Ki-ras point mutation in different types of colorectal carcinomas in early stages

Diseases of the Colon and Rectum

Volumn 40, Issue 2, 1997, Pages 161-167

  Kojima, M ^a   Konishi, F ^a   Tsukamoto, T ^a   Yamashita, K ^a   Kanazawa, K ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Colorectal carcinoma; early stage; Heterogeneity; Ki ras point mutation; Tumorigenesis

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CARCINOGENESIS; CLINICAL ARTICLE; COLORECTAL CARCINOMA; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; ONCOGENE K RAS; POINT MUTATION; RECTUM POLYP;

ADENOCARCINOMA; ADENOMATOUS POLYPS; AGED; CODON; COLON; COLORECTAL NEOPLASMS; DNA, NEOPLASM; FEMALE; GENES, RAS; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; POINT MUTATION; POLYMERASE CHAIN REACTION; RECTUM;

EID: 0031019760     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02054981     Document Type: Article

References (29)

1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
3. Kinzler KW, Nilbert MC, Vogelstein B, et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 1991;251: 1366-70.
4. Kinzler KW, Nilbert MC, Su L-K, et al. Identification of FAP locus genes from chromosome 5q21. Science 1991; 253:661-5.
5. Nishisho I, Nakamura Y, Miyoshi Y, et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991;253:665-9.
6. Baker S, Fearon E, Nigro J, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989;244:217-21.
7. Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247:49-56.
8. Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987;327:293-7.
9. Wolber RA, Owen DA. Flat adenoma of the colon. Hum Pathol 1991;22:70-4.
10. Laurent-Puig P, Olschwang S, Delattre O, et al. Association of Ki-ras mutation with differentiaton and tumor-formation pathways in colorectal carcinoma. Int J Cancer 1991;49:220-3.
11. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 1987;327: 298-302.
12. Miyaki M, Seki M, Okamoto M, et al. Genetic changes and histological types in colorectal tumors from patients with familial adenomatous polyposis. Cancer Res 1990; 50:7166-73.
13. Burmer GC, Loeb LA. Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proc Natl Acad Sci U S A 1989;86:2403-7.
14. Ando M, Maruyama M, Oto M, Takemura K, Endo M, Yuasa Y. Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas. Jpn J Cancer Res 1991;82:245-9.
15. Adachi M, Muto T, Morioka Y, Ikenaga T, Kara M. Flat adenoma and flat mucosal carcinoma (IIb type) - a new precursor of colorectal carcinoma? Report of two cases. Dis Colon Rectum 1988;31:236-43.
16. Kuramoto S, Oohara T. Flat early cancers of the large intestine. Cancer 1989;64:950-5.
17. Herrera L, Hanna S, Castillo N, Petrelli NJ. Primary de novo adenocarcinoma of the colon measuring 8 mm in diameter with lymph node metastases: report of a case. Dis Colon Rectum 1991;34:275-9.
18. Kudo S. Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy 1993;25:455-61.
19. Matsumoto T, Iida M, Yao T, Fujishima M. Role of nonpolypoid neoplastic lesions in the pathogenesis of colorectal cancer. Dis Colon Rectum 1994;37:450-5.
20. Tada S, Yao T, Iida M, Koga H, Hizawa K, Fujishima M. A clinicopathologic study of small flat colorectal carcinoma. Cancer 1994;74:2430-5.
21. Kuramoto S, Oohara T. Minute cancers arising de novo in the human large intestine. Cancer 1988;61:829-34.
22. Shimoda T, Ikegami M, Fujisaki J, Matsui T, Aizawa S, Ishikawa E. Early colorectal carcinoma with special reference to its development de novo. Cancer 1989;64: 1138-46.
23. Hermanek P, Sobin LH, UICC. TNM classification of malignant tumors. 4th ed. Berlin: Springer-Verlag, 1987.
24. Yanagisawa A, Kato Y, Ohtake K, et al. c-ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 1991;82: 1057-60.
25. Soh K, Yanagisawa A, Hiratsuka H, Sugano H, Kato Y. Variation in K-ras codon 12 point mutation with histological atypia within individual colorectal tumors. Jpn J Cancer Res 1993;84:388-93.
26. Saiki RK, Scharf S, Faloona F, et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985;230:1350-4.
27. Verlaan-de Vries M, Bogaard ME, van den Elst H, van Boom JH, van der Eb AJ, Bos JL. A dot blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. Gene 1986;50:313-20.
28. Shibata D, Schaeffer J, Li Z-H, Capella G, Perucho M. Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinoma. J Natl Cancer Inst 1993;85:1058-62.
29. Yamagata S, Muto T, Uchida Y, et al. Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenoma. Jpn J Cancer Res 1994;85: 147-51.