Sphingolipid receptor signaling and function in human bladder carcinoma cells: Inhibition of LPA- but enhancement of thrombin-stimulated cell motility

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 1, 2000, Pages 1-11

  Rümenapp, Ulrich ^a   Lümmen, Gerd ^a   Virchow, Sebastian ^a   Hanske, Jan ^a   Meyer Zu Heringdorf, Dagmar ^a   Jakobs, Karl H ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Actin cytoskeleton; Calcium signaling; Cell migration; J82 cells; Phospholipases; Rho GTPases; Sphingolipid receptors; Sphingolipids

Indexed keywords

ACTIN; CALCIUM ION; CELL SURFACE RECEPTOR; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RHO FACTOR; SPHINGOLIPID RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSYLPHOSPHORYLCHOLINE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CARCINOMA; CANCER CELL CULTURE; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; METABOLIC INHIBITION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACTINS; CALCIUM; CARCINOMA; CELL DIVISION; CELL MOVEMENT; CYCLIC AMP; GTP-BINDING PROTEINS; HUMANS; LYSOPHOSPHOLIPIDS; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PHOSPHORYLCHOLINE; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; SPHINGOSINE; THROMBIN; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0033968291     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900159     Document Type: Article

References (38)

1. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997a) Molecular cloning of the human Edg-2 protein and its identification as a functional receptor for lysophosphatidic acid. Biochem Biophys Res Commun 231:619-622
2. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ (1997b) Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett 417:279-282
3. Bornfeldt KE, Graves LM, Raines EW, Igarashi Y, Wayman G, Yamamura S, Yatomi Y, Sidhu SY, Krebs EG, Hakomori S-I, Ross R (1995) Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J Cell Biol 130:193-206
4. Bünemann M, Liliom K, Brandts BK, Pott L, Tseng J-L, Desiderio DM, Sun G, Miller D, Tigyi G (1996) A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. EMBO J 15:5517-5534
5. Gosh TK, Bian J, Gill DL (1990) Intracellular calcium release mediated by sphingosine derivates generated in cells. Science 248: 1653-1656
6. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514
7. Hannun YA, Linardic CM (1993) Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta 1154:223-236
8. Hla T, Maciag T (1990) An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 265:9308-9313
9. Huttenlocher A, Sandborg RR, Horwitz AF (1995) Adhesion in cell migration. Curr Opin Cell Biol 7:697-706
10. Imamura F, Horai T, Mukai M, Shinkai K, Sawada M, Akedo H (1993) Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D. Biochem Biophys Res Commun 193:497-503
11. Keller J, Schmidt M, Hussein B, Rümenapp U, Jakobs KH (1997) Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA. FEBS Lett 403:299-302
12. Lauffenburger DA, Horwitz AF (1996) Cell migration: a physically integrated molecular process. Cell 84:359-369
13. Lee M-J, van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzelev R, Spiegel S, Hla T (1998) Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279:1552-1555
14. Liotta LA, Starcke ML, Aznavoorian SA, Beckner ME, Schiffmann E (1991) Tumour cell motility. Sem Cancer Biol 2:111-114
15. Lümmen G, Virchow S, Rümenapp U, Schmidt M, Wieland T, Otto T, Rübben H, Jakobs KH (1997) Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells. Naunyn-Schmiedeberg's Arch Pharmacol 356:769-776
16. Mattie M, Brooker G, Spiegel S (1994) Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol Chem 269:3181-3188
17. Meyer zu Heringdorf D, van Koppen CJ, Windorfer B, Himmel HH, Jakobs KH (1996) Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. Naunyn-Schmiedeberg's Arch Pharmacol 354:397-403
18. Meyer zu Heringdorf D, van Koppen CJ, Jakobs KH (1997) Molecular diversity of sphingolipid signalling. FEBS Lett 410:34-38
19. 2+ signalling by G-protein-coupled receptors. EMBO J 17:2830-2837
20. Meyer zu Heringdorf D, Niederdräing N, Neumann E, Fröde R, Lass H, van Koppen CJ, Jakobs KH (1998b) Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine. Eur J Pharmacol 354:113-122
21. Moolenaar WH (1995) Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem 270:12949-12952
22. O'Toole C, Price ZH, Ohnuki Y, Unsgaard B (1978) Ultrastructure, karyology and immunology of a cell line originated from a human transitional-cell carcinoma. Br J Cancer 38:64-76
23. Postma FR, Jalink K, Hengeveld T, Moolenaar WH (1996) Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J 15:2388-2395
24. Sadahira Y, Ruan F, Hakamori S-I, Igarashi Y (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc Natl Acad Sci USA 89:9686-9690
25. Sadahira Y, Zheng M, Ruan F, Hakamori S-I, Igarashi Y (1994) Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. FEBS Lett 340:99-103
26. Schmidt M, Hüwe SM, Fasselt B, Homann D, Rümenapp U, Sandmann J, Jakobs KH (1994) Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation. Eur J Biochem 225:667-675
27. Spiegel S, Merrill AH Jr (1996) Sphingolipid metabolism and cell growth regulation. FASEB J 10:1388-1397
28. Spiegel S, Milstien S (1995) Sphingolipid metabolites: members of a new class of lipid second messengers. J Membr Biol 146: 225-237
29. Stossel TP (1993) On the crawling of animal cells. Science 260: 1086-1094
30. Takaishi K, Kikuchi A, Kuroda S, Kotani K, Sasaki T, Takai Y (1993) Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol 13: 72-79
31. Takaishi K, Sasaki T, Kato M, Yamochi W, Kuroda S, Nakamura T, Takeichi M, Takai Y (1994) Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility. Oncogene 9:273-279
32. i-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol 142:229-240
33. i protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J Biol Chem 271:2082-2087
34. Van Roy F, Vareel M (1992) Tumour invasion: effects of cell adhesion and motility. Trends Cell Biol 2:163-169
35. Yamamura S, Sadahira Y, Ruan F, Hakomori S-I, Igarashi Y (1996) Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. FEBS Lett 382:193-197
36. Yamamura S, Yatomi Y, Ruan F, Sweeney EA, Hakomori S-I, Igarashi Y (1997) Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. Biochemistry 36:10751-10759
37. Yatomi H, Ruan F, Hakomori S-I, Igarashi Y (1995) Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. Blood 86:193-202
38. Zondag GCM, Postman FR, van Etten I, Verlaan I, Moolenaar WH (1998) Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem J 330:605-609