A cautionary note: The actions of adenosine agonists and antagonists may be reversed under certain conditions in primary cultures

Brain Research Bulletin

Volumn 51, Issue 4, 2000, Pages 307-312

  Brooke, Sheila M ^a   Sapolsky, Robert M ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

2 chloroadenosine; 8 phenyltheophylline; Glutamate; Kainic acid; Neurotoxicity

Indexed keywords

2 CHLOROADENOSINE; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; GLUTAMIC ACID; KAINIC ACID;

ANIMAL CELL; ARTICLE; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FETUS; HIPPOCAMPUS; LONG TERM EXPOSURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PH; PRIORITY JOURNAL; RAT;

2-CHLOROADENOSINE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; RATS; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; TIME FACTORS;

EID: 0033998574     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(99)00238-5     Document Type: Article

References (45)

1. Abbracchio M.P., Ceruti S., Barbieri D., Franceschi C., Malorni W., Biondo L., Burnstock G., Cattabeni F. A novel action for adenosine Apoptosis of astroglial cells in rat brain primary cultures . Biochem. Biophys. Res. Commun. 213:1995;908-915.
2. Abbracchio M.P., Ceruti S., Brambilla R., Franceschi C., Malorni W., Jacobson K.A., von Lubitz D.K., Cattabeni F. Modulation of apoptosis by adenosine in the central nervous system A possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders . Ann. N.Y. Acad. Sci. 825:1997;11-22.
3. Abbracchio M.P., Fogliatto G., Paoletti A.M., Rovati G.E., Cattabeni F. Prolonged in vitro exposure of rat brain slices to adenosine analogues Selective desensitization of adenosine A1 but not A2 receptors . Eur. J. Pharmacol. 227:1992;317-324.
4. Askalan R., Richardson P.J. Role of histidine residues in the adenosine A2a receptor ligand binding site. J. Neurochem. 63:1994;1477-1484.
5. Banker G., Goslin K. Culturing nerve cells. 1991;MIT Press, Cambridge, MA.
6. Barnes E.M. Jr, Thampy K.G. Subclasses of adenosine receptors in brain membranes from adult tissue and from primary cultures of chick embryo. J. Neurochem. 39:1982;647-652.
7. Brooke S., Chan R., Howard S., Sapolsky R. Endocrine modulation of the neurotoxicity of gp120 Implications for AIDS-related dementia complex . PNAS. 94:1995;9457-9462.
8. Brooke S.M., Bliss T.M., Franklin L.R., Sapolsky R.M. Quantification of neuron survival in monolayer cultures using an enzyme-linked immunosorbent assay approach, rather than by cell counting. Neurosci. Lett. 267:1999;21-24. [In Process Citation].
9. Burke S.P., Nadler J.V. Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area Effects of adenosine and baclofen . J. Neurochem. 51:1988;1541-1551.
10. Correia-de-Sa P., Ribeiro J.A. Adenosine uptake and deamination regulate tonic A2a receptor facilitation of evoked [3H]acetylcholine release from the rat motor nerve terminals. Neuroscience. 73:1996;85-92.
11. Correia-de-Sa P., Timoteo M.A., Ribeiro J.A. Presynaptic A1 inhibitory/A2A facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm. J. Neurophysiol. 76:1996;3910-3919.
12. Corsi C., Pazzagli M., Bianchi L., Della Corte L., Pepeu G., Pedata F. In vivo amino acid release from the striatum of aging rats Adenosine modulation . Neurobiol. Aging. 18:1997;243-250.
13. Cunha R.A., Johansson B., van der Ploeg I., Sebastiao A.M., Ribeiro J.A., Fredholm B.B. Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Res. 649:1994;208-216.
14. Cunha R.A., Milusheva E., Vizi E.S., Ribeiro J.A., Sebastiao A.M. Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus. J. Neurochem. 63:1994;207-214.
15. Cunha R.A., Vizi E.S., Ribeiro J.A., Sebastiao A.M. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J. Neurochem. 67:1996;2180-2187.
16. de Mendonca A., Ribeiro J.A. Adenosine inhibits the NMDA receptor-mediated excitatory postsynaptic potential in the hippocampus. Brain Res. 606:1993;351-356.
17. Dixon A.K., Widdowson L., Richardson P.J. Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum. J. Neurochem. 69:1997;315-321.
18. Dolphin A.C., Archer E.R. An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus. Neurosci. Lett. 43:1983;49-54.
19. Dunwiddie T.V. The physiological role of adenosine in the central nervous system. Int. Rev. Neurobiol. 27:1985;63-139.
20. Dunwiddie T.V., Diao L., Kim H.O., Jiang J.L., Jacobson K.A. Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. J. Neurosci. 17:1997;607-614.
21. Fredholm B.B., Dunwiddie T.V. How does adenosine inhibit transmitter release? Trends Pharmacol. Sci. 9:1988;130-134.
22. 2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neurosci. Lett. 238:1997;73-77.
23. Heron A., Lasbennes F., Seylaz J. Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization. Brain Res. 608:1993;27-32.
24. Heron A., Lekieffre D., Le Peillet E., Lasbennes F., Seylaz J., Plotkine M., Boulu R.G. Effects of an A1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia. Brain Res. 641:1994;217-224.
25. Hettinger B.D., Leid M., Murray T.F. Cyclopentyladenosine-induced homologous down-regulation of A1 adenosine receptors (A1AR) in intact neurons is accompanied by receptor sequestration but not a reduction in A1AR mRNA expression or G protein alpha-subunit content. J. Neurochem. 71:1998;221-230.
26. Hettinger-Smith B.D., Leid M., Murray T.F. Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells. J. Neurochem. 67:1996;1921-1930.
27. Janigro D., Wender R., Ransom G., Tinklepaugh D.L., Winn H.R. Adenosine-induced release of nitric oxide from cortical astrocytes. Neuroreport. 7:1996;1640-1644.
28. Jones P.A., Smith R.A., Stone T.W. Protection against hippocampal kainate excitotoxicity by intracerebral administration of an adenosine A2A receptor antagonist. Brain Res. 800:1998;328-335.
29. Lloyd H.G., Lindstrom K., Fredholm B.B. Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem. Int. 23:1993;173-185.
30. Mitchell, H. L.; Frisella, W. A.; Brooker, R. W.; Yoon, K. W. Attenuation of traumatic cell death by an adenosine A1 agonist in rat hippocampal cells. Neurosurgery 36:1003-1007; 1995 [discussion: 1007-1008].
31. Monopoli A., Lozza G., Forlani A., Mattavelli A., Ongini E. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport. 9:1998;3955-3959.
32. Nantwi, K.; Goshgarian, H. The actions of theophylline and 8-phenyltheophylline in mediating functional resititution after cervical spinal cord injury. Soc. Neurosci. Abstr. 24:289.2; 1998.
33. Navarro A., Zapata R., Canela E.I., Mallol J., Lluis C., Franco R. Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line. Brain Res. 816:1999;47-57.
34. Pedata F., Giovannelli L., De Sarno P., Pepeu G. Effect of adenosine, adenosine derivatives, and caffeine on acetylcholine release from brain synaptosomes Interaction with muscarinic autoregulatory mechanisms . J. Neurochem. 46:1986;1593-1598.
35. Pedata F., Latini S., Pugliese A.M., Pepeu G. Investigations into the adenosine outflow from hippocampal slices evoked by ischemia-like conditions. J. Neurochem. 61:1993;284-289.
36. Phillis J.W. The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Res. 705:1995;79-84.
37. Poulsen S.A., Quinn R.J. Adenosine receptors New opportunities for future drugs . Bioorg. Med. Chem. 6:1998;619-641.
38. Rudolphi K.A., Schubert P., Parkinson F.E., Fredholm B.B. Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol. Sci. 13:1992;439-445.
39. Sebastiao A.M., Ribeiro J.A. Adenosine A2 receptor-mediated excitatory actions on the nervous system. Prog. Neurobiol. 48:1996;167-189.
40. Simpson R.E., O'Regan M.H., Perkins L.M., Phillis J.W. Excitatory transmitter amino acid release from the ischemic rat cerebral cortex Effects of adenosine receptor agonists and antagonists . J. Neurochem. 58:1992;1683-1690.
41. Sweeney M.I. Neuroprotective effects of adenosine in cerebral ischemia Window of opportunity . Neurosci. Behav. Rev. 21:1997;207-247.
42. Vendite D., Sanz J.M., Lopez-Alanon D.M., Vacas J., Andres A., Ros M. Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells. Neurochem. Res. 23:1998;211-218.
43. Von Lubitz D.K., Lin R.C., Melman N., Ji X.D., Carter M.F., Jacobson K.A. Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia. Eur. J. Pharmacol. 256:1994;161-167.
44. Williams M. Adenosine receptor agonists and antagonists. Stone T. Adenosine in the nervous system. 1991;136-169 Academic Press Ltd, London/San Diego.
45. Zhou J.G., Meno J.R., Hsu S.S., Winn H.R. Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia A histopathologic study in the rat . J. Cereb. Blood Flow Metab. 14:1994;166-173.