In vitro analysis of transformation potential associated with retroviral vector insertions

Human Gene Therapy

Volumn 10, Issue 13, 1999, Pages 2123-2132

  Powell, Sharon K ^a   Kaloss, Michele ^a   Burimski, Irina ^a   Weaver, Linda ^a   Long, Zhifeng ^a   Lyons, Russette ^a   McGarrity, Gerard J ^a   Otto, Edward ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

ARTICLE; CANCER RISK; CARCINOGENESIS; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; GENE INSERTION; GENE THERAPY; HUMAN; HUMAN CELL; MUTAGENESIS; PROVIRUS; RETROVIRUS;

3T3 CELLS; ANIMALS; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; FLOW CYTOMETRY; GENETIC VECTORS; LYMPHOCYTES; MICE; RETROVIRIDAE;

EID: 0033200146     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017112     Document Type: Article

References (50)

1. ARBEIT, J.M. (1996). Transgenic models of epidermal neoplasia and multistage carcinogenesis. Cancer Surv. 26, 7-34.
2. ARMELIN, M.C., JOAZEIRO, C.A., ROCHA, K.M., and ARMELIN, H.A. (1988). Generation of myc/fos transfectant BALB/C-3T3 cell lines. Arch. Biol. Med. Exp. Santiago 21, 429-433.
3. BARBACID, M. (1981). Cellular transformation by subgenomic feline sarcoma virus DNA. J. Virol. 37, 518-523.
4. BLACKMORE, P.F., OAKES, S.G., and SOMERS, K.D. (1992). Altered H1 histamine receptor signalling in BALB/C-3T3 cells transformed by v-k-ras and v-H-ras. Oncogene 7, 2053-2057.
5. CHANG, W.S., HUBBARD, C., FRIEDEL, C., and RULEY, H.E. (1993). Enrichment of insertional mutants following retrovirus gene trap selection. Virology 193, 737-747.
6. CORNETTA, K., MOEN, R.C., CULVER, K., MORGAN, R.A., McLACHLIN, J.R., STURM, S., SELEGUE, J., LONDON, W., BLAESE, R.M., and ANDERSON, W.F. (1990). Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. Hum. Gene Ther. 1, 15-30.
7. CORNETTA, K., MORGAN, R.A., and ANDERSON, W.F. (1991a). Safety issues related to retroviral-mediated gene transfer in humans. Hum. Gene Ther. 2, 5-14.
8. CORNETTA, K., MORGAN, R.A., GILLIO, A., STURM, S., BALTRUCKI, L., O'REILLY, R., and ANDERSON, W.F. (1991b). No retroviremia or pathology in a long-term follow-up of monkeys exposed to a murine amphotropic retrovirus. Hum. Gene Ther. 2, 5-14.
9. DONAHUE, R.E., KESSLER, S.W., BODINE, D., McDONAGH, K., DUNBAR, C., GOODMAN, S., AGRICOLA, B., BYRNE, E., RAFFELD, M., MOEN, R., BACHER, J., ZSEBO, K.M., and NIENHUIS, A.W. (1992). Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J, Exp. Med. 176, 1125-1135.
10. DORSSERS, L.C.J., VAN AGTHOVEN, T., DEKKER, A., VAN AGTHOVEN, T.L.A., and KOK, E.M. (1993). Induction of anti-estrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of bcar-1, a common integration site. Mol. Endocrinol. 7, 870-878.
11. FAN, H. (1997). Leukemogenesis by Moloney murine leukemia virus: A multi-step process. Trends Microbiol. 5, 74-81.
12. GOPAS, J., ONO, M., PRINCLER, G., SMITH, M.R., TAINSKY, M.A., SIDDIQUI, M.A.Q., WISHNIAK, O., SEGAL, S., KUWANO, M., and FUNG, H. (1992). EGF receptor activity and mitogenic response of BALB/3T3 cells expressing ras and myc oncogenes. Cell. Mol. Biol. 38, 605-614.
13. GRAY, D.A. (1991). Insertional mutagenesis: Neoplasia arising from retroviral integration. Cancer Invest. 9(3), 295-304.
14. GROSOVSKY, A.J., SKANDALIS, A., HASEGAWA, L., and WALTER, B.N. (1993). Insertional inactivation of the tk locus in a human B lymphoblastoid cell line by a retroviral shuttle vector. Mutat. Res. 289, 297-308.
15. HAUPT, Y., HARRIS, A.W., and ADAMS, J.M. (1992). Retroviral infection accelerates T lymphomagenesis in Eμ-N-ras transgenic mice by activating c-myc or N-mvc. Oncogene 7, 981-986.
16. HUBBARD, S.C., WALLS, L., RULEY, H.E., and MUCHMORE, E.A. (1994). Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. J. Biol. Chem. 269, 3717-3724.
17. HUNTER, T. (1997). Oncoprotein networks. Cell 88(3), 333-346.
18. ITO, N., HASEGAWA, R., IMAIDA, K., HIROSE, M., ASAMOTO, M., and SHIRAI, T. (1995). Concepts in multistage carcinogenesis. Crit. Rev. Oncol. Hematol. 21, 105-133.
19. JAENISCH, R., BREINDL, M., HARBERS, K., JAHNER, D., and LOHLER, J. (1985). Retroviruses and insertional mutagenesis. Cold Spring Harbor Symp. Quant. Biol. 50, 439-445.
20. JONKERS, J., and BERNS, A. (1996). Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys. Acta 1287, 29-57.
21. KAKUNAGA, T. (1973). A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB-3T3. Int. J. Cancer 12, 463-473.
22. KATOH, F., KLEIN, J.-L., BIGNAMI, M., and YAMASAKI, H. (1993). Association of viral oncogene-induced changes in gap junctional intercellular communication and morphological transformation in BALB/C-3T3 cells. Carcinogenesis 14, 435-440.
23. KING, W., PATEL, M.D., LOBEL, L.I., GOFF, S.P., and NUGYENHUU, M.C. (1985). Insertion mutagenesis of embryonal carcinoma cells by retroviruses. Science 228, 554-558.
24. KOGERMAN, P., SY, M., and CULP, L.A. (1996). CD44 protein levels and its biological activity are regulated in BALB/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J. Cell. Physiol. 169, 341-349.
25. KOTANI, H., NEWTON, P.B., ZHANG, S., CHIANG, Y.L., OTTO, E., WEAVER, L., BLAESE, R.M., ANDERSON, W.F., and Mc-GARRITY, G.J. (1994). Improved methods of retroviral vector transduction and production for gene therapy. Hum. Gene Ther. 5, 19-28.
26. KUNG, H.-J., BOERKOEL, C., and CARTER, T.H. (1991). Retroviral mutagenesis of cellular oncogenes: A review with insights into the mechanisms of insertional activation. Curr. Top. Microbiol. Immunol. 171, 1-25.
27. LIN, W.C., PRETLOW, T.P., PRETLOW, T.G., II, and CULP, L.A. (1992). High-resolution analyses of two different classes of tumor cells in situ tagged with alternative histochemical marker genes. Am. J. Pathol. 141(6), 1331-1342.
28. LIN, W.C., O'CONNOR, K.L., and CULP, L.A. (1993). Complementation of two related tumour cell classes during experimental metastasis tagged with different histochemical marker genes. Br. J. Cancer 67, 910-921.
29. LONG, Z., LI, L.-P., GROOMS, T., LOCKEY, C., NADER, K., MYCHKOVSKY, I., MUELLER, S., BURIMSKI, I., RYAN, P., KIKUCHI, G., ENNIST, D., MARCUS, S., OTTO, E., and McGARRITY, G. (1998). Biosafety monitoring of patients receiving intracerebral injections of murine retroviral vector producer cells. Hum. Gene Ther. 9, 1165-1172.
30. LU, S.J., MAN, S., BANI, M.R., ADACHI, D., HAWLEY, R.G., KERBEL, R.S., and BEN-DAVID, Y. (1995). Retroviral insertional mutagenesis as a strategy for the identification of genes associated with cis-diamminedichloroplatinum(II) resistance. Cancer Res. 55, 1139-1145.
31. LYONS, R.M., FORRY-SCHAUDIES, S., OTTO, E., WEY, C., PATIL-KOOTA, V., KALOSS, M., McGARRITY, C.J., and CHIANG, Y.L. (1995). An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo. Cancer Gene Ther. 2(4), 273-280.
32. MARTINEAU, D., KLUMP, W.M., McCORMACK, J.E., DEPOLO, N.J., KAMANTIGUE, E., PETROWSKI, M., HANLON, J., JOLLY, D.J., MENTO, S.J., and SAJJADI, N. (1997). Evaluation of PCR and ELISA assays for screening clinical trial subjects for replication-competent retrovirus. Hum. Gene Ther. 8, 1231-1241.
33. MATTHEWS, E.J. (1993). Transformation of BALB/C-3T3 cells. I. Investigation of experimental parameters that influence detection of spontaneous transformation. Environ. Health Perspect. 101(Suppl. 2), 277-291.
34. MERCOLA, D., CARPENTER, P.M., GROVER-BARDWICK, A., and MERCOLA, M. (1992). Rapid, complete and reversible transformation by v-sis precedes irreversible transformation. Oncogene 7, 1793-1803.
35. MOOLGAVKAR, S.H., and KNUDSON, A.G., JR. (1981). Mutation and cancer: A model for human carcinogenesis. J. Natl. Cancer Inst. 66(6), 1037-1052.
36. MOSCATELLO, D.K., MONTGOMERY, R.B., SUNDARESHAN, P., McDANEL, H., WONG, M.Y., and WONG, A.J. (1996). Transformation of altered signal transduction by a naturally occurring mutant EGF receptor. Oncogene 13, 85-96.
37. NAKASAWA, H., AGUELON, A.M., and YAMASAKI, H. (1992). Identification and quantification of a carcinogen-induced molecular initiation event in cell transformation. Oncogene 7, 2295-2301.
38. ORLANDINI, M., SEMPLICI, F., FERRUZZI, R., MEGGIO, F., PINNA, L.A., and OLIVIERO, S. (1998). Protein kinase Ck2α' is induced by serum as a delayed early gene and cooperates with Haras in fibroblast transformation. J. Biol. Chem. 273(33), 21291-21297.
39. PETERS, G.J., WETS, M., KEEPERS, Y.P.A.M., OSKAM, R., VAN ARK-OTTE, J., NOORDHUIS, P., SMID, K., and PINEDO, H.M. (1993). Transformation of mouse fibroblasts with the oncogenes H-ras or trk is associated with pronounced changes in drug sensitivity and metabolism. Int. J. Cancer 54, 450-455.
40. RUNDELL, J.O. (1984a). In Carcinogenesis and Mutagenesis Testing. J.F. Douglas, ed. (Humana Press, Totowa, NJ) pp. 39-61.
41. RUNDELL, J.O. (1984b). In Carcinogenesis and Mutagenesis Testing. J.F. Douglas, ed. (Humana Press, Totowa. NJ) pp. 279-285.
42. RUNDELL, J.O., et al. (1983). In Short-Term Bioassays in the Analysis Complex of Environmental Mixtures III. M.D. Waters, et al., eds. (Plenum, New York) pp. 309-327.
43. Val12 oncogene in transformed cell clones. Exp. Cell Res. 168, 518-530.
44. TSICHLIS, P.N. (1987). Oncogenesis by Moloney murine leukemia virus. Anticancer Res. 7, 171-180.
45. TSICHLIS, P.N., and LAZO, P.A. (1991). Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses. Curr. Top. Microbiol. Immunol. 171, 95-171.
46. VANIN, E.F., KALOSS, M., BROSCIUS, C., and NIENHUIS, A.W. (1994). Characterization of replication-competent retroviruses from non-human primates with virus-induced T-cell lymphoma and observations regarding the mechanism of oncogenesis. J. Virol. 68, 4241-4250.
47. VARMUS, H.E., QUINTRELL, N., and ORTIZ, S. (1981). Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell 25, 23-36.
48. VOGELSTEIN, B., and KINZLER, K.W. (1993). The multistep nature of cancer. Trends Genet. 9(4), 138-141.
49. YAMASAKI, H., HOLLSTEIN, M., MESNIL, M., MARTEL, N., and AGUELON, A.M. (1987). Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of BALB/c 3T3 cells. Cancer Res. 47, 5658-5664.
50. YUSPA, S.H., DLUGOSZ, A.A., CHENG, C.K., DENNING, M.F., TENNENBAUM, T., GLICK, A.B., and WEINBERG, W.C. (1994). Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J. Invest. Dermatol. 103, 90S-95S.