Post-transcriptional regulation of E2A proteins via lipopolysaccharide and CD40 signaling

European Journal of Immunology

Volumn 30, Issue 2, 2000, Pages 719-724

  Meyer, Kerstin B ^a,b   Mufti, Dina A H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

B cell; CD40; E2A; Lipopolysaccharide; Post transcriptional regulation

Indexed keywords

CD40 ANTIGEN; LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RIBONUCLEASE PROTECTION ASSAY;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RNA PROCESSING, POST-TRANSCRIPTIONAL; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS;

EID: 0033961340     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200002)30:2<719::AID-IMMU719>3.0.CO;2-5     Document Type: Article

References (29)

1. Murre, C. P., McCaw, P. S. and Baltimore, D., A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, myoD, and myc proteins. Cell 1989. 56: 777-783.
2. Zhuang, Y., Soriano, P. and Weintraub, H., The helix-loop-helix gene E2A is required for B cell formation. Cell 1994. 79: 875-884.
3. Bain, G., Maandag, E. C. R., Izon, D. J., Amsen, D., Kruisbeek, A. M., Weintraub, B. C., Krop, I., Schlissel, M. S., Feeney, A. J., van Roon, M., van der Valk, M., te Rile, J. P. J., Berns, A. and Murre, C., E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994. 79: 885-892.
4. Sigvardsson, M., O'Riordan, M. and Grosschedl, P., EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 1997. 7: 25-36.
5. Bain, G., Maandag, E. R., Riele, H. T., Feeney, A., Sheehy, A., Schlissel, M., Shinton, S. R., H. and Murre, C., Both E12 and E47 allow commitment to the B cell lineage. Immunity 1997, 6: 145-154.
6. Goldfarb, A. N., Flores, J. P. and Lewandowska, K., Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching. J. Exp. Med. 1996. 33: 947-956.
7. Singh, H., Gene targeting reveals a hierarchy of transcription factors regulating specifications of lymphoid cell fates. Curr. Opin. Immunol. 1996. 8: 160-165.
8. Staudt, L. M. and Lenardo, M. J., Immunoglobulin gene transcription. Annu. Rev. Immunol. 1991. 9: 373-398.
9. Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Bushkin, J. N., Hauschka, S. D., Lassar, A. B., Weintraub, H. and Baltimore, D., Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989. 58: 537-544.
10. Murre, C., Voronova, A. and Baltimore, D., B-cell and myocyte-specific E2-box binding factors contain E12/E47 like subunits. Mol. Cell. Biol. 1991. 11: 1156-1160.
11. Bain, G., Gruenwald, S. and Murre, C., E2A and E2-2 are subunits of B-cell specific E2-box DMA-binding proteins. Mol. Cell. Biol. 1993. 13: 3522-3529.
12. Shen, C.-P. and Kadesch, T., B-cell-specific transcription by an E47 homodimer. Mol. Cell. Biol. 1995. 15: 4518-4524.
13. Benezra, R., An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 1994. 79: 1057-1067.
14. Sloan, S. R., Shen, C.-P., McCarrick-Walmsley, R. and Kadesh, T., Phosphorylation of E47 as potential determinant of B-cell-specific activity. Mol. Cell. Biol. 1996. 16: 6900-6908.
15. Wilson, R. B., Kildjian, M., Shen, C. P., Benezra, R., Zwollo, P., Dymecki, S. M., Desiderio, S. V. and Kadesch, T., Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Mol. Cell. Biol. 1991. 11: 6185-6191.
16. Meyer, K. B., Skogberg, M., Margenfeld, C., Ireland, J. and Pettersson, S., Repression of the immunoglobulin heavy chain 3' enhancer by helix-loop-helix protein Id3 via a functionally important E47/E12 binding site: implications for developmental control of enhancer function. Eur. J. Immunol. 1995. 25: 1770-1777.
17. Meyer, K. B., Teh, Y.-M. and Neuberger, M. S., The Ign 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation. Int. Immunol. 1996. 8: 1561-1568.
18. Meyer, K. B., Induction of the Ign 3' enhancer by distinct pathways can be inhibited by cross-linking of the CD40 receptor. Eur. J. Immunol. 1999. 29: 872-877.
19. Pongubala, J. M. R. and Atchison, M. L., Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: Regulation by Id, a represser of helix-loop-helix transcription factors. Mol. Cell. Biol. 1991. 11: 1040-1047.
20. Pongubala, J. M. R., Ngulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A. and Atchison, M. L., PU.1 recruits a second nuclear factor to a site important for immunoglobulin n 3' enhancer activity. Mol. Cell. Biol. 1992. 12: 368-378.
21. Meyer, K. B. and Ireland, J., PMA/ionomycin induces immuno-globulin b3' enhancer activity which is part-mediated by a unique NFAT transcription complex. Eur. J. Immunol. 1998. 28: 1467-1480.
22. Roque, M. C., Smith, P. A. and Blasquez, V. C., A developmentally modulated chromatin structure at the mouse immunoglobulin n3' enhancer. Mol. Cell. Biol. 1996. 16: 3138-3155.
23. Jacobs, Y., Vierra, C. and Nelson, C., E2A expression, nuclear localization and in vivo formation of DNA- and non-DNA binding species during B cell development. Mol. Cell. Biol. 1993. 13: 7321-7333.
24. Rutherford, M. N. and LeBrun, D. P., Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation. Am. J. Pathol. 1998. 153: 165-173.
25. Axcrona, K., Gray, D. and Leanderson, T., Regulation of B cell growth and differentiation via CD21 and CD40. Eur. J. Immunol. 1996. 26: 2203-2207.
26. Meyer, K. B. and Ireland, J., Activation of the immunoglobulin K3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core. Nucleic Acids Res. 1994. 22: 1576-1582.
27. Loveys, D. A., Streiff, M. B., Schaefer, T. S. and Kato, G. J., The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factor. Gene 1997. 201: 169-177.
28. Kho, C. J., Huggins, G. S., Endege, W. O., Hsieh, C. M., Lee, M. E. and Haber, E., Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A. J. Biol. Chem. 1997. 272: 3845-3851.
29. Walker, M. D., Park, C. W., Rosen, A. and Aronheim, A., A cDNA from a mouse pancreatic β cell encoding a putative transcription factor fo the insulin gene. Nucleic Acids Res. 1990. 18: 1159-1166.