PMA/ionomycin induces Igχ 3' enhancer activity which is in part mediated by a unique NFAT transcription complex

European Journal of Immunology

Volumn 28, Issue 5, 1998, Pages 1467-1480

  Meyer, Kerstin B ^a,b   Ireland, John ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

light chain; Enhancer; Gene expression; Immunoglobulin; NFAT

Indexed keywords

CYCLOSPORIN A; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; DNA PROTEIN COMPLEX; ENHANCER REGION; FIBROBLAST; GENE EXPRESSION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CELL LINE; CYCLOSPORINE; DNA-BINDING PROTEINS; DRUG SYNERGISM; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IONOMYCIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, ANTIGEN, B-CELL; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0031897908     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199805)28:05<1467::AID-IMMU1467>3.0.CO;2-9     Document Type: Article

References (49)

1. Meyer, K. B., Teh, Y.-M. and Neuberger, M. S., The Ig(greek small letter script kappa) 3′-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation. Int. Immunol. 1996. 8: 1561-1568.
2. German, J. R., van der Stoep, N., Monroe, R., Cogne, M., Davidson, L. and Alt, F. W., The Igx 3′ enhancer influences the ratio of Ig(greek small letter script kappa) versus Igλ B lymphocytes. Immunity 1996. 5: 241-252.
3. Hiramatsu, R., Akagi, K., Matsuoka, M., Sakumi, K., Nakamura, H., Kingsbury, L., David, C., Hardy, R. R., Yamamura, K. and Sakano, H., The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin V(greek small letter script kappa)-J(greek small letter script kappa) joining. Cell 1995. 83: 1113-1123.
4. Sharpe, M. J., Milstein, S., Jarvis, J. M. and Neuberger, M. S., Somatic hypermutation of immunoglobulin (greek small letter script kappa) may depend on sequences 3′ of C(greek small letter script kappa) and occurs on passenger transgenes. EMBO J. 1991. 10: 2139-2145.
5. Rao, A., NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes, Immunol. Today 1994. 15: 274-281.
6. McCaffrey, P. G., Luo, C., Kerppola, T. K., Jain, J., Badalian, T. M., Ho, A. M., Burgeon, E., Lane, W. S., Lambert, J. N., Curren, T., Verdine, G. L., Rao, A. and Hogan, P. G., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 1993. 262: 750-754.
7. Rao, A., Luo, C. and Hogan, P. G., Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 1997. 15: 707-747.
8. Northrop, J. P., Ho, S. N., Chen, L., Thomas, D. J., Timmerman, L. A., No Ian, G. P., Admon, A. and Crabtree, G. R., NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 1994. 369: 497-502.
9. Park, J., Takeuchi, A. and Sharman, S., Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc. J. Biol. Chem. 1996. 271: 20914-20921.
10. Hoey, J. W., Sun, Y-L., Williamson, K. and Xu, X., Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 1995. 2: 461-472.
11. Masuda, E. S., Naito, Y., Tokumitsu, H., Campbell, D., Saito, F., Hannum, C., Arai, K.-I, and Arai, N., NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell. Biol. 1995. 15: 2697-2706.
12. Ho, S. N., Thomas, D. J., Timmerman, L. A., Li, X., Francke, U. and Crabtree, G. R., NFATc3, a lymphoid-specific NFATc family member that is calcium regulated and exhibits distinct DNA binding specificity. J. Biol. Chem. 1995. 270: 19898-19907.
13. Jain, J., Burgeon, E., Badalian, T. M., Hogan, P. G. and Rao, A., A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J. Biol. Chem. 1995. 270: 4138-4145.
14. Venkataraman, L., Francis, D. A., Wang, Z., Liu, J., Rothstein, T. L. and Sen, R., Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity 1994. 1: 189-196.
15. Choi, M. S. K., Brines, R. D., Holman, M. J. and Klaus, G. G. B., Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1994. 1: 179-187.
16. Weiss, D. L., Hural, J., Tara, D., Timmerman, L. A., Henkel, G. and Brown, M. A., Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex. Mol. Cell. Biol., 1996. 16: 228-235.
17. Ho, A. M., Jain, J., Rao, A. and Hogan, P. G., Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J. Biol. Chem. 1994. 269: 28198-12201.
18. Loh, C., Shaw, K. T.-Y., Carew, J., Viola, J. P. B., Luo, C., Perrino, B. A. and Rao, A., Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 1996. 271: 10884-10891.
19. Crabtree, G. R. and Clipstone, N. A., Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 1994. 63: 1045-1083.
20. Verweij, C. L., Guidos, C. and Crabtree, G. R., Cell type specificity and activation requirements for NF-AT-1 transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J. Biol. Chem. 1990. 265: 15788-15795.
21. Francis, D. A., Karras, J. G., Ke, X., Sen, R. and Rothstein, T. ., Induction of the transcription factors NF-(greek small letter script kappa)B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol. 1995. 7: 151-161.
22. Chiles, T. C. and Rothstein, T. L., Surface Ig receptor-induced nuclear AP-1-dependent gene expression in B lymphocytes. J. Immunol. 1992. 149: 825-831.
23. Kunkl, A. and Klaus, G. G. B., Selective effects of cyclosporin A on functional B cell subsets in the mouse. J. Immunol. 1980. 125: 2526-2531.
24. Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C. and Maki, R., The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 1990. 61: 113-124.
25. Fisher, R. J., Mavrothalassitis, G., Kondoh, A. and Papas, T. S., High-affinity DNA-protein interactions of the cellular ETS1 protein: the determination of the ETS binding motif. Oncogene 1991. 6: 2249-2254.
26. Boise, L. H., Petryniak, B., Mao, X., June, C. H., Wang, C.-Y., Lindsten, T., Bravon, R., Kovary, K., Leiden, J. M. and Thompson, C. B., The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol. Cell. Biol. 1993. 13: 1911-1919.
27. Yaseen, N. R., Park, J., Kerpopola, T., Curran, T. and Sharma, S., A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly. Mol. Cell. Biol. 1994. 14: 6886-6895.
28. Rooney, J. W., Hoey, T. and Glimcher, L. H., Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 1995. 2: 473-483.
29. Huo, L. and Rothstein, T. L., Receptor-specific induction of individual AP-1 components in B lymphocytes. J. Immunol. 1995. 154: 3300-3309.
30. Meyer, K. B., Sharpe, M. J., Surani, M. A. and Neuberger, M. S., The importance of the 3′ enhancer region in immunoglobulin (greek small letter script kappa) gene expression. Nucleic Acids Res. 1990. 18: 5609-5615.
31. Pongubala, J. M. R. and Atchison, M. L., Functional characterization of the developmentally controlled immunoglobulin kappa 3′ enhancer: regulation by ld, a repressor of helix-loop-helix transcription factors. Mol. Cell. Biol. 1991. 11: 1040-1047.
32. Duncliffe, K. N., Bert, A. G., Vadas, M. A. and Cockerill, P. N., AT cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site. Immunity 1997. 6: 175-185.
33. Hole, N., Hardindranath, N., Young-Cooper, G., Garcia, R. and Mage, R., Identification of enhancer sequences 3′ of the rabbit Ig (greek small letter script kappa)L chain loci. J. Immunol. 1991. 146: 4377-4384.
34. (greek small letter script kappa)-RS region show the presence of a conserved element. Eur. J. Immunol. 1990. 20: 1409-1411.
35. Pongubala, J. M. R., Ngulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A. and Atchison, M. L., PU.1 recruits a second nuclear factor to a site important for immunoglobulin (greek small letter script kappa) 3′ enhancer activity. Mol. Cell. Biol. 1992. 12: 368-378.
36. Pongubala, J. M. R. and Atchison, M. L., Activating transcription factor 1 and cyclic AMP respose element modulator can modulate the activity of the immunoglobulin (greek small letter script kappa)3′ enhancer. J. Biol. Chem. 1995. 270: 10304-10313.
37. Roque, M. C., Smith, P. A. and Blasquez, V. C., A developmentally modulated chromatin structure at the mouse immunoglobulin (greek small letter script kappa)3′ enhancer. Mol. Cell. Biol. 1996. 16: 3138-3155.
38. Park, K. and Atchison, M. L., Isolation of a candidate repressor/activator, NF-E1 (YY-1, δ), that binds to the immunoglobulin (greek small letter script kappa) 3′ enhancer and the immunoglobulin heavy-chein μE1 site. Proc. Natl. Acad. Sci. USA 1991. 88: 9804-9808.
39. Meyer, K. B. and Ireland, J., Activation of the immunoglobulin (greek small letter script kappa)3′ enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core. Nucleic Acids Res. 1994. 22: 1576-1582.
40. Costa, M. W. and Atchison, M. L., Identification of an Sp1-like element within the immunoglobulin kappa 3′ enhancer necessary for maximal enhancer activity. Biochemistry 1996. 35: 8662-8669.
41. Goyenechea, B., Klix, N., Yelamos, J., Williams, G. T., Ridded, A., Neuberger, M. S. and Milstein, C., Cells strongly expressing Ig(greek small letter script kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J. 1997. 16: 3987-3994.
42. Shaffer, A. L., Peng, A. and Schlissel, M. S., In vivo occupancy of the (greek small letter script kappa) light chain enhancers in primary pro-and pre-B cells: a model for (greek small letter script kappa) locus activation. Immunity 1997. 6: 131-143.
43. Klaus, G. G. B. and Hawrylowicz, C. M., Activation and proliferation signals in mouse B cells II. Evidence of activation (G0 to G1) signals differing in sensitivity to cyclosporine. Eur. J. Immunol. 1984. 14: 250-254.
44. Cantrell, D., T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 1996. 14: 259-274.
45. Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanatephenol chloroform extraction. Anal. Biochem. 1987. 162: 156-159.
46. Schreiber, E., Matthias, P., Müller, M. M. and Schaffner, W., Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 1989. 17: 6419.
47. Meyer, K. B. and Neuberger, M. S., The immunoglobulin (greek small letter script kappa) locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J. 1989. 8: 1959-1964.
48. Grant, P. A., Arulampalam, V., Ahrlund-Richter, L. and Pettersson, S., Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3′ enhancer. Nucleic Acids. Res. 1992. 17: 4401-4408.
49. Grant, P. A., Thompson, C. B. and Pettersson, S., IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function. EMBO J. 1995. 14: 4501-4513.