로고
    • Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: Direct evidence that lipoprotein lipase bridging occurs in vivo
    • 26 Merkel M, Kako Y, Radner H, Cho IS, Ramasamy R, Brunzell JD, et al. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci USA 1998; 95:13841-13846. This paper provided the first in-vivo evidence that catalytically inactive LPL can mediate lipoprotein uptake, presumably through a bridging effect.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13841-13846
    • Merkel, M.1    Kako, Y.2    Radner, H.3    Cho, I.S.4    Ramasamy, R.5    Brunzell, J.D.6
  • 27
    • 0031748544 scopus 로고    scopus 로고
    • The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
    • 27 Santamarina-Fojo S, Haudenschild C, Amar M. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 1998; 9:211-219.
    • (1998) Curr Opin Lipidol , vol.9 , pp. 211-219
    • Santamarina-Fojo, S.1    Haudenschild, C.2    Amar, M.3
  • 28
    • 0030922572 scopus 로고    scopus 로고
    • Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice
    • 28 Mezdour H, Jones R, Dengremont C, Castro G, Maeda N. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 1997; 272:13570-13575.
    • (1997) J Biol Chem , vol.272 , pp. 13570-13575
    • Mezdour, H.1    Jones, R.2    Dengremont, C.3    Castro, G.4    Maeda, N.5
  • 30
    • 0028305225 scopus 로고
    • Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice
    • 30 Busch SJ, Barnhart RL, Martin GA, Fitzgerald MD, Yates MT, Mao SJ, et al. Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J Biol Chem 1994; 269:16376-16382.
    • (1994) J Biol Chem , vol.269 , pp. 16376-16382
    • Busch, S.J.1    Barnhart, R.L.2    Martin, G.A.3    Fitzgerald, M.D.4    Yates, M.T.5    Mao, S.J.6
  • 32
    • 0028144804 scopus 로고
    • Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins
    • 32 Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JT. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci USA 1994; 91:8724-8728.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8724-8728
    • Fan, J.1    Wang, J.2    Bensadoun, A.3    Lauer, S.J.4    Dang, Q.5    Mahley, R.W.6    Taylor, J.T.7
  • 33
    • 0345643332 scopus 로고    scopus 로고
    • Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females
    • 33 De Oliveira E, Silva ER, Kong M, Han Z, Starr C, Kass EM, Juo SH, et al. Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. J Lipid Res 1999; 40:1211-1221. This paper described HDL metabolic studies in 36 normolipidemic females on a low-fat metabolic diet. Postheparin plasma HL activity (determined in part by HL genotype) was a determinant of HDL size, which in turn influenced apolipoprotein A-I catabolic rate and HDL-cholesterol levels. These results support the concept that variation at the HL locus influences HDL metabolism and therefore plasma levels.
    • (1999) J Lipid Res , vol.40 , pp. 1211-1221
    • De Oliveira, E.1    Silva, E.R.2    Kong, M.3    Han, Z.4    Starr, C.5    Kass, E.M.6    Juo, S.H.7
  • 34
    • 0032839019 scopus 로고    scopus 로고
    • Hepatic lipase: New insights from genetic and metabolic studies
    • 34 Cohen JC, Vega GL, Grundy SM. Hepatic lipase: new insights from genetic and metabolic studies. Curr Opin Lipidol 1999; 10:259-267.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 259-267
    • Cohen, J.C.1    Vega, G.L.2    Grundy, S.M.3
  • 35
    • 0031007874 scopus 로고    scopus 로고
    • The tissue-specific expression of lipoprotein lipase: Implications for energy and lipoprotein metabolism
    • 35 Zechner R. The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism. Curr Opin Lipidol 1997; 8:77-88.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 77-88
    • Zechner, R.1
  • 36
    • 0030931962 scopus 로고    scopus 로고
    • Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase
    • 36 Weinstock PH, Levak-Frank S, Hudgins LC, Radner H, Friedman JM, Zechner R, Breslow JL. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci USA 1997; 94:10261-10266.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10261-10266
    • Weinstock, P.H.1    Levak-Frank, S.2    Hudgins, L.C.3    Radner, H.4    Friedman, J.M.5    Zechner, R.6    Breslow, J.L.7
  • 38
    • 0030843662 scopus 로고    scopus 로고
    • Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium
    • 38 Yin B, Loike JD, Kako Y, Weinstock PH, Breslow JL, Silverstein SC, Goldberg IJ. Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium. J Clin Invest 1997; 100:649-657.
    • (1997) J Clin Invest , vol.100 , pp. 649-657
    • Yin, B.1    Loike, J.D.2    Kako, Y.3    Weinstock, P.H.4    Breslow, J.L.5    Silverstein, S.C.6    Goldberg, I.J.7
  • 39
    • 0031957128 scopus 로고    scopus 로고
    • Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    • 39 Calvo D, Gomez-Coronado D, Suarez Y, Lasuncion MA, Vega MA. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res 1998; 39:777-788.
    • (1998) J Lipid Res , vol.39 , pp. 777-788
    • Calvo, D.1    Gomez-Coronado, D.2    Suarez, Y.3    Lasuncion, M.A.4    Vega, M.A.5
  • 40
    • 0032958470 scopus 로고    scopus 로고
    • Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    • 40 Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nature Genet 1999; 21:76-83.
    • (1999) Nature Genet , vol.21 , pp. 76-83
    • Aitman, T.J.1    Glazier, A.M.2    Wallace, C.A.3    Cooper, L.D.4    Norsworthy, P.J.5    Wahid, F.N.6
  • 41
    • 0033516477 scopus 로고    scopus 로고
    • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    • 41 Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999; 274:19055-19062. This first report of the phenotype of CD36 knockout mice has potential implications for the role of CD36 in fatty acid transport and lipoprotein metabolism. Adipocytes from CD36-null mice were shown to lack the high affinity saturable component of long-chain fatty acid transport. Interestingly, HDL-cholesterol levels were higher in CD36-null mice, which is consistent with a potential role of CD36 in HDL metabolism.
    • (1999) J Biol Chem , vol.274 , pp. 19055-19062
    • Febbraio, M.1    Abumrad, N.A.2    Hajjar, D.P.3    Sharma, K.4    Cheng, W.5    Pearce, S.F.6    Silverstein, R.L.7
  • 42
    • 0030002205 scopus 로고    scopus 로고
    • Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase
    • 42 Shimada M, Ishibashi S, Inaba T, Yagyu H, Harada K, Osuga JI, et al. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci USA 1996; 93:7242-7246.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7242-7246
    • Shimada, M.1    Ishibashi, S.2    Inaba, T.3    Yagyu, H.4    Harada, K.5    Osuga, J.I.6
  • 43
    • 0032847139 scopus 로고    scopus 로고
    • Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice
    • 43 Yagyu H, Ishibashi S, Chen Z, Osuga J, Okazaki M, Perrey S, et al. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 1999; 40:1677-1685. Transgenic mice expressing LPL ubiquitously, but primarily in skeletal muscle and adipose tissue, exhibited significantly reduced atherosclerosis when they were crossed with apolipoprotein E-deficient mice, confirming the concept that systemic LPL expression is antiatherogenic.
    • (1999) J Lipid Res , vol.40 , pp. 1677-1685
    • Yagyu, H.1    Ishibashi, S.2    Chen, Z.3    Osuga, J.4    Okazaki, M.5    Perrey, S.6
  • 44
    • 0027260912 scopus 로고
    • The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis
    • 44 Tsutsumi K, Inoue Y, Shima A, Iwasaki K, Kawamura M, Murase T. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. J Clin Invest 1993; 92:411-417.
    • (1993) J Clin Invest , vol.92 , pp. 411-417
    • Tsutsumi, K.1    Inoue, Y.2    Shima, A.3    Iwasaki, K.4    Kawamura, M.5    Murase, T.6
  • 45
    • 0030967395 scopus 로고    scopus 로고
    • Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products
    • 45 Rutledge JC, Woo MM, Rezai AA, Curtiss LK, Goldberg IJ. Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products. Circ Res 1997; 80:819-828.
    • (1997) Circ Res , vol.80 , pp. 819-828
    • Rutledge, J.C.1    Woo, M.M.2    Rezai, A.A.3    Curtiss, L.K.4    Goldberg, I.J.5
  • 46
    • 0026604386 scopus 로고
    • Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix
    • 46 Saxena U, Klein MG, Vanni TM, Goldberg IJ. Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix. J Clin Invest 1992; 89:373-380.
    • (1992) J Clin Invest , vol.89 , pp. 373-380
    • Saxena, U.1    Klein, M.G.2    Vanni, T.M.3    Goldberg, I.J.4
  • 47
    • 0032746178 scopus 로고    scopus 로고
    • Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
    • +′+) mice, and were then fed an atherogenic diet. Mice that received the LPL ′ fetal liver cells had significantly less atherosclerosis than the other two groups, suggesting that macrophage LPL expression may be proatherogenic.
    • (1999) J Clin Invest , vol.103 , pp. 1697-1705
    • Babaev, V.R.1    Fazio, S.2    Gleaves, L.A.3    Carter, K.J.4    Semenkovich, C.F.5    Linton, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.