High incidence of allelic loss on chromosome 5 and inactivation of p15(INK4B) and p16(INK4A) tumor suppressor genes in oxystress-induced renal cell carcinoma of rats

Oncogene

Volumn 18, Issue 25, 1999, Pages 3793-3797

  Tanaka, Tomoyuki ^a   Iwasa, Yoko ^a   Kondo, Shohei ^a   Hiai, Hiroshi ^a   Toyokuni, Shinya ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Loss of heterozygosity; Methylation; Oxidative stress; p15(INK4B); p16(INK4A); Rat; Renal cell carcinoma

Indexed keywords

NITRILOTRIACETATE IRON; PROTEIN P15; PROTEIN P16;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHROMOSOME 5; CONTROLLED STUDY; DNA METHYLATION; GENE INACTIVATION; HETEROZYGOSITY LOSS; KIDNEY CARCINOMA; MARKER GENE; METASTASIS; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CARCINOGENS; CARCINOMA, RENAL CELL; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, PAIR 5; CPG ISLANDS; CROSSES, GENETIC; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, NEOPLASM; FERRIC COMPOUNDS; GENE DELETION; GENES, P16; GENES, TUMOR SUPPRESSOR; HUMANS; KIDNEY NEOPLASMS; KIDNEY TUBULES, PROXIMAL; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; NITRILOTRIACETIC ACID; OXIDATIVE STRESS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RATS; RATS, WISTAR; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0033600115     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202707     Document Type: Article

References (21)

1. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W, Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho KR, Hedrick L, Bova GS, Isaacs W, Koch W, Schwab D and Sidransky D. (1995a). Nat. Genet., 11, 210-212.
2. Cairns P, Tokino K, Eby Y and Sidransky D. (1995b). Cancer Res., 55, 224-227.
3. Ebina Y, Okada S, Hamazaki S, Ogino F, Li J-L and Midorikawa O. (1986). J. Natl. Cancer Inst., 76, 107-113.
4. Halliwell B and Aruoma OI. (1993). In: DNA and free radicals, Ellis Horwood Ltd., Chichester, England.
5. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB. (1996a). Proc. Natl. Acad. Sci. USA, 93, 9821-9826.
6. Herman JG, Jen J, Merlo A and Baylin SB. (1996b). Cancer Res., 56, 722-727.
7. Hino O, Mitani H, Katsuyama H and Kubo Y. (1994). Cancer Lett., 83, 117-121.
8. Hino O, Kobayashi E, Hirayama Y, Kobayashi T, Kubo Y, Tsuchiya H, Kikuchi Y and Mitani H. (1995). Mol. Carcinog., 14, 23-27.
9. Knapek DF, Serrano M, Beach D, Trono D and Walker CL. (1995). Cancer Res., 55, 1607-1612.
10. Knudson Jr AG, Hethcote HW and Brown BW. (1975). Proc. Natl. Acad. Sci. USA, 72, 5116-5120.
11. McBride TJ, Preston BD and Loeb LA. (1991). Biochemistry, 30, 207-213.
12. Nishiyama Y, Suwa H, Okamoto K, Fukumoto M, Hiai H and Toyokuni S. (1995). Jpn. J. Cancer Res., 86, 1150-1158.
13. Osaka M, Matsuo S, Koh T, Liang P, Kinoshita H, Maeda S and Sugiyama T. (1995). Cancer Lett., 91, 25-31.
14. Schwerdtle RF, Störkel S, Neuhaus C, Brauch H, Weidt E, Brenner W, Hohenfellner R, Huber C and Decker HJ. (1996). Cancer Res., 56, 2927-2930.
15. Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG and Belinsky SA. (1997). Mol. Cell. Biol., 17, 1366-1374.
16. Toyokuni S and Sagripanti J-L., (1993). Carcinogenesis, 14, 223-227.
17. Toyokuni S, Mori T and Dizdaroglu M. (1994a). Int. J. Cancer, 57, 123-128.
18. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H and Stadtman ER. (1994b). Proc. Natl. Acad. Sci. USA, 91, 2616-2620.
19. Toyokuni S. (1996). Free Radic. Biol. Med., 20, 553-566.
20. Toyokuni S, Okada K, Kondo S, Nishioka H, Tanaka T, Nishiyama Y, Hino O and Hiai H. (1998). Jpn. J. Cancer Res., 89, 814-820.
21. Toyokuni S. (1999). Pathol. Int., 49, 91-102