The Igκ 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation

International Immunology

Volumn 8, Issue 10, 1996, Pages 1561-1568

  Meyer, Kerstin B ^a,b   Teh, Yih Miin ^c   Neuberger, Michael S ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Allelic exclusion; B cell development; Transcription; Transgenes

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; GENE EXPRESSION; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA-CHAINS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC;

EID: 0029822867     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.10.1561     Document Type: Article

References (42)

1. Staudt, L. M. and Lenardo, M. J. 1991. Immunoglobulin gene transcription. Annu. Rev. Immunol. 9:373.
2. Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. and Neuberger, M. S. 1994. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
3. Meyer, K. B. and Neuberger, M. S. 1989. The immunoglobulin κ locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J. 8:1959.
4. Neuberger, M. S. 1983. Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2:1373.
5. Nishikawa, S.-I., Sasaki, Y., Kina, T., Amagai, T. and Katsura, Y. 1986. A monoclonal antibody against lgh6-4 determinant. Immunogenetics 23:137
6. Springer, T. A., Bhattacharya, A., Cardoza, J. T. and Sanchez-Madrid, F. 1982. Monoclonal antibodies specific for rat lgG1, lgG2a and lgG2b subclasses and κ light chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies. Hybridoma 1:257.
7. Yelton, D. E., Desaymard, C. and Scharff, M. D. 1981. Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies. Hybridoma 1:5.
8. Cooper, M. D., Mulvaney, D., Coutinho, A. and Cazenave, P.-A. 1986. A novel cell-surface molecule on early B-lineage cells. Nature 321:616.
9. Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
10. Meyer, K. B., Sharpe, M. J., Suran, M. A. and Neuberger, M. S. 1990 The importance of the 3′ enhancer region in immunoglobulin κ gene expression. Nucleic Acids Res. 18:5609.
11. Grosveld, F., Blom van Assendelft, G., Greaves, D. R. and Kollias, G. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975.
12. Kitamura, D., Roes, J., Kühn, R. and Rajewksy, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423.
13. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
14. Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H. and Melchers, F. 1994. IL-2 receptor α chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257
15. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W. and Rajewsky, K. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
16. Jack, H.-M. and Wabl, M. 1988. Immunoglobulin mRNA stability varies during B lymphocyte differentiation. EMBO J. 7:1041.
17. Mason, J. O., Williams, G. T. and Neuberger, M. S. 1988. The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. Genes Dev. 2:1003.
18. Leanderson, T. and Hogbom, E. 1991. Regulation of immunoglobulin transcription. Exp. Clin. Immunogenet. 8:75.
19. Yuan, D., Dang, T. Hawley, J., Jenuwein, T. and Grosschedl, R. 1995. Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation. Int. Immunol. 7:1163.
20. Roque, M. C., Smith, P. A. and Blasquez, V. C. 1996. A developmentally modulated chromatin structure at the mouse immunoglobulin κ 3′ enhancer. Mol. Cell. Biol. 16:3138.
21. Grawunder, U., Leu, T. M. J., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F. and Winkler, T. H. 1995. Down-regulation of RAG1 and RAG2 gene expression in pre-B cells after functional immunoglobulin heavy chain rearrangement. Immunity 3:601
22. κ joining. Cell 83:1113.
23. Blasquez, V. C., Xu, M., Moses, S. C. and Garrard, W. T. 1989. Immunoglobulin κ gene expression after stable integration. J. Biol. Chem. 264:21183.
24. Fulton, R. and Van Ness, B. 1993. Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions. Nucleic Acids Res. 21:4941
25. Pongubala, J. M. R. and Atchison, M. L. 1991. Functional characterization of the developmentally controlled immunoglobulin kappa 3′ enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors. Mol. Cell. Biol. 11:1040.
26. Klug, C. A., Gerety, S. J., Shah, P. C., Chen, Y., Rice, N. R., Rosenberg, N. and Singh, H. 1994. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factor and blocks κ gene transcription in pre-B lymphocytes. Genes Dev. 8:678.
27. Muller, B., Stappert, H. and Reth, M. 1990. A physical map and analysis of the murine C kappa-RS region show the presence of a conserved element. Eur. J. Immunol. 20:1409
28. Hole, N. J., Harindranath, N., Young-Cooper, G. O., Garcia, R. and Mage, R. G. 1991. Identification of enhancer sequences 3′ of the rabbit Igκ L chain loci. J. Immunol. 146:4377
29. Meyer, K. B., and Ireland, J. 1994. Activation of the immunoglobulin κ3′ enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core. Nucleic Acids Res. 22:1576.
30. Pongubala, J. M. R. and Atchison, M. L. 1995. Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin κ3′ enhancer. J. Biol. Chem. 270:10304.
31. Pongubala, J. M. R., Ngulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A. and Atchison, M. L. 1992. PU. 1 recruits a second nuclear factor to a site important for immunoglobulin κ3′ enhancer activity. Mol. Cell. Biol. 12:368.
32. Eisenbeis, C. F., Singh, H. and Storb, U. 1995. Pip, a novel IRF family member, is a lymphoid-specific, PU. 1-dependent transcriptional activator. Genes Dev. 9:1377.
33. Judde, J. and Max, E 1992. Characterization of the human immunoglobulin kappa gene 3′ enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprints. Mol. Cell. Biol. 12:5209.
34. Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C. and Maki, R. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113.
35. Murre, C., voronova, A. and Baltimore, D. 1991. B-cell and myocyte-specific E2-box binding factors contain E12/E47 like subunits, Mol. Cell. Biol. 11:1156.
36. Jacobs, Y., Vierra, C. and Nelson, C. 1993. E2A expression, nuclear localization and in vivo formation of DNA- and non-DNA binding species during B cell development. Mol. Cell. Biol. 13:7321
37. Mao, C., Ray-Gallet, D., Tavitian, A. and Moreau-Gachelin, F. 1996. Differential phosphorylations of Spi-B and Spi-1 transcription factors. Oncogene 12:863.
38. Hagemeier, C., Bannister, A. J., Cook, A. and Kouzarides, T. 1993. The activation domain of transcription factor PU.1 binds the retinoblastoma (Rb) protein and the transcription factor TFIID in vitro: Rb shows sequence similarity to TFIID and TFIIB. Proc. Natl Acad. Sci. USA 90:1580.
39. Xie, H., Chiles, T. C. and Rothstein, T. L. 1993. Induction of CREB activity via the surface Ig receptor of B cells J. Immunol. 151:880.
40. Xu, M., Hammer, R. E., Blasquez, V. C., Jones, S. L. and Garrard, W. T. 1989. Immunoglobin κ gene expression after stable integration. J. Biol. Chem. 264:21190.
41. κ rearrangement. Immunity 4:377.
42. Takeda, S., Zou, Y.-R., Bluethmann, H., Kitamura, D., Muller, U. and Rajewsky, K. 1993. Deletion of the immunoglobulin κ chain intron enhancer abolishes κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans. EMBO J. 12:2329.